Metastatic cardiac tumor from urothelial carcinoma detected by transthoracic echocardiography: a case report
[image: s13256-015-0740-3-1.gif] IntroductionCardiac metastasis of urothelial carcinoma is a very rare but clinically important complication. Most cardiac metastases are asymptomatic; symptoms from cardiac metastasis were seen in advanced stage and many of these cases were reported to have a poor prognosis. So it is important to find asymptomatic cardiac metastasis and to start chemotherapy early in order to improve the patient's prognosis.Case presentationA 73-year-old Asian man was referred to our hospital because of a right ventricular tumor. He had a history of left ureteral ca...περισσότερα »
Therapeutic Challenges to End-Stage Kidney Disease in a Patient with Tetralogy of Fallot
In this report, we describe the case of an end-stage kidney disease patient with tetralogy of Fallot (TOF). A 33-year-old female with TOF was admitted to our hospital with complaints of general fatigue and appetite loss probably due to uremic milieu. She was ultimately treated with peritoneal dialysis (PD) with a favorable clinical course. TOF patients with chronic kidney disease are not exceptional, although the currently available information regarding the association between TOF and renal failure severe enough to require dialysis treatment is limited. We also discuss the comple... περισσότερα »
Drugs, Vol. 75, Issue 17 - New Issue Alert
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 11/15/2015 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Drugs*. Volume 75 Number 17 is now available online. Important news Make greater discoveries with AdisInsight See the bigger picture of a drug or disease landscape with a unique, joined-up view of drug treatments being developed worldwide - how well they work, how safe they are, who is working on them, and how soon they will be available. AdisInsight is ... περισσότερα »
TWiV 363: Eat flu and dyad
Hosts: Vincent Racaniello, Alan Dove, from Infection via ola Kala on Inoreader http://ift.tt/1Su1fRl via IFTTT
Protection of Health Imagery by Region Based Lossless Reversible Watermarking Scheme
Providing authentication and integrity in medical images is a problem and this work proposes a new blind fragile region based lossless reversible watermarking technique to improve trustworthiness of medical images. The proposed technique embeds the watermark using a reversible least significant bit embedding scheme. The scheme combines hashing, compression, and digital signature techniques to create a content dependent watermark making use of compressed region of interest (ROI) for recovery of ROI as reported in literature. The experiments were carried out to prove the performance...περισσότερα »
Stem Cell-Based Therapeutics to Improve Wound Healing
Issues surrounding wound healing have garnered deep scientific interest as well as booming financial markets invested in novel wound therapies. Much progress has been made in the field, but it is unsurprising to find that recent successes reveal new challenges to be addressed. With regard to wound healing, large tissue deficits, recalcitrant wounds, and pathological scar formation remain but a few of our most pressing challenges. Stem cell-based therapies have been heralded as a promising means by which to surpass current limitations in wound management. The wide differentiation p... περισσότερα »
Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants
Background. Functional abnormalities of high-density lipoprotein (HDL) could contribute to cardiovascular disease in chronic kidney disease patients. We measured a validated marker of HDL dysfunction, nitrated apolipoprotein A-I, in kidney transplant recipients to test the hypothesis that a functioning kidney transplant reduces serum nitrated apoA-I concentrations. Methods. Concentrations of nitrated apoA-I and apoB were measured using indirect sandwich ELISA assays on sera collected from each transplant subject before transplantation and at 1, 3, and 12 months after transplantati... περισσότερα »
The prevalence of obstructive sleep apnea in symptomatic patients with syndromic craniosynostosis
The prevalence of obstructive sleep apnea in symptomatic patients with syndromic craniosynostosis: The reported prevalence of obstructive sleep apnea (OSA) in patients with syndromic craniosynostosis (SCS) varies due to inconsistent definitions of OSA, lack of uniform diagnostic testing, and different mixes of syndromic diagnoses. The purpose of this study was to determine the prevalence of OSA in symptomatic patients with SCS, and to determine whether this differs by phenotypic diagnosis. A retrospective cohort study of children with SCS was conducted. The primary outcome was prese...περισσότερα »
Estimation of the width of free margin with a significant impact on local recurrence in surgical resection of oral squamous cell carcinoma
Estimation of the width of free margin with a significant impact on local recurrence in surgical resection of oral squamous cell carcinoma: The purpose of this study was to estimate the width of free margin with a significant impact on local recurrence in surgical resection of oral squamous cell carcinoma (OSCC). Clinical and pathological data of 127 consecutive patients who underwent radical resection of OSCC were analyzed retrospectively. The local control rate was compared between patients with clear, close, and involved surgical margins, changing the required width of free margi... περισσότερα »
Three-dimensional evaluation of healing joint morphology after closed treatment of condylar fractures
Three-dimensional evaluation of healing joint morphology after closed treatment of condylar fractures: In this study, computed tomography images of 26 patients (35 sides) who had undergone closed treatment for condylar fractures were used to perform a comparative investigation of three-dimensional (3D) bone morphology before and after treatment. (Source: International Journal of Oral and Maxillofacial Surgery)
Can we predict the insertion torque using the bone density around the implant?
Can we predict the insertion torque using the bone density around the implant?: The purpose of this study was to examine the correlation between initial stability and bone density in patients undergoing implant treatment. Twenty-five screw-type dental implants were inserted in 12 patients. All patients underwent multi-detector computed tomography (CT) examination prior to implant insertion. The implant sockets were prepared according to the drilling protocol, and peak insertion torque values were measured. CT values around the implants were measured using preoperatively scanned CT d... περισσότερα »
Homogenous demineralized dentin matrix and platelet-rich plasma for bone tissue engineering in cranioplasty of diabetic rabbits: biochemical, radiographic, and histological analysis
Homogenous demineralized dentin matrix and platelet-rich plasma for bone tissue engineering in cranioplasty of diabetic rabbits: biochemical, radiographic, and histological analysis: This study evaluated the effects of homogenous demineralized dentin matrix (HDDM) slices and platelet-rich plasma (PRP) in surgical defects created in the parietal bones of alloxan-induced diabetic rabbits, treated with a guided bone regeneration technique. Biochemical, radiographic, and histological analyses were performed. Sixty adult New Zealand rabbits were divided into five groups of 12: normoglyca... περισσότερα »
A review of the peri-operative risk stratification assessment tools used for the prediction of cardiovascular complications in non-cardiac surgery.
*A review of the peri-operative risk stratification assessment tools used for the prediction of cardiovascular complications in non-cardiac surgery.* Perfusion. 2015 Nov 12; Authors: Magapu P, Haskard D, Fisher M Abstract The development of atherosclerosis is a complex process that involves several inflammatory mechanisms. The evolution of a fatty streak to a mature occlusive atheromatous plaque occurs over several decades. However, during acute plaque rupture, to a varying degree, these same inflammatory systems are involved.Evidence exists that suggests a relationship between ...περισσότερα »
Feline calicivirus and other respiratory pathogens in cats with Feline calicivirus-related symptoms and in clinically healthy cats in Switzerland.
*Feline calicivirus and other respiratory pathogens in cats with Feline calicivirus-related symptoms and in clinically healthy cats in Switzerland.* BMC Vet Res. 2015;11(1):282 Authors: Berger A, Willi B, Meli ML, Boretti FS, Hartnack S, Dreyfus A, Lutz H, Hofmann-Lehmann R Abstract BACKGROUND: Cats with feline calicivirus (FCV)-related symptoms are commonly presented to veterinary practitioners. Various clinical manifestations have been attributed to FCV, i.e. upper respiratory tract disease (URTD), oral ulcerations, gingivostomatitis, limping syndrome and virulent systemic dis... περισσότερα »
Symptoms and medical conditions in 204 912 patients visiting primary health-care practitioners in India: a 1-day point prevalence study (the POSEIDON study).
*Symptoms and medical conditions in 204 912 patients visiting primary health-care practitioners in India: a 1-day point prevalence study (the POSEIDON study).* Lancet Glob Health. 2015 Dec;3(12):e776-84 Authors: Salvi S, Apte K, Madas S, Barne M, Chhowala S, Sethi T, Aggarwal K, Agrawal A, Gogtay J Abstract BACKGROUND: India has one of the highest disease burdens in the world. A better understanding of what ails India will help policy makers plan appropriate health-care services and infrastructure development, design medical education curricula, and identify health research prio...περισσότερα »
[Estimation of hospitalization rate of laboratory confirmed influenza cases in Jingzhou city, Hubei province, 2010-2012].
Related Articles *[Estimation of hospitalization rate of laboratory confirmed influenza cases in Jingzhou city, Hubei province, 2010-2012].* Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Mar;36(3):222-7 Authors: Zheng J, Chen H, Chen M, Huai Y, Jiang H, Xing X, Peng Z, Xiang N, Zhang Y, Liu L, Huang J, Feng L, Guan X, Klena J, Zhan F, Yu H Abstract OBJECTIVE: To estimate the hospitalization rate of severe acute respiratory infection (SARI) cases attributable to influenza in Jingzhou city, Hubei province from 2010 to 2012. METHODS: SARI surveillance was conducted at four hospitals in Jin... περισσότερα »
[Clinical characteristics of adult influenza inpatients in ten provinces in China and analysis of severe risk factors].
Related Articles *[Clinical characteristics of adult influenza inpatients in ten provinces in China and analysis of severe risk factors].* Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Mar;36(3):216-21 Authors: Jiang H, Yu D, Ruan F, Xu W, Huang T, Li L, Wang K, Liu S, Zhang H, Jia P, Yang P, Peng Z, Zheng J, Feng L, Yu H Abstract OBJECTIVE: To identity the clinical characteristics and severe case risk factors for the adult inpatient cases confirmed of influenza monitored by the sentinel surveillance system for severe acute respiratory infection (SARI) inpatient cases in ten provinces ... περισσότερα »
[Clinical characteristics of hospitalized cases of severe acute respiratory infection with laboratory-confirmed influenza and the risk factors analysis of influenza infection for children under 15 years old in ten provinces in China during 2009-2014].
Related Articles *[Clinical characteristics of hospitalized cases of severe acute respiratory infection with laboratory-confirmed influenza and the risk factors analysis of influenza infection for children under 15 years old in ten provinces in China during 2009-2014].* Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Mar;36(3):210-5 Authors: Peng Z, Xu J, Yu Z, Sun Q, Li L, Yang P, Jiang Z, Kang M, Xiong X, Liu L, Weng Y, Zhu G, Liu L, Dong X, Pan H, Cao Z, Lin H, Guo H, Li L, Jiang H, Zheng J, Xu Z, Feng L, Yu H Abstract OBJECTIVE: To identify clinical characteristics of hospitalized l... περισσότερα »
[Analysis of morbidity and mortality characteristics of the notifiable diseases reported in 2013 in China].
Related Articles *[Analysis of morbidity and mortality characteristics of the notifiable diseases reported in 2013 in China].* Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Mar;36(3):194-8 Authors: Wang L, Zeng L, Ren X, Geng M, Li Z, Yu H Abstract OBJECTIVE: To learn the characteristics of morbidity and mortality of notifiable diseases reported in China in 2013. METHODS: Descriptive analysis method was used to analyze the morbidity and mortality of notifiable diseases in China in 2013, with Microsoft Excel 2010 and ArcGIS 10.0 used to develop statistical charts. RESULTS: In 2013, the m...περισσότερα »
[Clinical value of viral detection of liquid chip method in community-acquired pneumonia].
Related Articles *[Clinical value of viral detection of liquid chip method in community-acquired pneumonia].* Zhonghua Yi Xue Za Zhi. 2015 Jan 27;95(4):264-8 Authors: Gu X, Feng W, Zhu M, Wang M, Huang Y, Zhang M, Tian X, Zheng C, Ma A, Liu S, Xu M, Lu X Abstract OBJECTIVE: To evaluate the clinical value of viral detection of liquid chip method in community-acquired pneumonia (CAP). METHODS: A total of 342 swabs were collected from 171 patients of community-acquired pneumonia from October 2013 to September 2014. The methods of xTAG(RVP) and Seeplex RV15 ACE were employed to detec... περισσότερα »
[Perioperative management of bilateral bronchial foreign bodies in infants].
Related Articles *[Perioperative management of bilateral bronchial foreign bodies in infants].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jan;50(1):54-6 Authors: Ren H, Li Y, Han F Abstract OBJECTIVE: To explore the perioperative management of bilateral bronchial foreign bodies in infants to improve the cure rate in the children. METHODS: The medical charts of 45 infants with bilateral bronchial foreign bodies were reviewed. Clinical features and key points to surgery as well as post-operative care were analyzed. RESULTS: All foreign bodies were removed with rigid bronch... περισσότερα »
[A national investigation on the application of Chinese guideline for the diagnosis and treatment of chronic rhinosinusitis].
Related Articles *[A national investigation on the application of Chinese guideline for the diagnosis and treatment of chronic rhinosinusitis].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jan;50(1):50-3 Authors: Zuo K, Chu Y, Zhang Z, Luo X, Deng J, Chen F, Lai Y, Xu G, Shi J Abstract OBJECTIVE: To investigate the application of Chinese guideline for the diagnosis and treatment of chronic rhinosinusitis (2008, Nanchang) on a national scale. METHODS: The contents of the guideline and its relevant applied indicators were designed into an initial questionnaire and, after a p... περισσότερα »
Diabetes Mellitus in Patients Presenting with Adhesive Small Bowel Obstruction: Delaying Surgical Intervention Results in Worse Outcomes.
*Diabetes Mellitus in Patients Presenting with Adhesive Small Bowel Obstruction: Delaying Surgical Intervention Results in Worse Outcomes.* World J Surg. 2015 Nov 13; Authors: Karamanos E, Dulchavsky S, Beale E, Inaba K, Demetriades D Abstract INTRODUCTION: The impact of diabetes mellitus (DM) on outcomes in patients undergoing emergency laparotomy for adhesive small bowel obstruction (ASBO) remains unknown. METHODS: Low-risk (ASA class of I and II) patients requiring emergency operation for ASBO were identified using the ACS NSQIP database. Propensity score matching was used to ... περισσότερα »
Is Chemotherapy or Radiation Therapy in Addition to Surgery Beneficial for Locally Advanced Rectal Cancer in the Elderly? A National Cancer Data Base (NCDB) Study.
*Is Chemotherapy or Radiation Therapy in Addition to Surgery Beneficial for Locally Advanced Rectal Cancer in the Elderly? A National Cancer Data Base (NCDB) Study.* World J Surg. 2015 Nov 13; Authors: Bergquist JR, Thiels CA, Shubert CR, Habermann EB, Hayman AV, Zielinski MD, Mathis KL Abstract INTRODUCTION: Current National Comprehensive Cancer Network guidelines for Stages II and III rectal cancer recommend neoadjuvant chemoradiation followed by curative intent surgery and adjuvant chemotherapy. It is unclear whether therapies in addition to surgery are truly beneficial in e...περισσότερα »
Vitamins in Pancreatic Cancer: A Review of Underlying Mechanisms and Future Applications.
*Vitamins in Pancreatic Cancer: A Review of Underlying Mechanisms and Future Applications.* Adv Nutr. 2015 Nov;6(6):774-802 Authors: Davis-Yadley AH, Malafa MP Abstract Although there is increasing evidence that vitamins influence pancreatic adenocarcinoma biology and carcinogenesis, a comprehensive review is lacking. In this study, we performed a PubMed literature search to review the anticancer mechanisms and the preclinical and clinical studies that support the development of the bioactive vitamins A, C, D, E, and K in pancreatic cancer intervention. Preclinical studies have ... περισσότερα »
Health-related quality of life in patients with locally advanced or metastatic breast cancer treated with eribulin mesylate or capecitabine in an open-label randomized phase 3 trial.
*Health-related quality of life in patients with locally advanced or metastatic breast cancer treated with eribulin mesylate or capecitabine in an open-label randomized phase 3 trial.* Breast Cancer Res Treat. 2015 Nov 14; Authors: Cortes J, Hudgens S, Twelves C, Perez EA, Awada A, Yelle L, McCutcheon S, Kaufman PA, Forsythe A, Velikova G Abstract The clinical benefit of eribulin versus capecitabine was evaluated using health-related quality of life (HRQoL) data from a phase 3 randomized trial in patients with pretreated advanced/metastatic breast cancer (ClinicalTrials.gov iden... περισσότερα »
Monoclonal antibodies-based treatment in gastric cancer: current status and future perspectives.
*Monoclonal antibodies-based treatment in gastric cancer: current status and future perspectives.* Tumour Biol. 2015 Nov 13; Authors: Roviello G, Polom K, Petrioli R, Marano L, Marrelli D, Paganini G, Savelli V, Generali D, De Franco L, Ravelli A, Roviello F Abstract Gastric cancer (GC) is the second leading cause of cancer-related death, and despite having improved treatment modalities over the last decade, for most patients, only modest improvements have been seen in overall survival. Recent progress in understanding the molecular biology of GC and the related signaling pathwa... περισσότερα »
[Clinicopathological analyses of accessory breast cancer: a report of 22 cases].
Related Articles *[Clinicopathological analyses of accessory breast cancer: a report of 22 cases].* Zhonghua Yi Xue Za Zhi. 2015 Jan 27;95(4):260-3 Authors: Wang H, Duan J, Xin F, Cao X Abstract OBJECTIVE: To explore the clinicopathological characteristics, diagnosis, multi-disciplinary therapy and prognosis of accessory breast cancer. METHODS: The clinical data were retrospectively analyzed for 22 patients with accessory breast cancer from December 2000 and September 2013. RESULTS: Three patients underwent breast-conserving local wide excision of tumor plus axillary lymph node di...περισσότερα »
Restless legs syndrome is associated with poor sleep quality and quality of life in patients with ankylosing spondylitis: a questionnaire-based study
Restless legs syndrome is associated with poor sleep quality and quality of life in patients with ankylosing spondylitis: a questionnaire-based study: AbstractWe aimed to investigate the frequency of restless legs syndrome (RLS) and the associations between RLS and quality of sleep and life in patients with ankylosing spondylitis (AS). One hundred and eight AS patients and 64 controls were included in this study. Demographics, clinical, and laboratory data were recorded. The presence of RLS was determined with face-to-face interview by an experienced neurologist based on the Intern...περισσότερα »
Immune-Related Response Criteria-Capturing Clinical Activity in Immuno-Oncology.
CCR 20th Anniversary Commentary: Immune-Related Response Criteria-Capturing Clinical Activity in Immuno-Oncology.: *CCR 20th Anniversary Commentary: Immune-Related Response Criteria-Capturing Clinical Activity in Immuno-Oncology.* Clin Cancer Res. 2015 Nov 15;21(22):4989-91 Authors: Hoos A, Wolchok JD, Humphrey RW, Hodi FS Abstract To evaluate antitumor responses to chemotherapeutic agents, investigators would typically rely upon Response Evaluation Criteria in Solid Tumors (RECIST) or modified WHO criteria, which do not comprehensively capture responses with immunotherapeutic ag... περισσότερα »
Technical and surgical aspects of the sphenopalatine ganglion (SPG) microstimulator insertion procedure
Technical and surgical aspects of the sphenopalatine ganglion (SPG) microstimulator insertion procedure: Cluster headache (CH) is a debilitating, severe form of headache. A novel non-systemic therapy has been developed that produces therapeutic electrical stimulation to the sphenopalatine ganglion (SPG). A transoral surgical technique for inserting the Pulsante SPG Microstimulator into the pterygopalatine fossa (PPF) is presented herein. Technical aspects include detailed descriptions of the preoperative planning using computed tomography or cone beam computed tomography scans for p... περισσότερα »
Carotid endarterectomy in an asymptomatic patient with contralateral agenesis of the internal carotid artery
Carotid endarterectomy in an asymptomatic patient with contralateral agenesis of the internal carotid artery: A 64-year-old man was referred to the vascular surgery department with an incidental finding of right internal carotid artery stenosis during thyroid ultrasound imaging. Carotid artery color duplex revealed an ulcerated type III plaque producing stenosis of the right internal carotid artery of 70% and agenesis of the left internal carotid artery. Further imaging with computed tomography angiography confirmed the initial findings and excluded cerebral vascular malformations a... περισσότερα »
IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer.
*IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer.* Tumour Biol. 2015 Nov 13; Authors: Wu X, Yang T, Liu X, Guo JN, Xie T, Ding Y, Lin M, Yang H Abstract Gastric cancer is the world's second most common malignancy and is a major threat to global health. IL-17, a CD4 T cell-derived mediator of angiogenesis, plays a major role in stimulating angiogenesis by regulating the production of a variety of proangiogenic factors, including the vascular endothelial growth factor (VEGF). The level of VEGF expression correlates with tumor...περισσότερα »
[Effect of bifunctional IL2-GMCSF in promoting dendritic cell activation in vitro in simulated tumor-induced immune suppression].
Related Articles *[Effect of bifunctional IL2-GMCSF in promoting dendritic cell activation in vitro in simulated tumor-induced immune suppression].* Nan Fang Yi Ke Da Xue Xue Bao. 2015 Aug;35(9):1239-44 Authors: Wen Q, Xiong W, Liu S, Zhou C, Ma L Abstract OBJECTIVE: To test the effect of bifunctional molecule IL2-GMCSF in promoting the activation of dendritic cells (DCs) cultured in tumor conditioned medium. METHODS: We prepared a tumor conditioned medium using mouse melanoma cell line B16F10 supplemented with IL2-GMCSF, GM-CSF, IL-2, or the combination of the latter two. After ...περισσότερα »
The effects of hypoxia-inducible factor (HIF)-1α protein on bone regeneration during distraction osteogenesis: an animal study
The effects of hypoxia-inducible factor (HIF)-1α protein on bone regeneration during distraction osteogenesis: an animal study: The aim of this study was to observe the effect of hypoxia-inducible factor (HIF)-1α on bone regeneration during distraction osteogenesis (DO). Fifty-one New Zealand white rabbits underwent mandibular lengthening with a distraction rate of 2mm/day, and were divided randomly into three groups (17 in each). Group C rabbits received 20μg rHIF-1α, group B received 10μg rHIF-1α, and group A received 100μl saline injection in the distraction gap every day for 10 ... περισσότερα »
Swallowing performance and tube feeding status in patients treated with parotid-sparing intensity-modulated radiotherapy for head and neck cancer.
Swallowing performance and tube feeding status in patients treated with parotid-sparing intensity-modulated radiotherapy for head and neck cancer.: *Swallowing performance and tube feeding status in patients treated with parotid-sparing intensity-modulated radiotherapy for head and neck cancer.* Head Neck. 2015 Nov 13; Authors: Roe JW, Carding PN, Drinnan MJ, Harrington KJ, Nutting CM Abstract BACKGROUND: The purpose of this prospective study was to evaluate the swallowing performance of patients with head and neck cancer treated with parotid-sparing intensity-modulated radiothera...περισσότερα »
Evaluating the anatomical location of the posterior superior alveolar artery in cone beam computed tomography images
Evaluating the anatomical location of the posterior superior alveolar artery in cone beam computed tomography images: The purpose of this study was to examine the diameter, location, and frequency of the appearance of the posterior superior alveolar artery (PSAA) in preoperative cone beam computed tomography (CBCT) scans. Two hundred and eleven pre-implant CBCT scans were reviewed. The following criteria were considered in all subjects: (1) the location of the artery: intra-sinus or below the membrane (type I), intraosseous (type II), or superficial (type III); (2) the distance betw... περισσότερα »
Mitoxantrone as a contributing factor in medication-related osteonecrosis of the jaws
Mitoxantrone as a contributing factor in medication-related osteonecrosis of the jaws: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is usually initiated by dental surgery, but is occasionally exacerbated by other antiresorptive (denosumab) and anti-angiogenic therapies, and in such cases is currently termed medication-related osteonecrosis of the jaws (MRONJ). The case of a 58-year-old female with breast cancer who developed multiple and ultimately fatal metastases despite 3 years of treatment with chemotherapeutic drugs and intravenous bisphosphonates, is presented herei...περισσότερα »
Local full-thickness skin graft to cover the radial forearm free flap donor site
Local full-thickness skin graft to cover the radial forearm free flap donor site: I recently read with great interest the article by Riecke et al.1, concerning the use of a local full-thickness skin graft (FTSG) from the donor arm for closure of the radial forearm free flap (RFFF) donor site. The authors report their experience with the use of a FTSG from the forearm skin in 30 patients undergoing head and neck reconstruction with a RFFF. The main feature of the technique described is the performance of a sinusoidal curvilinear incision in the forearm skin proximal to the RFFF skin ... περισσότερα »
Immediate implant placement in fresh sockets versus implant placement in healed bone for full-arch fixed prostheses with conventional loading
Immediate implant placement in fresh sockets versus implant placement in healed bone for full-arch fixed prostheses with conventional loading: This retrospective study assessed the success of immediate and non-immediate implants installed in patients undergoing planned extraction of all remaining teeth and rehabilitation with implant-supported full fixed prostheses. Patients in need of dental implants for full fixed prostheses to replace teeth extracted in the maxilla and mandible were included in this study. Dental implants were installed in the same surgical procedure, immediately... περισσότερα »
Continuous postoperative pain control using a multiple-hole catheter after iliac bone grafting: comparison between ropivacaine and levobupivacaine
Continuous postoperative pain control using a multiple-hole catheter after iliac bone grafting: comparison between ropivacaine and levobupivacaine: The aim of this study was to compare the analgesic effects of ropivacaine and levobupivacaine in continuous infiltration anaesthesia delivered via a multiple-hole catheter for the purpose of postoperative analgesia after iliac bone grafting. Thirty-four patients scheduled for iliac bone grafting in the maxillofacial region participated in this study. The patients were randomized to a ropivacaine group (Ropi group) and a levobupivacaine gr... περισσότερα »
The relative survival of composite free flaps in head and neck reconstruction
The relative survival of composite free flaps in head and neck reconstruction: Various composite free flaps are available for reconstruction of bony head and neck defects. The aim of this study was to compare the relative success of four different bony free flaps. One hundred and seventy-three microvascular composite free flap reconstructions for bony defects of the head and neck region, performed over the period April 2008 to April 2015, were reviewed retrospectively. The type of free flap, indication for free flap reconstruction, age at harvesting of the free flap, use of pre- or ... περισσότερα »
Juvenile idiopathic arthritis and rheumatoid arthritis: bacterial diversity in temporomandibular joint synovial fluid in comparison with immunological and clinical findings
Juvenile idiopathic arthritis and rheumatoid arthritis: bacterial diversity in temporomandibular joint synovial fluid in comparison with immunological and clinical findings: Temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA) occurs in up to 80% of affected children. The purpose of this study was to investigate the presence of bacterial DNA in synovial fluid, and to compare this with clinical and immunological findings in children with JIA, adults with persistent JIA, and adults with rheumatoid arthritis, in order to detect whether bacteria contribute to... περισσότερα »
Does the piezoelectric surgical technique produce fewer postoperative sequelae after lower third molar surgery than conventional rotary instruments? A systematic review and meta analysis
Does the piezoelectric surgical technique produce fewer postoperative sequelae after lower third molar surgery than conventional rotary instruments? A systematic review and meta analysis: A systematic review and meta-analysis was conducted to answer the clinical question “Does the piezoelectric surgical technique produce fewer postoperative sequelae after lower third molar surgery than conventional rotary instruments?” A systematic and electronic search of several databases with specific key words, a reference search, and a manual search were performed from respective dates of incep... περισσότερα »
Effects of pulsed electromagnetic fields on swelling and pain after implant surgery: a double-blind, randomized study
Effects of pulsed electromagnetic fields on swelling and pain after implant surgery: a double-blind, randomized study: The aim of this split-mouth, double-blind, randomized study was to determine whether pulsed electromagnetic field therapy (PEMF) can improve swelling and the management of pain after full-arch immediate loading implant surgery. Eleven patients were selected for the study. Each patient received four distal tilted implants in the upper or lower jaw and underwent full-arch immediate loading rehabilitation. After surgery, two PEMF devices were applied to each patient, o... περισσότερα »
Mechanical resistance of the periorbita and the orbital floor complex—are isolated orbital floor fractures only a soft tissue problem?
Mechanical resistance of the periorbita and the orbital floor complex—are isolated orbital floor fractures only a soft tissue problem?: The primary aims of orbital floor reconstruction are to prevent enophthalmos and herniation of the orbital contents in order to achieve correct globe position. Theoretically, the mechanical load of the orbital floor is approximately 0.0005N/mm2 (30g orbital content onto 600mm2 of orbital floor area). Therefore, low mechanical stress from orbital floor reconstruction materials is expected. The periorbita and orbital floor complex (bony orbital floor ... περισσότερα »
Anthropomorphic assessment of the retromolar foramen and retromolar nerve: anomaly or variation of normal anatomy?
Anthropomorphic assessment of the retromolar foramen and retromolar nerve: anomaly or variation of normal anatomy?: The retromolar foramen, retromolar canal, and retromolar nerve constitute a variation of the inferior alveolar nerve (IAN) with a prevalence of 12–75%; this represents type 1 bifidity of the IAN. The aim of this study was to assess the prevalence of the retromolar nerve in our population and to obtain related data. One hundred and thirty-six mandibles of fresh cadavers aged 20–75 years were dissected. The buccolingual location, diameter, and distance from the third mola... περισσότερα »
Polymorphisms are associated with comorbidity of temporomandibular disorders and rotator cuff disease
polymorphisms are associated with comorbidity of temporomandibular disorders and rotator cuff disease: Temporomandibular disorders (TMD) are associated with comorbidity. Shoulder pain is among the symptoms associated with TMD. The purpose of this study was to investigate the association between TMD and rotator cuff disease (RCD) and related genetic aspects. All subjects underwent orofacial and shoulder examinations. The control group comprised 30 subjects with no pain. Affected subjects were divided into three groups: RCD (TMD-free, n=16), TMD (RCD-free, n=13), and TMD/RCD (patients... περισσότερα »
Orthodontic principles and guidelines for the surgery-first approach to orthognathic surgery
Orthodontic principles and guidelines for the surgery-first approach to orthognathic surgery: The surgery-first approach has become a new paradigm in orthognathic surgery. With the surgery-first approach, most of the patient's teeth are in their original positions and have not undergone orthodontic treatment prior to the patient undergoing orthognathic surgery. A ‘treatable’ malocclusion should be attained following orthognathic surgery. Orthodontists must ensure that they can manage the ‘treatable’ malocclusion by actively participating in the patient's surgical plan. Therefore, or... περισσότερα »
EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors.
EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors.: *EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors.* Neuro Oncol. 2015 Nov 12; Authors: Milojkovic Kerklaan B, Pluim D, Bol M, Hofland I, Westerga J, van Tinteren H, Beijnen JH, Boogerd W, Schellens JH, Brandsma D Abstract BACKGROUND: Moderate diagnostic accuracy of MRI and initial cerebrospinal fluid (CSF) cytology analysis results in at least 10%-15% fa...περισσότερα »
Metabolic and Sensory Influences on Odor Sensitivity in Humans.
*Metabolic and Sensory Influences on Odor Sensitivity in Humans.* Chem Senses. 2015 Nov 12; Authors: Ramaekers MG, Verhoef A, Gort G, Luning PA, Boesveldt S Abstract Our olfactory sense plays an important role in eating behavior by modulating our food preferences and intake. However, hunger or satiety may also influence how we perceive odors. Albeit speculative, contradictory results found in the past may have resulted from confounding by type of meal that participants ate to induce satiety. We aimed to investigate the influence of hunger state on olfactory sensitivity, comparing... περισσότερα »
Celebrating 35 Years of the AJNR: November 1980 edition.
*Celebrating 35 Years of the AJNR: November 1980 edition.* AJNR Am J Neuroradiol. 2015 Nov;36(11):2191 Authors: PMID: 26567385 [PubMed - in process] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1RWKz5c via IFTTT
[In Process Citation].
*[In Process Citation].* AJNR Am J Neuroradiol. 2015 Nov;36(11):1995 Authors: Pauranik A PMID: 26567384 [PubMed - in process] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1kxBW6H via IFTTT
The associations between Parkinson’s disease and cancer
The associations between Parkinson’s disease and cancer: the plot thickens: AbstractEpidemiological studies support a general inverse association between the risk of cancer development and Parkinson’s disease (PD). In recent years however, increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic groups. This positive association has been supported by several common genetic mutations in *SNCA*, *PARK2*, *PARK8*, *ATM*, *p53*, *PTEN*, and *MC1R* resulting in cellular changes such as mitochondrial dys...περισσότερα »
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
*Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.* J Am Soc Nephrol. 2015 Nov 13; Authors: Kumar Vr S, Darisipudi MN, Steiger S, Devarapu SK, Tato M, Kukarni OP, Mulay SR, Thomasova D, Popper B, Demleitner J, Zuchtriegel G, Reichel C, Cohen CD, Lindenmeyer MT, Liapis H, Moll S, Reid E, Stitt AW, Schott B, Gruner S, Haap W, Ebeling M, Hartmann G, Anders HJ Abstract Endothelial dysfunction is a central pathomechanism in diabetes-associated complications. We hypothesized a pathogenic role in this dysfunction of... περισσότερα »
Seasonal Difference in Postthyroidectomy Hypocalcemia: A Montreal-Based Study.
*Seasonal Difference in Postthyroidectomy Hypocalcemia: A Montreal-Based Study.* Otolaryngol Head Neck Surg. 2015 Nov 13; Authors: Mascarella MA, Forest VI, Nhan C, Leboeuf R, Tamilia M, Mlynarek AM, Payne RJ Abstract OBJECTIVE: Hypocalcemia following thyroidectomy often prolongs hospital stay and is potentially life-threatening. The objective of this study is to determine whether the season when thyroidectomy is performed is associated with postoperative hypocalcemia. STUDY DESIGN: Retrospective case series of patients undergoing thyroid surgery from 2009 to 2015. SETTING: Tert...περισσότερα »
Innate Immune Response of the Pig Laryngeal Mucosa to Endotracheal Intubation.
*Innate Immune Response of the Pig Laryngeal Mucosa to Endotracheal Intubation.* Otolaryngol Head Neck Surg. 2015 Nov 13; Authors: Hughes OR, Ayling SM, Birchall MA Abstract OBJECTIVE: The aim of this study was to measure the effects of endotracheal intubation on innate immune response within the pig laryngeal mucosa. STUDY DESIGN: Prospective controlled basic science study. SETTING: The animal experiments and analyses were conducted at the University of Bristol. SAMPLES AND METHODS: Eighteen pigs, matched at the major histocompatibility complex (MHC), were used in the study. The ... περισσότερα »
Morbidity, mortality and cost from HPV-related oropharyngeal cancer: Impact of 2-, 4- and 9-valent vaccines.
*Morbidity, mortality and cost from HPV-related oropharyngeal cancer: Impact of 2-, 4- and 9-valent vaccines.* Hum Vaccin Immunother. 2015 Nov 13;:0 Authors: Ward G, Mehta V, Moore M Abstract OBJECTIVE: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) related to human papillomavirus (HPV) is increasing at a dramatic rate, with men affected more commonly than women. Individuals who develop this disease suffer significant morbidity and potential mortality from their cancer and its associated treatment. We aim to evaluate the possible impact that the currently availab...περισσότερα »
A novel regulatory function for miR-29a in keloid fibrogenesis.
*A novel regulatory function for miR-29a in keloid fibrogenesis.* Clin Exp Dermatol. 2015 Nov 14; Authors: Zhang GY, Wu LC, Liao T, Chen GC, Chen YH, Zhao YX, Chen SY, Wang AY, Lin K, Lin DM, Yang JQ, Gao WY, Li QF Abstract BACKGROUND: A growing body of evidence has shown that microRNA-29 (miR-29) plays a central role in the progression of fibrosis. However, the mechanisms underlying the role of miR-29 in keloid fibrogenesis remain unknown. AIM: To investigate the roles of miR-29 in dermal fibroblasts in the pathogenesis of keloids. METHODS: Primary fibroblasts from 9 patients wi... περισσότερα »
Swallowing performance and tube feeding status in patients treated with parotid-sparing intensity-modulated radiotherapy for head and neck cancer.
*Swallowing performance and tube feeding status in patients treated with parotid-sparing intensity-modulated radiotherapy for head and neck cancer.* Head Neck. 2015 Nov 13; Authors: Roe JW, Carding PN, Drinnan MJ, Harrington KJ, Nutting CM Abstract BACKGROUND: The purpose of this prospective study was to evaluate the swallowing performance of patients with head and neck cancer treated with parotid-sparing intensity-modulated radiotherapy (IMRT). METHODS: Sixty-two patients were recruited. Data were collected before and up to 12 months after treatment. Measures included the Perform...περισσότερα »
Hypoechogenicity of brainstem raphe nuclei is associated with increased attack frequency in episodic migraine.
Hypoechogenicity of brainstem raphe nuclei is associated with increased attack frequency in episodic migraine.: *Hypoechogenicity of brainstem raphe nuclei is associated with increased attack frequency in episodic migraine.* Cephalalgia. 2015 Nov 12; Authors: Ayzenberg I, Nastos I, Strassburger-Krogias K, Obermann M, Gold R, Krogias C Abstract INTRODUCTION: Reduced echogenicity of the brainstem raphe nuclei (BRN) was demonstrated in major depression, possibly indicating serotonergic dysfunction. Postulating that migraine may constitute a "chronic low serotonin syndrome," we aime... περισσότερα »
Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache.
Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache.: *Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache.* Cephalalgia. 2015 Nov 12; Authors: Levy D, Edut S, Baraz-Goldstein R, Rubovitch V, Defrin R, Bree D, Gariepy H, Zhao J, Pick CG Abstract BACKGROUND: Chronic post-traumatic headache (PTH) is one of the most common symptoms of mild traumatic brain injury (mTBI) but its underlyi... περισσότερα »
Computer simulation in the daily practice of orthognathic surgery
Computer simulation in the daily practice of orthognathic surgery: The availability of computers and advances in imaging, especially over the last 10 years, have allowed the adoption of three-dimensional (3D) imaging in the office setting. The affordability and ease of use of this modality has led to its widespread implementation in diagnosis and treatment planning, teaching, and follow-up care. 3D imaging is particularly useful when the deformities are complex and involve both function and aesthetics, such as those in the dentofacial area, and for orthognathic surgery. (Source: Int... περισσότερα »
[Low expression of succinate dehydrogenase subunit B in locally recurrent nasopharyngeal carcinoma and implication for prognosis].
[Low expression of succinate dehydrogenase subunit B in locally recurrent nasopharyngeal carcinoma and implication for prognosis].: Related Articles*[Low expression of succinate dehydrogenase subunit B in locally recurrent nasopharyngeal carcinoma and implication for prognosis].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jan;50(1):38-42 Authors: Lin S, Dai Z, Chen C, Pan S, Liao Z Abstract OBJECTIVE: To study the expression of succinate dehydrogenase subunit B (SDHB) in the tissues of locally recurrent nasopharyngeal carcinoma (rNPC) and the correlation with the clinicop...περισσότερα »
Cerebral Venous Thrombosis: Current and Newer Anticoagulant Treatment Options
Cerebral Venous Thrombosis: Current and Newer Anticoagulant Treatment Options: [image: image]Background: Cerebral venous thrombosis (CVT) is rare and involves thrombosis of the veins and sinuses of the brain, most commonly the superior sagittal sinus. Approximately 5 CVT cases occur per 1 million persons in western countries. CVT causes 0.5% of strokes. Early diagnosis is crucial to prevent such outcomes as hydrocephalus, intracranial hypertension, and further seizures. Standard medical treatment of CVT consists of low-molecular-weight heparin and endovascular thrombolysis. Small ca...περισσότερα »
Differential Lesion Patterns on T2WI and FLAIR Sequences in Cryptogenic Stroke Patients With Patent Foramen Ovale
Differential Lesion Patterns on T2WI and FLAIR Sequences in Cryptogenic Stroke Patients With Patent Foramen Ovale: Objectives: The purpose of this study was to determine lesion patterns and stroke mechanisms in cryptogenic ischemic stroke patients with patent foramen ovale (PFO) on T2-weighted magnetic resonance imaging and fluid-attenuated inversion recovery sequences combined. Participants and Methods: Twenty-nine patients with cryptogenic ischemic stroke and an isolated PFO (CS-PFO+ group) compared with 51 cryptogenic stroke patients without PFO (CS-PFO− group) were evaluated and... περισσότερα »
Bilateral Paramedian Thalamic Infarction
Bilateral Paramedian Thalamic Infarction: [image: image]Introduction: Rarely, both paramedian thalami receive arterial blood flow from a single unilateral vessel arising from the first segment of 1 posterior cerebral artery. This artery has received the name of artery of Percheron (AP). There is no consensus regarding the true prevalence of this anatomical variant. Bilateral paramedian thalamic infarcts are uncommon (0.1% to 2% of ischemic strokes). The main cause is the occlusion of the AP due to cardioembolism. Diffusion-weighted magnetic resonance imaging demonstrates the lesion ... περισσότερα »
Morphology of muscular function in chronic tension-type headache: a pilot study
Morphology of muscular function in chronic tension-type headache: a pilot study: AbstractChronic pain has been thought to induce muscular changes in chronic tension-type headache (CTTH) patients. As the knowledge of muscular responses in CTTH is inconsistent, we decided to introduce new electromyogram signal shape descriptors. We also wanted to compare the discriminatory power of proposed indices with classical measures to establish their potential to act as markers for CTTH. Thirty-eight headache patients with twenty healthy volunteers were recruited. Twenty patients had CTTH, wh...περισσότερα »
Facial palsy in cerebral venous thrombosis
*Facial palsy in cerebral venous thrombosis: an atypical case in adults: * - *Case Reports* Facial Palsy in Cerebral Venous ThrombosisTranscranial Stimulation and Pathophysiological Considerations *1. J. Straub, MD; 2. M. R. Magistris, MD; 3. J. Delavelle, MD; 4. T. Landis, MD* *-**Author Affiliations* 1. *From the Departments of Neurology (J.S., M.R.M., T.L.), and Radiology (J.D.), University Hospital of Geneva, Geneva, Switzerland.* 1. *Correspondence to Dr J. Straub, c/o Dr M.R. Magistris, Clinique de Neurologie, Hôpital Cantonal Universitaire de Genève... περισσότερα »
Intravenous theophylline rapidly decreases post-lumbar puncture headaches
Intravenous theophylline rapidly decreases post-lumbar puncture headaches: AbstractWhen managing therapy for the post-lumbar puncture headaches (PLPHs), an efficacious, fast-acting, practical and safe method is preferred. Invasive methods have known complications and oral medications might be problematic when nausea and vomiting occurs with severe headaches. The aim of this study was to highlight the brief initial time for a remarkable decrease of PLPH pain levels after the administration of IV theophylline infusion. We observed that IV theophylline infusion has a rapid and marked ...περισσότερα »
Acid-sensing ion channels: potential therapeutic targets for neurologic diseases
Acid-sensing ion channels: potential therapeutic targets for neurologic diseases: AbstractMaintaining the physiological pH of interstitial fluid is crucial for normal cellular functions. In disease states, tissue acidosis is a common pathologic change causing abnormal activation of acid-sensing ion channels (ASICs), which according to cumulative evidence, significantly contributes to inflammation, mitochondrial dysfunction, and other pathologic mechanisms (i.e., pain, stroke, and psychiatric conditions). Thus, it has become increasingly clear that ASICs are critical in the progres... περισσότερα »
Vitamins in Pancreatic Cancer: A Review of Underlying Mechanisms and Future Applications.
*Vitamins in Pancreatic Cancer: A Review of Underlying Mechanisms and Future Applications.* Adv Nutr. 2015 Nov;6(6):774-802 Authors: Davis-Yadley AH, Malafa MP Abstract Although there is increasing evidence that vitamins influence pancreatic adenocarcinoma biology and carcinogenesis, a comprehensive review is lacking. In this study, we performed a PubMed literature search to review the anticancer mechanisms and the preclinical and clinical studies that support the development of the bioactive vitamins A, C, D, E, and K in pancreatic cancer intervention. Preclinical studies have ... περισσότερα »
Health-related quality of life in patients with locally advanced or metastatic breast cancer treated with eribulin mesylate or capecitabine in an open-label randomized phase 3 trial.
*Health-related quality of life in patients with locally advanced or metastatic breast cancer treated with eribulin mesylate or capecitabine in an open-label randomized phase 3 trial.* Breast Cancer Res Treat. 2015 Nov 14; Authors: Cortes J, Hudgens S, Twelves C, Perez EA, Awada A, Yelle L, McCutcheon S, Kaufman PA, Forsythe A, Velikova G Abstract The clinical benefit of eribulin versus capecitabine was evaluated using health-related quality of life (HRQoL) data from a phase 3 randomized trial in patients with pretreated advanced/metastatic breast cancer (ClinicalTrials.gov iden... περισσότερα »
Monoclonal antibodies-based treatment in gastric cancer: current status and future perspectives.
*Monoclonal antibodies-based treatment in gastric cancer: current status and future perspectives.* Tumour Biol. 2015 Nov 13; Authors: Roviello G, Polom K, Petrioli R, Marano L, Marrelli D, Paganini G, Savelli V, Generali D, De Franco L, Ravelli A, Roviello F Abstract Gastric cancer (GC) is the second leading cause of cancer-related death, and despite having improved treatment modalities over the last decade, for most patients, only modest improvements have been seen in overall survival. Recent progress in understanding the molecular biology of GC and the related signaling pathwa... περισσότερα »
Nervus Intermedius Guides Auditory Brainstem Implant Surgery in Children with Cochlear Nerve Deficiency.
Nervus Intermedius Guides Auditory Brainstem Implant Surgery in Children with Cochlear Nerve Deficiency.: *Nervus Intermedius Guides Auditory Brainstem Implant Surgery in Children with Cochlear Nerve Deficiency.* Otolaryngol Head Neck Surg. 2015 Nov 13; Authors: Colletti G, Mandalà M, Colletti L, Colletti V Abstract OBJECTIVE: To investigate the anatomic features of the nervus intermedius and cranial nerve VII in children with cochlear nerve deficiency and to verify whether the nervus intermedius can provide an additional landmark to help guide placement of the auditory brainstem... περισσότερα »
Innate Immune Response of the Pig Laryngeal Mucosa to Endotracheal Intubation.
Innate Immune Response of the Pig Laryngeal Mucosa to Endotracheal Intubation.: *Innate Immune Response of the Pig Laryngeal Mucosa to Endotracheal Intubation.* Otolaryngol Head Neck Surg. 2015 Nov 13; Authors: Hughes OR, Ayling SM, Birchall MA Abstract OBJECTIVE: The aim of this study was to measure the effects of endotracheal intubation on innate immune response within the pig laryngeal mucosa. STUDY DESIGN: Prospective controlled basic science study. SETTING: The animal experiments and analyses were conducted at the University of Bristol. SAMPLES AND METHODS: Eighteen pigs, ... περισσότερα »
Treatment Outcomes and Risk Factors for Recurrence after Definitive Surgery of Locally Invasive Well-Differentiated Papillary Thyroid Carcinoma.
*Treatment Outcomes and Risk Factors for Recurrence after Definitive Surgery of Locally Invasive Well-Differentiated Papillary Thyroid Carcinoma.* Thyroid. 2015 Nov 13; Authors: Kim JW, Roh JL, Gong G, Cho KJ, Choi SH, Nam SY, Kim SY Abstract BACKGROUND: Papillary thyroid carcinoma (PTC) is generally an indolent tumor that has a favorable prognosis. However, locally invasive PTC can recur after treatment, and its optimal treatment is still controversial. This study aimed to evaluate treatment outcomes and identify risk factors for recurrence and survival in patients with locally...περισσότερα »
A Randomized Controlled Trial to Evaluate the Benefits of a Multimedia Educational Program for First-Time Hearing Aid Users.
A Randomized Controlled Trial to Evaluate the Benefits of a Multimedia Educational Program for First-Time Hearing Aid Users.: Related Articles*A Randomized Controlled Trial to Evaluate the Benefits of a Multimedia Educational Program for First-Time Hearing Aid Users.* Ear Hear. 2015 Nov 12; Authors: Ferguson M, Brandreth M, Brassington W, Leighton P, Wharrad H Abstract OBJECTIVES: The aims of this study were to (1) develop a series of short interactive videos (or reusable learning objects [RLOs]) covering a broad range of practical and psychosocial issues relevant to the auditory ...περισσότερα »
The association between Parkinson’s disease and melanoma
The association between Parkinson’s disease and melanoma: a systematic review and meta-analysis: Abstract ObjectiveTo assess the association between Parkinson’s disease (PD) and melanoma via systematic review and meta-analysis. MethodsComprehensive search in PubMed, Web of Science, Embase and four China databases (SinoMed, WanFang data, CNKI and VIP database) of epidemiologic evidences on PD and melanoma published before April 30, 2015. Studies which reported risk estimates of melanoma among PD patients or risk estimates of PD in patients with melanoma were included. Pooled odd... περισσότερα »
The Possible Role of Tumor Necrosis Factor-α Gene Polymorphisms in Association with Ischemic Stroke
Systematic Review by Multivariate Meta-analyses on the Possible Role of Tumor Necrosis Factor-α Gene Polymorphisms in Association with Ischemic Stroke: AbstractA number of studies have investigated the association between tumor necrosis factor (TNF)-α gene polymorphisms and ischemic stroke susceptibility. However, results of different individual studies are often inconsistent. To provide a more robust evaluation of the association between polymorphisms of the TNF-α gene and ischemic stroke risk, we performed a systematic review with multivariate meta-analyses. PubMed, Embase, CNKI...περισσότερα »
Noninvasive measurement of cerebrospinal fluid flow using an ultrasonic transit time flow sensor
Noninvasive measurement of cerebrospinal fluid flow using an ultrasonic transit time flow sensor: a preliminary study: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECT Mechanical failure—which is the primary cause of CSF shunt malfunction—is not readily diagnosed, and the specific reasons for mechanical failure are not easily discerned. Prior attempts to measure CSF flow noninvasively have lacked the ability to either quantitatively or qualitatively obtain data. To address these needs, this preliminary study evaluates an ultrasonic transit time flow sensor in pediatric a... περισσότερα »
Pituitary macroadenomas with oculomotor cistern extension and tracking
Pituitary macroadenomas with oculomotor cistern extension and tracking: implications for surgical management: Journal of Neurosurgery, Ahead of Print. OBJECT Oculomotor cistern extension of pituitary adenomas is an overlooked feature within the literature. In this study, 7 cases of pituitary macroadenoma with oculomotor cistern extension and tracking are highlighted, and the implications of surgical and medical management are discussed. METHODS The records of patients diagnosed with pituitary macroadenomas who underwent resection and in whom preoperative pituitary protocol MRI sca...περισσότερα »
Risk factors for neurological worsening and symptomatic watershed infarction in internal carotid artery aneurysm treated by extracranial-intracranial bypass using radial artery graft
Risk factors for neurological worsening and symptomatic watershed infarction in internal carotid artery aneurysm treated by extracranial-intracranial bypass using radial artery graft: Journal of Neurosurgery, Ahead of Print. OBJECT The revascularization technique, including bypass created using the external carotid artery (ECA), radial artery (RA), and M2 portion of middle cerebral artery (MCA), has remained indispensable for treatment of complex aneurysms. To date, it remains unknown whether diameters of the RA, superficial temporal artery (STA), and C2 portion of the internal car...περισσότερα »
Orbit-associated tumors
Orbit-associated tumors: navigation and control of resection using intraoperative computed tomography: Journal of Neurosurgery, Ahead of Print. OBJECT Treatment of skull base lesions is complex and usually requires a multidisciplinary approach. In meningioma, which is the most common tumor entity in this region, resection is considered to be the most important therapeutic step to avoid tumor recurrence. However, resection of skull base lesions with orbital or optic nerve involvement poses a challenge due to their anatomical structure and their proximity to eloquent areas. Therefor...περισσότερα »
Defensive medicine in neurosurgery
Defensive medicine in neurosurgery: the Canadian experience: Journal of Neurosurgery, Ahead of Print. OBJECT Recent studies have examined the impact of perceived medicolegal risk and compared how this perception impacts defensive practices within the US. To date, there have been no published data on the practice of defensive medicine among neurosurgeons in Canada. METHODS An online survey containing 44 questions was sent to 170 Canadian neurosurgeons and used to measure Canadian neurosurgeons’ perception of liability risk and their practice of defensive medicine. The survey include... περισσότερα »
Symptomatic large or giant capillary telangiectasias: management and outcome in 5 cases
Symptomatic large or giant capillary telangiectasias: management and outcome in 5 cases: Journal of Neurosurgery, Ahead of Print. Brain capillary telangiectasias (BCTs) are usually small and benign with a predilection in the pons and basal ganglion. Reports of large and symptomatic BCTs are rare. Large BCTs have a much higher risk of causing uncontrolled bleeding and severe neurological defects, and they can be fatal if left untreated. Therefore, large BCTs should be managed with special caution. Because of the lack of reports, diagnosis of large BCTs has been difficult. Strategies... περισσότερα »
Intracranial-to-intracranial bypass for posterior inferior cerebellar artery aneurysms: options, technical challenges, and results in 35 patients
Intracranial-to-intracranial bypass for posterior inferior cerebellar artery aneurysms: options, technical challenges, and results in 35 patients: Journal of Neurosurgery, Ahead of Print. OBJECT Intracranial-to-intracranial (IC-IC) bypasses are alternatives to traditional extracranial-to-intracranial (EC-IC) bypasses to reanastomose parent arteries, reimplant efferent branches, revascularize branches with in situ donor arteries, and reconstruct bifurcations with interposition grafts that are entirely intracranial. These bypasses represent an evolution in bypass surgery from using s... περισσότερα »
The feasibility of producing patient-specific acrylic cranioplasty implants with a low-cost 3D printer
The feasibility of producing patient-specific acrylic cranioplasty implants with a low-cost 3D printer: Journal of Neurosurgery, Ahead of Print. OBJECT Commercially available, preformed patient-specific cranioplasty implants are anatomically accurate but costly. Acrylic bone cement is a commonly used alternative. However, the manual shaping of the bone cement is difficult and may not lead to a satisfactory implant in some cases. The object of this study was to determine the feasibility of fabricating molds using a commercial low-cost 3D printer for the purpose of producing patient-... περισσότερα »
A review of the current and potential oxygen delivery systems and techniques utilized in cluster headache attacks.
A review of the current and potential oxygen delivery systems and techniques utilized in cluster headache attacks.: *A review of the current and potential oxygen delivery systems and techniques utilized in cluster headache attacks.* Cephalalgia. 2015 Nov 12; Authors: Oude Nijhuis JC, Haane DY, Koehler PJ Abstract BACKGROUND: Despite oxygen therapy being one of the foremost acute treatments for cluster headache (CH) attacks, little is known about the different techniques and systems. OBJECTIVES: In this review we will examine the efficacy of the standard non-rebreather mask (NRM)... περισσότερα »
Angiographically occult vascular malformation of the intracranial accessory nerve: case report
Angiographically occult vascular malformation of the intracranial accessory nerve: case report: Journal of Neurosurgery, Ahead of Print. Angiographically occult cerebral vascular malformations (AOVMs) are usually found in the supratentorial brain parenchyma. Uncommonly, AOVMs can be found within the cavernous sinus or basal cisterns and can be associated with cranial nerves. AOVMs involving the intracranial segment of the spinal accessory nerve have not been described. A 46-year-old female patient presented with a history of episodic frontal headaches and episodes of nausea and diz...περισσότερα »
Seasonal Difference in Postthyroidectomy Hypocalcemia: A Montreal-Based Study.
Seasonal Difference in Postthyroidectomy Hypocalcemia: A Montreal-Based Study.: *Seasonal Difference in Postthyroidectomy Hypocalcemia: A Montreal-Based Study.* Otolaryngol Head Neck Surg. 2015 Nov 13; Authors: Mascarella MA, Forest VI, Nhan C, Leboeuf R, Tamilia M, Mlynarek AM, Payne RJ Abstract OBJECTIVE: Hypocalcemia following thyroidectomy often prolongs hospital stay and is potentially life-threatening. The objective of this study is to determine whether the season when thyroidectomy is performed is associated with postoperative hypocalcemia. STUDY DESIGN: Retrospective ca... περισσότερα »
Ultrasound-induced opening of the blood-brain barrier to enhance temozolomide and irinotecan delivery: an experimental study in rabbits
Ultrasound-induced opening of the blood-brain barrier to enhance temozolomide and irinotecan delivery: an experimental study in rabbits: Journal of Neurosurgery, Ahead of Print. OBJECT The blood-brain barrier (BBB) limits the intracerebral penetration of drugs and brain tumor treatment efficacy. The effect of ultrasound-induced BBB opening on the intracerebral concentration of temozolomide (TMZ) and irinotecan (CPT-11) was assessed. METHODS This study was performed using 34 healthy New Zealand rabbits. Half had unilateral BBB opening, and half served as controls. Sonications were p...περισσότερα »
Association of apolipoprotein E gene polymorphism with small-vessel lesions and stroke type in moyamoya disease: a preliminary study
Association of apolipoprotein E gene polymorphism with small-vessel lesions and stroke type in moyamoya disease: a preliminary study: Journal of Neurosurgery, Ahead of Print. OBJECT The present study was conducted to investigate whether microbleeds or microinfarcts are associated with apolipoprotein E (APOE) gene polymorphisms in patients with moyamoya disease (MMD), and if so, whetherAPOE gene polymorphisms are also associated with stroke type in patients with MMD. METHODS This cross-sectional, multicenter study included 86 consecutive patients with MMD who underwent T2*-weighted ... περισσότερα »
Cell Death and Cancer Therapy: Don't Forget to Kill the Cancer Cell!
Cell Death and Cancer Therapy: Don't Forget to Kill the Cancer Cell!: *Cell Death and Cancer Therapy: Don't Forget to Kill the Cancer Cell!* Clin Cancer Res. 2015 Nov 15;21(22):5015-20 Authors: Letai A Abstract In our current age of targeted therapies, there is understandably considerable attention paid to the specific molecular targets of pharmaceutical intervention. For a targeted drug to work, it must bind to a target selectively and impair its function. Monitoring biomarkers of the impaired target function can provide vital in vivo pharmacodynamic information. Moreover, genet... περισσότερα »
BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis.
BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis.: *BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis.* Clin Cancer Res. 2015 Nov 15;21(22):5021-9 Authors: Gibson CJ, Davids MS Abstract Despite significant improvements in treatment, cure rates for many cancers remain suboptimal. The rise of cytotoxic chemotherapy has led to curative therapy for a subset of cancers, though intrinsic treatment resistance is difficult to predict for individual patients. The recent wave of molecularly targeted therapies has focused on druggable-ac... περισσότερα »
Promises and Challenges of Smac Mimetics as Cancer Therapeutics.
Promises and Challenges of Smac Mimetics as Cancer Therapeutics.: *Promises and Challenges of Smac Mimetics as Cancer Therapeutics.* Clin Cancer Res. 2015 Nov 15;21(22):5030-6 Authors: Fulda S Abstract Inhibitor of Apoptosis (IAP) proteins block programmed cell death and are expressed at high levels in various human cancers, thus making them attractive targets for cancer drug development. Second mitochondrial activator of caspases (Smac) mimetics are small-molecule inhibitors that mimic Smac, an endogenous antagonist of IAP proteins. Preclinical studies have shown that Smac mimet... περισσότερα »
Autophagy, Metabolism, and Cancer.
Autophagy, Metabolism, and Cancer.: *Autophagy, Metabolism, and Cancer.* Clin Cancer Res. 2015 Nov 15;21(22):5037-46 Authors: White E, Mehnert JM, Chan CS Abstract Macroautophagy (autophagy hereafter) captures intracellular proteins and organelles and degrades them in lysosomes. The degradation breakdown products are released from lysosomes and recycled into metabolic and biosynthetic pathways. Basal autophagy provides protein and organelle quality control by eliminating damaged cellular components. Starvation-induced autophagy recycles intracellular components into metabolic pa... περισσότερα »
Lack of autophagy induces steroid-resistant airway inflammation
Lack of autophagy induces steroid-resistant airway inflammation: [image: gr1.sml] Neutrophilic corticosteroid-resistant asthma accounts for a significant proportion of asthma; however, little is known about the mechanisms that underlie the pathogenesis of the disease.
Shifting Fundamental Frequency in Simulated Electric-Acoustic Listening: Effects of F0 Variation.
Shifting Fundamental Frequency in Simulated Electric-Acoustic Listening: Effects of F0 Variation.: Related Articles*Shifting Fundamental Frequency in Simulated Electric-Acoustic Listening: Effects of F0 Variation.* Ear Hear. 2015 Nov 12; Authors: Brown CA, Helms Tillery K, Apoux F, Doyle NM, Bacon SP Abstract OBJECTIVE: Shifting the mean fundamental frequency (F0) of target speech down in frequency may be a way to provide the benefits of electric-acoustic stimulation (EAS) to cochlear implant (CI) users whose limited residual hearing precludes a benefit typically, even with ampli... περισσότερα »
A novel regulatory function for miR-29a in keloid fibrogenesis.
A novel regulatory function for miR-29a in keloid fibrogenesis.: *A novel regulatory function for miR-29a in keloid fibrogenesis.* Clin Exp Dermatol. 2015 Nov 14; Authors: Zhang GY, Wu LC, Liao T, Chen GC, Chen YH, Zhao YX, Chen SY, Wang AY, Lin K, Lin DM, Yang JQ, Gao WY, Li QF Abstract BACKGROUND: A growing body of evidence has shown that microRNA-29 (miR-29) plays a central role in the progression of fibrosis. However, the mechanisms underlying the role of miR-29 in keloid fibrogenesis remain unknown. AIM: To investigate the roles of miR-29 in dermal fibroblasts in the pathog... περισσότερα »
Food insecurity and migraine
*Food insecurity and migraine* *by Rist, P., Kurth, T. via Cephalalgia * *Editorial Food insecurity and migraine Pamela Rist1,2 and Tobias Kurth1,2,3 Food security describes the concept of having access to food under the aspect of nutritional well-being (1). In contrast, food insecurity occurs when individuals do not have adequate physical, social, or economic access to sufficient, safe, and nutritious food which meets their dietary needs and food preferences for an active and healthy life (2). A large body of research has identified risk factors for food insecurity, including inco... περισσότερα »
Understanding the impact of survival and human papillomavirus tumor status on timing of recurrence in oropharyngeal squamous cell carcinoma
Understanding the impact of survival and human papillomavirus tumor status on timing of recurrence in oropharyngeal squamous cell carcinoma: Recent studies have evaluated the impact of human papillomavirus (HPV) tumor status on the clinical presentation and prognosis of recurrent oropharyngeal squamous cell carcinoma (OPSCC) [1–5]. The prognostic implication of HPV-positive tumor status at primary diagnosis is well established [6,7], and recent data have also shown that HPV-positive tumor status continues to confer improved prognosis at the time of disease recurrence [1,2,4]. Howeve...περισσότερα »
Lymphoma cell–specific α-Gal immunotherapy is safe, effective and has great potential for the treatment of refractory B-cell lymphoma.
Combination of cytokine-induced killer and dendritic cells pulsed with antigenic α-1,3-galactosyl epitope–enhanced lymphoma cell membrane for effective B-cell lymphoma immunotherapy via Cytotherapy Publication date: Available online 10 November 2015 *Source:*Cytotherapy Author(s): Ying Qiu, Mark M. Yun, Xuebin Dong, Mingbao Xu, Ruidong Zhao, Xia Han, Erxia Zhou, Feiyu Yun, Wuyun Su, Caixia Liu, Haiyan Zhao, Xin Tong, Jin Gao, Xiaohui Ouyang, Sheng Yun Background aimsRefractory B-cell lymphomas are difficult to successfully treat with current chemotherapeutic regimens; however, immunoth... περισσότερα »
Treatment for bronchopleural fistula using adipose-derived stromal cells
Novel bronchoscopic via Cytotherapy Publication date: Available online 6 November 2015 *Source:*Cytotherapy Author(s): Prudencio J. Díaz-Agero Álvarez, Yury A. Bellido-Reyes, Joaquín G. Sánchez-Girón, Damián García-Olmo, Mariano García-Arranz Background aimsIn this report, we describe the successful bronchoscopic management of bronchopleural fistula in two patients, using autologous adipose-derived stromal cells. Cell therapy was considered for 2 cases of bronchopleural fistula refractory to conventional surgical treatment after control of the primary disease was confirmed and active ...περισσότερα »
Cross-reactivity of anti-fungal T cells
Stimulation with lysates of Aspergillus terreus, Candida krusei and Rhizopus oryzae maximizes cross-reactivity of anti-fungal T cells via Cytotherapy Publication date: Available online 6 November 2015 *Source:*Cytotherapy Author(s): Shivashni S. Deo, Balaji Virassamy, Catriona Halliday, Leighton Clancy, Sharon Chen, Wieland Meyer, Tania C. Sorrell, David J. Gottlieb Background aims. Invasive fungal diseases caused by filamentous fungi and yeasts are significant causes of morbidity and mortality in immunosuppressed hematology patients. We previously published a method to expand Aspergil...περισσότερα »
Cytotherapy
Combination of cytokine-induced killer and dendritic cells pulsed with antigenic α-1,3-galactosyl epitope–enhanced lymphoma cell membrane for effective B-cell lymphoma immunotherapy Publication date: Available online 10 November 2015 *Source:*Cytotherapy Author(s): Ying Qiu, Mark M. Yun, Xuebin Dong, Mingbao Xu, Ruidong Zhao, Xia Han, Erxia Zhou, Feiyu Yun, Wuyun Su, Caixia Liu, Haiyan Zhao, Xin Tong, Jin Gao, Xiaohui Ouyang, Sheng Yun Background aims Refractory B-cell lymphomas are difficult to successfully treat with current chemotherapeutic regimens; however, immunotherapy may be ... περισσότερα »
An anatomic study of the attachments on the condylar process of the mandible: muscle bundles from the temporalis.
*An anatomic study of the attachments on the condylar process of the mandible: muscle bundles from the temporalis.* Surg Radiol Anat. 2015 Nov 13; Authors: Sakaguchi-Kuma T, Hayashi N, Fujishiro H, Yamaguchi K, Shimazaki K, Ono T, Akita K Abstract PURPOSE: The aim of this study was to evaluate anatomically the relationship between bone and muscles by detailed observation of the bone shape and the structure of muscles to facilitate an understanding of the function of the muscles involved in jaw movement. METHODS: 36 specimens of 24 Japanese cadavers were examined. The insertion a...περισσότερα »
Pneumorrhachis Secondary to Spontaneous Pneumomediastinum
Case Series: Pneumorrhachis Secondary to Spontaneous Pneumomediastinum: [image: gr1.sml] Pneumorrhachis (PR) describes the clinical finding of air within the spinal canal and rarely has been associated with spontaneous pneumomediastinum. There is little medical literature addressing the evaluation and management of these patients in the emergency department.
Ultrasound-guided Greater Auricular Nerve Block for Emergency Department Ear Laceration and Ear Abscess Drainage
Ultrasound-guided Greater Auricular Nerve Block for Emergency Department Ear Laceration and Ear Abscess Drainage: [image: gr1.sml] Adequate emergency department (ED) anesthesia for painful ear conditions, such as ear lacerations or ear abscesses, can be challenging. Much of the sensory innervation of the ear is supplied from the anterior and posterior branches of the greater auricular nerve (GAN). The GAN is a branch of the superficial cervical plexus, which arises from the C2/C3 spinal roots. The GAN innervation includes most of the helix, antihelix, the lobule, and the skin o... περισσότερα »
Stress Cardiomyopathy Caused by Diving
Stress Cardiomyopathy Caused by Diving: Case Report and Review of the Literature: Stress cardiomyopathy is characterized by transient myocardial dysfunction that mimics a myocardial infarction in the absence of obstructive coronary artery disease. The onset is frequently triggered by an acute illness or intense physical or emotional stress. AbstractBackground Stress cardiomyopathy is characterized by transient myocardial dysfunction that mimics a myocardial infarction in the absence of obstructive coronary artery disease. The onset is frequently triggered by an acute illness or i...περισσότερα »
Respiratory Distress in an Infant: An Uncommon Cause for a Common Complaint
Respiratory Distress in an Infant: An Uncommon Cause for a Common Complaint: Respiratory distress and tachycardia are common presenting complaints in infants and young children, and evaluation typically focuses on respiratory infections. Tachydysrhythmias causing heart failure are rare and can be difficult to diagnose in young children, but are reversible if recognized and treated early. AbstractBackground Respiratory distress and tachycardia are common presenting complaints in infants and young children, and evaluation typically focuses on respiratory infections. Tachydysrhythmi... περισσότερα »
Acute Concussion Management with Remove-Reduce/Educate/Adjust-Accommodate/Pace (REAP)
Acute Concussion Management with Remove-Reduce/Educate/Adjust-Accommodate/Pace (REAP): With increased concussion awareness and significantly increased numbers of emergency department (ED) visits for pediatric concussion, a seamless process of managing a patient with a concussion can begin in the ED. AbstractBackground With increased concussion awareness and significantly increased numbers of emergency department (ED) visits for pediatric concussion, a seamless process of managing a patient with a concussion can begin in the ED. Case Report This article demonstrates the effectivene... περισσότερα »
A Rare Case of Nonsecretory Multiple Myeloma in Lagos, Nigeria: A Case Report and Literature Review
Multiple myeloma (MM) is a plasma cell disorder associated with clonal proliferation of plasma cells. Nonsecretory multiple myeloma (NSMM) is a rare variant of MM and accounts for approximately 1% to 5% of all cases. It is defined as symptomatic myeloma without detectable monoclonal immunoglobulin on serum or urine electrophoresis. This variant usually poses a diagnostic challenge to the clinician. We present a 60-year-old Nigerian man who was investigated extensively for bone pain, weight loss, and anaemia. He was eventually diagnosed as having nonsecretory multiple myeloma based... περισσότερα »
How Do Cytotoxic Lymphocytes Kill Cancer Cells?
How Do Cytotoxic Lymphocytes Kill Cancer Cells?: *How Do Cytotoxic Lymphocytes Kill Cancer Cells?* Clin Cancer Res. 2015 Nov 15;21(22):5047-56 Authors: Martínez-Lostao L, Anel A, Pardo J Abstract In the past few years, cancer immunotherapy has emerged as a safe and effective alternative for treatment of cancers that do not respond to classical treatments, including those types with high aggressiveness. New immune modulators, such as cytokines, blockers of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) and PD-1(programmed cell death protein 1)/PD-L1 (programmed death-ligand ... περισσότερα »
[Feature Extraction of Brainstem Auditory Evoked Potential Based on Wavelet Multi-resolution Analysis].
[Feature Extraction of Brainstem Auditory Evoked Potential Based on Wavelet Multi-resolution Analysis].: Related Articles*[Feature Extraction of Brainstem Auditory Evoked Potential Based on Wavelet Multi-resolution Analysis].* Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2015 Jun;32(3):514-9 Authors: Tian F, Sun Y Abstract We proposed a multi-resolution-wavelet-transform based method to extract brainstem auditory evoked potential (BAEP) from the background noise and then to identify its characteristics correctly. Firstly we discussed the mother wavelet and wavelet transform algorithm a...περισσότερα »
The Pivotal Roles of Risk Factors for Acute Respiratory Distress Syndrome
The Pivotal Roles of Risk Factors for Acute Respiratory Distress Syndrome: We read with interest the article entitled, “Terlipressin [TP] Decreases Vascular Endothelial Growth Factor [VEGF] Expression and Improves Oxygenation in Patients with Acute Respiratory Distress Syndrome [ARDS] and Shock,” by Hua et al (1). The authors compared the impact of TP vs. dopamine on hemodynamic variables and vascular VEGF in ARDS patients with shock. VEGF concentration in plasma was significantly lower in ARDS patients with shock who were treated with TP than in those treated with dopamine.
Abdominal Pain in a Young Man with Oral Pigmentations
Abdominal Pain in a Young Man with Oral Pigmentations: [image: gr1.sml] An 18-year-old man presented to the Emergency Department (ED) with 1 day of lower abdominal pain associated with nausea and vomiting. He denied fevers, chills, sweats, diarrhea, constipation, or blood in the stool. There was no history of unusual food intake or ingestions, sick contacts, or recent foreign travel. On examination, the patient was afebrile with normal vital signs and appeared otherwise healthy, but in acute distress secondary to pain. His abdominal examination was notable for periumbilical and ... περισσότερα »
The Effect of Noise Distraction on Emergency Medicine Resident Performance During Intubation of a Patient Simulator
The Effect of Noise Distraction on Emergency Medicine Resident Performance During Intubation of a Patient Simulator: [image: gr1.sml] The environment in the Emergency Department (ED) is chaotic, and physicians are expected to perform procedures amongst distractions.
Risk of infection among patients with non-metastatic solid tumors or non-Hodgkin's lymphoma receiving myelosuppressive chemotherapy and antimicrobial prophylaxis in US clinical practice
Risk of infection among patients with non-metastatic solid tumors or non-Hodgkin's lymphoma receiving myelosuppressive chemotherapy and antimicrobial prophylaxis in US clinical practice: Purpose Guidelines generally do not recommend oral antimicrobials for prophylaxis against chemotherapy-related infections in patients with solid tumors. Evidence on antimicrobial prophylaxis use, and associated chemotherapy-related infection risk, in US clinical practice is limited. Methods A retrospective cohort design and data from two US private healthcare claims repositories (2008–2011) were em...περισσότερα »
Mixed primary squamous cell carcinoma, follicular carcinoma, and micropapillary carcinoma of the thyroid gland: A case report
Mixed primary squamous cell carcinoma, follicular carcinoma, and micropapillary carcinoma of the thyroid gland: A case report: Primary squamous cell carcinoma of the thyroid gland is rare, and mixed squamous cell and follicular carcinoma is even rarer still, with only a few cases reported in the literature. The simultaneous presentation of three primary cancers of the thyroid has not been reported previously. Here we report a case of primary squamous cell carcinoma of the thyroid, follicular thyroid carcinoma, and micropapillary thyroid carcinoma. A 62-year-old female patient presen... περισσότερα »
Applied anatomy of the anterior cranial fossa: what can fracture patterns tell us?
Applied anatomy of the anterior cranial fossa: what can fracture patterns tell us?: The skull base is uniquely placed to absorb anteriorly directed forces imparted either via the midfacial skeleton or cranial vault. A variety of skull base fracture classifications exist. Less well understood, however, is fracture extension beyond the anterior cranial fossa (ACF) into the middle and posterior cranial fossae. The cases of 81 patients from two UK major trauma centres were studied to examine the distribution of fractures across the skull base and any relationship between the vector of f... περισσότερα »
An anatomic study of the attachments on the condylar process of the mandible: muscle bundles from the temporalis.
An anatomic study of the attachments on the condylar process of the mandible: muscle bundles from the temporalis.: *An anatomic study of the attachments on the condylar process of the mandible: muscle bundles from the temporalis.* Surg Radiol Anat. 2015 Nov 13; Authors: Sakaguchi-Kuma T, Hayashi N, Fujishiro H, Yamaguchi K, Shimazaki K, Ono T, Akita K Abstract PURPOSE: The aim of this study was to evaluate anatomically the relationship between bone and muscles by detailed observation of the bone shape and the structure of muscles to facilitate an understanding of the function of...περισσότερα »
Ventilator waveforms on anesthesia machine: A simple tool for intraoperative mapping of phrenic nerve and mid-cervical roots
Ventilator waveforms on anesthesia machine: A simple tool for intraoperative mapping of phrenic nerve and mid-cervical roots: Abstract BackgroundA crucial aspect of surgery on the supraclavicular region, lateral neck, and mid-cervical vertebral region is the identification and sparing of the phrenic nerve and cervical (C4) root that are responsible for diaphragmatic innervation. Therefore intraoperative mapping of these nerve structures can be useful for difficult cases. Electrical stimulation with simultaneous observation of the ventilator waveforms of the anesthesia machine prov... περισσότερα »
Shoelace watertight dural closure in extended transsphenoidal surgery
How I do it: shoelace watertight dural closure in extended transsphenoidal surgery: Abstract BackgroundSkull base reconstruction after extended transsphenoidal surgery is essential to prevent postoperative cerebrospinal fluid leakage. MethodsA novel and simple technique for skull base reconstruction termed “shoelace dural closure” was devised. The dura mater was closed with a fat graft using a continuous running suture with both ends of a double-armed suture. ConclusionsThe shoelace dural closure is an effective method for achieving watertight closure of the anterior skull ...περισσότερα »
Extended endoscopic endonasal transclival clipping of posterior circulation aneurysms—an alternative to the transcranial approach
Extended endoscopic endonasal transclival clipping of posterior circulation aneurysms—an alternative to the transcranial approach: Abstract BackgroundTranscranial clipping of most posterior circulation aneurysms is one of the most difficult procedures, with high morbidity, and endovascular coiling is an alternative with less risk, but is not devoid of complications and not suitable for all aneurysms. Here we describe four cases of posterior circulation aneurysms clipped via the extended endoscopic endonasal transclival route. To the best of our knowledge, this is the first report ... περισσότερα »
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale
Editorial Board Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 2015, année de la chirurgie ambulatoire en France ? Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): F. Denoyelle Abécédaire : qui suis-je ? R’… Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): A. Werner, I. McGill, O. ... περισσότερα »
Peanut sensitization pattern
Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences: Abstract BackgroundPeanuts contain potent food allergens and the prevalence of allergy is reported to increase, especially in children. Since peanut sensitization may differ between different geographical regions, we wanted to investigate the sensitization pattern to the individual peanut allergens in a Norwegian population. MethodsCases reported to the Norwegian Food Allergy Register with sera positive to peanut extract were analyzed for specific IgE (sIgE) t... περισσότερα »
Multidrug-Resistant Escherichia coli Strains Isolated from Patients Are Associated with Class 1 and 2 Integrons
Multidrug-Resistant Escherichia coli Strains Isolated from Patients Are Associated with Class 1 and 2 Integrons: Conclusion: Our results showed that int1 and int2 genes present in E. coli isolates obtained from patients cause MDR in this isolates. Since such bacteria are a reservoir for the transmission of MDR bacteria, appropriate programs are necessary to reduce this problem.Chemotherapy 2015–16;61:72–76 (Source: Chemotherapy)
Anti-cancer effect of bee venom
Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B.: Authors: Zheng J, Lee HL, Ham YW, Song HS, Song MJ, Hong JT Abstract Bee venom (BV) has been used as a traditional medicine to treat arthritis, rheumatism, back pain, cancerous tumors, and skin diseases. However, the effects of BV on the colon cancer and their action mechanisms have not been reported yet. We used cell viability assay and soft agar colony formation assay for testing cell viability, electro mobility shift assay for detecting DNA bindin... περισσότερα »
Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice.
Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice.: Authors: Hattinger E, Scheiblhofer S, Roesler E, Thalhamer T, Thalhamer J, Weiss R Abstract Recently, mRNA vaccines have been introduced as a safety-optimized alternative to plasmid DNA-based vaccines for protection against allergy. However, it remained unclear whether the short persistence of this vaccine type would limit memory responses and whether the protective immune response type would be maintained during recurrent exposure to allergen. We tested the duration o...περισσότερα »
Thrombolyse auch bei sehr schweren Schlaganfällen sicher
Thrombolyse auch bei sehr schweren Schlaganfällen sicher: Geringes Blutungsrisiko Bei sehr schweren Insulten ist die I.v.-Lyse kontraindiziert, weil ein erhöhtes Blutungsrisiko angenommen wird. Offenbar zu Unrecht: Nach dem SITS-Register ist das Risiko für Hirnblutungen ähnlich gering wie bei weniger schweren Infarkten. Original enclosures:
There was no benefit from the use of antioxidant agents for tinnitus
Antioxidant therapy in the elderly with tinnitus by Brazilian Journal of Otorhinolaryngology via MedWorm ENT & OMF Top 20 Conclusion There was no benefit from the use of antioxidant agents for tinnitus in this sample. (Source: Brazilian Journal of Otorhinolaryngology) AbstractIntroduction *Several approaches have been tried for the treatment of tinnitus, from cognitive-behavioral therapies and sound enrichment to medication. In this context, antioxidants, widely used in numerous areas of medicine, appear to represent a promising approach for the control of this symptom, which often is... περισσότερα »
Vocational Education at the Intersection of Workplace and School
When Expectations Clash: Vocational Education at the Intersection of Workplace and School: AbstractNext to highly regarded varieties of apprenticeship-based vocational education there are, in many countries, forms of mainly school-based VET (vocational education and training) that suffer from a clash of expectations between schools and workplaces as sites of vocational education. School-based VET is viewed as of lesser value compared to work experience or workplace based training and one reason for such negative views on mainly school-based VET is the lack of authentic work-related...περισσότερα »
