The Effect of Wheel Exercise on Functional Indices of Cachexia

a.lsfakia shared this article with you from Inoreader The Effect of Wheel Exercise on Functional Indices of Cachexia in Tumor-bearing Mice Via Medicine & Science in Sports & Exercise - Featured Articles - Featured Articles Introduction Cancer-related fatigue and muscle wasting have received significant attention over the last few decades with the goal of establishing interventions that can improve cancer patient life quality and survival. Increased physical activity has shown to reduce cancer-associated fatigue and has been proposed as a promising therapeutic to attenuate cancer-induced wasting. However, significant gaps remain in our understanding of how physical activity affects the compositional and functional changes that initiate muscle wasting. The purpose of the current study was to determine the effect of wheel exercise on body composition and functional indices of cancer cachexia before the development of significant wasting. Methods Thirteen-week-old male ApcMin/+ (MIN) and C57BL/6 (B6) mice were given free wheel access (W) or a locked wheel (Sed) for 5 wk. Results Wheel activity was reduced in the MIN compared with B6; however, wheel access increased complex II expression in isolated skeletal muscle mitochondria regardless of genotype. Wheel access had no effect on tumor burden or plasma interleukin-6 in the MIN. MIN-W increased body weight and lean mass compared with MIN-Sed, and there was a direct correlation between wheel distance and lean mass change. MIN-W increased grip strength and treadmill time to fatigue compared with MIN-Sed. Within MIN-W mice, skeletal muscle fatigability was only improved in high runners (>60 min·d−1). Conclusions Our results suggest that there were therapeutic benefits of increased activity related to body composition, behavior, and whole-body function that were not dependent on exercise duration; however, there was an exercise threshold needed to improve skeletal muscle fatigability in tumor-bearing mice. Interestingly, wheel access was able to improve compositional and functional outcomes without mitigating tumor number or size. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Respiratory Muscle Fatigue Alters Cycling Performance and Locomotor Muscle Fatigue

a.lsfakia shared this article with you from Inoreader Respiratory Muscle Fatigue Alters Cycling Performance and Locomotor Muscle Fatigue Via Medicine & Science in Sports & Exercise - Featured Articles - Featured Articles Purpose This study aimed to determine if preexisting respiratory muscle fatigue (RMF) alters motoneuronal output, locomotor muscle fatigue, and cycling performance. Methods Eight trained male cyclists performed 5-km cycling time trials after a resistive breathing task that induced RMF and under control conditions (CON). Motoneuronal output was estimated using vastus lateralis surface electromyography, and locomotor muscle fatigue was quantified as the change in potentiated quadriceps twitch force from preexercise to postexercise. Results Time to complete the time trial was 1.9% ± 0.9% longer in RMF compared with CON (P View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PLCD1: A Potential Therapeutic Target in the Treatment of Esophageal Squamous Cell Carcinoma?

a.lsfakia shared this article with you from Inoreader PLCD1: A Potential Therapeutic Target in the Treatment of Esophageal Squamous Cell Carcinoma? Via Latest Results for Digestive Diseases and Sciences View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Apical pelvic organ prolapse repair via vaginal‐assisted natural orifice transluminal endoscopic surgery: Initial experience from a tertiary care hospital

a.lsfakia shared this article with you from Inoreader Apical pelvic organ prolapse repair via vaginal‐assisted natural orifice transluminal endoscopic surgery: Initial experience from a tertiary care hospital Via Asian Journal of Endoscopic Surgery Abstract Introduction Natural orifice transluminal endoscopic surgery has been used for gynecologic operations in recent years. The aim of the study is to describe our initial experience using vaginal‐assisted natural orifice transluminal endoscopic surgery (vNOTES) for apical pelvic organ prolapse repair. Methods After patients underwent vaginal hysterectomy, vNOTES sacrocolpopexy (n = 4) or vNOTES high uterosacral ligament suspension (n = 7) were performed to treat symptomatic apical pelvic organ prolapse. Sociodemographic and clinical characteristics, Pelvic Organ Prolapse Quantification results, and recorded surgical data (eg, duration of surgery, intraoperative complications, additional prolapse and incontinence surgeries) were obtained from patient files and the hospital's database. Information from postoperative follow‐up visits, including complications and anatomical results, were also recorded. Results The mean age of the patients was 60.7 ± 9.1 years. The mean total operative time was 121.3 ± 22.7 minutes. The mean operative time for vaginal hysterectomy, vNOTES sacrocolpopexy, and vNOTES uterosacral ligament suspension was 46 ± 11.9, 65 ± 38, 25 ± 8.2 minutes, respectively. There were no intraoperative and postoperative complications observed. The mean postoperative 24‐hour visual analog scale score was 3.5 ± 1.9 for vNOTES sacrocolpopexy patients and 3.2 ± 0.9 for vNOTES uterosacral ligament suspension patients. Only one patient in the vNOTES sacrocolpopexy group had a recurrence; she experienced stage 2 anterior compartment prolapse 8 months after surgery. Conclusion As a treatment for apical pelvic organ prolapse, vNOTES is a feasible approach in both sacrocolpopexy and uterosacral ligament suspension. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Single‐incision laparoscopic full‐thickness anterior abdominal wall repair of a Morgagni hernia using a suture‐assisting needle in a child: A case report

a.lsfakia shared this article with you from Inoreader Single‐incision laparoscopic full‐thickness anterior abdominal wall repair of a Morgagni hernia using a suture‐assisting needle in a child: A case report Via Asian Journal of Endoscopic Surgery Abstract Single‐incision laparoscopic repair of a congenital Morgagni diaphragmatic hernia using a suture‐assisting needle was performed in a 1‐year‐old boy. Three ports were inserted through a single umbilical incision to repair the 2.5 × 2.3‐cm defect. The full‐thickness muscle layer of the anterior abdominal wall and the posterior rim of the defect were penetrated with the suture‐assisting needle holding a thread, which was then released. The needle tip was pulled back over the muscle layer, shifted laterally, and again passed through the muscle layer and the posterior rim. The thread was then captured by the needle and pulled out through the anterior abdominal wall. Five mattress sutures were placed in this way and tied subcutaneously. The postoperative course was uneventful, and the cosmetic outcome was favorable. A suture‐assisting needle is useful for completing full‐thickness anterior abdominal wall repair, which is important for preventing the recurrence of a congenital Morgagni diaphragmatic hernia. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients

a.lsfakia shared this article with you from Inoreader Does the time from symptom onset to surgery affect the outcomes of patients with acute appendicitis? A prospective cohort study of 255 patients Via Asian Journal of Endoscopic Surgery Abstract Introduction The objective of this study was to evaluate the impact of operative timing on outcomes of acute appendicitis. Methods This study examined adult patients who had presented to the hospital with acute appendicitis and had undergone appendectomy from December 2017 to February 2019. Time delay and outcomes of perforated and non‐perforated appendicitis were compared. Patients were classified into five groups based on the period from symptom onset to operation: group 1, <24 hours; group 2, ≥24 and <48 hours; group 3, ≥48 and <72 hours; group 4, ≥72 and <96 hours; and group 5, ≥96 hours. The five groups were compared, with risk of perforation assessed in particular. Results A total of 255 patients were included in the analysis. Symptom duration, operative time, and length of postoperative hospital stay (P < .001) were significantly longer in the perforated group (n = 49) than in the non‐perforated group (n = 206). The perforated group also had a higher conversion rate to open procedures (P = .002) and a higher rate of wound infection (P = .034). Group 1 had 53 patients, group 2 had 95 patients, group 3 had 57 patients, group 4 had 32 patients, and group 5 had 18 patients. The incidence of appendiceal perforation and median operative time progressively increased along with symptom duration in the five groups. In multivariate analyses, independent risk factors for appendiceal perforation were male gender (odds ratio = 2.33, 95% confidence interval [CI]: 1.07‐5.08) and symptom duration ≥48 hours (relative to ≥24 and <48 hours) (odds ratio = 4.64, 95%CI: 1.76‐12.27). Patients with symptom duration ≥72 ho urs had a significantly longer operative time than those with symptom duration ≥48 and <72 hours (β = 21.38, 95%CI: 5.66‐37.11, P = .008). Conclusion The risk of perforation increased significantly 48 hours after the onset of appendicitis. Symptoms duration ≥72 hours was associated with a longer operative time. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Laparoscopic surgery in patients with cystic fibrosis: A systematic review

a.lsfakia shared this article with you from Inoreader Laparoscopic surgery in patients with cystic fibrosis: A systematic review Via Asian Journal of Endoscopic Surgery Abstract Introduction Laparoscopic surgery may be advantageous for cystic fibrosis (CF) patients because it leads to fewer complications than open surgery. However, it could still lead to pulmonary and cardiovascular complications in CF patients. We aimed to systematically review the use of laparoscopic surgery in CF patients. Methods A systematic review was performed in compliance with PRISMA guidelines. A literature search was performed using PubMed/MEDLINE, ScienceDirect, EMBASE, and Google Scholar, with "cystic fibrosis and laparoscopic surgery" and "cystic fibrosis and minimally invasive surgery" used as the search terms. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria were applied. The protocol was registered with the PROSPERO register. Results Six studies met the predetermined inclusion criteria; accordingly, two studies provided high‐quality evidence and four provided moderate‐quality evidence. The interrater correlation was convincing (r s = .95, P = .02, two‐tailed). Therefore, three quantitative studies and three qualitative studies were assessed and evidence‐graded in accordance with the GRADE protocol. Conclusion The benefits of laparoscopic surgical interventions for patients with CF were supported with good evidential value and recognized as a safe and suitable surgical option. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Intestinal blood flow evaluation using the indocyanine green fluorescence imaging method

a.lsfakia shared this article with you from Inoreader Intestinal blood flow evaluation using the indocyanine green fluorescence imaging method in a case of incarcerated obturator hernia: A case report Via Asian Journal of Endoscopic Surgery Abstract In surgery for incarcerated hernia, intestinal blood flow is an important factor in intraoperative decision‐making given that irreversible ischemia can result in intestinal necrosis. Here, we report a case of incarcerated obturator hernia in which the bowel was successfully preserved by evaluating intestinal blood flow with the indocyanine green fluorescence imaging method. A woman in her 80s was diagnosed with incarcerated right obturator hernia, and a laparoscopic operation was performed. The small bowel tissue that had been incarcerated exhibited dark red discoloration. Fluorescence examination of the bowel wall indicated that the ischemic changes were reversible, and accordingly, the bowel was not resected. The postoperative course was uneventful. The indocyanine green fluorescence imaging method is a useful new source of evidence that will improve intraoperative decision‐making regarding bowel ischemia. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Primary anterior perineal hernia: A case report and review of the literature

a.lsfakia shared this article with you from Inoreader Primary anterior perineal hernia: A case report and review of the literature Via Asian Journal of Endoscopic Surgery Abstract Perineal hernia is a type of pelvic floor hernia and an extremely rare pathologic state. Perineal hernias can be classified into anterior and posterior types according to their positional relationship to the superficial transverse perineal muscle. A 49‐year‐old woman presented with bulging of the right labium major while standing. Standing external ultrasonography revealed a mass in the bulge, which could not be identified by transvaginal ultrasonography, CT, or MRI. Although hernia content could not be identified preoperatively, the patient was given a diagnosis of primary perineal hernia and underwent laparoscopic repair. Symptoms resolved postoperatively, and no sign of relapse has been noted for 8 months postoperatively. Here, we report the case details and review previous case reports. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of postoperative plasma D‐dimer levels between patients undergoing laparoscopic resection and conventional open resection for colorectal cancer

a.lsfakia shared this article with you from Inoreader Comparison of postoperative plasma D‐dimer levels between patients undergoing laparoscopic resection and conventional open resection for colorectal cancer Via Asian Journal of Endoscopic Surgery Abstract Introduction D‐dimer is widely used in clinical pretests for venous thromboembolism exclusion, and its elevation suggests the presence of thrombus. The extent of hypercoagulability after colorectal surgery has not been systematically compared between patients who have undergone laparoscopic surgery and open surgery. The present study measured D‐dimer levels sequentially in patients undergoing colorectal surgery and compared the extent of hypercoagulability between laparoscopic surgery and open surgery. Methods A prospective cohort study involving 169 patients who underwent resection of colorectal cancer at Saitama Medical Center, Dokkyo Medical University, was conducted between January 2013 and September 2014. To measure D‐dimer level, peripheral blood was obtained on postoperative day (POD) 1, POD4, and POD7. Enoxaparin sodium was administered twice daily as the routine prophylactic anticoagulant therapy on POD2 to 7. Results D‐dimer levels on POD1, POD4, and POD7 were significantly higher after open surgery than after laparoscopic surgery. Older age, pathologically advanced stage cancer, greater intraoperative blood loss and higher preoperative D‐dimer levels were significantly associated with higher D‐dimer levels on POD1, POD4, and POD7. Patients who completed the course of postoperative enoxaparin injections had significantly lower D‐dimer levels on POD7 than those who did not receive postoperative enoxaparin injections. Multiple regression analyses of postoperative D‐dimer level showed that laparoscopic surgery was a significant and independent factor affecting D‐dimer level on POD4 and POD7. Conclusion This study showed that postoperative D‐dimer levels were lower after laparoscopic surgery than after open surgery. The limited invasiveness of laparoscopic surgery may be beneficial to reduce the risk of postoperative deep vein thrombosis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is laparoscopic and endoscopic cooperative surgery (LECS) for gastric subepithelial tumor at the esophagogastric junction safe?

a.lsfakia shared this article with you from Inoreader Is laparoscopic and endoscopic cooperative surgery (LECS) for gastric subepithelial tumor at the esophagogastric junction safe? Via Asian Journal of Endoscopic Surgery Abstract Introduction With technique improvements, indications for laparoscopic and endoscopic cooperative surgery (LECS) for gastric subepithelial tumor (SET) are gradually expanding for tumors technically difficult to resect. However, surgical outcomes of LECS, including for esophagogastric junction (EGJ) tumors requiring advanced skills, remain unknown. Methods We reviewed patients in whom LECS had initially been attempted for gastric SET at the Cancer Institute Hospital in Tokyo from June 2006 to May 2018. Indications for LECS at the EGJ have gradually expanded during the study period to include tumors with esophageal invasion up to 2 cm, or less than half the EJG circumference, preoperatively. Surgical outcomes and risk factors for conversion to other procedures were investigated. Results Twenty (9.3%) of the 214 total patients had EGJ tumors. Four patients (20%) with EGJ tumors developed postoperative complications (Clavien‐Dindo grade ≥ II). Among 12 patients in whom LECS could be completed for EGJ tumors, only one non‐serious complication occurred. Eight patients required conversion to another operation for EGJ tumors (two laparotomy, six proximal gastrectomy). Among conversion cases with EGJ tumors, anastomotic leakage occurred in both patients undergoing laparotomy after LECS, necessitating additional defect closure. There was only one non‐serious complication in six proximal gastrectomy patients. On multivariate analysis, EGJ tumor was an independent risk factor for conversion to another operation. Conclusion LECS at the EGJ may be a risk factor for conversion operation, and when performing LECS at the EGJ is difficult, conversion to proximal gastrectomy, which can be performed safely, should be considered. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Causes of peritoneal injury during laparoscopic totally extraperitoneal inguinal hernia repair and methods of repair

a.lsfakia shared this article with you from Inoreader Causes of peritoneal injury during laparoscopic totally extraperitoneal inguinal hernia repair and methods of repair Via Asian Journal of Endoscopic Surgery Abstract Introduction Peritoneal injury during laparoscopic totally extraperitoneal (TEP) inguinal hernia repair is an intraoperative complication that affects accomplishment. We retrospectively examined the causes of peritoneal injury and methods of TEP repair. Methods This study examined 58 patients with inguinal hernia (43 unilateral, 15 bilateral) who had undergone TEP repair; all procedures were performed by the same surgeon. The incidence of peritoneal injury, clinical characteristics that could have influenced peritoneal injury, and management of the injury were analyzed. Results Peritoneal injury was noted in 16 inguinal hernias (21.9%, 16 /73). Injury occurred more frequently in right‐sided hernias than in left‐sided hernias (31.6% vs 11.4%, P = .049). No other factors were related to injury. Peritoneal injury occurred due to anatomical misrecognition in five hernias (31.3%, 5/16) and unintentional dissection in six hernias (37.5%, 6/16). All injuries due to unintentional dissection occurred in right‐sided hernias. The procedures used for peritoneal injury repair were endoscopic suturing for 4 hernias, pre‐tied loop ligation for 1 hernia, and ligation clips in 11 hernias. Additional techniques were required in three hernias repaired by endoscopic suturing (75% 3/4). After introduction of the ligation clips, endoscopic suturing was discontinued, and no additional techniques were needed. Conclusion Peritoneal injury more frequently occurred in right‐sided inguinal hernia than in left‐sided inguinal hernia during TEP repair. The common reasons for peritoneal injury were anatomical misrecognition and unintentional dissection. Repair using ligation clips is the best option for peritoneal injuries that occur during TEP repair. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.