Compelling Reasons for Repairing Human Germlines

Under normal circumstances, if you combined sperm half of which carried a dominant disease allele with unaffected oocytes, only 50% of the resulting human embryos would be expected to have unaffected copies of the gene in question. Researchers Ma, Mitalipov, and colleagues recently reported that…

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Designing Ethical Trials of Germline Gene Editing

The recent announcement that researchers have successfully used the CRISPR (clustered regularly interspaced short palindromic repeats) gene-editing technique to correct a mutation that leads to hypertrophic cardiomyopathy in human embryos is the latest reminder of the urgency of the social and…

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Case 35-2017: A 57-Year-Old Woman with Hypoesthesia and Weakness in the Legs and Arms

Presentation of Case. Dr. Daniel B. Rubin (Neurology): A 57-year-old-woman was admitted to this hospital because of progressive hypoesthesia, paresthesia, and weakness in the arms and legs. The patient had been in her usual health until 18 months before this admission, when paresthesia developed in…

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An Unusual Cause of Leg Pain

A 67-year-old woman presented to her primary care physician with pain in her legs. Approximately 7 weeks earlier, she had noticed a cramping sensation in the back of both thighs and both calves that occurred after walking a couple of blocks and was relieved with rest. . . .

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Diuretic Treatment in Heart Failure

Most accepted pharmacologic treatments for heart failure are supported by evidence from large clinical trials. In contrast, evidence from large, well-controlled clinical trials to guide the use of diuretics, among the most frequently used drugs in heart failure, is generally lacking. Fluid…

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Falciform Ligament Sign

Figure 1.

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"Popeye" Sign

Figure 1.

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