The Intestinal Microbiome, Plasma Metabolome and Liver Transcriptome‐ A Conspiracy Driving Hepatic Steatosis

Abstract

With chronic overnutrition the storage of triglyceride in numerous cells including hepatocytes seems inevitable, and can be explained by well recognized pathways of lipid metabolism. This seemingly obvious association between chronic overnutrition and hepatocyte steatosis appears to be regulated by an unnervingly complex set of pathways that are not traditionally thought of as metabolic regulators. The study of regulation of steatosis is traditionally approached by hypothesis driven manner which examine the role of an individual molecules and pathways.

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