Αρχειοθήκη ιστολογίου

Αναζήτηση αυτού του ιστολογίου

Παρασκευή 19 Ιουλίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


JAMA Otolaryngology
Author Interview: Tinnitus Retraining Therapy vs Standard of Care and Tinnitus-Related Quality of LifeVIEWPOINTThe Search for and Conduct of the Elusive Phase 3 Randomized Clinical Trial: Snipe Hunting With the MilitaryCraig Formby, PhD; Roberta W. Scherer, PhDInvited Commentary: Role of the US Department of Defense Hearing Center of Excellence in Studying the Treatment of Tinnitus; Tanisha L. Hammill, PhD; Carlos R. Esquivel, MDORIGINAL INVESTIGATIONEffect of Tinnitus Retraining Therapy vs Standard...
Αλέξανδρος Γ. Σφακιανάκης
4m
MASP-1 of the complement system alters fibrinolytic behaviour of blood clots Publication date: October...
MASP-1 of the complement system alters fibrinolytic behaviour of blood clotsPublication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Lorenz Jenny, Danilo Noser, Julie Brogaard Larsen, József Dobó, Péter Gál, Gábor Pál, Verena SchroederAbstractBackgroundThe lectin pathway serine protease mannan-binding lectin-associated serine protease 1 (MASP-1) has been demonstrated to be a major link between complement and coagulation, yet little is known about its interactions with the...
Αλέξανδρος Γ. Σφακιανάκης
6m
The Early–Middle Ordovician graptolite genus Azygograptus in South China: New material and paleogeographic...
The Early–Middle Ordovician graptolite genus Azygograptus in South China: New material and paleogeographic implicationsPublication date: 1 November 2019Source: Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 533Author(s): Wenhui Wang, Linna Zhang, Hao Liu, Xin Deng, Jingqiang TanAbstractThis study presents a new analysis of three species of the Ordovician graptolite genus Azygograptus Nicholson & Lapworth from the Wenxiakou section in the Zhongxiang area of Hubei Province. The paleogeographic...
Αλέξανδρος Γ. Σφακιανάκης
7m
Direct evidence for agricultural intensification during the first two millennia AD in northeast Burkina...
Direct evidence for agricultural intensification during the first two millennia AD in northeast Burkina FasoPublication date: August 2019Source: Journal of Archaeological Science, Volume 108Author(s): Amy K. Styring, Alexa Höhn, Veerle Linseele, Katharina NeumannAbstractArchaeobotanical evidence from archaeological sites in northeast Burkina Faso dating to the first and second millennia AD has provided a useful insight into crop cultivation and the development of the West African savanna landscape....
Αλέξανδρος Γ. Σφακιανάκης
7m
Thromboelastography testing in mice following blood collection from facial vein and cardiac puncture...
Thromboelastography testing in mice following blood collection from facial vein and cardiac punctureBlood collection is critical for mouse research studies particularly in hemostatic testing. Cardiac puncture; a standard effective method requires anesthesia and is a terminal procedure while facial vein technique allows multiple collections. Thromboelastography (TEG) is a global hemostasis test, provides a dynamic real-time picture of coagulation. However, TEG experiments in mice require large number...
Αλέξανδρος Γ. Σφακιανάκης
8m
Efficacy and Safety of Low-dose Codeine Containing Combination Analgesics for Pain: Systematic Review...
Efficacy and Safety of Low-dose Codeine Containing Combination Analgesics for Pain: Systematic Review and Meta-analysis,Objective: To investigate the efficacy and safety of combination analgesic products containing low-dose codeine (up to 30▒mg per dose) for pain. Methods: We used electronic databases to identify eligible placebo-controlled RCTs. Two authors extracted data and assessed risk of bias. Data were pooled using a random effects model with strength of evidence assessed using GRADE. The...
Αλέξανδρος Γ. Σφακιανάκης
10m
Photodermatology, Photoimmunology & Photomedicine, Volume 35, Issue 4,Pages: 199-292, July 2019...
Photodermatology, Photoimmunology & Photomedicine,Volume 35, Issue 4,Pages: 199-292,July 2019ISSUE INFORMATIONIssue InformationPages: 199-200 | First Published: 17 July 2019ORIGINAL ARTICLES Open AccessPhotoaging and actinic keratosis in Danish outdoor and indoor workersKasper Grandahl, Jonas Olsen, Kersti Brosbøl Engelund Friis, Ole Steen Mortensen, Kristina Sophie IblerPages: 201-207 | First Published: 28 January 2019Long‐term efficacy of photodynamic therapy with methyl aminolevulinate in...
Αλέξανδρος Γ. Σφακιανάκης
11m
Anaphylaxis in adolescents, Purpose of review The frequency of hospitalization for anaphylaxis has increased...
Anaphylaxis in adolescents,Purpose of review The frequency of hospitalization for anaphylaxis has increased over the last 20 years across Europe, Australia, and North America, particularly, for food and medication triggers. Adolescents show the highest risk for morbidity and fatality from food-induced anaphylaxis, yet there is little high-quality evidence addressing the reasons for this disproportionate vulnerability. Recent findings Recent data seem to suggest a possible increasing burden of food-induced...
Αλέξανδρος Γ. Σφακιανάκης
11m
Wound Repair and Regeneration, Early View, Online Version of Record before inclusion in an issue ...
Wound Repair and Regeneration,Early View,Online Version of Record before inclusion in an issueImmunomodulatory potential of Nisin A with application in wound healingMichelle V. Mouritzen PhD, Athina Andrea PhD, Katrine Qvist MSc, Steen S. Poulsen PhD, Håvard Jenssen ScDVersion of Record online: 09 July 2019Wound Repair and RegenerationAccepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.Non‐invasive Staging...
Αλέξανδρος Γ. Σφακιανάκης
14m
Key role of inferior turbinectomy and partial middle turbinectomy in endoscopic surgery for allergic...
Key role of inferior turbinectomy and partial middle turbinectomy in endoscopic surgery for allergic fungal sinusitis: A comparative study,Ahmad Mostafa, Wael A Alzamil, Essam Fatehy, Mohammad M GaballahJournal of Medicine in Scientific Research 2019 2(1):65-70Background Proper eradication of allergic fungal sinusitis (AFS) depends on three factors: first is proper preoperative evaluation and mapping via computed tomography and MRI. Second is the availability of adequate surgical tools in experienced...
Αλέξανδρος Γ. Σφακιανάκης
15m
Medicine in Scientific Research
The use of microplates for fixation of mandibular fractures: a systematic reviewMagdy M Zaky, Nabila A Fayed, Mohamed F Shehab, Usama S HellalJournal of Medicine in Scientific Research 2019 2(1):1-7Background Microplates have thin diameter making them less palpable, more malleable, easily applied, and adaptable to fracture site. In the past, microplates were used in midface fractures only, but we can obtain their benefits in mandibular fractures as well. Objective The aim of this systematic review...
Αλέξανδρος Γ. Σφακιανάκης
16m
Cardiovascular Medicine
A meta-analysis of impact of low-flow/low-gradient aortic stenosis on survival after transcatheter aortic valve implantationAims To determine whether low-flow/low-gradient (LF/LG) aortic stenosis affects survival after transcatheter aortic valve implantation (TAVI), we performed a meta-analysis of currently available studies. Methods MEDLINE and EMBASE were searched through January 2019 using PubMed and OVID. Observational studies comparing all-cause mortality after TAVI for patients with classical...
Αλέξανδρος Γ. Σφακιανάκης
17m
Curative effect of aqueous extract of Cyperus esculentus on flutamide-induced testicular dysfunction
 in male Wistar ratsLuqman Adepoju Hassan, Godson Emeka Anyanwu, Nto Johnson Nto, Emmanuel Nebuwa Obikili, Elizabeth Finbarrs-Bello, L Ifeanacho Ezeteonu AbirehJournal of Experimental and Clinical Anatomy 2018 17(1):13-17BACKGROUND: The health of the testis is important for a man's sexual functioning and fertility. This study investigated the effect of aqueous extract of Cyperus esculentus on flutamide-induced testicular dysfunction in male Wistar rats. MATERIALS AND METHODS: Sixteen adult male Wistar...
Αλέξανδρος Γ. Σφακιανάκης
19m
Morphological effects of chronic administration of zidovudine on the intracranial auditory relay centers...
Morphological effects of chronic administration of zidovudine on the intracranial auditory relay centers of adult Wistar ratsPatrick Sunday Igbigbi, Josiah O Adjene, Kingsley Afoke Iteire, Babatunde Samson OgunladeJournal of Experimental and Clinical Anatomy 2018 17(1):8-12BACKGROUND: Zidovudine is one of the very active antiretroviral treatments which have been effective in several combination regimens for the treatment of HIV disease. Widely accepted theories have recognized that such treatment...
Αλέξανδρος Γ. Σφακιανάκης
20m
Experimental and Clinical Anatomy
Hepatoprotective effect of methanol fruit pulp extract of Musa paradisiaca on carbon tetrachloride-induced liver toxicity in Wistar ratsMustapha Tosin Issa, Abel Nosereme Agbon, Sadiya Ufeli Balogun, Onesimus Mahdi, Khadijat Abubakar Bobbo, Felix Olu AyegbusiJournal of Experimental and Clinical Anatomy 2018 17(1):1-7CONTEXT: Musa paradisiaca (Banana) fruit pulp has been used in folk medicine to treat various kinds of ailments, such as dysentery, diarrhea, bronchitis, ulcer, fevers, and hemorrhages...
Αλέξανδρος Γ. Σφακιανάκης
21m
19th Internarional Symposium of ISTU 5th European Symposium of EUFUS Barcelona 2019 | 13th - 15th...
19th Internarional Symposium of ISTU5th European Symposium of EUFUSBarcelona 2019 | 13th - 15th JuneABSTRACT BOOK ORGANIZING COMMITEEScientific Organizing CommitteeRobin Cleveland, Co-Chair Vera Khokhlova, Co-ChairLocal Organizing CommitteeJoan Vidal-Jové, ChairEUFUS Organizing CommitteeAndreas Melzer, Co-Chair Wladyslaw Gedroyc Alessandro Napoli Matthias Matzko Lisa Landgraf ISTUJoo Ha Hwang, President Kim Butts Pauly, Secretary General Jean-François Aubry Gail ter Haar Thursday, June 13th 2019Friday,...
Αλέξανδρος Γ. Σφακιανάκης
22m
Investigation of Complications Following Port Insertion in a Cancer Patient Population: A Retrospective...
Investigation of Complications Following Port Insertion in a Cancer Patient Population: A Retrospective AnalysisWilliam Paul Skelton, IV1, Aaron J Franke1, Samantha Welniak1, Raphael C Bosse1, Fares Ayoub1, Martina Murphy2, Jason S Starr2First Published April 24, 2019.https://doi.org/10.1177/1179554919844770AbstractHide PreviewAbstractCentral venous access devices, specifically implantable ports, play an essential role in the care of oncology patients; however, complications are prevalent. This retrospective...
Αλέξανδρος Γ. Σφακιανάκης
29m
Follicular Dendritic Cell Sarcoma or Not? A Series of 5 Diagnostically Challenging Cases Nicolas Lopez-Hisijos,...
Follicular Dendritic Cell Sarcoma or Not? A Series of 5 Diagnostically Challenging CasesNicolas Lopez-Hisijos, Reeba Omman, Stefan Pambuccian, Kamran MirzaFirst Published May 23, 2019.https://doi.org/10.1177/1179554919844531AbstractHide PreviewAbstractImperfect or unusual presentation, morphology, or immunophenotype can make the diagnosis of follicular dendritic cell sarcoma (FDCS) very challenging. To illustrate this, we present 5 unique cases from the archives of our tertiary care academic medical...
Αλέξανδρος Γ. Σφακιανάκης
29m
Improvement of Chemotherapy Solutions Production Procedure in a Hospital Central Chemotherapy Preparation...
Improvement of Chemotherapy Solutions Production Procedure in a Hospital Central Chemotherapy Preparation Unit: A Systematic Risk Assessment to Prevent Avoidable Harm in Cancer PatientsKlio Bourika1, Angelos Koutras2, Haralambos Kalofonos2, Anna Vicha3, Ekaterini Tsiata4, Evangelia Papadimitriou1, Konstantinos Avgoustakis5, Zoi Panagi4AbstractObjective:This study was designed to reevaluate and improve the quality and safety of the chemotherapy preparation in a Central Chemotherapy Preparation Unit...
Αλέξανδρος Γ. Σφακιανάκης
29m
The Nephroprotective Effect of Mannitol in Head and Neck Cancer Patients Receiving Cisplatin Therapy...
The Nephroprotective Effect of Mannitol in Head and Neck Cancer Patients Receiving Cisplatin TherapyErik Hägerström1, Lotte Lindberg2, Jens Bentzen3, Kasper Brødbæk4, Bo Zerahn2, Bent Kristensen2Introduction:Cisplatin is used as treatment for several different malignancies and a well-known complication is irreversible kidney damage. To protect the kidneys, this treatment is often combined with mannitol infusion to promote osmotic diuresis. Earlier studies investigating the nephroprotective effect...
Αλέξανδρος Γ. Σφακιανάκης
31m
Correlation Between the Sites of Onset of Basal Cell Carcinoma and the Embryonic Fusion Planes in the...
Correlation Between the Sites of Onset of Basal Cell Carcinoma and the Embryonic Fusion Planes in the AuricleGiovanni Nicoletti123, Marco Mario Tresoldi13, Alberto Malovini4, Sebastien Prigent1, Manuela Agozzino5, Angela Faga236AbstractObjectives:This study aims at the identification of the distribution of basal cell carcinomas (BCCs) in the auricle in correlation with the currently most credited sites of the embryonic fusion planes of the auricle.Methods:An overall number of 69 patients with 72...
Αλέξανδρος Γ. Σφακιανάκης
32m
A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review, Yanling Zhang12, Heng...
A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review,Yanling Zhang12, Heng Tang2, Huaiyuan Hu2, Xiang Yong2AbstractPrimary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Frozen sections showed a spindle cell tumor of the thyroid gland. The nuclei of some of the tumor cells were obviously enlarged and deeply stained....
Αλέξανδρος Γ. Σφακιανάκης
33m
Clinical Medicine Insights: Oncology
Articles 1 – 20 of 343Original ResearchOpen AccessEpidemiological Determinants of Advanced Prostate Cancer in Elderly Men in the United StatesJinani Jayasekera1, Eberechukwu Onukwugha2, Christopher Cadham1, Sarah Tom3, Donna Harrington4, Michael Naslund5First Published June 26, 2019.https://doi.org/10.1177/1179554919855116AbstractHide PreviewAbstractIn this study, we examined the effects of individual-level and area-level characteristics on advanced prostate cancer diagnosis among Medicare eligible...
Αλέξανδρος Γ. Σφακιανάκης
33m
Pain management and prescribing practices in otolaryngology residency programs☆, Author links open overlay...
Pain management and prescribing practices in otolaryngology residency programs☆,Author links open overlay panelJaclynKlimczakArvindBadheyAnniWongPatrickColleyMaritaTengDepartment of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USAReceived 12 May 2019, Available online 18 July 2019.Show lesshttps://doi.org/10.1016/j.amjoto.2019.07.009Get rights and contentAbstractPurposeTo understand the knowledge, competency and influencing factors regarding postoperative...
Αλέξανδρος Γ. Σφακιανάκης
36m
WHAT CAN PHYSICS AND MODELLING DO FOR NEUROSURGEONS AND NEUROLOGISTS? J.-F. Aubry1 1Physics for Medicine...
WHAT CAN PHYSICS AND MODELLING DO FOR NEUROSURGEONS AND NEUROLOGISTS? J.-F. Aubry1 1Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Paris, France e-mail: jean-francois.aubry@espci.fr OBJECTIVES This talk will give an overview of the underlying physics and modelling for transcranial brain therapy. METHODS Due to the increased defocusing effect of the human skull with increasing frequency, transcranial focusing techniques divide into two groups: (i) the use of very low...
Αλέξανδρος Γ. Σφακιανάκης
39m
CONTRIBUTION TO THERAPEUTIC ULTRASOUND. BRIEF OVERVIEW L.R. Gavrilov Acoustics Institute, Moscow, Russia,...
CONTRIBUTION TO THERAPEUTIC ULTRASOUND. BRIEF OVERVIEWL.R. GavrilovAcoustics Institute, Moscow, Russia, e-mail: lrgavrilov@gmail.comBelow is a short list of contributions to therapeutic ultrasound made with my participation. 1971. Research on the use of HIFU for local ablation of deep brain structures was initiated in theSoviet Union. (Together with the Brain Institute, Academy of Medical Sciences of the USSR). 1972-1973. The possibility of ablating deep brain structures through an intact human...
Αλέξανδρος Γ. Σφακιανάκης
40m
A HEALTHY FUTURE FOR FOCAL CONFORMAL THERAPEUTIC ULTRASOUND W.A. N'Djin1 1 LabTAU, INSERM, Centre Léon...
A HEALTHY FUTURE FOR FOCAL CONFORMAL THERAPEUTIC ULTRASOUND W.A. N'Djin1 1 LabTAU, INSERM, Centre Léon Bérard, Université Lyon 1, Univ Lyon, F-69003, Lyon, France e-mail: apoutou.ndjin@inserm.fr Therapeutic ultrasound is in constant evolution. Focal/conformal strategies are now often sought after to improve the patient care, but their development remains challenging and requires bringing together new solutions. In open surgery, we proposed an unconventional toroidal focusing strategy for USgHIFU...
Αλέξανδρος Γ. Σφακιανάκης
40m
EXPLODING DROPLETS AND SINGING BUBBLES IN THERAPEUTIC ULTRASOUND K. J. Haworth1,2 1 Department of Internal...
EXPLODING DROPLETS AND SINGING BUBBLES IN THERAPEUTIC ULTRASOUND K. J. Haworth1,2 1 Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA 2 Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA e-mail: hawortkn@ucmail.uc.edu Though widely used clinically for diagnostic imaging, microbubbles also provide a rich opportunity for inducing bioeffects, both intended and unintended. Phase-change agents that take advantage of acoustic droplet vaporization...
Αλέξανδρος Γ. Σφακιανάκης
40m
TOWARDS AN INCREASED CLINICAL IMPACT OF FOCUSED ULTRASOUND Chrit Moonen Imaging Division, University...
TOWARDS AN INCREASED CLINICAL IMPACT OF FOCUSED ULTRASOUNDChrit MoonenImaging Division, University Medical Center, The NetherlandsE-mail C.Moonen@umcutrecht.nlHIFU is a disruptive, minimally invasive, therapeutic technology in medicine, and its historyfollows the nature cycle from the inventive stage, technical developments, preclinical andclinical applications. Following early promise by the Fry brothers, the advent of imageguidance and many technical refinements, clinical applications started with...
Αλέξανδρος Γ. Σφακιανάκης
41m
MRgFUS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS: A CLINICAL UPDATE Raul Martinez Fernandez, Centro...
MRgFUS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS: A CLINICAL UPDATE Raul Martinez Fernandez, Centro Integral en Neurociencias A.C. (HM CINAC), Madrid e-mail: rmartinez.hmcinac@hmhospitales.com Since the first studies using MRgFUS for the treatment of essential tremor came out in 2013, its applications for neurological diseases have progressively increased. Today, MRgFUS thalamotomy is a FDA-approved treatment for both essential and parkinsonian tremors and some evidence suggests that it can also...
Αλέξανδρος Γ. Σφακιανάκης
41m
Prostate Cancer Salvage Surgery, Ablation Offer Similar Outcomes, Jody A. Charnow, Editor AUA 2017,...
Prostate Cancer Salvage Surgery, Ablation Offer Similar Outcomes,Jody A. Charnow, EditorAUA 2017, doctors performing surgery, prostate cancer, biopsy, prostate biopsy, prostate surgeryRadical prostatectomy and ablation for salvage treatment of radiorecurrent prostate cancer do not differ significant with regard to cancer-specific and metastasis-free survival, a study found.Salvage radical prostatectomy (SRP) and salvage ablation (SA) therapies for localized recurrence of prostate cancer following...
Αλέξανδρος Γ. Σφακιανάκης
42m
Fishy approach to treating brain tumors
Researchers say lampreys might hold the key to getting mammalian brain tissue to accept chemotherapy drugs.source-imageJun 25, 2019By Brendan Howard, Business Channel DirectorDVM360 MAGAZINERostislav/stock.adobe.comIt's a rare veterinarian who would see a lamprey in practice, but researchers at the University of Wisconsin-Madison and University of Texas at Austin are digging into some of the animal's antigen receptors to explore a new path to treating cancer in the brain.What's a lamprey again?Lampreys,...
Αλέξανδρος Γ. Σφακιανάκης
43m
Ultrasound and Microbubbles Used to Penetrate the Blood-Brain Barrier, JUNE 27TH, 2019  MEDGADGET EDITORS MATERIALS, NEUROLOGY, NEUROSURGERY, ONCOLOGY, RADIOLOGY...
Ultrasound and Microbubbles Used to Penetrate the Blood-Brain Barrier,JUNE 27TH, 2019  MEDGADGET EDITORS MATERIALS, NEUROLOGY, NEUROSURGERY, ONCOLOGY, RADIOLOGYWhile the blood-brain barrier (BBB) protects the brain from infections, it also makes it difficult to get drugs that treat neurological conditions to where they're needed. Now, researchers at Columbia University have shown that their ultrasound technique can open up the BBB and allow for the delivery of therapeutic proteins and genes into...
Αλέξανδρος Γ. Σφακιανάκης
43m
Celsion (CLSN) Granted IRB Approval to Commence Clinical Study of ThermoDox Plus High Intensity Focused...
Celsion (CLSN) Granted IRB Approval to Commence Clinical Study of ThermoDox Plus High Intensity Focused Ultrasound,Celsion Corporation (NASDAQ: CLSN), an oncology drug-development company, announces that the University Medical Center Utrecht in the Netherlands has received Institutional Review Board (IRB) approval to begin a Phase I study to determine the safety, tolerability and feasibility of ThermoDox® (lyso-thermosensitive liposomal doxorubicin) in combination with Magnetic Resonance Guided High...
Αλέξανδρος Γ. Σφακιανάκης
44m
FOCUSED ULTRASOUND FOR THE TREATMENT OF ESSENTIAL TREMOR TARGETING THE VENTRALIS INTERMEDIUS NUCLEUS AND THE ZONA INCERTA
Research Spotlight: New Targets in Treating Essential Tremor ,A team in London has developed a new method for treating essential tremor patients involving ablating two areas in the brain. READ MORE >BEYOND THE THALAMUS - UNILATERAL MR GUIDED FOCUSED ULTRASOUND FORTHE TREATMENT OF ESSENTIAL TREMOR TARGETING THE VENTRALISINTERMEDIUS NUCLEUS AND THE ZONA INCERTAA.J. Jameel1, P.G. Bain2, D Nandi1, B Jones1, O Kirmi1, W Gedroyc11Imperial College NHS Healthcare Trust, London. 2Imperial College of Science...
Αλέξανδρος Γ. Σφακιανάκης
47m
CarThera's low-intensity pulsed ultrasound device, the SonoCloud, is designed to temporarily open the blood-brain barrier (BBB), potentially improving the penetration of therapeutic agents into the brain to increase efficacy.
FDA Approves New Focused Ultrasound Trial to Treat Deadly Brain Tumors ,French manufacturer, CarThera, recently announced that the US Food & Drug Administration (FDA) has granted approval to begin a US clinical trial of their SonoCloud-9 ultrasound device in patients with recurrent glioblastoma (GBM).READ MORE >CARTHERA RECEIVES FDA APPROVAL FOR PHASE 1/2A TRIAL IN GLIOBLASTOMASonoCloud ultrasound device for glioblastoma patients will be tested for first time at US clinical sitesCategory:...
Αλέξανδρος Γ. Σφακιανάκης
50m
Critique, Tweaked,Tom Perrin Critique, Tweaked Guilty Aesthetic Pleasures , Timothy Aubry. Harvard...
Critique, Tweaked,Tom PerrinCritique, TweakedGuilty Aesthetic Pleasures , Timothy Aubry. Harvard University Press, 2018.Paraliterary: The Making of Bad Readers in Postwar America , Merve Emre. Chicago University Press, 2017.Guilty Pleasures: Popular Novels and American Audiences in the Long Nineteenth Century , Hugh McIntosh. University of Virginia Press, 2018.Elements of Surprise: Our Mental Limits and the Satisfactions of Plot , Vera Tobin. Harvard University Press, 2018.Tom PerrinAmerican Literary...
Αλέξανδρος Γ. Σφακιανάκης
50m
Projected number of people with onchocerciasis-loiasis co-infection in Africa, 1995 to 2025,  Natalie...
Projected number of people with onchocerciasis-loiasis co-infection in Africa, 1995 to 2025,  Natalie V S Vinkeles Melchers; Luc E Coffeng; Michel Boussinesq ; Belén Pedrique; Sébastien D S Pion ...
Αλέξανδρος Γ. Σφακιανάκης
52m
Trauma and Acute Care Surgery
Helmet Use is Associated with Higher Injury Severity Scores in Alpine Skiers and Snowboarders Evaluated at a Level 1 Trauma CenterBackground There is uncertainty regarding the efficacy of ski helmets in preventing traumatic injury. We investigated the relationship between helmet use, injury types and injury severity among skiers and snowboarders. Methods The trauma registry at a Northeast ACS Level 1 trauma center was queried by ICD 9/10-code for skiing and snowboarding injury between 2010 and 2018....
Αλέξανδρος Γ. Σφακιανάκης
53m

The power of mantis shrimp strikes: interdisciplinary impacts of an extreme cascade of energy release,  S...
The power of mantis shrimp strikes: interdisciplinary impacts of an extreme cascade of energy release,  S N Patek 
Αλέξανδρος Γ. Σφακιανάκης
55m
Pitfalls of a Shared Neuraxial Space: Wandering Epidural Catheter,  Rani A. Sunder, M.D.; Eric J. Monroe,...
Pitfalls of a Shared Neuraxial Space: Wandering Epidural Catheter, Rani A. Sunder, M.D.; Eric J. Monroe, M.D.; Sean H. Flack, M.B., Ch.B., F.C.A.Anesthesiology Published online July 17, 2019. doi:10.1097/ALN.0000000000002900Newly PublishedImages in Anesthesiology  |   July 2019Pitfalls of a Shared Neuraxial Space: Wandering Epidural CatheterRani A. Sunder, M.D.; Eric J. Monroe, M.D.; Sean H. Flack, M.B., Ch.B., F.C.A. Author NotesFrom the Department of Anesthesiology and Pain Medicine (R.A.S., S.H.F.),...
Αλέξανδρος Γ. Σφακιανάκης
57m
Anesthesiology
CorrespondenceCrystalloid/Colloid Renal and Disability Outcomes: CommentReuven Pizov, M.D.; Simon Gelman, M.D., Ph.D.Anesthesiology Published online July 17, 2019. doi:10.1097/ALN.0000000000002873Crystalloid/Colloid Renal and Disability Outcomes: ReplyAlexandre Joosten, M.D., Ph.D.; Joseph Rinehart, M.D.; Philippe Van der Linden, M.D., Ph.D.Anesthesiology Published online July 17, 2019. doi:10.1097/ALN.0000000000002874Images in AnesthesiologyPitfalls of a Shared Neuraxial Space: Wandering Epidural...
Αλέξανδρος Γ. Σφακιανάκης
58m
Quantitative Brain Sodium MRI Depicts Corticospinal Impairment in Amyotrophic Lateral Sclerosis Aude-Marie...
Quantitative Brain Sodium MRI Depicts Corticospinal Impairment in Amyotrophic Lateral SclerosisAude-Marie Grapperon, Ben Ridley, Annie Verschueren, Adil Maarouf, Sylviane Confort-Gouny, Etienne Fortanier, Lothar Schad, Maxime Guye, Jean-Philippe Ranjeva,  … Show all AuthorsAuthor AffiliationsFrom the Aix Marseille University, CRMBM, UMR CNRS 7339, 27 Boulevard Jean Moulin, 13005 Marseille, France (A.M.G., B.R., A.V., A.M., S.C., E.F., M.G., J.P.R., W.Z.); APHM, Hôpital de la Timone, Referral Centre...
Αλέξανδρος Γ. Σφακιανάκης
59m
Contrast-enhanced chest and abdominopelvic CT and/or whole-body fluorine 18 fluorodeoxyglucose PET/CT for initial staging, as well as for recurrence of suspected primary central nervous system lymphoma, had a low diagnostic yield.
Primary Central Nervous System Lymphoma: Diagnostic Yield of Whole-Body CT and FDG PET/CT for Initial Systemic ImagingChong Hyun Suh, Ho Sung Kim , Ji Eun Park, Seung Chai Jung, Choong Gon Choi, Sang Joon KimAuthor AffiliationsFrom the Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Olympic-ro 33, Seoul 05505, Republic of Korea.Address correspondence to H.S.K. (e-mail: radhskim@gmail.com).Published Online:Jun 25 2019https://doi.org/10.1148/radiol.2019190133See...
Αλέξανδρος Γ. Σφακιανάκης
59m
Inferior Vena Cava Thrombosis in Behçet Disease, Furkan Ufuk Author Affiliations From Pamukkale University,...
Inferior Vena Cava Thrombosis in Behçet Disease,Furkan Ufuk Author AffiliationsFrom Pamukkale University, School of Medicine, Department of Radiology, 20070, Denizli, Turkey.Address correspondence to F.U. (e-mail: furkan.ufuk@hotmail.com).Published Online:Jun 18 2019https://doi.org/10.1148/radiol.2019190351
Αλέξανδρος Γ. Σφακιανάκης
1h
Breast Imaging,          Influence of Mammography Volume on Radiologists' Performance: Results...
Breast Imaging,        Influence of Mammography Volume on Radiologists' Performance: Results from BreastScreen NorwaySolveig Roth Hoff, Tor-Åge Myklebust...Solveig HofvindEditorial: Optimizing Breast Cancer Screening Programs: Experience and StructuresRobert D. Rosenberg, David SeidenwurmMammography, US, and MRI to Assess Outcomes of Invasive Breast Cancer with Extensive Intraductal Component: A Matched Cohort StudySu Min Ha, Joo Hee Cha...Hak Hee KimEditorial: Breast Cancer: Let Imaging Be Our Guide...
Αλέξανδρος Γ. Σφακιανάκης
1h
Radiology
Review Imaging Diagnosis and Follow-up of Advanced Prostate Cancer: Clinical Perspectives and State of the Art Raquel Perez-Lopez, Nina Tunariu...Dow-Mu KohImages in Radiology Large Intussusception after Total GastrectomySo Hyun Kang, Sang-Hoon AhnInferior Vena Cava Thrombosis in Behçet Disease Furkan UfukOriginal ResearchBreast Imaging Influence of Mammography Volume on Radiologists' Performance: Results from BreastScreen NorwaySolveig Roth Hoff, Tor-Åge Myklebust...Solveig HofvindEditorial: Optimizing...
Αλέξανδρος Γ. Σφακιανάκης
1h
Imaging findings of subcutaneous human dirofilariasis, Author links open overlay panelSyed IntakhabAlamMDaPankajNepalMDbSong...
Imaging findings of subcutaneous human dirofilariasis,Author links open overlay panelSyed IntakhabAlamMDaPankajNepalMDbSong ChiLucAhmedElramadidJoshua M.SapireMDeaHamad Medical Corporation, Doha, QatarbSt. Vincent's Medical Center, Bridgeport, CT, USAcFrank H. Netter MD School of Medicine, North Haven, CT, USAdHamad Medical Corporation, Doha, QatareSt. Vincent's Medical Center, Bridgeport, CT, USAAvailable online 12 July 2019.Show lesshttps://doi.org/10.1067/j.cpradiol.2019.07.001Get rights and contentAbstractDirofilariasis...
Αλέξανδρος Γ. Σφακιανάκης
1h
Current Problems in Diagnostic Radiology
How many radiographs does it take to screen for femoral cam morphology?: A non-inferiority studyPublication date: Available online 12 July 2019Source: Current Problems in Diagnostic RadiologyAuthor(s): Tony T. Wong, Joanna K. Weeks, Firas S. Ahmed, Mark A. Francescone, Michael J. Rasiej, Michael Z. Liu, Jonathan K. KazamAbstractPurposeTo compare a 2-view radiograph series (AP of the pelvis and 45° Dunn of the hip) with a 5-view radiograph series for sensitivity in identifying femoral cam morphology.Materials...
Αλέξανδρος Γ. Σφακιανάκης
1h
"Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem...
"Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell-specific chemokine recruitment of T cells and microglia", Guo et al. 2019, Neuro-Oncology  Marlene Arzt; Michelle Monje
Αλέξανδρος Γ. Σφακιανάκης
1h
Otology & Neurotology
Speech Perception Growth Patterns in Prelingual Deaf Children With Bilateral Sequential Cochlear ImplantationObjective: To evaluate speech perception following the first (CI-1) and second (CI-2) cochlear implantation (CI) in children with sequential bilateral CI. Study Design: Retrospective. Patients: Seventy children with follow-up for 60 months post CI-1 and 36 months post CI-2. Main Outcome Measures: Word recognition score (WRS) was the main outcome. WRSs were compared by age at CI operation (group...
Αλέξανδρος Γ. Σφακιανάκης
1h
Antimicrobial resistance three ways: healthcare crisis, major concepts, and the relevance of biofilms,  Paula...
Antimicrobial resistance three ways: healthcare crisis, major concepts, and the relevance of biofilms,  Paula Jorge; Andreia Patrícia Magalhães; Tânia Grainha; Diana Alves ; Ana Margarida Sousa ...
Αλέξανδρος Γ. Σφακιανάκης
1h
Weaving Chiapas: Maya Women's Lives in a Changing World. Edited by Yolanda Castro Apreza, Charlene M....
Weaving Chiapas: Maya Women's Lives in a Changing World. Edited by Yolanda Castro Apreza, Charlene M. Woodcock, and A.C. K'inal Antsetik,  Daisy R Herrera  Nothing to Speak of: Wartime Experiences of the Danish Jews 1943-1945. By Sofie Lene Bak  Frances E Davey
Αλέξανδρος Γ. Σφακιανάκης
1h
The Resilience of Religion in American Higher Education. By John Schmalzbauer and Kathleen A. Mahoney,  Perry...
The Resilience of Religion in American Higher Education. By John Schmalzbauer and Kathleen A. Mahoney,  Perry L Glanzer  The Holy Roman Empire. A Short History. By Barbara Stollberg-Rilinger. Translated and with a Preface by Yair Mintzker  Joachim Whaley  Armenian Christians in Iran: Ethnicity, Religion and Identity in the Islamic Republic. By James Barry  Houri Berberian  Pope Eugenius III (1145-1153): The First Cistercian Pope. Edited by Iben Fonnesberg-Schmidt and Andrew Jotischky  Katharine Sykes  Dagger...
Αλέξανδρος Γ. Σφακιανάκης
1h
Guidelines for Adult Stroke Rehabilitation and Recovery,   Michelle Gittler, MD1; Andrew M. Davis,...
Guidelines for Adult Stroke Rehabilitation and Recovery, Michelle Gittler, MD1; Andrew M. Davis, MD, MPH2Author Affiliations Article Information1Schwab Rehabilitation Hospital, Chicago, Illinois2University of Chicago, Chicago, IllinoisJAMA. 2018;319(8):820-821. doi:10.1001/jama.2017.22036Guideline title Guidelines for Adult Stroke Rehabilitation and RecoveryDeveloper American Heart Association (AHA)/American Stroke Association (ASA)Release date May 4, 2016Prior version 2005Funding source AHATarget...
Αλέξανδρος Γ. Σφακιανάκης
1h
JAMA
Guidelines for Adult Stroke Rehabilitation and RecoveryVIEWPOINTElectronic Fetal Monitoring to Prevent Fetal Brain Injury: A Ubiquitous Yet Flawed ToolEmmet Hirsch, MDJAMA CLINICAL GUIDELINES SYNOPSISManagement of Patients With Acute Ischemic StrokeJames R. Brorson, MD; Adam S. Cifu, MDTRENDING NOW ON JAMA NETWORK OPENAssociation of Preterm Birth With Social Relationships in AdulthoodAndrogen Deprivation Therapy and Dementia Diagnosis in Men With Prostate CancerAssociation of Cardiorespiratory Fitness...
Αλέξανδρος Γ. Σφακιανάκης
1h
Adding voxel-based color maps of initial and final 90-second time-signal intensity areas under the curve from dynamic contrast-enhanced MR imaging to conventional MR imaging increases the diagnostic accuracy to detect local recurrence in head and neck squamous cell carcinoma by improving the specificity without sacrificing the sensitivity.
Detection of Local Recurrence in Patients with Head and Neck Squamous Cell Carcinoma Using Voxel-Based Color Maps of Initial and Final Area under the Curve Values Derived from DCE-MRIJ.Y. Lee, K.L. Cheng, J.H. Lee, Y.J. Choi, H.W. Kim, Y.S. Sung, S.R. Chung, K.H. Ryu, M.S. Chung, S.Y. Kim, S.-W. Lee and J.H. BaekAmerican Journal of Neuroradiology July 2019, DOI: https://doi.org/10.3174/ajnr.A6130ArticleFigures & DataSupplementalInfo & MetricsReferences PDFThis article requires a subscription...
Αλέξανδρος Γ. Σφακιανάκης
1h
Distal Balloon Angioplasty of Cerebral Vasospasm Decreases the Risk of Delayed Cerebral Infarction M.-A....
Distal Balloon Angioplasty of Cerebral Vasospasm Decreases the Risk of Delayed Cerebral InfarctionM.-A. Labeyrie, S. Gaugain, G. Boulouis, A. Zetchi, J. Brami, J.-P. Saint-Maurice, V. Civelli, S. Froelich and E. HoudartAmerican Journal of Neuroradiology July 2019, DOI: https://doi.org/10.3174/ajnr.A6124ArticleFigures & DataSupplementalInfo & MetricsReferences PDFThis article requires a subscription to view the full text. If you have a subscription you may use the login form below to view...
Αλέξανδρος Γ. Σφακιανάκης
1h
Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis...
Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal MeningitisS.F. Kralik, M.K. Kukreja, M.J. Paldino, N.K. Desai and J.G. VallejoAmerican Journal of Neuroradiology July 2019, DOI: https://doi.org/10.3174/ajnr.A6134ArticleFigures & DataInfo & MetricsReferences PDFThis article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.AbstractBACKGROUND...
Αλέξανδρος Γ. Σφακιανάκης
1h

Pediatrics Online eFirst Pages, (for the period 17 Jul 2019 to 18 July 2019) Article Neighborhood...
Pediatrics Online eFirst Pages,(for the period 17 Jul 2019 to 18 July 2019)ArticleNeighborhood Social Conditions, Family Relationships, and Childhood AsthmaEdith Chen, Robin Hayen, Van Le, Makeda K. Austin, Madeleine U. Shalowitz, Rachel E. Story and Gregory E. MillerCase ReportThe Challenge of Treating Pulmonary Vasculitis in Behçet Disease: Two Pediatric CasesSelcan Demir, Erdal Sag, Ummusen Kaya Akca, Tuncay Hazirolan, Yelda Bilginer and Seza OzenSpecial ArticleCognitive and Behavioral Impact...
Αλέξανδρος Γ. Σφακιανάκης
1h
Molecular and Cellular Endocrinology
Acetylation modulates thyroid hormone receptor intracellular localization and intranuclear mobilityPublication date: 15 September 2019Source: Molecular and Cellular Endocrinology, Volume 495Author(s): Cyril S. Anyetei-Anum, Rochelle M. Evans, Amanda M. Back, Vincent R. Roggero, Lizabeth A. AllisonAbstractThe thyroid hormone receptor (TR) undergoes nucleocytoplasmic shuttling, but is primarily nuclear-localized and mediates expression of genes involved in development and homeostasis. Given the proximity...
Αλέξανδρος Γ. Σφακιανάκης
1h
Uterus globulin associated protein 1 (UGRP1) is a potential marker of progression of Graves' disease...
Uterus globulin associated protein 1 (UGRP1) is a potential marker of progression of Graves' disease into hypothyroidism,Publication date: 20 August 2019Source: Molecular and Cellular Endocrinology, Volume 494Author(s): Zheng Zhou, Chun-Lin Zuo, Xue-Song Li, Xiao-Ping Ye, Qian-Yue Zhang, Ping Wang, Rong-Xin Zhang, Gang Chen, Jia-Lin Yang, Yue Chen, Qin-Yun Ma, Huai-Dong SongAbstractApproximately 20% of Graves' disease (GD) patients may result eventually in hypothyroidism in their natural course....
Αλέξανδρος Γ. Σφακιανάκης
1h
Clinical Immunology
The protective effect of interfering TLR9-IRF5 signaling pathway on the development of CVB3-induced myocarditisPublication date: October 2019Source: Clinical Immunology, Volume 207Author(s): Shu Nie, Boqi Dong, Shuang Gao, Yan Zhou, Wenting Lu, Mingli Fang, Shucheng Hua, Yongli Yu, Liying WangAbstractSince toll-like receptor 9 (TLR9) or interferon regulatory factor 5 (IRF5) was reported to be associated with the development of myocarditis, we wondered if the TLR9-IRF5 pathway could contribute to...
Αλέξανδρος Γ. Σφακιανάκης
1h
Evaluation of the frequency of invariant natural killer T (iNKT) cells in nasal polyps, Publication...
Evaluation of the frequency of invariant natural killer T (iNKT) cells in nasal polyps,Publication date: August 2019Source: Clinical Immunology, Volume 205Author(s): Mohammad Fereidouni, Afshin Derakhshani, Simon Yue, Saeed Nasseri, Reza Farid Hosseini, Mehdi Bakhshaee, Fatemeh Vahidian, Mark A. ExleyAbstractNasal polyps (NP) are associated with inflamed mucosa of unknown etiology. The role of T cells in nasal polyposis is unclear. Invariant natural killer T cells (iNKT) can promote Th2 responses...
Αλέξανδρος Γ. Σφακιανάκης
1h
Molecular Testing for Indeterminate Thyroid Nodules—When the Rubber Meets the Road Jennifer L. Marti, MD1; Ashok...
Molecular Testing for Indeterminate Thyroid Nodules—When the Rubber Meets the RoadJennifer L. Marti, MD1; Ashok R. Shaha, MD2Author Affiliations Article Information1Department of Surgery, Endocrine & Breast Surgery, Weill Cornell Medical Center, New York, New York2Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New YorkJAMA Otolaryngol Head Neck Surg. Published online July 18, 2019. doi:10.1001/jamaoto.2019.1465related articles icon RelatedArticlesIn...
Αλέξανδρος Γ. Σφακιανάκης
1h
Saline Irrigation and Topical Nasal Steroids Janalee K. Stokken, MD Article Information JAMA Otolaryngol...
Saline Irrigation and Topical Nasal SteroidsJanalee K. Stokken, MDArticle InformationJAMA Otolaryngol Head Neck Surg. Published online July 18, 2019. doi:10.1001/jamaoto.2019.1713View LargeDownloadWhy Your Physician Recommends Nasal IrrigationNasal irrigation with salt water (saline) is also called nasal wash, rinse, douche, or lavage. This is often recommended by physicians to reduce the frequency and severity of the symptoms associated with inflammation of the nose owing to allergies or other causes....
Αλέξανδρος Γ. Σφακιανάκης
1h
Plasmablastic Lymphoma of the Nasal Septum Jonathan N. Perkins, DO1,2; Anthony W. Chi, MD3; Nitinkumar...
Plasmablastic Lymphoma of the Nasal SeptumJonathan N. Perkins, DO1,2; Anthony W. Chi, MD3; Nitinkumar J. Patel, MD2Author Affiliations Article Information1Department of Otolaryngology–Head & Neck Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland2Department of Otolaryngology–Head & Neck Surgery, Kaiser Permanente–Mid Atlantic Permanente Group, Falls Church, Virginia3Department of Pathology, Kaiser Permanente Mid Atlantic, Regional Laboratory, Rockville, MarylandJAMA...
Αλέξανδρος Γ. Σφακιανάκης
1h
A Case of Childhood Hearing Loss, Lauren Buck, MD1; Kandice C. Bailey1; Jeffery D. Carron, MD1 Author...
A Case of Childhood Hearing Loss,Lauren Buck, MD1; Kandice C. Bailey1; Jeffery D. Carron, MD1Author Affiliations Article Information1Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, JacksonJAMA Otolaryngol Head Neck Surg. Published online July 18, 2019. doi:10.1001/jamaoto.2019.1701CaseAn 8-year-old boy accompanied by his mother presented with hearing loss. The patient failed a school-administered hearing screening as well as a subsequent hearing...
Αλέξανδρος Γ. Σφακιανάκης
1h
American Journal of Neuroradiology, Publication Preview articles for 18 July 2019 HEAD & NECK...
American Journal of Neuroradiology,Publication Preview articles for 18 July 2019HEAD & NECKDetection of Local Recurrence in Patients with Head and Neck Squamous Cell Carcinoma Using Voxel-Based Color Maps of Initial and Final Area under the Curve Values Derived from DCE-MRIJ.Y. Lee, K.L. Cheng, J.H. Lee, Y.J. Choi, H.W. Kim, Y.S. Sung, S.R. Chung, K.H. Ryu, M.S. Chung, S.Y. Kim, S.-W. Lee and J.H. BaekAJNR Am J Neuroradiol first published on 18 July 2019 doi:10.3174/ajnr.A6130http://www.ajnr.org/content/early/2019/07/18/ajnr.A6130.abstractINTERVENTIONALA...
Αλέξανδρος Γ. Σφακιανάκης
1h
The Need for Routine Assessment of Masseter Function After Masseteric Nerve Harvest With the Borschel...
The Need for Routine Assessment of Masseter Function After Masseteric Nerve Harvest With the Borschel Method,Elena Pescarini, MD1,2; Catriona Neville, BSc1; Tamsin Gwynn, BSc1; et al Karen Young, BSc1; Lekha Chandrasekharan, FRCR, DNB(Radiodiagnosis)3; Charles Nduka, MA(Oxon), MD, FRCSEng, FRCS(Plast)1; Ruben Yap Kannan, MB, MRCSEd, PhD, FRCS(Plast), Dip(Otol)HNS1Author Affiliations Article Information1Facial Palsy Unit, Queen Victoria Hospital, East Grinstead, United Kingdom2Department of Plastic...
Αλέξανδρος Γ. Σφακιανάκης
1h
JAMA Otolaryngology–Head & Neck Surgery
ORIGINAL INVESTIGATIONComparison of Postmarketing Findings vs the Initial Clinical Validation Findings of a Thyroid Nodule Gene Expression Classifier: A Systematic Review and Meta-analysisPablo Valderrabano, MD, PhD; Julie E. Hallanger-Johnson, MD; Ram Thapa, PhD; et al.Invited Commentary: Molecular Testing for Indeterminate Thyroid Nodules—When the Rubber Meets the Road ; Jennifer L. Marti, MD; Ashok R. Shaha, MDAssessment of Voice Outcomes Following Surgery for Thyroid CancerKevin J. Kovatch, MD;...
Αλέξανδρος Γ. Σφακιανάκης
1h
Geopolitics Turned Inwards: The Princeton Military Studies Group and the National Security Imagination,  Dexter...
Geopolitics Turned Inwards: The Princeton Military Studies Group and the National Security Imagination,  Dexter Fergie
Αλέξανδρος Γ. Σφακιανάκης
1h
3D Research
A Multi-sprite Based Anaglyph 3D Video Watermarking Approach Robust Against CollusionAbstract3D video watermarking is far from the maturity of watermarking algorithms dedicated to audio, image or 2D video. In fact, little work has been proposed for anaglyph 3D videos. Such methods have not been robust against malicious attacks such as compression and collusion. The latter one is a very dangerous attack that can be applied on video content and can easily remove an embedded signature to obtain original...
Αλέξανδρος Γ. Σφακιανάκης
1h
Threats Underestimated in Freshwater Plastic Pollution: Mini-Review Abstract Plastic pollution is one...
Threats Underestimated in Freshwater Plastic Pollution: Mini-ReviewAbstractPlastic pollution is one of the most acute environmental topics of our time. While there is a great scientific effort to tackle this problem, it has not always been well-coordinated or properly targeted. In this short review, we call for scientists to get involved in three crucial topics (threats) underestimated—or ignored—in freshwater systems: (i) plastic-species entanglement, (ii) plastic as nesting material, and (iii)...
Αλέξανδρος Γ. Σφακιανάκης
1h
Water, Air, & Soil Pollution
Incorporation of Electrochemically Exfoliated Graphene Oxide and TiO 2 into Polyvinylidene Fluoride-Based Nanofiltration Membrane for Dye RejectionAbstractIn this work, the novel direct synthesis method of dimethylacetamide-based graphene oxide (GO) was performed through electrochemical exfoliation assisted by commercially available single-tail sodium dodecyl sulphate (SDS) surfactant. Then, the synthesised GO (SDS–GO) was incorporated into polyvinylidene fluoride (PVDF) solution to produce a nanofiltration...
Αλέξανδρος Γ. Σφακιανάκης
1h
Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance
 in aged miceBackground: Depression affects approximately 5% of elderly people and its etiology might be related to chronic stress exposure during neurodevelopmental periods. In this study, we examined the effects of adolescent chronic social stress in aged mice on depressive behaviors and the excitatory-inhibitory (E/I) balance in stress-sensitive regions of the brain. Methods: Sixty-four adolescent, male C57BL/6 mice were randomly assigned to either the 7-week (from post-natal days 29 to 77) social...
Αλέξανδρος Γ. Σφακιανάκης
1h
Ectodermal dysplasia
Anhidrotic X-Linked Ectodermal DysplasiasAnodontiaBook SyndromeChaund's Ectodermal DysplasiasChondroectodermal DysplasiasChrist-Siemans-Touraine SyndromeCloustons SyndromeCurly Hair-Ankyloblephanon-Nail DysplasiaDentooculocutaneous SyndromeEctrodactyly Ectodermal Dysplasias Clefting SyndromeEllis-van Creveld SyndromeFacial Ectodermal DysplasiasFreire-Maia SyndromeGorlin's SyndromeHidrotic Ectodermal DysplasiasHypohidrotic Ectodermal Dysplasias, AutorecessiveHypoplastic Enamel-Onycholysis-HypohidrosisIncontinentia...
Αλέξανδρος Γ. Σφακιανάκης
1h
Deafness oligodontia syndrome | Genetic and Rare Diseases ..., https://rarediseases.info.nih.gov/diseases/1698/deafness-oligodontia-syndrome...
Deafness oligodontia syndrome | Genetic and Rare Diseases ...,https://rarediseases.info.nih.gov/diseases/1698/deafness-oligodontia-syndromeA collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Deafness oligodontia ...Deafness oligodontia syndromeOther Names: Congenital profound sensorineural deafness and oligodontia; Autosomal recessive sensorineural hearing impairment, dizziness, and hypodontiaCategories: Congenital and...
Αλέξανδρος Γ. Σφακιανάκης
1h
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome
Clinical and electrophysiological profiles in early recognition of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndromeBackground: The detection of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome at early stage is challenging for neurologists. Since polyneuropathy could be the first manifestation, it could be misdiagnosed as chronic inflammatory demyelinating polyneuropathy (CIDP). The present study aimed to determine the clinical...
Αλέξανδρος Γ. Σφακιανάκης
1h
Risk factors for acute kidney injury in patients with acute myocardial infarction, Background: Acute...
Risk factors for acute kidney injury in patients with acute myocardial infarction,Background: Acute kidney injury (AKI) is a serious and fatal complication of acute myocardial infarction (AMI). It has high short- and long-term mortality rates and a poor prognosis but is potentially preventable. However, the current incidence, risk factors, and outcomes of AKI in the Chinese population are not well understood and would serve the first step to identify high-risk patients who could receive preventative...
Αλέξανδρος Γ. Σφακιανάκης
1h
Endothelial function and T-lymphocyte subsets in patients with overlap syndrome of chronic obstructive...
Endothelial function and T-lymphocyte subsets in patients with overlap syndrome of chronic obstructive pulmonary disease and obstructive sleep apneaBackground: The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is termed overlap syndrome (OS). COPD and OSA both have increased risks of developing cardiovascular diseases. This study aimed to explore if patients with OS exhibited a higher prevalence of cardiovascular complications, and if patients with...
Αλέξανδρος Γ. Σφακιανάκης
1h
Chinese Medical Journal
Factors associated with unprotected anal intercourse among male students who have sex with men in three Northern regions of ChinaBackground: Unprotected anal intercourse (UAI) has previously been associated with human immunodeficiency virus (HIV) infection. Male students who have sex with men (SMSM) are at increased exposure to experience UAI. The aim of this study was to investigate the status of UAI and related factors among SMSM in three northern regions of China. Methods: From November 2018 to...
Αλέξανδρος Γ. Σφακιανάκης
1h
Anti-Cancer Drugs
Melanoma: the new perspectives from clinical and translational researchThe prognosis of metastatic melanoma has not changed throughout the 20th century. However, in the last decade, we have witnessed a continuous improvement in survival, with many long-term survivors. These results are largely because of the simultaneous development of the knowledge in the biology of metastatic malignant melanoma and of the relationship between the disease and the host's immune system that allowed the development...
Αλέξανδρος Γ. Σφακιανάκης
1h
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Solid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According...Solid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According to SizeRiccardo De Robertis1, Giovanni Marchegiani2, Matteo Catania3, Maria Chiara Ambrosetti3, Paola Capelli4, Roberto Salvia2 and Mirko D'Onofrio3 Show lessShare Share+ Affiliations:Citation: American Journal of Roentgenology: 1-8. 10.2214/AJR.18.20715AbstractFull TextReferencesPDFPDF PlusAdd to...
Αλέξανδρος Γ. Σφακιανάκης
23h
Auris Nasus Larynx
Endoscopic sinus surgery with and without computer assisted navigation: A retrospective studyPublication date: August 2019Source: Auris Nasus Larynx, Volume 46, Issue 4Author(s): Bruno Galletti, Francesco Gazia, Francesco Freni, Federico Sireci, Francesco GallettiAbstractObjectiveIn the last years endoscopic sinus surgery (ESS) is improved with the introduction of computer assisted navigation (CAN). In this retrospective study we evaluated the usefulness of CAN in endoscopic sinus surgery and studied...
Αλέξανδρος Γ. Σφακιανάκης
1d
Dermatologic Surgery
Aesthetic Outcomes of Nasal Burow's Grafts With Interdomal Sutures After Mohs Micrographic SurgeryBACKGROUND Post-Mohs reconstruction of distal nasal defects is challenging. Many repair options exist, each with advantages and disadvantages. Utilization of a Burow's graft in combination with manipulation of the underlying nasal cartilages with interdomal sutures is an underreported yet effective repair option. OBJECTIVE To present the authors' experience with Burow's grafts facilitated by interdomal...
Αλέξανδρος Γ. Σφακιανάκης
1d
The contribution by MRI and CT in the clinical staging of early glottic cancer (T1-T2) for the evaluation of submucosal areas that can change the stage of the disease and reassess the therapeutic approach. In particular, MRI shows a sensitivity of 100% and a specificity of 97% in assessing areas such as paraglottic space, anterior commissure, thyroid, and arytenoid cartilages, with various indications for conservative surgery. Instead, the sensitivity of CT reaches lower values, 40%, but it has high specificity (100%). In our series, CT staging was accurate in 70% of cases, while the MRI was accurate in 80% of cases.
Early Glottic Cancer: Role of MRI in the Preoperative Staginghttps://www.hindawi.com/journals/bmri/2014/890385/  Eugenia Allegra,1 Pierpaolo Ferrise,1 Serena Trapasso,1 Orazio Trapuzzano,2 Antonio Barca,2 Stefania Tamburrini,3 and Aldo Garozzo11Department of Experimental and Clinical Medicine-Otolaryngology Head and Neck Surgery, University of Catanzaro, Viale Europa, Località Germaneto, 88100 Catanzaro, Italy2Department of Experimental and Clinical Medicine-Radiology, University of Catanzaro, Viale...
Αλέξανδρος Γ. Σφακιανάκης
1d
Computer Assisted Tomography
Imaging of Usual and Unusual Complication of Rotator Cuff RepairSeveral complications may be encountered after rotator cuff (RC) repair. A thorough knowledge of surgical interventions, normal postoperative findings, and postoperative complications is crucial to provide a timely diagnosis, improving the clinical outcome of patients. Postoperative complications may involve RC, implanted device, osteochondral tissue, surgical-site infection, peripheral nerves, soft tissues, and vascular structures....
Αλέξανδρος Γ. Σφακιανάκης
1d
Bone & Joint Surgery
Publons: The Next Step in Reviewer RecognitionNo abstract availableWhat's New in Orthopaedic TraumaNo abstract availableUse of Povidone-Iodine Irrigation Prior to Wound Closure in Primary Total Hip and Knee Arthroplasty: An Analysis of 11,738 CasesBackground: Povidone-iodine (PI) irrigation is often used prior to wound closure in total joint arthroplasty, but there are limited reports evaluating its efficacy in decreasing joint infections. The goal of this study was to compare the rate of any reoperation...
Αλέξανδρος Γ. Σφακιανάκης
1d
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Ear, Nose & Throat Journal- Volume: 98, Number: 6 (July 2019) EditorialAccess to Quaternary Care:...Ear, Nose & Throat Journal- Volume: 98, Number: 6 (July 2019)EditorialAccess to Quaternary Care: Studies Needed in OtolaryngologyRobert T. SataloffOtoscopic ClinicExophytic CholesteatomaMarcus L. Elias and Robert W. JyungRhinoscopic ClinicEndoscopic View of Fungus Ball in the Most Posterior Ethmoid Cell via the Supreme MeatusJae Hoon LeeLaryngoscopic ClinicsAn Unusual Hypopharyngeal Foreign...
Αλέξανδρος Γ. Σφακιανάκης
2d





Otology & Neurotology
Speech Perception Growth Patterns in Prelingual Deaf Children With Bilateral Sequential Cochlear ImplantationObjective: To evaluate speech perception following the first (CI-1) and second (CI-2) cochlear implantation (CI) in children with sequential bilateral CI. Study Design: Retrospective. Patients: Seventy children with follow-up for 60 months post CI-1 and 36 months post CI-2. Main Outcome Measures: Word recognition score (WRS) was the main outcome. WRSs were compared by age at CI operation (group...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
09:16
Anti-Cancer Drugs
Melanoma: the new perspectives from clinical and translational researchThe prognosis of metastatic melanoma has not changed throughout the 20th century. However, in the last decade, we have witnessed a continuous improvement in survival, with many long-term survivors. These results are largely because of the simultaneous development of the knowledge in the biology of metastatic malignant melanoma and of the relationship between the disease and the host's immune system that allowed the development...
Medicine by Alexandros G. Sfakianakis
08:38

Πέμπτη 18 Ιουλίου 2019

Otology & Neurotology

Speech Perception Growth Patterns in Prelingual Deaf Children With Bilateral Sequential Cochlear Implantation
Objective: To evaluate speech perception following the first (CI-1) and second (CI-2) cochlear implantation (CI) in children with sequential bilateral CI. Study Design: Retrospective. Patients: Seventy children with follow-up for 60 months post CI-1 and 36 months post CI-2. Main Outcome Measures: Word recognition score (WRS) was the main outcome. WRSs were compared by age at CI operation (group A ≤ 3.5 yr, B 3.6–8.6, for CI-1; group I ≤ 3.5 yr, II 3.6–7.0, III 7.1–13, IV > 13, for CI-2). Results: For CI-1, the WRS of group A exceeded 80% at 24 months post procedure, earlier than group B (54 mo). Group A also had a shorter period of CI-1 use up to the WRS plateau than group B. CI-2 showed an initial burst of WRS growth much earlier than CI-1. This initial burst was most robust within 3 months in group II, but modest in group IV. The periods of CI-2 use (11–17 mo) up to the WRS plateau were much shorter than CI-1 (40–64 mo). Group I did not show the best WRS at 1 month post CI but later exceeded the other groups. Conclusion: Children received an immediate benefit by a burst of WRS growth from CI-2 earlier than CI-1, even within 3 months, suggesting that CI-1 gets the auditory cortex ready to foster speech processing from CI-2. The CI-2 performance depends on age at CI-2 implantation and on CI-1 performance. Our current findings will be relevant for clinicians who are counselling parents on CI-2 surgery. Address correspondence and reprint requests to Hong Ju Park, M.D., Ph.D., Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea; E-mail: dzness@hotmail.com The authors disclose no conflicts of interest. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Long-term outcomes of bone conduction hearing implants in patients with bilateral microtia-atresia
Objectives: To evaluate the long-term outcomes of three different types of bone conduction hearing implants (BCHI)—BAHA, Ponto, and Bonebridge—in Mandarin-speaking patients with bilateral microtia-atresia. Methods: This cohort study enrolled 59 patients affected by bilateral microtia-atresia, with an upper bone conduction threshold limit of 30 dB HL at frequencies of 0.5 to 4 kHz. All subjects underwent unilateral BCHI surgery, including 26 (18 males, 8 females, of mean age 8.7 ± 1.9 yr) implanted with BAHA devices; 10 (7 males, 3 females, of mean age 11.7 ± 2.8 yr) implanted with Ponto devices; and 23 (14 males, 9 females, of mean age 9.0 ± 1.8 yr) implanted with Bonebridge devices. The main outcome measures included long-term audiological benefits, patient satisfaction, and complications. Each subject acted as his or her own control. Results: Two years after BCHI surgery, the mean hearing thresholds in the BAHA, Ponto, and Bonebridge groups had improved to 22.6 ± 1.6 dB HL, 21.6 ± 1.2 dB HL, and 22.5 ± 1.5 dB HL, respectively. The mean percentages of subjects in these three groups recognizing speech at 65 dB SPL under quiet conditions were 97.7 ± 4.2%, 96.3 ± 1.1%, and 94.4 ± 9.4%, respectively, whereas the mean percentages recognizing speech under noise conditions (signal:noise ratio +5) were 87.0 ± 1.8%, 89.3 ± 9.3%, and 85.3 ± 4.7%, respectively. Questionnaires revealed patients' benefits and satisfaction with this surgery. Three (11.5%) of 26 patients in the BAHA group and 1 (10%) of 10 in the Ponto group experienced skin irritation, but all recovered after local treatment. Five (19.2%) patients in the BAHA group and two (20%) in the Ponto experienced abutment extrusion about 6 months postoperatively, with all achieving good results after revision surgery to replace the abutment. One (3.8%) patient in the BAHA group experienced local chronic inflammation and underwent surgery to replace the BAHA with a Bonebridge implant. One (4.3%) patient in the Bonebridge group developed a local infection 3 months postoperatively and underwent implant removal. Conclusions: All three BCHIs were well tolerated after long-term follow-up, and all improved audiometric thresholds and the intelligibility of speech in the presence of both quiet and noise. These implants should be considered valid and safe options for the functional rehabilitation of patients with bilateral microtia-atresia. Address correspondence and reprint requests to Xiaowei Chen, M.D., Department of Otolaryngology, Peking Union Medical College Hospital, #1 shuaifuyuan, Beijing 100730, China; E-mail: chenxw_pumch@163.com This work was supported by grant to X.C. from the General Programs of National Natural Science Foundation of China (81271053) and The National Key Research and Development Program of China (2016YFC0901501). The authors have received no payment in the preparation of this manuscript. The authors alone are responsible for the content and writing of this article. X.C. acted as head surgeon for the BCHIs performed in this study and collected data. X.F. analyzed data, composed the manuscript, and participated in some of the operations as an assistant. T.Y., X.N., Y.W., and Y.F. participated in some of the operations as assistants, and collected and analyzed data. All authors read and approved the final manuscript. The authors disclose no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://journals.lww.com/otology-neurotology). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Anatomical Correlates and Surgical Considerations for Localized Therapeutic Hypothermia Application in Cochlear Implantation Surgery
Hypothesis: Application of localized, mild therapeutic hypothermia during cochlear implantation (CI) surgery is feasible for residual hearing preservation. Background: CI surgery often results in a loss of residual hearing. In preclinical studies, local application of controlled, mild therapeutic hypothermia has shown promising results as a hearing preservation strategy. This study investigated a suitable surgical approach to deliver local hypothermia in patients utilizing anatomical and radiologic measurements and experimental measurements from cadaveric human temporal bones. Methods: Ten human cadaveric temporal bones were scanned with micro-computed tomography and anatomical features and measurements predicting round window (RW) visibility were characterized. For each bone, the standard facial recess and myringotomy approaches for delivery of hypothermia were developed. The St. Thomas Hospital (STH) classification was used to record degree of RW visibility with and without placement of custom hypothermia probe. Therapeutic hypothermia was delivered through both approaches and temperatures recorded at the RW, RW niche, over the lateral semicircular canal and the supero-lateral mastoid edge. Results: The average facial recess area was 13.87 ± 5.52 mm2. The introduction of the cooling probe through either approach did not impede visualization of the RW or cochleostomy as determined by STH grading. The average temperatures at RW using the FR approach reduced by 4.57 ± 1.68 °C for RW, while using the myringotomy approach reduced by 4.11 ± 0.98 °C for RW. Conclusion: Local application of therapeutic hypothermia is clinically feasible both through the facial recess and myringotomy approaches without limiting optimal surgical visualization. Address correspondence and reprint requests to Suhrud M. Rajguru, Ph.D., University of Miami Ear Institute, 1095 NW 14 Terrance, Lois Pope Life Center, Room 4-25, Miami, Florida 33134; E-mail: s.rajguru@miami.edu E.P. and A.V.E. have equal contribution. This work was supported by a Research Grant from Cochlear, R01 DC01379801A1 and a pilot award from National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR002736, Miami Clinical and Translational Science Institute. S.M.R. and C.K. are named inventors on intellectual property related to the design of hypothermia system and probe discussed here. The authors declare no competing financial interests related to the findings presented. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Evaluation of the Effect of Diclofenac Sodium and 5-Fluourasil in a 3D Cholesteatoma Cell Culture Model
Introduction: Middle ear cholesteatoma is a benign disease with invasive and destructive clinical behaviors. It increases the rate of both chronic otitis media complications and revision surgeries. The most effective treatment of middle ear cholesteatoma is surgical excision, and there is no medical treatment for this disease. Exploring new medical treatment options may help to create treatment alternatives instead of surgery. Materials and Methods: Required cholesteatoma tissues for cell culture were excised from 4 different participants who underwent surgery in our clinic and agreed to give tissue for the study. Cholesteatoma-derived keratinocytes and fibroblasts were cocultured in temperature-sensitive culture dishes to make a three-dimensional (3D) cholesteatoma model. Then, the effects of 1% and 2% diclofenac sodium on viability and cell proliferation rates were examined using WST-1 and annexin-V tests. Results: Cell viability and proliferation rates were found to be lower and apoptosis rates were higher in the diclofenac sodium group versus the negative and positive control groups. Conclusion: In this present study, we described a new 3D cholesteatoma cell culture model developed using cell sheet technology and demonstrated the efficacy of diclofenac sodium on cholesteatoma for the first time in the literature. It may be used in patients with chronic otitis media with cholesteatoma, but further studies investigating ototoxic and neurotoxic effects of this molecule are needed. Address correspondence and reprint requests to Ahmet Kara, Sakarya University Training and Research Hospital, 54000 Korucuk, Sakarya, Turkey. E-mail: doktor.kbb@hotmail.com Funding: This study has been funded by Turkey Scientific and Technological Research Center (project number: 216S961) (TUBITAK). Date of presentation at scientific meeting: AAO-HNSF Annual Meeting & OTO Experience, 7–10.10.2018. The research protocol was approved by the Kocaeli University Animal Ethics Committee (KU GOKAEK 2013). The authors report no conflicts of interest Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Hearing Preservation With the Use of Flex20 and Flex24 Electrodes in Patients With Partial Deafness
Objective: To evaluate the impact of electrode length on hearing preservation (HP) in Partial Deafness Treatment–Electrical Complement (PDT-EC) subjects. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twenty-three PDT-EC patients (with preoperative air-conduction thresholds ≤30 dB up to 500 Hz) were divided into two groups: Flex20 electrode (Med-EL GmbH, Innsbruck, Austria) (12 patients) and Flex24 electrode (Med-EL GmbH, Innsbruck, Austria) (11 patients). Interventions: All participants were subjected to minimally invasive cochlear implantation using the round window approach. Main Outcome Measure(s): Pure tone audiometry (125–8000 Hz) was performed preoperatively and at 1, 6, 12, and 24 months postoperatively. HP was established using the HEARRING group formula. Speech understanding was assessed preoperatively and at 12 and 24 months postoperatively. Results: Analysis of HP for every individual indicates that more than half the patients with Flex20 and Flex24 had complete HP at 6 months follow-up. None of the patients from either group had complete loss of hearing. At activation, average air-conduction thresholds for low frequencies (125–500 Hz) were slightly better for the short electrode (M = 29.03) than for the long (M = 39.10) but the difference was not statistically significant (p = 0.067). The effect of electrode (Flex20 versus Flex24) was not significant in terms of pure tone audiometry and speech recognition at long-term follow-up. Conclusions: In the early postoperative period, complete HP was possible in a majority of patients from both groups, but slightly better HP outcomes were achieved by Flex20. In the long term, the length of the electrodes does not affect the degree of HP or speech understanding. Address correspondence and reprint requests to Piotr H. Skarzynski, Ph.D., M.D., M.S., Mokra 17 Street, 05-830 Kajetany, Poland; E-mail: p.skarzynski@ifps.org.pl No other benefits were received. The authors disclose no conflicts of interest. Supplemental digital content is available in the text. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://journals.lww.com/otology-neurotology). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Validating a New Tablet-Based Tool in the Determination of Cochlear Implant Angular Insertion Depth
Objective: The objective of this study is to determine the reliability of a new tablet-based software that utilizes postoperative computed tomography to determine angular insertion depth (AID), cochlear duct length (CDL), and the cochlear place frequency of individual electrodes in cochlear implant recipients. Patients: Twenty adult cochlear implant recipients with lateral-wall electrode arrays of varying lengths were included in the study. Intervention: Cochlear and electrode array measurements were made by 2 otolaryngologists using a tablet-based software. The user manually identifies the modiolus, round window, and each electrode contact to calculate AID. The user also manually identifies cochlear landmarks to calculate the CDL. The AID and CDL are applied to the Greenwood function to obtain an estimate of the cochlear place frequency for each electrode. Main Outcome Measure(s): The primary outcome measure was the reliability of the instrument, as assessed with intra and interrater reliability of measured AID and CDL. The resultant differences in the estimated cochlear place frequency of the most apical electrode were also evaluated. Results: A broad range of AIDs were observed (390°–659°). Intraclass correlation coefficients for intra (0.991) and interrater reliability (0.980) of AID of the most apical electrode contact were excellent. Intra (0.820) and interrater reliability (0.784) of CDL were also excellent. The estimated cochlear place frequency for the most apical electrode differed by an average of 6.7% (0–18.7%) across the 2 raters. Conclusion: There is excellent agreement amongst clinicians in the determination of AID and CDL, resulting in small changes in estimated cochlear place frequency of the most apical electrode using this new software. Address correspondence and reprint requests to Michael W. Canfarotta, M.D., Department of Otolaryngology/Head and Neck Surgery, 170 Manning Drive, CB 7070, Physicians Office Building, Room G-190, Chapel Hill, NC 27599-7070, USA. E-mail: michael.canfarotta@unchealth.unc.edu Financial Disclosures/Conflicts of Interest: This project was funded in part by the NIH through NIDCD (T32 DC005360). The senior authors, H.C.P., K.D.B., and B.P.O., serve on the surgical advisory board for MED-EL Corporation. M.T.D. is supported by a research grant from MED-EL Corporation. M.W.C. and E.B. declare that involvement in research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Author Contributions: M.W.C., M.T.D., and B.P.O. designed experiments. Implanting surgeons were H.C.P., K.D.B., and B.P.O. M.W.C., M.T.D., E.B., and B.P.O. wrote the article, and all authors contributed significantly to analysis and revisions leading to its final form. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Differentiation Between Eosinophilic Otitis Media and Otitis Media Associated With Eosinophilic Granulomatosis With Polyangiitis
Objective: To perform comparisons and clarify differences in clinical manifestations between eosinophilic otitis media (EOM) and otitis media associated with eosinophilic granulomatosis with polyangiitis (EGPA). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twenty-two ears of 11 patients exhibiting EOM (EOM group) and 20 ears of 12 patients exhibiting otitis media associated with EGPA (EGPA group). Main Outcome Measures: Otological manifestations, nasal and paranasal manifestations, incidence of asthma, positivity for serum antineutrophil cytoplasmic antibodies (ANCA), total serum immunoglobulin (Ig) E level, peripheral blood eosinophil fraction, and hearing outcomes. Results: The incidence and age of onset of asthma and chronic rhinosinusitis were comparable between the EOM and EGPA groups. Moreover, otological findings and hearing outcomes at the initial visit were similar in both groups. Computed tomography images of the paranasal sinus showed predominant opacification of the ethmoid sinus in both groups. Although the total serum IgE level was not significantly different, the peripheral blood eosinophil fraction was significantly larger in the EGPA group than in the EOM group (p = 0.0035). Furthermore, the rate of myeloperoxidase–antineutrophil cytoplasmic antibodies (ANCA) positivity was significantly higher in the EGPA group than in the EOM group (p = 0.019). Conclusions: The findings of the present study suggest that the phenotypic characteristics of EOM closely resemble those of otitis media associated with EGPA in early stages before the appearance of vasculitis. Therefore, it is challenging to differentiate the two conditions purely on the basis of otorhinological examinations. Address correspondence and reprint requests to Atsushi Fukuda, M.D., Department of Otolaryngology–Head & Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan; E-mail: atsushi.fukuda@huhp.hokudai.ac.jp The authors do not have any conflicts of interest to declare. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Characteristics and Outcomes of Pediatric Vestibular Schwannomas
Objective: To review the demographics, treatment modalities, and survival of children with vestibular schwannomas. Study Design: Analysis using the Surveillance, Epidemiology, and End Results (SEER) database. Subjects and Methods: Pediatric patients from birth to 18 years in the SEER database were included from 2004 to 2014 based on a diagnosis of vestibular schwannoma using the primary site International Classification of Diseases (ICD) O-3 code of C72.4: acoustic nerve and the ICD O-3 histology codes of 9540/1: neurofibromatosis, Not Otherwise Specified (NOS); 9560/0: neurilemoma, NOS; or 9570/0: neuroma, NOS. Results: One hundred forty-eight pediatric vestibular schwannomas (VSs) cases were identified. The mean age at diagnosis was 13.9 years (range, 4.0–18.0). Eighty-five (57.4%) patients were women. Seventy-seven (52.0%) patients had isolated unilateral VSs while 71 (48.0%) patients had either bilateral VSs or unilateral VSs with other brain, spinal cord, or cranial nerve tumors. Eighty two (55.4%) patients received surgical resection only, 45 (30.4%) received no treatment, 6 (4.1%) received radiation only, and 12 (8.1%) received surgery and radiation. The median tumor size for patients who received no treatment was 9.5 mm (interquartile range [IQR]: 8.0) compared with 33.5 mm (IQR: 23.0) for patients who received surgical care and 41.0 mm (IQR: 1.5) for patients who received both surgery and radiation (p < 0.001). The 5-year overall survival rate was 97%. Conclusion: Pediatric VSs tend to be diagnosed in adolescence. No men or women predominance was appreciated. Treatment varied according to tumor size. Survival rates for children with vestibular schwannomas are excellent. These data may assist healthcare providers when counseling children with vestibular schwannomas and their families. Address correspondence and reprint requests to Tyler A. Janz, M.D., University of Central Florida College of Medicine, Orlando, FL; E-mail: tjanz@knights.ucf.edu This is the first submission on this topic. The authors have no funding, financial relationships, or conflicts of interest to disclose. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

High-dose Corticosteroids for Adult Bell's Palsy: Systematic Review and Meta-analysis
Objectives: To compare the efficacy and safety of high-dose corticosteroids (initial prednisolone [PSL] of 100 mg or more daily) and standard-dose corticosteroids (initial PSL of 50–60 mg) in patients with Bell's palsy. Study Design: A systematic review and meta-analysis. Data Sources: Medline, Embase, Cochrane Central Register of Controlled Trials, Ichushi-Web, Web of Science, and CINAHL, combined with data from ClinicalTrials.gov. Study Selection: Published and unpublished cohort studies comparing high- and standard-dose corticosteroids in adult patients with Bell's palsy were included. Data Extraction: Study characteristics (study design, patient's number), patient characteristics (sex, age, disease severity, prescription of antivirals), and outcomes (nonrecovery, any adverse effects). Data Synthesis: From the 1,974 identified articles, 8 studies were met eligible criteria. Of the included studies, the initial dose in high-dose corticosteroids regimens varied from 120 mg to 200 mg PSL daily. Compared with standard-dose corticosteroids, high-dose corticosteroids were associated with a significantly decreased nonrecovery at 6 months after disease onset (odds ratio 0.42, 95% confidence interval 0.22–0.80; very low quality) in patients with Bell's palsy. No severe adverse effects were observed in patients receiving high- or standard-dose corticosteroids. Conclusion: High-dose corticosteroids reduce nonrecovery in patients with Bell's palsy. The dose of high-dose corticosteroids was varied and further prospective study is needed to identify an adequate dose of corticosteroids in these patients. Address correspondence and reprint requests to Takashi Fujiwara, M.D., Ph.D., Department of Otolaryngology Head and Neck Surgery, Kurashiki Central Hospital, 1-1-1 Miwa, Kurahiki, Okayama 710-8602, Japan; E-mail: t.fujiwarabi@gmail.com All authors declare: no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work. The authors disclose no conflicts of interest. Supplemental digital content is available in the text. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jcraniofacialsurgery.com). Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Endre Hőgyes (1847–1906), Forgotten Father of the Vestibulo-Ocular Reflex
Objective: Throughout the history of vestibular research, the discovery of the vestibulo-ocular reflex in 1881 by Endre Hőgyes (1847–1906) is rarely mentioned. The aim of this study is to review Hőgyes' vestibular research articles, all originally written in Hungarian and emphasize their epoch-making content. Main Data Sources: Hőgyes' vestibular publications, originally written in Hungarian, which describe various eye movements of the rabbit in response to vestibular stimulation by rotation about three axes. Results: Hőgyes was the first to use a three-axis turntable on an experimental animal, in this case a rabbit. He found that depending on the plane of rotation, different types of binocular eye movements were produced. He then demonstrated by destructive and excitatory experiments, the anatomical pathways and the physiological function producing this phenomenon. Ultimately, he explained the exact connections between the inner ear labyrinth and certain muscle contractions during eye movements. He identified this pathway as the "associating center of the ocular movements," later defined as the vestibulo-ocular reflex. Hőgyes' discovery was only superficially noted during his lifetime and ignored after his death. Conclusion: Hőgyes was the first to demonstrate the vestibulo-ocular reflex. He was forgotten during the ensuing 140 years probably because his articles were appeared only in Hungarian and because a short time later, Róbert Bárány's award of the Nobel Prize overshadowed many of Bárány's predecessors and contemporaries, including Hőgyes and relegated them to the background. Address correspondence and reprint requests to László T. Tamás, M.D., 9028, Győr, Vak Bottyán u.14/A, Hungary; E-mail: ltamas@gyor.net Dr. L.T.T. and Dr. A.M. helped in data collection, analysis, and interpretation, critically reviewing and editing the manuscript. The authors disclose no conflicts of interest. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Anti-Cancer Drugs

Melanoma: the new perspectives from clinical and translational research
imageThe prognosis of metastatic melanoma has not changed throughout the 20th century. However, in the last decade, we have witnessed a continuous improvement in survival, with many long-term survivors. These results are largely because of the simultaneous development of the knowledge in the biology of metastatic malignant melanoma and of the relationship between the disease and the host's immune system that allowed the development of effective new treatments. In this overview, we summarize the therapies available today, their biological rationale, and the research field currently under investigation divided into three main chapters: target therapies, immunotherapies, and their combination.

Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer
imageOvarian cancer is a heterogeneous disease with complex molecular and genetic hallmarks. Benefitting from profound understanding of molecular mechanisms in ovarian cancer pathogenesis, novel targeted drugs have been actively explored in preclinical studies and clinical trials. Considered as one of the most potent and effective targeted therapies for the treatment of ovarian cancer, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) take advantages of synthetic lethality mechanisms to prevent DNA damage repair in cancer cells and cause their death, especially in cancers with BRCA mutations. Mounting evidence has indicated that the combination of PARPis with cytotoxic drugs or other targeted drugs has shown favorable synergistic effects. Excitingly, the antitumor activity of combination therapy of PARPis has been actively tested in multiple clinical trials and in-vitro or in-vivo experiments. In this review, we will briefly discuss the molecular mechanisms of PARPis combined with other therapeutic small-molecular compounds for the treatment of ovarian cancer.

Knockdown of long noncoding RNA-taurine-upregulated gene 1 inhibits tumor angiogenesis in ovarian cancer by regulating leucine-rich α-2-glycoprotein-1
imageTo investigate the role of long noncoding RNA taurine-upregulated gene 1 (TUG1) on ovarian cancer-induced angiogenesis and to explore possible signaling pathways. Ovarian cancer cell line SKOV3 or CAOV3 was transfected with short hairpin-TUG1 to suppress TUG1 expression. Supernatant from cultured cancer cells was used as a condition medium to incubate endothelial cell line human umbilical vein endothelial cells, whose proliferation rate was quantified by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Migration and invasion of endothelial cells were examined by wound healing and Transwell assays, followed by in-vitro angiogenesis assay. One of the secretory factors mediating angiogenesis, leucine-rich α-2-glycoprotein-1 (LRG1), was measured in ovarian cancer cells. Signaling pathway mediating angiogenesis was further detected by western blotting. TUG1 was down-regulated in ovarian cancer cells by short hairpin RNA. Conditional medium originating from TUG1-knockdown cancer cells led to suppressed proliferation, migration, or invasion of endothelial cell line human umbilical vein endothelial cells. LRG1 expression and secretion was suppressed in ovarian cancer cells after TUG1 knockdown. Moreover, recombinant LRG1 rescued TUG1 knockdown-induced angiogenesis inhibition, and LRG1 probably mediated angiogenesis by tumor growth factor-β signaling pathway in endothelial cells. Long noncoding RNA-TUG1 mediates angiogenesis of endothelial cells by regulating LRG1 secretion from ovarian cancer cells partially through tumor growth factor-β pathway. Our results indicate the potency of TUG1 as a biomarker and therapeutic target for tumor-induced angiogenesis.

Pyrimethamine exerts significant antitumor effects on human ovarian cancer cells both in vitro and in vivo
imagePyrimethamine has been used principally to treat infections from protozoan parasites. Although previous studies have shown that pyrimethamine exhibited anticancer activity by inducing cellular apoptosis, there are none that show that pyrimethamine possesses anticancer activity with respect to ovarian cancer. We examined the roles of pyrimethamine on apoptosis and proliferation, DNA damage, and cell cycle distribution of human ovarian cancer cell lines in vitro. To investigate the antitumor efficacy of pyrimethamine in vivo, we established two intraperitoneal ovarian carcinoma models in nude mice. Pyrimethamine significantly induced apoptosis of ovarian cancer cells via growth inhibition, cell cycle arrest, and nuclear DNA damage in vitro and manifested antitumor activity by inhibiting tumor growth, thereby prolonging the survival time of tumor-bearing mice. We also demonstrated that pyrimethamine increased the expression of caspase-9 and decreased the expression of X-linked inhibitor of apoptosis protein. In conclusion, the antitumor effects of pyrimethamine were associated with enhanced apoptosis of tumor cells and inhibition of the growth of intratumoral microvessels. Our results indicate that pyrimethamine may provide an effective approach toward inhibiting the growth of ovarian cancer with minimal adverse effects.

MiR-29a inhibits cell proliferation and migration by targeting the CDC42/PAK1 signaling pathway in cervical cancer
imageCervical cancer is the second most common gynecological malignancy worldwide and the tumorigenesis mechanisms of cervical cancer are still unclear. This study aimed to reveal the role of miR-29a in cervical cancer. The expression level of miR-29a and CDC42 was measured using qRT-PCR. Cell proliferation, apoptosis, migration, and invasion were detected using colony formation, flow cytometry analysis, wound-healing assay, and Transwell assay, respectively. Luciferase reporter assay was used to determine the binding of miR-29a with CDC42. CDC42/p21-activated kinase 1 (PAK1) pathway-related proteins were measured by western blotting. MiR-29a was downregulated and CDC42 was upregulated in cervical cancer cells. Luciferase reporter assay showed that miR-29a negatively regulated the expression of CDC42 by directly targeting 3′-UTR of CDC42. Cell proliferation, migration, and invasion were markedly inhibited, whereas cell apoptosis was significantly increased in Hela and CaSki cells transfected with miR-29a mimics. These effects were partly recovered by CDC42 overexpression. Protein levels of PAK1, p-PAK1, p-LIMK, and p-cofilin were significantly downregulated by miR-29a mimics, which was reversed by CDC42 overexpression and was increased by the miR-29a inhibitor. MiR-29a inhibited cell proliferation, migration, and invasion, as well as promoted cell apoptosis through repressing the PAK1/LIMK signaling pathway by targeting CDC42 in cervical cancer.

Construction of an miRNA–mRNA regulatory network in colorectal cancer with bioinformatics methods
imageColorectal cancer (CRC) is the third most common cancer worldwide. This study aimed to explore the regulatory mechanisms of miRNAs in CRC. Differentially expressed miRNAs (DEMs) and differentially expressed genes (DEGs) in CRC tissue samples compared with control samples in mRNA and miRNA datasets were screened. Functional and pathway enrichment analysis of the DEGs was carried out. Targets of the DEMs were identified. Overlaps between the DEGs and targets of DEMs were selected. The miRNA–mRNA regulatory network of these overlaps was constructed and visualized. The candidate genes selected were validated by quantitative real-time PCR. DEGs were identified and considered DEGs-1 and DEGs-2. A total of 584 genes in DEGs-1 and 527 genes in DEGs-2 were obtained, including 465 overlaps, and 44 DEMs were identified. The overlaps were enriched in 46 Gene Ontology terms and 19 Kyoto Encyclopedia of Genes and Genomes pathways. Moreover, 137 overlapped genes between targets of the DEMs and the 465 overlaps were obtained. The miRNA–mRNA regulating network of the 137 overlapped genes was constructed. Extracellular matrix-related proteins and pathways might play critical roles in the development of CRC. The quantitative real-time PCR results of the candidates were in agreement with the bioinformatics analysis. miR-128, miR-182, and miR-143 might be key miRNAs regulating cell proliferation and metastasis of CRC.

Upregulation of sine oculis homeobox homolog 3 is associated with proliferation, invasion, migration, as well as poor prognosis of esophageal cancer
imageEsophageal cancer (EC) is a common cancer worldwide. Sine oculis homeobox homolog (SIX3) is a human transcription factor that regulates the progression of vertebrate eye and fetal forebrain. However, studies on the function of SIX3 in human tumorigenesis remain rare. In this study, we aim to evaluate the role and the significance of SIX3 in EC. The TCGA database and clinical samples were used to assess the expression of SIX3 in EC patients. The Kaplan–Meier method and Cox's proportional hazards model were performed to analyze the correlations between SIX3 expression and EC clinical outcomes. The expressions of SIX3 in EC cells were measured by quantitative reverse transcription PCR analysis. The cell proliferation was detected using cell counting kit-8 and colony formation assay. The migration and invasion capacity of EC cells were evaluated using wound healing and Transwell methods. Western blot assay was used to measure the alterations in some important protein expression levels in the PI3K/Akt signaling pathway. We found that SIX3 was highly expressed in the EC tissues and cells. In addition, high expression of SIX3 was related to poor survival. The knockdown of SIX3 significantly inhibited the proliferation, migration, and invasion of ECA109 cells. A similar pattern was also found in the proliferation and migration of SKGT-4 cell line. The expression levels of some key proteins in the PI3K/Akt signaling pathway were obviously decreased after cells were transfected with si-SIX3, possibly resulting in PI3K/AKT signaling inactivation. In addition, E-cadherin and N-cadherin showed some change. Collectively, the results shed light on a potentially promoting role of SIX3 in human EC. Thus, SIX3 might be considered a novel prognostic biomarker and therapeutic target for EC patients.

Development of transferrin-modified poly(lactic-co-glycolic acid) nanoparticles for glioma therapy
imageGlioma is a primary intracranial malignant tumor with poor prognosis. In this study, we aimed to develop transferrin (Tf)-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles to deliver temozolomide (TMZ) to glioma and evaluate their efficacy to kill glioma. TMZ-loaded nanoparticles were prepared by nanoprecipitation technique and targeted by Tf. Tf-PLGA-TMZ and PLGA-TMZ were characterized for average particle sizes and zeta potentials, cellular uptake and cytotoxicity as well as in-vitro drug release of these nanoparticles were evaluated in human glioma U87MG cells. In-vivo antiglioma efficacy of Tf-PLGA-TMZ was evaluated in nude mice. Polydispersity ratio increased from 0.132 to 0.150, while encapsulation efficiency decreased from 69.4 to 55.8% after Tf modification of PLGA-TMZ. High performance liquid chromatography test showed that Tf-targeted nanoparticles were better internalized into U87MG cells than nontargeted nanoparticles. Moreover, Tf-PLGA-TMZ significantly decreased the viability of U87MG cells compared with nontargeted nanoparticles (P<0.05). In addition, Tf-PLGA-TMZ significantly decreased tumor volume and improved the survival of nude mice injected with U87MG cells. Tf-modified PLGA nanoparticles could be used for effective delivery of TMZ and have promise for the treatment of glioma.

Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer
imageColorectal cancer (CRC) is one of the most difficult cancers to cure. An important prognostic factor is metastasis, which precludes curative surgical resection. Recent evidences show that Evodiamine (EVO) exerts an inhibitory effect on cancer cell apoptosis, migration, and invasion. In this study, we investigated the effects of EVO on the metastasis of CRC cells in vitro and in vivo. In vitro, wound-healing and transwell assay showed that migration and invasion of HT-29 and HCT-116 CRC cells were inhibited significantly by EVO. Western blot and RT-PCR showed that EVO reduced the expression of matrix metalloproteinase-9 in a dose-dependent manner. In EVO-induced cells, the intracellular NAD+/NADH ratio was increased, the level of Sirt1 was increased, and acetyl-NF-κB P65 was decreased. This process was inhibited by nicotinamide, an inhibitor of Sirt1. In vivo, EVO reduced tumor metastasis markedly. These findings provide evidences that EVO suppresses the migration and invasion of CRC cells by inhibiting the acetyl-NF-κB p65 by Sirt1, resulting in suppression of metalloproteinase-9 expression in vitro and in vivo.

Novel small molecule decreases cell proliferation, migration, clone formation, and gene expression through ERK inhibition in MCF-7 and MDA-MB-231 breast cancer cell lines
imageThe Ras–Raf–MEK1/2–ERK1/2 pathway is an attractive target for the development of anticancer agents because of the high prevalence of ERK activation in human cancers. However, resistance is often developed despite initial clinical response, most likely because of activation of cross-talk pathways. In Research Genetic Cancer Center (RGCC), we are in the process of synthesizing a novel ERK inhibitor, targeting the final stage of the pathway, thus minimizing cross-talk. We have synthesized an intermediate molecule –RGCC416 – and tested its biological activity. MCF-7 and MDA-MB-231 cells were used. Cell viability was measured by crystal violet and cell proliferation by the methyl tetrazolium assay using various compound concentrations. Cell migration and colony formation were determined to assess the ability of invasion and single cancer cell growth, respectively. Expression of genes linked to MAPK/PI3K pathways was determined by PCR. ERK and phospho-ERK levels were determined in both the cytoplasm and the nucleus by western blot. It was found that although the compound did not affect viability, it significantly decreased cell proliferation, migration, and colony formation in both cell lines. In MDA-MB-231, this is possibly through retaining phospho-ERK to the cytoplasm, where it cannot activate cancer-associated genes. There was no difference in ERK levels in MCF-7 cells. This could be because of the different pathways that these cells utilize for survival. We have synthesized a molecule, which could be a promising ERK inhibitor, leading to possible novel treatment options for breast cancer patients.



Clinical Reports
 
 
 

Treatment of ALK-rearranged non-small-cell lung cancer with brigatinib as second or later lines: real-world observations from a single institution
Maximilian Hochmair, Christoph Weinlinger, Sophia Schwab, Jakob Naber, Ulrike Setinek, Dagmar Krenbek, Matthias H. Urban, Hannah Fabikan, Stefan Watzka, Renate Koger, Andreas Fazekas, Erwin Bitterlich, Arschang Valipour, Otto C. Burghuber

Poor outcome for patients with gastric cancer and lung metastases treated with ramucirumab and paclitaxel
Giandomenico Roviello, Silvia P. Corona, Andrea G. Multari, Roberto Petrioli, Pietro Rosellini, Michele Aieta

 
Case Reports
 
 
 

Misleading impaired liver function in a non-small-cell lung cancer patient treated with pembrolizumab: a case report
Giorgia A. Osman, Arnaldo Marra, Daniela Iacono, Valerio Giannelli, Serena Ricciardi, Daniele Remotti, Andrea Vecchione, Alberto Ricci, Paolo Palange, Maria R. Migliorino

Apatinib, combined with chemotherapy or alone is effective in treating angiosarcoma: a case report
Mingyang Liu, Yongmin Liu, Huannan Guo, Dongwei Fu, Lili Lv, Chunhong Chen, Yanlin Li, Wenqian Zhang, Ming Yao, Limin Zhao



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480