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Δευτέρα 15 Μαΐου 2017

Obesity and Weight Control: Is There Light at the End of the Tunnel?

Abstract

Purpose of Review

Our global population recently arrived at the landmark figure of seven billion, and the nutrition problems we face are increasing as rapidly, with the longstanding crisis of undernutrition joined by the escalating problem of overconsumption and obesity. Over the past 30 years, it has become clear that control of body weight is as simple as matching energy intake to expenditure, yet how to achieve this in the current obesigenic environment is far from simple. A review of causative mechanisms shows controlling eating behaviour and food intake as central to regulation of body weight, but in an environment where the need to suppress intake is uppermost, there are few physiological mechanisms with which to tackle this.

Recent Findings

Macronutrient composition, energy density, food format (beverages), palatability, portion size and hedonics all influence intake and readily promote overeating. Currently, the most successful obesity treatment is restrictive bariatric surgery, both invasive and expensive, achieving better outcomes than diet and exercise. Despite considerable advances, there remains a critical gap in translation of underpinning knowledge into successful public health outcomes, as recently outlined in the 2nd Lancet series in obesity with no country reporting decreased obesity prevalence in the last 30 years.

Summary

Future contribution may come from better understanding of mechanisms including gut-brain axis and regulation of appetite, the gut microbiome and the genetic underpinning of bodyweight control. Clearly, prevention is the key, with nutrition education required to lead changes in behaviour, and possibly the only viable long-term approach. Whether the global obesity trend can be reversed without significant change in national food policies and/or the built environment however is under debate, and without doubt a major public health challenge for tomorrow if there is to be light at the end of the obesity tunnel.



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Induction of Cellular Differentiation and Single Cell Imaging of Vibrio parahaemolyticus Swimmer and Swarmer Cells

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This protocol enables single cell microscopy of the differentially distinct Vibrio parahaemolyticus swimmer and swarmer cells. The method produces a population of swarmer cells easily available for single cell analysis and covers preparation of cell cultures, induction of swarmer differentiation, sample preparation, and image analysis.

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Will it be cheese, bologna, or peanut butter?



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The combined association of alcohol consumption with dementia risk is likely biased due to lacking account of death cases



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The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer

Abstract

Ovarian cancer (OC) is one of the three types of malignant tumors in the female reproductive system, and epithelial ovarian cancer (EOC) is its most typical form. Due to the asymptomatic nature of the early stages and resistance to chemotherapy, EOC has both a poor prognosis and a high fatality rate. Current treatments for OC are very limited, and the 5-years survival rate is approximately 30%. Exosomes, which are microvesicles ranging from approximately 30–100 nm in size that are secreted by living cells, can be produced from different cell types and detected in various body fluids. Cancer cells can secrete more exosomes than healthy cells, and more importantly, the content of cancer cell-derived exosomes is distinct. The exosomes shedding from tumor cells are considered to be involved in tumor progression and metastasis. As such, exosomes are expected to be potential tools for tumor diagnosis and treatment. In this review, we briefly present the emerging roles of exosomes in OC and summarize related articles about their roles as diagnostic or prognostic biomarkers and in the treatment and drug resistance of OC.



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Single-Center Experience Using the 3MAX Reperfusion Catheter for the Treatment of Acute Ischemic Stroke with Distal Arterial Occlusions

Abstract

Purpose

Most recent guidelines recommend the use of stent retriever devices in endovascular treatment of acute ischemic stroke with large vessel occlusion (LVO). Recently published data reported convincing results with thromboaspiration devices such as the Penumbra System (Penumbra, Alameda, CA, USA) combined with supple reperfusion catheters by using the ADAPT (A Direct Aspiration First-Pass Thrombectomy) technique. The aim of this study was to report our initial experience with the 3MAX (3.8 F) reperfusion catheter for the recanalization of distal intracranial arteries.

Methods

From August 2015 to December 2016, 32 consecutive patients (16 females, 50%; mean age = 67.4 ± 18.7 years, range: 22–91) for 38 distal occlusions underwent mechanical thrombectomy (MT) by thromboaspiration using the 3MAX. Median NIHSS score at admission was 14 (IQR: 9–19). Distal occlusions were distributed as follows: M2 (n: 23), M3 (n: 6), P1 (n: 3), P2 (n: 2), P3 (n: 2), A3 segment (n: 1) and superior cerebellar artery (n: 1).

Results

In 1/38 (2.6%) target artery, the 3MAX could not be navigated. Of the 37 (59.5%) remaining arteries, 22 were successfully reperfused (TICI 2b/3) after ADAPT with the 3MAX alone. Additional stent retriever thrombectomy allowed a 76.3% final reperfusion rate. Good functional outcome (mRS ≤2) was obtained in 45.5% of patients at 3 months. Three (9.4%) 3MAX-related complications occurred: 2 emboli to new territory (ENT) and one vascular perforation.

Conclusions

The 3MAX is well-navigable in distal arteries making it useful as a frontline technique. However, the reperfusion rate with the 3MAX catheter alone seems lower than the ones reported with stent retrievers for such distal occlusions.



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Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens & anti-proliferative activity against cancer cell line

Emerging drug resistance and hindrance of treatment is provoking scientists to search new, less expensive medicinally active compounds. Dental diseases caused by oral pathogens are very frequent chronic infect...

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