Rejuvenation Research , Vol. 0, No. 0.
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Σάββατο 27 Φεβρουαρίου 2016
Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice
Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens
Rejuvenation Research , Vol. 0, No. 0.
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A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
Rejuvenation Research , Vol. 0, No. 0.
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Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats
Rejuvenation Research , Vol. 0, No. 0.
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Novel Food Supplement “CP1” Improves Motor Deficit, Cognitive Function, and Neurodegeneration in Animal Model of Parkinson's Disease
Rejuvenation Research , Vol. 0, No. 0.
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Change in the Multidimensional Prognostic Index Score During Hospitalization in Older Patients
Rejuvenation Research , Vol. 0, No. 0.
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Values in Elderly People for Exhaled Nitric Oxide Study
Rejuvenation Research , Vol. 0, No. 0.
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Rejuvenation Research Feb 2016, Vol. 19, No. 1: 100-104.
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 100-104.
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Commentary on Some Recent Theses Relevant to Combating Aging: February 2016
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 94-99.
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Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 3-12.
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How Can We Make the Health Span Focus of Biomedical Gerontology “Stickier”?
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 1-2.
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Thymus Maintenance and Regeneration by Specific Molecular Factors
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 90-93.
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Diabetes and Age-Related Differences in Vascular Function of Renal Artery: Possible Involvement of Endoplasmic Reticulum Stress
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 41-52.
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Serum- and Glucocorticoid-Inducible Kinase 1 Delay the Onset of Endothelial Senescence by Directly Interacting with Human Telomerase Reverse Transcriptase
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 79-89.
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Increased Physical Activity and Fitness above the 50th Percentile Avoid the Threat of Older Adults Becoming Institutionalized: A Cross-sectional Pilot Study
Rejuvenation Research Feb 2016, Vol. 19, No. 1: 13-20.
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Effect of Low-Magnitude, High-Frequency Vibration Treatment on Retardation of Sarcopenia: Senescence-Accelerated Mouse-P8 Model
Rejuvenation Research , Vol. 0, No. 0.
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Higher Cognitive Function in Elderly Individuals with Previous Cataract Surgery: Cross-Sectional Association Independent of Visual Acuity in the HEIJO-KYO Cohort
Rejuvenation Research , Vol. 0, No. 0.
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Multi-Axis Soft Sensors Based on Dielectric Elastomer
Soft Robotics , Vol. 0, No. 0.
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Three-dimensional Particle Tracking Velocimetry for Turbulence Applications: Case of a Jet Flow
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Full title with Editorial board members
Source:International Journal of Psychophysiology, Volume 101
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Instructions to Authors
Source:International Journal of Psychophysiology, Volume 101
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IOP-details
Source:International Journal of Psychophysiology, Volume 101
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Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
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Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Fetal left modified myocardial performance index measured by the Auto Mod-MPI system: development of reference values and application to recipients of twin-to-twin transfusion syndrome
Abstract
Objectives
To establish normal reference ranges for the fetal left modified myocardial performance index (Mod-MPI) measured by the Auto Mod-MPI system and evaluate Mod-MPI changes in recipients of twin-to-twin transfusion syndrome (TTTS) before and after fetoscopic laser coagulation. This article is protected by copyright. All rights reserved.
Methods
This was a prospective longitudinal study of normal singleton fetuses from 12.0 to 40.0 weeks of gestation. TTTS cases treated by laser coagulation were reviewed for Mod-MPI measurements of recipients. All measurements were performed using the Auto Mod-MPI system by a single experienced operator.
Results
Among a total 447 examinations from 222 fetuses, we were unable to measure the Mod-MPI in two cases, and therefore, 445 examinations were analyzed. The median Mod-MPI consistently increased from 0.44 to 0.56 throughout gestation. The median isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) also increased with advancing gestational age. The ejection time (ET) increased until 27 weeks of gestation and decreased thereafter. In the 30 recipients, Mod-MPI, ICT, and IRT increased before laser coagulation and significantly decreased after laser coagulation.
Conclusion
Normal reference values for left Mod-MPI were established using the Auto Mod-MPI system and these might be useful for assessing cardiac function in TTTS.
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Non-Ventilator ICU-Acquired Pneumonia After Cardiothoracic Surgery: Accuracy of Diagnostic Tools and Outcomes
BACKGROUND:Non-ventilator ICU-acquired pneumonia after cardiothoracic surgery is challenging to diagnose, and little is known about its impact on patient outcomes. Here, our primary objective was to compare the sensitivity and specificity of cultures of 2 types of fiberoptic bronchoscopy (FOB) specimens: endotracheal aspirates (FOB-EA) and bronchoalveolar lavage fluid (FOB-BAL). The secondary objectives were to evaluate the sensitivity and specificity of spontaneous sputum cultures and of the modified Clinical Pulmonary Infection Score (CPIS) and to describe patient outcomes.METHODS:We conducted a prospective observational study of consecutive cardiothoracic surgery subjects with suspected non-ventilator ICU-acquired pneumonia. Using FOB-BAL cultures ≥104 cfu/mL as the reference standard, we evaluated the accuracy of FOB-EA ≥105 cfu/mL and spontaneous sputum ≥107 cfu/mL. On the day of FOB, we determined the modified CPIS. Mortality and antibiotic treatments were recorded.RESULTS:Of 105 subjects, 57 (54.3%) received a diagnosis of non-ventilator ICU-acquired pneumonia. FOB-EA cultures had 82% (95% CI 69–91%) sensitivity and 100% (95% CI 89–100%) specificity and were significantly less sensitive than FOB-BAL cultures (P < .004). Spontaneous sputum was obtained from one-third of subjects. Spontaneous sputum cultures had 82% (95% CI 56–95%) sensitivity and 94% (95% CI 68–100%) specificity and were non-significantly less sensitive than FOB-BAL (P = .061). A modified CPIS >6 had 42% (95% CI 29–56%) sensitivity and 87% (95% CI 74–95%) specificity for non-ventilator ICU-acquired pneumonia. Antibiotic therapy was stopped in all subjects without non-ventilator ICU-acquired pneumonia, after 1.6 ± 1.2 d, without deleterious effects.CONCLUSIONS:The modified CPIS has low diagnostic accuracy for non-ventilator ICU-acquired pneumonia. FOB-EA cultures perform less well than do FOB-BAL cultures for diagnosing non-ventilator ICU-acquired pneumonia. Spontaneous sputum is valuable when FOB cannot be performed but could be obtained in only a minority of subjects. When cultures are negative, antibiotic discontinuation is safe.
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Evaluating the Effect of Flow and Interface Type on Pressures Delivered With Bubble CPAP in a Simulated Model
BACKGROUND:Bubble CPAP, used for spontaneously breathing infants to avoid intubation or postextubation support, can be delivered with different interface types. This study compared the effect that interfaces had on CPAP delivery. We hypothesized that there would be no difference between set and measured levels between interface types.METHODS:A validated preterm infant nasal airway model was attached to the ASL 5000 breathing simulator. The simulator was programmed to deliver active breathing of a surfactant-deficient premature infant with breathing frequency at 70 breaths/min inspiratory time of 0.30 s, resistance of 150 cm H2O/L/s, compliance of 0.5 mL/cm H2O, tidal volume of 5 mL, and esophageal pressure of −10 cm H2O. Nasal CPAP prongs, size 4030, newborn and infant RAM cannulas were connected to a nasal airway model and a bubble CPAP system. CPAP levels were set at 4, 5, 6, 7, 8, and 9 cm H2O with flows of 6, 8, and 10 L/min each. Measurements were recorded after 1 min of stabilization. The analysis was performed using SAS 9.4. The Kolmogorov-Smirnov test assessed normality of the data. The Friedman test was used to compare non-normally distributed repeated measures. The Wilcoxon signed-rank test was used to conduct post hoc analysis. All tests were 2-sided, and P values of <.05 were considered as indicating significant differences unless otherwise indicated.RESULTS:At lower set CPAP levels, 4–6 cm H2O, measured CPAP dropped precipitously with the nasal prongs with the highest flow setting. At higher CPAP levels, 7–9 cm H2O measured CPAP concomitantly increased as the flow setting increased. Statistically significant differences in set and measured CPAP occurred for all devices across all CPAP levels, with the measured CPAP less than set for all conditions, P < .001.CONCLUSIONS:Set flow had a profound effect on measured CPAP. The concomitant drop in measured pressure with high and low flows could be attributed to increased resistance to spontaneous breathing or insufficient flow to meet inspiratory demand. Clinicians should be aware of the effect that the interface and flow have on CPAP delivery.
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
