Establishing a framework to understand the regulation and control of dogs in urban environments: a case study of Melbourne, Australia

This study examines the effectiveness of animal management from a critical theory perspective, establishing a framework to describe the animal management activities of local government. In creating sustainable...

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To Your Health: NLM update: Exercise reduces cancer risks

Listen to the To Your Health: NLM update on Exercise reduces cancer risks. The transcript is also available.

Moderate exercise is associated with a reduced risk of 13 types of cancer in an international, comprehensive study recently published in JAMA Internal Medicine.

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Endophenotype best practices

Publication date: Available online 27 July 2016
Source:International Journal of Psychophysiology
Author(s): William G. Iacono, Stephen M. Malone, Scott I. Vrieze
This review examines the current state of electrophysiological endophenotype research and recommends best practices that are based on knowledge gleaned from the last decade of molecular genetic research with complex traits. Endophenotype research is being oversold for its potential to help discover psychopathology relevant genes using the types of small samples feasible for electrophysiological research. This is largely because the genetic architecture of endophenotypes appears to be very much like that of behavioral traits and disorders: they are complex, influenced by many variants (e.g., tens of thousands) within many genes, each contributing a very small effect. Out of over 40 electrophysiological endophenotypes covered by our review, only resting heart, a measure that has received scant advocacy as an endophenotype, emerges as an electrophysiological variable with verified associations with molecular genetic variants. To move the field forward, investigations designed to discover novel variants associated with endophenotypes will need extremely large samples best obtained by forming consortia and sharing data obtained from genome wide arrays. In addition, endophenotype research can benefit from successful molecular genetic studies of psychopathology by examining the degree to which these verified psychopathology-relevant variants are also associated with an endophenotype, and by using knowledge about the functional significance of these variants to generate new endophenotypes. Even without molecular genetic associations, endophenotypes still have value in studying the development of disorders in unaffected individuals at high genetic risk, constructing animal models, and gaining insight into neural mechanisms that are relevant to clinical disorder.



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Full title with Editorial board members

Publication date: September 2016
Source:International Journal of Psychophysiology, Volume 107





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Instructions to Authors

Publication date: September 2016
Source:International Journal of Psychophysiology, Volume 107





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IOP-details

Publication date: September 2016
Source:International Journal of Psychophysiology, Volume 107





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Correction for Perry et al., Rapid behavioral maturation accelerates failure of stressed honey bee colonies [Correction]

ECOLOGY Correction for "Rapid behavioral maturation accelerates failure of stressed honey bee colonies," by Clint J. Perry, Eirik Søvik, Mary R. Myerscough, and Andrew B. Barron, which appeared in issue 11, March 17, 2015, of Proc Natl Acad Sci USA (112:3427–3432; first published February 9, 2015; 10.1073/pnas.1422089112). The authors note...

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