Glycoconjugated Metallohelices have Improved Nucl...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Τετάρτη 3 Ιουνίου 2020
Medicine by Alexandros G. Sfakianakis
Glycoconjugated Metallohelices have Improved Nucl...
Monosaccharides are added to the hydrophilic face of a self‐assembled asymmetric Fe(II) metallohelix, using CuAAC chemistry. The sixteen resulting architectures are water‐stable and optically pure, and exhibit improved antiproliferative selectivity against colon cancer cells (HCT116 p53 +/+ ) with respect to the non‐cancerous ARPE‐19 cell line. While the most selective compound is a glucose‐appended enantiomer, its cellular entry is not mainly glucose transporter‐mediated. Glucose conjugation nevertheless...
Tue Jun 02, 2020 17:16
We use the Preyssler polyoxoanion, [NaP5W30O110 ]14− ({P5W30}), as a platform for evaluating the role of non‐bridging cations in the formation of transition‐metal‐bridged polyoxometalate coordination frameworks. Specifically, we show that the assembly architecture of Co2+‐bridged frameworks is dependent on the identity and amount of alkali or alkaline earth cations present during crystallization. The inclusion of Li+ , Na+ , K+ , Mg2+ or Ca2+ in the framework synthesis is used to selectively...
Tue Jun 02, 2020 17:15
Heteroarenes are structural motifs found in many bioactive compounds and functional materials. Dehydrogenative cross‐coupling of heteroarenes with aliphatic C–H bonds provides straightforward access to functionalized heteroarenes from readily available materials. Established methods employ stoichiometric chemical oxidants under conditions of heating or light irradiation. By merging electrochemistry and photochemistry, we have achieved efficient photoelectrochemical dehydrogenative cross‐coupling...
Tue Jun 02, 2020 17:13
Understanding the characteristics of radicals formed from silicon‐containing heavy analogues of alkenes is of great importance for their application in radical polymerization. Bulky and electronic substituent effects in such compounds as phosphasilenes not only stabilize the Si=P double bond, but also influence the structure and species of the formed radicals. Herein we report our first investigations of radicals derived from phosphasilenes with Mes (2,4,6‐trimethylphenyl), Tip (2,4,6‐triisopropylphenyl),...
Tue Jun 02, 2020 17:11
All systems Ar go : A PdII‐catalyzed enantioselective C(sp3)−H arylation of ketones using an α‐amino acid as a chiral transient directing group is reported. 3‐Nitro‐5‐trifluoromethyl‐2‐pyridone was identified as an effective ligand, and acts as an acetate surrogate to accelerate C−H bond cleavage. Combining an electron‐deficient 2‐pyridone ligand with different silver salts enables control of the rate‐limiting step (RLS), thereby leading to high enantioselectivity. Abstract The use of chiral...
Tue Jun 02, 2020 16:33
Background: Most patients with stage III non–small cell lung cancer (NSCLC) develop metastases and succumb to their cancer. Approaches to the treatment of stage III disease can be highly variable. Understanding current treatment patterns can inform the optimal integration of emerging therapies. In this study, we describe contemporary treatment patterns and outcomes for a population-based cohort of stage III NSCLC patients from a large Canadian province. Methods: On the basis of the...
Fri May 29, 2020 03:00
Objectives: Pancreatic adenocarcinoma is frequently associated with pain requiring opioid therapy. Opioids, however, have been implicated in causing tumor progression, ultimately shortening survival. We examined the impact of pain, opioid use, and the mu-opioid receptor (MOP-R) expression in tumor tissue on progression-free survival and overall survival of patients with metastatic pancreatic cancer. Methods: We identified 103 patients with metastatic pancreatic adenocarcinoma receiving...
Fri May 29, 2020 03:00
Abstract Purpose The correlation between right hepatic vein (RHV) diameter and inferior RHV (IRHV) incidence and that between IRHV incidence and other clinical features remain unclear. We investigated factors correlated with IRHV incidence as well as provide a simple and reliable method for predicting IRHV presence preoperatively. Methods We obtained...
Wed Jun 03, 2020 03:00
Abstract Cancer is driven by genetic mutations in oncogenes and tumor suppressor genes and by cellular events that develop a misregulated molecular microenvironment in the growing tumor tissue. The tumor microenvironment is guided by the excessive action of specific cytokines including transforming growth factor‐b (TGF‐b), which normally controls embryonic development and the homeostasis of young or adult tissues. As a consequence of the genetic alterations generating a given tumor, TGF‐β can preserve...
Tue Jun 02, 2020 22:00
Tue Jun 02, 2020 22:01
Purpose: The aim of this study was to evaluate the feasibility and efficacy of the suprafascially elevated anterolateral thigh (ALT) perforator flap for reconstructing oral and maxillofacial defects. Patients and Methods: The authors analyzed a retrospective case series of 15 patients who underwent reconstruction of oral and maxillofacial defects with the suprafascially raised ALT perforator flap from June 2015 through January 2017 at the Second Xiangya Hospital. The flap harvest and...
Thu May 28, 2020 03:00
Background: Uncertain clinical evidence for treating positional plagiocephaly, especially with helmet therapy, creates difficulties in counseling parents of patients. This study investigates layperson perceptions and treatment preferences for positional plagiocephaly to provide patient-oriented evidence for management. Methods: Adult laypersons were recruited through crowdsourcing to view digitally-modified images of normal, mildly, moderately, or severely plagiocephalic infant heads....
Thu May 28, 2020 03:00
No abstract available
Thu May 28, 2020 03:00
Dermoid cyst is a rare benign tumor and about 7% of occurrences are found in the head and neck region. Its location is almost always in the midline of the body such as the orbit, oral cavity, and nose, but it is rarer in and around the auricle. The authors present a 31-year-old woman with dermoid cyst in the postauricular area which is a rare site for this lesion. In surgery under local anesthesia, the mass was limited to the subcutaneous area and excised completely. Surgical excision should be considered...
Thu May 28, 2020 03:00
Greater petrosal and deep petrosal nerves unite in foramen lacerum to form vidian nerve which innervate lacrimal, buccal, nasopharynx, and nasal glands. Moreover, the superior part of this foramen transmits lacerum part of internal carotid artery which irrigates major part of brain. Change in the morphology of foramen lacerum may result in compression of neurovascular structures creating neurovascular complications which at times may be fatal/morbid. In addition to this, there is paucity of literature...
Thu May 28, 2020 03:00
No abstract available
Thu May 28, 2020 03:00
Previous studies demonstrated that recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered using a collagen sponge could be a candidate for periodontal regeneration therapy. However, there is little evidence related to rhBMP-2 delivered with a bilayer collagen matrix. The aim of this study was to investigate the proper dose of rhBMP-2 using a bilayer collagen matrix for periodontal regeneration in a 1-wall defect. The mandibular first premolars and first molars of 6 beagle dogs were extracted,...
Thu May 28, 2020 03:00
Background: Orthodontists and surgeons have been looking for more accurate methods to predict surgical outcomes in patients with skeletal discrepancies. Methods: The sample consisted of 20 patients from the surgical clinic of a graduate orthodontic program who had been treated with Le Fort I maxillary movement, bilateral sagittal split osteotomy, with or without genioplasty. All patients had to have preoperative (T0) and at least 6 months postoperative (T1) cone-beam computed tomographies...
Thu May 28, 2020 03:00
Introduction: Congenital unilateral lower lip palsy – also known as asymmetric crying facies – is isolated asymmetry of the lower lip unilaterally. It is characterized by isolated lower lip asymmetry during smiling and speech. Although etiology is unknown, depressor labii inferioris (DLI) weakness is hold responsible. Aim: Purpose of this study was to evaluate the effectiveness of contralateral depressor labii inferioris botulinum toxin injection on patients’ concern levels and patient...
Thu May 28, 2020 03:00
Spiral computed tomography is a gold standard in diagnostics of intraorbital pathological changes. Modern software provides great opportunities at viewing and analyzing DICOM files. Earlier, the authors introduced a method of computed exophthalmometry for precise measurement of globes’ position even in the cases of lateral orbital rim fracture. However, eye proptosis is known to be depending on the eye length (ocular component), retrobulbar volume (orbital component), as well as anatomy of neurocranium...
Thu May 28, 2020 03:00
Utilization, wastage, and adverse consequences of assigning one full red blood cell (RBC) unit were investigated for children undergoing craniosynostosis surgery. The authors hypothesized that significant RBC wastage in the perioperative period exists for pediatric craniofacial surgery. The authors sought to determine what factors could guide patient-specific blood product preparation by evaluating utilization and wastage of RBCs in pediatric patients undergoing surgical correction of craniosynostosis....
Thu May 28, 2020 03:00
Background: Autogenous bone is the best material in cranioplasty because of biological advantages. Previously, skull, rib, ilium, and fibula have been used in the reconstruction of cranial defects. However, the application of autologous mandibular outer plate in the treatment of skull defect is rarely reported. This study evaluated the application of the autogenous mandibular outer plate in the reconstruction of cranial defect. Methods: Eleven patients who underwent cranioplasty with...
Thu May 28, 2020 03:00
We introduce a new approach to evaluating the frontal sinus using the “external supraorbital line” (ESOL), to determine whether frontal sinus similarity reflects known genetic relationships in both measurements and morphology. Significant relationships were found between biological distance and the maximum height and morphology of the frontal sinuses. Abstract Frontal sinus analysis has potential utility for detecting biologically related individuals. However, the methodological approach...
Tue Jun 02, 2020 21:44
The soft tissue around the remora acts as a vascular hydrostat to create a viscoelastic seal. Blood flow is modulated by the jubilee muscle, which closes off drainage to the anterior cardinal sinus network. Abstract Remoras are fishes that attach to a broad range of hosts using an adhesive disc on their head that is derived from dorsal fin elements. Research on the adhesive mechanism of remoras has focused primarily on the skeletal components of the disc and their contribution to generating suction...
Tue Jun 02, 2020 21:43
This is the first detailed description of gekkotan skull development in a pre‐hatching developmental series. Our results show that ossification in most cranial elements, including cartilage bones, begins early by comparison with many other lizards. This pattern is not consistent with skeletal paedomorphosis. Abstract Tarentola annularis is a climbing gecko with a wide distribution in Africa north of the equator. In the present paper, we describe the development of the osteocranium of this lizard,...
Tue Jun 02, 2020 21:29
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:To evaluate the patterns of failure in patients treated for head and neck carcinoma of unknown primary and to discuss treatment practices concerning radiotherapy target volumes definition and dose prescription.Methods:Eleven patients presenting a locoregional recurrence after head and neck carcinoma of unknown primary treatment with curative-intent radiochemotherapy performed between 2007 and 2017 in...
Tue Jun 02, 2020 13:10
Lay Summary Currently, the complexity of clinical trial development in oncology is being further complicated by the coronavirus disease 2019 (COVID‐19) pandemic, which is reducing the resources needed to comply with protocol‐specific procedures while putting patients in units, who are already vulnerable, at increased general risk not only for COVID‐19 infection but also with respect to their baseline disease. Individualizing the management of patients while ensuring their safety and adherence...
Tue Jun 02, 2020 22:10
Background Human papillomavirus (HPV) is associated with a substantial percentage of cervical cancer, and a significant percentage of anal, penile, vaginal, vulvar, oral cavity, oropharyngeal, and laryngeal cancers. Understanding the burden and trends of HPV‐attributable cancers is crucial to HPV prevention strategies. In the current study, the authors estimated the latest burden and trends of HPV‐attributable cancers in China. Methods Data from the following sources were used. The number...
Tue Jun 02, 2020 21:34
Background High out‐of‐pocket costs (OOPCs) often are found to be inversely associated with adherence to medical treatment. The introduction of generic aromatase inhibitors (GAIs) significantly reduced the OOPCs of patients. The objective of the current study was to explore the impact of the introduction of GAIs on adjuvant hormone therapy (AHT) adherence over the full course of breast cancer treatment. Methods Women aged ≥65 years who were diagnosed with hormone receptor–positive breast cancer...
Tue Jun 02, 2020 21:34
Background Poor outcomes for patients with ovarian cancer relate to dormant, drug‐resistant cancer cells that survive after primary surgery and chemotherapy. Ovarian cancer (OvCa) cells persist in poorly vascularized scars on the peritoneal surface and depend on autophagy to survive nutrient deprivation. The authors have sought drugs that target autophagic cancer cells selectively to eliminate residual disease. Methods By using unbiased small‐interfering RNA (siRNA) screens, the authors observed...
Tue Jun 02, 2020 21:34
Background Although there are a growing number of survivors of adolescent and young adult (AYA) cancer, to the authors' knowledge the long‐term overall survival (OS) patterns for AYA cancer survivors are underreported. The objective of the current study was to assess the long‐term survival of AYA cancer survivors and identify factors associated with diminished long‐term survival. Methods The authors used The University of Texas MD Anderson Cancer Center's tumor registry to identify 5‐year...
Tue Jun 02, 2020 21:33
Background A randomized phase 3 study was performed to investigate the efficacy and safety of maintenance therapy with S‐1 after induction therapy with carboplatin plus S‐1 in patients with advanced squamous non–small cell lung cancer (NSCLC). Methods Chemotherapy‐naive patients with advanced or relapsed squamous NSCLC were treated with carboplatin (area under the curve of 5 on day 1 every 3 weeks) plus S‐1 (40 mg/m2 twice per day on days 1‐14 every 3 weeks) as induction therapy. Patients...
Tue Jun 02, 2020 21:33
Background To the authors' knowledge, the etiology of survival disparities in patients with epithelial ovarian cancer (EOC) is not fully understood. Residential segregation, both economic and racial, remains a problem within the United States. The objective of the current study was to analyze the effect of residential segregation as measured by the Index of Concentration at the Extremes (ICE) on EOC survival in Florida by race and/or ethnicity. Methods All malignant EOC cases were identified...
Tue Jun 02, 2020 21:33
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
