The lipidome of plant plasma membranes – enriched in cellular phospholipids containing at least one polyunsaturated fatty acid tails and a variety of phytosterols and phytosphingolipids – is adapted to significant abiotic stresses. But how mesoscale membrane properties of these membranes, such as permeability and deformability, which arise from their unique molecular compositions and corresponding lateral organization, facilitate response to global mechanical stresses is largely unknown. Here, using giant vesicles reconstituting mixtures of polyunsaturated lipids (Soy-PC), glucosylceramide (GlcCer), and sitosterol common to plant membranes, we find that the membranes adopt "janus-like" domain morphologies and display anomalous solute permeabilities.
https://ift.tt/2CwcZ8t
Σάββατο 6 Οκτωβρίου 2018
Permeability and line tension dependent response of polyunsaturated membranes to osmotic stresses
SAMHD1 and the innate immune response to cytosolic DNA during DNA replication
Flavie Coquel | Christoph Neumayer | Yea-Lih Lin | Philippe Pasero
https://ift.tt/2PgZGvh
Innate immunosensing of DNA in cellular senescence
Selene Glück | Andrea Ablasser
https://ift.tt/2OLT23i
Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance
Mark Noviski | Julie Zikherman
https://ift.tt/2Pp7rz6
Enhancement in Iron Absorption on Intake of Chemometrically Optimized Ratio of Probiotic Strain Lactobacillus plantarum 299v with Iron Supplement Pearl Millet
Abstract
This research article aims to establish the intake ratio of probiotic Lactobacillus plantarum 299v with iron supplement pearl millet by central composite design of response surface methodology so as to enhance iron absorption. In anemic rat models, the food intake pattern, body weight, hemoglobin content, and hematocrit values were found to be significantly increased on treatment with pearl millet:probiotic; however, incorporation of probiotics at lower dose (0.5 g) was significantly (p < 0.05) effective in enhancing iron absorption, and further increment in probiotic doses (1.0 g) did not produce significant increase in hemoglobin and hematocrit values as evidenced by the experimental findings.
https://ift.tt/2QwSCuu
Combination of Soy Protein, Amylopectin, and Chromium Stimulates Muscle Protein Synthesis by Regulation of Ubiquitin–Proteasome Proteolysis Pathway after Exercise
Abstract
The present study was undertaken to investigate the effect of the combination of soy protein, amylopectin, and chromium (SAC) on muscle protein synthesis and signal transduction pathways involved in protein synthesis (mTOR pathways, IGF-1, and AktSer473) and proteolysis (FOXO1Ser256; MURF1, MAFbx) after exercise. Thirty-five Wistar rats were randomly divided into five groups: (1) control (C); (2) exercise (E); (3) exercise + soy protein (3.1 g/kg/day) (E + S); (4) exercise + soy protein + chromium (E + S + Cr); (5) exercise + soy protein + amylopectin + chromium (E + S + A + Cr). Post-exercise ingestion of SAC significantly increased the fractional rate of protein synthesis (FSR), insulin, glycogen, and amino acid levels with the highest effect observed in E + S + A + Cr group (P ˂ 0.05). However, SAC supplementation decreased the lactic acid concentration (P ˂ 0.05). A reduction in forkhead box protein O1 (FOXO1) and forkhead box protein O3 (FOXO3) (regulators of ubiquitin-related proteolysis) and muscle atrophy F-box (MAFbx) levels was noted after treatment with SAC (P < 0.05). Insulin-like growth factor 1(IGF-1) level was increased in the E + S, E + S + Cr, and E + S + A + Cr groups (P < 0.05). While the phosphorylation of 4E-BP1Thr37/46, AktSer473, mTORSer2448, and S6K1Thr389 levels increased after SAC supplementation, phosphorylated muscle ring finger 1 (MuRF-1, an E3-ubiquitin ligase gene) was found to be significantly lower compared with the E group (P ˂ 0.05). These results indicate that SAC supplementation improves FSR, insulin, and glycogen levels after exercise. SAC improves protein synthesis by inhibiting the ubiquitin–proteasome pathway and inducing anabolic metabolism.
https://ift.tt/2y3bBWY
Semen Uranium Concentrations in Depleted Uranium Exposed Gulf War Veterans: Correlations with Other Body Fluid Matrices
Abstract
Environmental metal exposure, as well as dietary metals, may adversely affect semen quality even as others play an essential role in normal spermatogenesis and fertility. Measures of seminal fluid metals have therefore been of high interest in the last several decades but have shown inconsistent results in correlations with some semen quality parameters. As well, environmental metal measures across various body fluid matrices have not been consistently correlated contrary to what one might hypothesize based on a systemic body burden of metal. This may be due to the body fluid matrices assessed and to other differences in laboratory methods and sample preparation. Measures of uranium, a potentially toxic metal in humans, have not previously been reported in the semen of environmentally metal-exposed populations. We report here uranium seminal fluid results and the high correlation of uranium concentrations across several body fluid matrices in a cohort of military veterans exposed to depleted uranium in combat events during the Iraqi Gulf War. These results inform the risk communication conversation for exposed populations and broaden the public health assessments from various exposure scenarios.
https://ift.tt/2Ntotuc
ASGE high-risk criteria for choledocholithiasis − are they applicable in cholecystectomized patients?
The guidelines by the American Society for Gastrointestinal Endoscopy (ASGE) suggest that in patients with gallbladder in situ, endoscopic retrograde cholangiopancreatography (ERCP) should be performed in the presence of high-risk criteria for choledocholithiasis, after biochemical tests and abdominal ultrasound. There are no specific recommendations for cholecystectomized patients. The aim of this study was to evaluate the applicability of ASGE criteria for ERCP in cholecystectomized patients with suspected choledocholithiasis.
https://ift.tt/2PcCn5I
The Needs and Benefits of Continuous Model Updates on the Accuracy of RT-induced Toxicity Prediction Models within a Learning Health System
Development of outcome prediction models from clinical data can form the foundation for a learning health system offering precision radiotherapy. We hypothesize that regular prediction model updates along with prospective data collection is important to maintain the prediction accuracy. Prediction models for grade≥2 xerostomia were developed by bivariate logistic regression. Four methods of model updating (sliding training period/increasing training period/conditionally increasing training period/no updates) were compared. Updating prediction models was effective for maintaining the prediction performance.
https://ift.tt/2OF2c1k
Molecular mechanisms of non-thermal plasma-induced effects in cancer cells
Journal Name: Biological Chemistry
Issue: Ahead of print
https://ift.tt/2OFbQ3V
Microbial transglutaminase for biotechnological and biomedical engineering
Journal Name: Biological Chemistry
Issue: Ahead of print
https://ift.tt/2PcIGpL
A Versatile Model of Hard Tick Infestation on Laboratory Rabbits
We have developed a simple and versatile system to feed hard ticks on laboratory rabbits. Our non-laborious protocol uses easily accessible materials and can be adjusted depending on the requirements of the various experimental settings. The method allows comfortable monitoring and/or sampling of ticks during the entire feeding period.
https://ift.tt/2pGnQUQ
A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
https://ift.tt/2pEtIhb
Dorsal Root Ganglia Isolation and Primary Culture to Study Neurotransmitter Release
Dorsal root ganglia (DRG) primary cultures are frequently used to study physiological functions or pathology-related events in sensory neurons. Here, we demonstrate the use of lumbar DRG cultures to detect the release of neurotransmitters after neuropeptide FF receptor type 2 stimulation with a selective agonist.
https://ift.tt/2ykVx2c
Histopathological study of gastric infection with Spirocerca lupi in Pallas’s cat ( Otocolobus manul )
Abstract
Spirocerca lupi (family: Spirocercidae; order: Spirurida) are parasitic nematodes found in the esophagus of cats and dogs, as well as in other carnivore animals throughout the tropical, subtropical, and temperate countries of Asia and the Americas. These animals become infested by eating an intermediate host or a transport host. In adult felines, this parasite often resides in the mucosa of the esophagus, where it forms granulomatous nodules. In this work, a wild immature female Pallas's cat (Otocolobus manul) that was younger than 1 year old was killed by a herding dog (heeler) in Mashhad, Iran. After necropsy, parasite samples were gathered from the stomach and after clarification by lactophenol, the nematodes were recognized as Spirocerca lupi. Microscopic diagnoses in the stomach include granulomatous nodules, mucosal gland destruction, necrosis, and inflammatory cell infiltration. This report characterizes the first documented case of spirocercosis in a Pallas's cat in the world.
https://ift.tt/2y3Ioej
Correction to: Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress
The original version of this article contained a mistake. The bands for HA Tag and t-ERK in Figs. 2d, 2h, 3d are incorrect. The author informs that these errors had no influence in the scientific content of the paper. The corrected figures (Figs. 2 and 3) are given below.
https://ift.tt/2y3zFZV
Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration
Abstract
Background
Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes in neutrophil regulation remains unclear.
Methods
We investigated the effects of gastric cancer cell-derived exosomes (GC-Ex) on the pro-tumor activation of neutrophils and elucidated the underlying mechanisms.
Results
GC-Ex prolonged neutrophil survival and induced expression of inflammatory factors in neutrophils. GC-Ex-activated neutrophils, in turn, promoted gastric cancer cell migration. GC-Ex transported high mobility group box-1 (HMGB1) that activated NF-κB pathway through interaction with TLR4, resulting in an increased autophagic response in neutrophils. Blocking HMGB1/TLR4 interaction, NF-κB pathway, and autophagy reversed GC-Ex-induced neutrophil activation. Silencing HMGB1 in gastric cancer cells confirmed HMGB1 as a key factor for GC-Ex-mediated neutrophil activation. Furthermore, HMGB1 expression was upregulated in gastric cancer tissues. Increased HMGB1 expression was associated with poor prognosis in patients with gastric cancer. Finally, gastric cancer tissue-derived exosomes acted similarly as exosomes derived from gastric cancer cell lines in neutrophil activation.
Conclusion
We demonstrate that gastric cancer cell-derived exosomes induce autophagy and pro-tumor activation of neutrophils via HMGB1/TLR4/NF-κB signaling, which provides new insights into mechanisms for neutrophil regulation in cancer and sheds lights on the multifaceted role of exosomes in reshaping tumor microenvironment.
https://ift.tt/2zVdiqU
Is the Birthing Unit Design Spatial Evaluation Tool valid for diverse groups?
Publication date: Available online 5 October 2018
Source: Women and Birth
Author(s): Sara Menke, Bec Jenkinson, Maralyn Foureur, Sue Kildea
Abstract
Background
Awareness of the impact of the built environment on health care outcomes and experiences has led to efforts to redesign birthing environments. The Birth Unit Design Spatial Evaluation Tool was developed to inform such improvements, but it has only been validated with caseload midwives and women birthing in caseload models of care.
Aim
To assess the content validity of the tool with four new participant groups: Birth unit midwives, Aboriginal or Torres Strait Islander women; women who had anticipated a vaginal birth after a caesarean; and women from refugee or culturally and linguistically diverse backgrounds.
Methods
Participants completed a Likert-scale survey to rate the relevance of The Birth Unit Design Spatial Evaluation Tool's 69 items. Item-level content validity and Survey-level validity indices were calculated, with the achievement of validity set at >0.78 and >0.9 respectively.
Results
Item-level content validity was achieved on 37 items for birth unit midwives (n = 10); 35 items for Aboriginal or Torres Strait Islander women (n = 6); 33 items for women who had anticipated a vaginal birth after a caesarean (n = 6); and 28 items for women from refugee or culturally and linguistically diverse backgrounds (n = 20). Survey-level content validity was not demonstrated in any group.
Conclusion
Birth environment design remains significant to women and midwives, but the Birth Unit Design Spatial Evaluation Tool was not validated for these participant groups. Further research is needed, using innovative methodologies to address the subconscious level on which environment may influence experience and to disentangle the influence of confounding factors.
https://ift.tt/2y4I3bi
Racial/ethnic differences in the outcomes of patients with metastatic breast cancer: contributions of demographic, socioeconomic, tumor and metastatic characteristics
Abstract
Purpose
Population-based estimates of racial disparities in metastatic breast cancer are lacking. We quantified the contributions of demographic, socioeconomic, tumor, and metastatic characteristics to racial differences in metastatic breast cancer and characterized the most disproportional subgroup.
Methods
Patients diagnosed with metastatic breast cancer between 2010 and 2014 were identified using the Surveillance, Epidemiology, and End Results database. A multivariable Cox proportional hazards model was used to adjust each set of variables. The excess relative risk of cancer-specific and all-cause death in non-Hispanic black (NHB) versus non-Hispanic white women diagnosed with metastatic breast cancer was expressed as a percentage and was stratified by the age at diagnosis.
Results
We identified 13,066 female patients. NHB women exhibited substantially higher morbidity and mortality than women of other races/ethnicities. The greatest excess mortality risk for NHB women was observed in the young-onset group (18–49 years; hazard ratio: 1.57), followed by the middle-age group (50–64 years; hazard ratio: 1.42); the trend was not significant among the elderly group. Socioeconomic factors stably explained one-half of the excess risk, whereas the contribution of tumor characteristics obviously decreased with age (18–49 years, 40.7%; 50–64 years, 33.9%), and the metastatic pattern accounted for approximately one-tenth of the excess risk. Additionally, the disproportional death burden of NHB women persisted in less aggressive subgroups.
Conclusions
By providing a comprehensive assessment of racial differences in the incidence and outcomes of patients with metastatic breast cancer, we urge the implementation of targeted preventive efforts in both the public health and clinical arenas.
https://ift.tt/2DZCOiQ
Patient-reported outcomes unbiased by length of follow-up after lumbar degenerative spine surgery: Do we need 2 years of follow-up?
Publication date: Available online 5 October 2018
Source: The Spine Journal
Author(s): Victor E. Staartjes, Alessandro Siccoli, Marlies P. de Wispelaere, Marc L. Schröder
Abstract
Background
In modern clinical research, the accepted minimum follow-up for patient-reported outcome measures (PROMs) after lumbar spine surgery is 24 months, particularly after fusion. Recently, this minimum requirement has been called into question.
Purpose
We aim to quantify the concordance of 1- and 2-year PROMs to evaluate the importance of long-term follow-up after elective lumbar spine surgery.
Study Design
Retrospective analysis of data from a prospective registry.
Patient Sample
We identified all patients in our prospective institutional registry who underwent degenerative lumbar spine surgery with complete baseline, 12-month, and 24-month follow-up for ODI and NRS back and leg pain.
Outcome Measures
Oswestry Disability Index (ODI) and numeric rating scales for back and leg pain at 1 year and at 2 years.
Methods
We evaluated concordance of 1- and 2-year change scores by means of Pearson's product-moment correlation and performed logistic regression to assess if achieving the minimum clinically important difference (MCID) at 12 months predicted 24-month MCID. Odds ratios (OR) and their 95% confidence intervals (CI), as well as model areas-under-the-curve (AUC) were obtained.
Results
A total of 210 patients were included. We observed excellent correlation among 12- and 24-month ODI (r = 0.88), NRS-LP (r = 0.76) and NRS-BP (r = 0.72, all p < 0.001). Equal results were obtained when stratifying for discectomy, decompression, or fusion. Patients achieving 12-month MCID were likely to achieve 24-month MCID for ODI (OR: 3.3, 95% CI: 2.4 to 4.1), NRS-LP (OR: 2.99, 95% CI: 2.2 to 4.2) and NRS-BP (OR: 3.4, 95% CI: 2.7 to 4.2, all p < 0.001) with excellent AUC values of 0.81, 0.77, and 0.84, respectively. Concordance rates between MCID at both follow-ups were 87.2%, 83.8%, and 84.2%. A post-hoc power analysis demonstrated sufficient statistical power.
Conclusions
Irrespective of the surgical procedure, 12-month PROMs for functional disability and pain severity accurately reflect those at 24 months. In support of previous literature, our results suggest that 12 months of follow-up may be sufficient for evaluating spinal patient care in clinical practice as well as in research.
https://ift.tt/2pENdqc
Postoperative complications in adult spinal deformity patients with a mental illness undergoing reconstructive thoracic or thoracolumbar spine surgery
Publication date: Available online 5 October 2018
Source: The Spine Journal
Author(s): Ishan Shah, Christopher Wang, Nick Jain, Blake Formanek, Zorica Buser, Jeffrey Wang
Abstract
Background Context
: Previous studies have found an association between mental illness and poor outcomes in spine surgery, but little is known about the effects of depression and/or anxiety on the adult spinal deformity population. In addition, most relevant studies exclusively focused on the lumbar spine and had relatively small patient sizes.
Purpose
The aim of this study was to investigate whether adult spinal deformity patients with depression and/or anxiety have an increased risk of postoperative complications and reoperation following posterior thoracolumbar spinal surgery.
Study Design/Setting
Retrospective database study.
Methods
Adult patients (over 18 years of age) with a diagnosis of spinal deformity undergoing any reconstructive thoracic or thoracolumbar spinal procedure with a posterior approach between 2007 and 2015 Q2 were identified using Current Procedural Terminology (CPT) codes to query the Pearl Diver patient record database (Pearl Diver Technologies, West Conshohocken, PA, USA). The database includes records of approximately 18 million patients across the United States who have Humana insurance. Further selection of patients with depression and/or anxiety and their associated postoperative complications were identified using ICD-9 and ICD-10 diagnosis codes (International Classification of Diseases 9th-10th edition). The mental illness cohort was matched to a control group according to age, sex, and Charlson Comorbidity Index (CCI). Patient data was analyzed for reoperation rates and incidence of common post-operative complications.
Results
Multi-level posterolateral fusion was the most common included posterior thoracic reconstructive surgery. The mental illness cohort (n = 327) had significantly increased rates of infection (OR = 1.743, P = 0.022) and respiratory complications (OR = 1.492, P = 0.02) at the 90-day postoperative period. The rates of incision and drainage (OR = 1.379, P = 0.475) and pneumonia (OR = 1.22, P = 0.573) were increased in the mental illness cohort at the 90-day postoperative period, but not significantly. There were no significant differences in complication and reoperation rates at 1-year post-operatively.
Conclusions
Patients with spinal deformity and pre-existing depression and/or anxiety treated with a posterior thoracolumbar reconstructive spinal surgery had significantly elevated risk of postoperative infections and respiratory complications when compared with the control group.
https://ift.tt/2Ph99mr
The Impact of Surgical Reduction of High-Grade Lumbosacral Spondylolisthesis on Proximal Femoral Angle and Quality of Life
Publication date: Available online 5 October 2018
Source: The Spine Journal
Author(s): Imad S Nahle, Hubert Labelle, Stefan Parent, Julie Joncas, Jean-Marc Mac-Thiong
Abstract
Backgound Context: Abnormal proximal femoral angle (PFA) was recently found to be associated with deteriorating sagittal balance and quality of life (QoL) in high-grade spondylolisthesis (HGS). However, the influence of PFA on the QoL of patients undergoing surgery remains unknown.
Purpose: This study compares the pre- and postoperative measurements of sagittal balance including PFA in patients with lumbosacral HGS after surgery. It also determines if PFA is a radiographic parameter that is associated with QoL in patients undergoing surgery.
Study Design: Retrospective cohort study.
Patient Sample: Thirty-three patients (mean age 15.6±3.0 years) operated for L5-S1 HGS between July 2002 and April 2015. Thirteen had in situ fusion and 20 had reduction to a low-grade slip.
Outcome Measures: The outcome measures included PFA and QoL scores measured from the Scoliosis Research Society SRS-30 QoL questionnaire.
Methods: The minimum follow-up was 2 years. PFA and QoL were compared pre- and postoperatively. Statistical analysis used non-parametric Mann-Whitney and Wilcoxon Signed Rank tests, Chi square tests to compare proportions, and bivariate correlations with Spearman's coefficients.
Results: A decreasing PFA correlated with less pain (R=-0.56, p=0.010), improved function (R=-0.51, p=0.022) and better self-image (R=-0.46, p=0.044) post-reduction. Reduction decreased PFA by 5.1° (p=0.002), while in situ fusion did not alter PFA significantly. Patients with normal preoperative PFA had similar postoperative QoL regardless of the type of surgery, except for self-image, which improved further with reduction (3.73±0.49 to 4.26±0.58, p=0.015). Patients with abnormal preoperative PFA tended to have a higher QoL in all domains after reduction.
Conclusion: Decreasing PFA correlates with less pain, better function and self-image. Reduction of HGS decreases PFA. Reduction also relates to a better postoperative QoL when the preoperative PFA is abnormal. When the preoperative PFA is normal, in situ fusion is equivalent to reduction except for self-image, which is better improved after reduction.
https://ift.tt/2pFZISh
Beyond the pillars of the ankle: a prospective randomized CT analysis of syndesmosis' injuries in Weber B and C type fractures
Publication date: Available online 5 October 2018
Source: Injury
Author(s): Massimiliano Carrozzo, Giovanni Vicenti, Vito Pesce, Giuseppe Solarino, Francesco Rifino, Antonio Spinarelli, Caterina Campagna, Davide Bizzoca, Biagio Moretti
Abstract
Background
This study compared clinical and radiographic results of patients who underwent stabilization of syndesmosis with one tricortical syndesmotic screw divided into three different groups: Group A without preoperative fractured ankle computed tomography (CT) scan, Group B with preoperative fractured CT scan, and Group C with preoperative bilateral ankle CT analysis.
Methods
Between June 2016 and May 2017, fifty-one patients with fracture type AO/OTA 44 B and C were analyzed. Of those, 14 (27.45%) were assigned to Group A, 19 (37.25%) to Group B, and 18 (35.30%) to Group C. Clinical outcomes with AOFAS score at 3, 6 and 12 months were recorded. Seven measurements on axial CT scan images were confronted between the injured and uninjured ankle to check the accuracy of reduction.
Results
At three months of follow up the median AOFAS score was 70.86 ± 2.98 with no significative difference between groups (p = 0.105). At 12 months of follow up the median AOFAS score was higher in group C (93.44 ± 3.01) compared to Group B and Group C. The seven variables measured at the CT scan after syndesmotic reduction were statistically different between groups. We found a better restoration of the tibiofibular distances and the correct ankle anatomy in Group C respect to Group A and Group B.
Conclusions
Use of the pre-operative CT scan of the injured and uninjured ankle give to the surgeons the more and accurate information for the reduction and help him intraoperative in the correct maneuvers. The accuracy of the syndesmosis reduction determines better clinical outcomes.
https://ift.tt/2QxV4B5
Wearable Sensors to Monitor, Enable Feedback, and Measure Outcomes of Activity and Practice
Abstract
Purpose of Review
Measurements obtained during real-world activity by wearable motion sensors may contribute more naturalistic accounts of clinically meaningful changes in impairment, activity, and participation during neurologic rehabilitation, but obstacles persist. Here we review the basics of wearable sensors, the use of existing systems for neurological and rehabilitation applications and their limitations, and strategies for future use.
Recent Findings
Commercial activity-recognition software and wearable motion sensors for community monitoring primarily calculate steps and sedentary time. Accuracy declines as walking speed slows below 0.8 m/s, less so if worn on the foot or ankle. Upper-extremity sensing is mostly limited to simple inertial activity counts. Research software and activity-recognition algorithms are beginning to provide ground truth about gait cycle variables and reveal purposeful arm actions. Increasingly, clinicians can incorporate inertial and other motion signals to monitor exercise, activities of daily living, and the practice of specific skills, as well as provide tailored feedback to encourage self-management of rehabilitation.
Summary
Efforts are growing to create a compatible collection of clinically relevant sensor applications that capture the type, quantity, and quality of everyday activity and practice in known contexts. Such data would offer more ecologically sound measurement tools, while enabling clinicians to monitor and support remote physical therapies and behavioral modification when combined with telemedicine outreach.
https://ift.tt/2pESwG7
The Role of Tau Imaging in Parkinsonian Disorders
Abstract
Purpose of Review
Differential diagnosis of atypical Parkinson syndromes (APS) is difficult as clinical presentations may vary and as there is a strong overlap between disease entities. Aggregations of misfolded and hyperphosphorylated tau proteins are the common denominator of many of these diseases.
Recent Findings
Several tau targeting positron emission tomography (PET) tracers have been evaluated as possible biomarkers in APS in the recent years. For Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration, promising results have been reported with regard to the ability to detect the presence of disease and to discriminate patients from controls. However, the discussion about the specificity of the first-generation radiotracers and their value in the clinical context is ongoing.
Summary
A combined interpretation of signal strength and distribution pattern in PET scans with first- and second-generation tracers may be helpful in clinical diagnosis and follow-up of patients with APS.
https://ift.tt/2Ph1swz
Consensus on management of castration-resistant prostate cancer on behalf of the Urological Tumours Working Group (URONCOR) of the Spanish Society of Radiation Oncology
Abstract
Background
The knowledge in the field of castration-resistant prostate cancer (CRPC) is developing rapidly, with emerging new therapies and advances in imaging. Nonetheless, in multiple areas there is still a lack of or very limited evidence, and clear guidance from clinicians regarding optimal strategy is required.
Methods
A modified Delphi method, with 116 relevant questions divided into 7 different CRPC management topics, was used to develop a consensus statement by the URONCOR group.
Results
A strong consensus or unanimity was reached on 93% of the proposed questions. The seven topics addressed were: CRPC definition, symptomatic patients, diagnosis of metastasis, CRPC progression, M0 management, M1 management and sequencing therapy, and treatment monitoring.
Conclusions
The recommendations based on the radiation oncology experts' opinions are intended to provide cancer specialists with expert guidance and to standardise CRPC patient management in Spain, facilitating decision-making in different clinically relevant issues regarding CRPC patients.
https://ift.tt/2QzS8nG
Anti-tumor effect of endostatin in a sleep-apnea mouse model with tumor
Abstract
Background
Obstructive sleep apnea (OSA) is associated with cancer incidence and mortality. The underlying mechanism is unclear. This study aims to evaluate the influence of intermittent hypoxia (IH), a novel hallmark of OSA, on tumor and to access the anti-tumor effect of endostatin on a mouse model with OSA.
Methods
The C57BL/6 J mice were randomly classified into four groups: control (normoxia) (CTL), control plus endostatin (CTL + ED), IH, and IH plus endostatin (IH + ED). Mice in IH and IH + ED groups were subjected to IH 8 h per day in 5 weeks. Lewis lung cancer cells were injected into the flank of each mouse after 1 week of IH exposure. Endostatin was also intraperitoneally injected after tumor volume reached about 200 mm3. The maximum standard uptake values (SUVmax) were detected by micro-positron emission tomography–computed tomography (micro-PET–CT) imaging prior and post-endostatin administration. Microvessel density (MVD) and vascular endothelial growth factor (VEGF) were determined for evaluating the anti-tumor effect of endostatin among the normoxia and IH conditions.
Results
Mice had higher SUVmax in the IH group than the CTL group (p < 0.01). When compared with mice in the CTL group, those in the IH group had significantly greater MVD values (p < 0.001). The SUVmax can be attenuated by endostatin both in the CTL (p < 0.01) and IH conditions (p < 0.001). When compared with CTL group, mice in the IH group had increased MVD values (p < 0.001) and VEGF expression both at mRNA (p < 0.05) and protein levels (p < 0.001 in western blotting results). Treatment with endostatin attenuated serum and tissue VEGF levels, lowering the MVD values. As compared to normoxia condition, the endostatin-therapeutic effects were more significant under the IH condition (p < 0.05 in western blotting results).
Conclusions
Micro-PET–CT imaging is a promising non-invasive technique to evaluate the tumor metabolic characteristics under IH condition in vivo. The anti-tumor effect of endostatin under IH condition is superior to that of the normoxia condition.
https://ift.tt/2OGGxG3
Real-world data on the efficacy and safety of weekly oral vinorelbine in breast cancer patients previously treated with anthracycline or taxane-based regimens
Abstract
Purpose
To evaluate the efficacy and safety of oral weekly vinorelbine 60 mg/m2 for metastatic breast cancer (MBC) in patients previously treated with anthracyclines or taxanes in routine clinical practice.
Materials and methods
Fifty-five patients were enrolled in a prospective multicentre study conducted in Spain. Women ≥ 18 years of age with locally advanced breast cancer who were not candidates for surgical treatment with a radical intention or patients with stage IV disease, and who had received a prior taxane or anthracycline regimen were eligible for participation.
Results
Median age was 67 years. Median progression-free survival was 3.7 months (95% CI 2.5–4.9), median overall survival 10 months (95% CI 6.6–13.5), and overall response rate and clinical benefit rate were 29.1% and 49.1%, respectively. Main grade 3 and 4 toxicities were neutropenia 9.1%, febrile neutropenia 3.6% and constipation 3.6%. In total, 86% of the patients received complete treatment without delays or dose reduction. Moreover, HER2-positive patients who received oral vinorelbine concomitantly with trastuzumab showed better response (complete response: HER2-positive 14.3% vs. HER2-negative 0%; partial response: HER2-positive 42.9% vs. HER2-negative 25.6%; p = 0.008), better disease control rate (HER2-positive 100% vs. HER2-negative 46.2%; p = 0.011), and better values for the remaining analysed variables than HER2-negative patients.
Conclusion
Our study provides real-world data on the use of oral weekly vinorelbine, which proves an effective and well-tolerated regimen for MBC patients previously treated with taxanes or anthracyclines. Patients with HER2-positive disease could also benefit from this treatment in combination with trastuzumab.
https://ift.tt/2Qw0cWl
A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study
Abstract
Purpose
Breast cancer patients receiving hormonal therapies face risks of relapse, increased rates of cardiovascular events, and toxicities of therapy such as aromatase inhibitor (AI)-associated musculoskeletal symptoms (AIMSS). C-reactive protein (CRP), a marker for inflammation, is associated with breast cancer outcomes. We evaluated whether the olive-derived polyphenol hydroxytyrosol combined with omega-3 fatty acids and curcumin would reduce CRP and musculoskeletal symptoms in breast cancer patients receiving adjuvant hormonal therapies.
Experimental design
This prospective, multicenter, open-label, single arm, clinical trial enrolled post-menopausal breast cancer patients (n = 45) with elevated C-reactive protein (CRP) taking predominantly aromatase inhibitors to receive a combination of hydroxytyrosol, omega-3 fatty acids, and curcumin for 1 month. CRP, other inflammation-associated cytokines, and pain scores on the Brief Pain Inventory were measured before therapy, at the end of therapy and 1 month after completion of therapy.
Results
CRP levels declined during the therapy [from 8.2 ± 6.4 mg/L at baseline to 5.3 ± 3.2 mg/L (p = 0.014) at 30 days of treatment], and remained decreased during the additional 1 month off therapy. Subjects with the highest baseline CRP levels had the greatest decrease with the therapy. Pain scores also decreased during the therapy. There were no significant adverse events.
Conclusions
The combination of hydroxytyrosol, omega-3 fatty acids, and curcumin reduced inflammation as indicated by a reduction in CRP and reduced pain in patients with aromatase-induced musculoskeletal symptoms. Longer studies comparing this combination to other anti-inflammatories in larger groups of patients with clinical outcome endpoints are warranted.
https://ift.tt/2OEUFj2
Response ‘Adverse effects of a single dose of gentamicin’ by Halmagyi and Curthoys
British Journal of Clinical Pharmacology, EarlyView.
https://ift.tt/2Oe8aHe
The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumor growth
British Journal of Clinical Pharmacology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2E3Kxfy
Enhanced triage for patients with suspected cardiac chest pain: the History and Electrocardiogram-only Manchester Acute Coronary Syndromes (HE-MACS) decision aid
https://ift.tt/2zVnYFO
Regulatory IFN‐γ‐producing killer dendritic cells are enhanced in B6.MLR‐Faslpr/J lupus‐prone mice
European Journal of Immunology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2pCvyz5
Nilotinib induction of melanogenesis via reactive oxygen species‐dependent JNK activation in B16F0 mouse melanoma cells
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2pESu0H
Brimonidine displays anti‐inflammatory properties in the skin through the modulation of the vascular barrier function
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2PgTJhI
BRCA mutations: is everything said?
Abstract
Background
Mutations in the BRCA1 and BRCA2 genes constitute a risk factor for breast cancer development. BRCA mutation research has been an active field since the discovery of the genes, and new mutations in both genes are constantly described and classified according to several systems.
Aim
We intend to provide an overview of the current state of BRCA1 and BRCA2 mutation description and classification. We wanted to know whether there was a trend towards a more frequently described mutation type and what the proportion of pathogenic mutations was.
Results
We found that, although new mutations are described each year as reflected in current database records, very few of them are reported in papers. Classification systems are highly heterogeneous and a consensus among them is still under development. Regarding their function, a large number of mutations are yet to be analyzed, a very complex task, due to the great number of possible variations and their diverse effect in the BRCA gene functions. After individual analysis, many variants of unknown significance turn out to be pathogenic, and many can disrupt interactions with other proteins involved in mechanisms such as DNA damage repair pathways. Recent data suggest that looking for mutation patterns or combinations would shed a wider light on BRCA-derived cancer susceptibility in the upcoming years.
https://ift.tt/2pDsQte
Possible role of p53/Mieap‐regulated mitochondrial quality control as a tumor suppressor in human breast cancer
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2PjPQJf
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2pESqOv
A group of lncRNAs identified by data mining can predict the prognosis of lung adenocarcinoma
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2PheOc0
Forkhead box C1 boosts triple‐negative breast cancer metastasis through activating the transcription of chemokine receptor‐4
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2pGCPxP
Transduced CDX2/CDX1 can induce growth inhibition on CDX‐deficient gastric cancer via rapid intestinal differentiation
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2PfWhge
Exploration of resistance mechanisms for EGFR‐TKIs based on plasma analysis by digital PCR and next‐generation sequencing
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2pBCZqo
Efficacy of liquid‐based genetic diagnosis of endometrial cancer
Cancer Science, Volume 0, Issue ja, -Not available-.
https://ift.tt/2Pf3ux5
Issue Information
Cancer Science, Volume 109, Issue 10, Page 2993-2995, October 2018.
https://ift.tt/2pGCNGd
In this Issue
Cancer Science, Volume 109, Issue 10, Page 2996-2997, October 2018.
https://ift.tt/2Ph9MMv
Issue Information ‐ TOC
Annals of Neurology, Volume 84, Issue S22, October 2018.
https://ift.tt/2pFGsEs
Issue Information ‐ Copyright
Annals of Neurology, Volume 84, Issue S22, October 2018.
https://ift.tt/2PcY1H3
47th Annual Meeting of the Child Neurology Society
Annals of Neurology, Volume 84, Issue S22, Page S281-S428, October 2018.
https://ift.tt/2pCtqY7
Issue Information ‐ Masthead
Annals of Neurology, Volume 84, Issue S22, October 2018.
https://ift.tt/2PerEaR
143rd Annual Meeting American Neurological Association
Annals of Neurology, Volume 84, Issue S22, Page S1-S280, October 2018.
https://ift.tt/2pCtqHB
Dual functions of ARP101 in targeting membrane type‐1 matrix metalloproteinase : Impact on U87 glioblastoma cell invasion and autophagy signaling
Chemical Biology &Drug Design, Volume 0, Issue ja, -Not available-.
https://ift.tt/2yk3N2r
Knowledge Regarding and Patterns of Genetic Testing in Patients Newly Diagnosed With Breast Cancer Participating in the iCanDecide Trial
Cancer, EarlyView.
https://ift.tt/2E44C5E
Salvage Surgery for Squamous Cell Carcinoma of the Head and Neck in the Era of Immunotherapy: Is It Time to Clarify Our Guidelines?
Cancer, EarlyView.
https://ift.tt/2OavHZy
Association between treatment of superficial bladder cancer and 10‐year mortality in older adults with multiple chronic conditions
Cancer, EarlyView.
https://ift.tt/2E1gtkX
What Do Transplant Physicians Think About Palliative Care? A National Survey Study
Cancer, EarlyView.
https://ift.tt/2O73ClP
Low Clinical Trial Accrual of Patients With Myelodysplastic Syndromes: Causes and Potential Solutions
Cancer, EarlyView.
https://ift.tt/2DZmZZu
Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy
Cancer, EarlyView.
https://ift.tt/2OavBRG
Visions of Eye Commensals: The Known and the Unknown About How the Microbiome Affects Eye Disease
BioEssays, EarlyView.
https://ift.tt/2DZmWwM
Copy number variants in hypoplastic right heart syndrome
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2ykSCGD
In memoriam James L. German, a pioneer in early human genetic research
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2RvB7ft
Mutations in the tRNA methyltransferase 1 gene TRMT1 cause congenital microcephaly, isolated inferior vermian hypoplasia and cystic leukomalacia in addition to intellectual disability
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2yk4E3a
Haploinsufficiency of NCOR1 associated with autism spectrum disorder, scoliosis, and abnormal palatogenesis
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2RufEDK
Risk of hepatic neoplasms in Wolf–Hirschhorn syndrome (4p‐): Four new cases and review of the literature
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2yjukgi
Basan gets a new fingerprint: Mutations in the skin‐specific isoform of SMARCAD1 cause ectodermal dysplasia syndromes with adermatoglyphia
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2RvBerp
Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2RvBcQj
Preliminary observations of mitochondrial dysfunction in Prader–Willi syndrome
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2ykSzKX
An additional patient with a homozygous mutation in DCPS contributes to the delination of Al‐Raqad syndrome
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2RvAXET
Mosaic KRAS mutation in a patient with encephalocraniocutaneous lipomatosis and renovascular hypertension
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2ykSwyL
The characteristics of temper outbursts in Prader–Willi syndrome
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2RsusTo
Prenatal profile of Pallister‐Killian syndrome: Retrospective analysis of 114 pregnancies, literature review and approach to prenatal diagnosis
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2yiGp5g
Dental and craniofacial characteristics caused by the p.Ser40Leu mutation in IFITM5
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2RvAP8n
A de novo in‐frame deletion of CASK gene causes early onset infantile spasms and supratentorial cerebral malformation in a female patient
American Journal of Medical Genetics Part A, EarlyView.
https://ift.tt/2yiA6yx
Bile Acids, Microbiota, and Metabolism
Hepatology, Volume 68, Issue 4, Page 1229-1231, October 2018.
https://ift.tt/2CtTZrg
Direct recanalization of the pancreaticogastrostomy obstruction with a forward‐viewing echoendoscope
Digestive Endoscopy, Volume 0, Issue ja, -Not available-.
https://ift.tt/2Ct5wqL
Impact of all‐oral direct‐acting antivirals on clinical and economic outcomes in chronic hepatitis C patients in the U.S
Hepatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2ILRL6V
Proton pump inhibitors use and risk of hepatocellular carcinoma
Hepatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2CsQlxG
Proton pump inhibitors are associated to minimal and overt hepatic encephalopathy and increase mortality in cirrhotics
Hepatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2ILRIYN
Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice
Hepatology, Volume 68, Issue 4, Page 1519-1533, October 2018.
https://ift.tt/2CuESO3
Hepatology Highlights
Hepatology, Volume 68, Issue 4, Page 1213-1216, October 2018.
https://ift.tt/2IFdwF7
Low‐Dose Interleukin‐2 for Refractory Autoimmune Hepatitis
Hepatology, Volume 68, Issue 4, Page 1649-1652, October 2018.
https://ift.tt/2CtUtxA
Diabetes, Plasma Glucose, and Incidence of Fatty Liver, Cirrhosis, and Liver Cancer: A Prospective Study of 0.5 Million People
Hepatology, Volume 68, Issue 4, Page 1308-1318, October 2018.
https://ift.tt/2IEvgR3
Reframing the approach to patients with hepatocellular carcinoma: Longitudinal assessment with hazard associated with liver transplantation for HCC (HALTHCC) improves ablate and wait strategy
Hepatology, Volume 68, Issue 4, Page 1448-1458, October 2018.
https://ift.tt/2ILRp05
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI‐110) in Hepatocellular Carcinoma
Hepatology, Volume 68, Issue 4, Page 1412-1428, October 2018.
https://ift.tt/2CtU3Hw
Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort
Hepatology, Volume 68, Issue 4, Page 1376-1390, October 2018.
https://ift.tt/2IHGowE
Influence of Progenitor‐Derived Regeneration Markers on Hepatitis C Virus–Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort)
Hepatology, Volume 68, Issue 4, Page 1534-1548, October 2018.
https://ift.tt/2CsDoE5
De Novo Hepatocellular Carcinoma Among Liver Transplant Registrants in the Direct Acting Antiviral Era
Hepatology, Volume 68, Issue 4, Page 1288-1297, October 2018.
https://ift.tt/2IGTbPH
12 Weeks of a Ribavirin‐Free Sofosbuvir and Nonstructural Protein 5A Inhibitor Regimen Is Enough to Treat Recurrence of Hepatitis C After Liver Transplantation
Hepatology, Volume 68, Issue 4, Page 1277-1287, October 2018.
https://ift.tt/2IG7297
The Impact of Autoimmune Hepatitis and Its Treatment on Health Utility
Hepatology, Volume 68, Issue 4, Page 1487-1497, October 2018.
https://ift.tt/2IFyiEz
Response anisocoria in the pupillary light and darkness reflex
European Journal of Neuroscience, Volume 0, Issue ja, -Not available-.
https://ift.tt/2OGBFRh
Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study
European Journal of Neuroscience, Volume 0, Issue ja, -Not available-.
https://ift.tt/2QxUa7Q
Neural Basis of Goal‐Driven Changes in Knowledge Activation
European Journal of Neuroscience, Volume 0, Issue ja, -Not available-.
https://ift.tt/2OGBCF5
Measuring relative vibrotactile spatial acuity: effects of tactor type, anchor points and tactile anisotropy
Abstract
Vibrotactile displays can compensate for the loss of sensory function of people with permanent or temporary deficiencies in vision, hearing, or balance, and can augment the immersive experience in virtual environments for entertainment, or professional training. This wide range of potential applications highlights the need for research on the basic psychophysics of mechanisms underlying human vibrotactile perception. One key consideration when designing tactile displays is determining the minimal possible spacing between tactile motors (tactors), by empirically assessing the maximal throughput of the skin, or, in other words, vibrotactile spatial acuity. Notably, such estimates may vary by tactor type. We assessed vibrotactile spatial acuity in the lower thoracic region for three different tactor types, each mounted in a 4 × 4 array with center-to-center inter-tactor distances of 25 mm, 20 mm, and 10 mm. Seventeen participants performed a relative three-alternative forced-choice point localization task with successive tactor activation for both vertical and horizontal stimulus presentation. The results demonstrate that specific tactor characteristics (frequency, acceleration, contact area) significantly affect spatial acuity measurements, highlighting that the results of spatial acuity measurements may only apply to the specific tactors tested. Furthermore, our results reveal an anisotropy in vibrotactile perception, with higher spatial acuity for horizontal than for vertical stimulus presentation. The findings allow better understanding of vibrotactile spatial acuity and can be used for formulating guidelines for the design of tactile displays, such as regarding inter-tactor spacing, choice of tactor type, and direction of stimulus presentation.
https://ift.tt/2y5EFx4
Therapeutic Activity of DCC‐2036, a Novel Tyrosine Kinase Inhibitor, against Triple‐Negative Breast Cancer Patient‐Derived Xenografts by Targeting AXL/MET
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2y4NEyl
The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NtvmvT
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2y2OImu
Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NrZ0Bk
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2y6jJWD
LKB1 regulates PRMT5 activity in breast cancer
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NrYYcG
CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival, and tumor growth
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2xYV8TJ
Inhibition of NF‐κB improves sensitivity to irradiation and EGFR‐TKIs and decreases irradiation‐induced lung toxicity
International Journal of Cancer, Volume 0, Issue ja, -Not available-.
https://ift.tt/2No5AZD
Sodium nitrite food poisoning in one family
Abstract
Sodium nitrite is used as a coloring agent or preservative in food, as well as an antimicrobial agent in meat and fish and some cheeses. In high amounts it can be toxic for humans, causing methemoglobinemia. This is an unusual and potentially fatal condition in which hemoglobin is oxidized to methemoglobin (MHb), reducing the amount of oxygen that is released from hemoglobin, similar to carbon monoxide poisoning. MHb levels of 70% are generally lethal, but the existence of underlying anemia, acidosis, respiratory compromise, and cardiac disease may exacerbate the toxicity of MHb. We present a case of poisoning with sodium nitrite in three family members after eating homemade sausages given to them by their neighbor who was a butcher. According to the findings of the veterinary inspectorate in charge of food control in this case, the concentration of sodium nitrite in the homemade sausages was about 3.5 g per 1 kg of meat, almost 30 times higher than allowed according to legislation. In this case report, a 70-year-old man died about 7 h after consuming the meal, while two women, 53 and 67 years of age, respectively, were admitted to a toxicology clinic the following day due to food poisoning, with the maximum concentration of MHb in blood of 33.7 and 20.4%, respectively. They were discharged 3 days later. The autopsy of the deceased man showed sodium nitrite poisoning with a relatively low concentration of MHb in his blood – 9.87%. Death was attributed to the exacerbation of hypertensive and ischemic heart disease, resulting from accidental sodium nitrite poisoning. The presented cases illustrate the necessity of close cooperation between the authorities, medical staff, veterinary inspectorate, and forensic pathologists in determining the source of poisoning, the cause of death of the victim, and preventing the outbreak of poisoning among a greater number of consumers.
https://ift.tt/2BXwYfc
Melioidosis mimicking miliary tuberculosis
Abstract
Melioidosis is an infectious disease caused by Burkholderia pseudomallei, a gram-negative intracellular bacillus. Tuberculosis, also an infectious disease, is caused by Mycobacterium tuberculosis, an acid fast bacillus. In both diseases, patients commonly present with fever and respiratory symptoms due to sepsis which might lead to respiratory failure or sudden death if left untreated. Not only are these two entities similar in clinical presentation, but the autopsy findings may mimic each other, giving rise to difficulties in determining the cause of death. We report a case of melioidosis and compare it to a typical case of miliary tuberculosis. Similarities between the cases on gross and histopathological examinations are discussed. In such circumstances, microbiological culture of bodily fluids and internal organs should be performed to ascertain the correct cause of death.
https://ift.tt/2zVJVVg
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
