Response

We thank Raimondi et al for their attention and insightful comments in response to our recent publication1 describing how ultrasound is used to diagnose transient tachypnea of newborns (TTN). Raimondi et al have conducted a large amount of research in this field, and reviewing their publications has increased our knowledge.

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Efficacy of EGFR Tyrosine Kinase Inhibitors in the Adjuvant Treatment for Operable Non-small Cell Lung Cancer by a Meta-Analysis

Background

The role of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in the adjuvant treatment of non-small cell lung cancer (NSCLC) has not been well-established. Our meta-analysis aimed to determine whether the administration of EGFR-TKIs could improve the outcomes of patients with NSCLC undergoing complete resection.

Methods

We comprehensively searched databases and extracted data from eligible studies. Disease-free survival (DFS) and overall survival (OS) with hazard ratios (HRs) as well as disease relapse with odds ratios (OR) were calculated using random and/or fixed-effects models. Meta-regression analysis and test for interaction between subgroups were also carried out.

Results

A total of 1,960 patients in five studies were included. Adjuvant EGFR-TKI treatment was associated with a significant benefit on DFS (HR, 0.63; 95% CI, 0.41-0.99), corresponding to an absolute benefit of 3.1% at 3 years, yet with significant heterogeneity (I2 = 83.4%, P Conclusions

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When Patients and Surrogates Disagree About Advance Directives

In a recent issue of CHEST (February 2016), Bruce et al1 describe decision-making when surrogates disagree with an advance directive and then lay out four considerations for overriding an advance directive. The authors may be comforted to know that there is empiric evidence showing that most patients would welcome having their advance directive ignored. In a study of 300 terminally ill patients who were asked whether they would want their advance directive followed should a loved one object, 54% said they would want their advance directive ignored.2 Reasons given were that surrogates made better decisions, or the patients were concerned that the surrogates' best interest be paramount.

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Pseudohyperkalemia due to severe leukocytosis: case presentation

Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)
Issue: Ahead of print


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June Issue of NIH News in Health Now Available

The June issue of NIH News in Health is now available.

Featured stories include "Can You Lengthen Your Life?: Researchers Explore How To Stay Healthy Longer" and "Seeking Allergy Relief: When Breathing Becomes Bothersome". Also, check out the health capsules and the featured Web site.

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Right Ventricular Myocardial Ischemia with Arrhythmia in an Asphyxiated Newborn

AJP Rep 2016; 06: e203-e205
DOI: 10.1055/s-0036-1584279

Background Infant and neonatal myocardial infarction (MI) has been described in association with congenital heart disease, coronary artery abnormalities, myocarditis, and tumors. MI in the perinatal period in a structurally normal heart and with ventricular arrhythmia as a presenting feature has not been thoroughly described. Published case reports describe treatment methods extrapolated from adult MI. However, due to the rare occurrence, the most appropriate acute treatment for both MI and ventricular arrhythmia in newborn infants remains unknown. Case A male term infant with perinatal asphyxia and need for extensive cardiopulmonary resuscitation at birth had ventricular tachyarrhythmia and ST-elevations on electrocardiogram. Four hours after birth, he died from cardiogenic failure. A thrombus at the right coronary artery was found on autopsy. Conclusion MI in the perinatal period in a structurally normal heart is very rare and mortality is high. Although acute treatments extrapolated from adult MI has been described to result in favorable outcomes in newborn infants, guidelines are lacking on how to manage acute MI and associated ventricular arrhythmia.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  open access Full text

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The Effect of a Universal Cervical Length Screening Program on Antepartum Management and Birth Outcomes

AJP Rep 2016; 06: e206-e211
DOI: 10.1055/s-0036-1584240

Objective The objective of this study was to evaluate the effect of a universal cervical length screening program on the incidence of antepartum interventions. Study Design This retrospective cohort study included women delivering ≥ 20 weeks of gestation with singleton pregnancies before and after implementing universal cervical length screening. Antepartum interventions included admission for threatened preterm birth, ≥ 2 cervical length measurements, cervical cerclage, neonatology consultation, betamethasone, antibiotic administration for preterm premature rupture of membranes, and tocolysis. Results There were 1,131 women—506 before the screening program (unexposed) and 625 afterward (exposed). The screening program resulted in significantly more women screened (3.0 vs. 69.9%, p < 0.0001). The exposed group was more likely to undergo ≥ 1 intervention (20.0 vs. 9.5%, p < 0.0001); specifically, admission for threatened preterm birth (3.8 vs. 1.8%, p = 0.04) and ≥ 2 cervical measurements (11.2 vs. 2.0%, p < 0.001). Other interventions were similar between groups (all p ≥ 0.06). Median gestation length was significantly longer in the exposed (39.6 weeks [interquartile, IQR: 38.6–40.4] vs. 39.0 weeks [IQR: 38.0–40.0, p < 0.001]); however, preterm delivery incidence was unaffected (9.4 vs. 10.9%, p = 0.43). Remaining neonatal outcomes were similar (all p ≥ 0.14). Conclusion Implementing universal cervical length screening significantly increased the proportion of women undergoing ≥ 1 antepartum intervention. With the exception of a modestly prolonged gestation, other outcomes were unaffected.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  open access Full text

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KT2130 Wireless Veterinary Endoscopy Set

Firefly's KT2130 Veterinary Endoscopy Set is a perfect starter kit for veterinary professionals. It contains a comprehensive array of tools for a variety of clinical and surgical applications. These rugged tools were designed to work in conjunction with each other to create a complete and affordable endoscopy system

Stainless steel instruments and high quality optics allow this set to handle the tough demands of a veterinary clinic. The Firefly Wireless Endo-Camera and Compact LED Light Source are also compatible with most third-party endoscopes.

With its many uses and applications, the KT2130 Wireless Veterinary Endoscopy Set is a versatile, easy to use endoscopy kit at a very affordable price. Please contact us for more information.

[See image gallery at fireflyglobal.com]

Features

• System includes all hardware and software
• Completely wireless operation
• Observes and records in real time (30 FPS)
• Captures pictures and videos
• Transmits within a range up to 20ft
• Durable, stainless steel instruments
• Ultra-bright LED Light Source
• Rugged industrialized construction
• Long battery life
• 1 Year Warranty

Uses

• Ear, Nose, Throat Diagnostics
• Urologic and Gynecologic Imaging
• Rectal Imaging
• Arthroscopic Imaging
• Dental Imaging
• Many other areas where an endoscope camera can be useful

What's Included

• DE1250 Wireless Endoscope Camera
• ES201 Compact LED Light Source
• 2 Rechargeable Light Source Batteries and AC Charger
• ES301 Endoscope (105mm / 2.7mm)
• ES301A Sheath with working channel
• FireflyPro Software CD
• ES150 Wireless Receiver
• AC Outlet Charger and cables for DE1250
• USB Cable
• Carrying Case
• OPTIONAL: ES160 TV Adapter Kit

For more information contact sales@fireflyglobal.com

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To Your Health: NLM update: NIH MedlinePlus magazine Spring 2016

Listen to the To Your Health: NLM update on NIH MedlinePlus magazine Spring 2016. The transcript is also available.

The new edition of NIH MedlinePlus Magazine covers fibromyalgia, health disparities, as well as women and heart disease.

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To Your Health: NLM update: Ethics and health prevention

Listen to the To Your Health: NLM update on Ethics and health prevention. The transcript is also available.

The inconsistencies between the willingness to fund cost-ineffective clinical treatments versus cost-effective primary prevention services should be more frequently perceived as a medical ethics issue, notes a stimulating perspective recently published in the New England Journal Medicine.

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The application of health literacy measurement tools (collective or individual domains) in assessing chronic disease management: a systematic review protocol

The term "health literacy" (HL) was first coined in 1974, and its most common definition is currently defined as a person's ability to access, understand, evaluate, communicate, and use health information to m...

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Factors contributing to chronic ankle instability: a protocol for a systematic review of systematic reviews

Ankle sprains are a significant clinical problem. Researchers have identified a multitude of factors contributing to the presence of recurrent ankle sprains including deficits in balance, postural control, kin...

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Adverse effects of extracorporeal carbon dioxide removal (ECCO2R) for acute respiratory failure: a systematic review protocol

The extracorporeal membrane carbon dioxide removal (ECCO2R) system is primarily designed for the purpose of removing CO2 from the body for patients with potentially reversible severe acute hypercapnic respiratory...

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Effectiveness and content analysis of interventions to enhance medication adherence in hypertension: a systematic review and meta-analysis protocol

Hypertension control through pharmacological treatment has led to substantial benefits in the prevention of morbidity and mortality from cardiovascular diseases. However, evidence from a number of studies sugg...

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Domains of quality for clinical ethics case consultation: a mixed-method systematic review

"Clinical ethics consultation" (CEC) is the provision of consultative services by an individual or team with the aim of helping health professionals, patients, and their families grapple with difficult ethical...

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Efficacy and safety of auricular point acupressure treatment for gastrointestinal dysfunction after laparoscopic cholecystectomy: study protocol for a randomized controlled trial

Practitioners of traditional Chinese medicine know that auricular point acupressure (APP) using vaccaria seeds on the large intestine point (CO7) has a significant effect on postoperative gastrointestinal dysf...

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Adjunctive use of essential oils following scaling and root planing –a randomized clinical trial

Hitherto no study has been published on the effect of the adjunctive administration of essential oils following scaling and root planing (SRP). This study describes the effect of a mouthrinse consisting of ess...

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Trends in Obesity Among Adults in the United States, 2005 to 2014

This study compares obesity prevalence from 2013-2014 NHANES data and previous NHANES survey cycles (2005-2012) to assess obesity trends. Read the article at: http://ja.ma/22Adth3.

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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Here we present a protocol to detect miRNA expression in breast cancer patient samples using miRNA in situ hybridization.

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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Here we present a protocol to describe the localization of angiotensin II Type 1 receptors in the rat brain by quantitative, densitometric, in vitro receptor autoradiography using an iodine-125 labeled analog of angiotensin II.

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Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Studies have shown that cathodal transcranial direct-current stimulation can produce suppressive effects on drug-resistant seizures. In this study, an in vitro experimental setup was devised in which the direct-current stimulation and multielectrode array recording of seizure-like activity were evaluated in mice brain slice preparation. The direct-current stimulation parameters were evaluated.

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Facile Probe Design: Fluorescent Amphiphilic Nucleic Acid Probes without Quencher Providing Telomerase Activity Imaging Inside Living Cells

Analytical Chemistry

DOI: 10.1021/acs.analchem.6b01777

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The deepithelialized skin flap for closure of large myelomeningoceles: a common plastic surgery technique for a novel neurosurgery application

Abstract

Purpose

The study aims to demonstrate proof of principle of a common plastic surgery technique of deepithelialization for repair of large myelomeningoceles (MMCs). Whereas repair typically consists of a watertight dural closure followed by a muscle or fasciocutaeneous layer, excess skin, however, need not be discarded and can be deepithelialized to augment or, in selective cases, replace the muscle repair.

Methods

The study was performed through a retrospective chart review of two patients.

Results

Step-by-step figures illustrate the technique. Two patients each born with large MMCs measuring 10 × 11 cm and 6 × 9 cm, respectively, were reviewed. Excess skin was deepithelialized to create an additional layer of vascularized tissue over the muscle repair. There were no post-operative complications at 3-month follow-up.

Conclusions

In large MMCs with excess skin, the use of a deepithelialized skin flap can potentially be an alternative or adjunct to a muscle flap to buttress the dural repair.

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Extensive miRNA expression analysis in craniopharyngiomas

Abstract

Purpose

Craniopharyngiomas are benign tumors of the sellar or parasellar regions. They arise from the remnants of Rathke's pouch and are considered a "developmental disease." microRNAs are short non-coding RNAs that play a key regulatory role in the control of expression of entire gene networks. We performed an extensive analysis of miRNAs in craniopharyngiomas aiming to identify a miRNA expression signature that might aid in the prognosis of disease progression and outcome.

Methods

Thirty-seven craniopharyngioma samples from twenty-three patients, ten age-matched controls from autopsy, and ten infant controls from the developing pituitary from autopsy were evaluated for the expression of 754 miRNAs using TaqMan® Low Density Arrays (TLDAs) v2.0 (Applied Biosystems, Foster City, CA).

Results

Among the most differentially expressed miRNAs, downregulation of miR-132 appears to be a marker of aggressiveness and also plays a role in epithelial–mesenchymal transition.

Conclusions

This is the first time that an extensive study of miRNA expression has been performed in craniopharyngiomas. Further research needs to be performed to investigate the potential role of miR-132 in the development and progression of craniopharyngiomas, and its value as a prognostic marker of aggressiveness.

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Effects of photobiomodulation therapy (PBMT) on bovine sperm function

Abstract

Fertilization rates and subsequent embryo development rely on sperm factors related to semen quality and viability. Photobiomodulation therapy (PBMT) is based on emission of electromagnetic waves of a laser optical system that interact with cells and tissues resulting in biological effects. This interaction is mediated by photoacceptors that absorb the electromagnetic energy. Effects are dependent of irradiation parameters, target cell type, and species. In sperm, PBMT improves several features like motility and viability, affecting sperm aerobic metabolism and energy production. The aim of this study was to investigate, under same conditions, how different output powers (5, 7.5, and 10 mW) and time of irradiation (5 and 10 min) of laser (He-Ne laser, 633 nm) may affect frozen/thawed bovine sperm functions. Results showed significant effects depending on power while using 10 min of irradiation on motility parameters and mitochondrial potential. However, no effect was observed using 5 min of irradiation, regardless of power applied. In conclusion, PBMT is effective to modulate bovine sperm function. The effectiveness is dependent on the interaction between power applied and duration of irradiation, showing that these two parameters simultaneously influence sperm function. In this context, when using the same fluency and energy with different combinations of power and time of exposure, we observed distinct effects, revealing that biological effects should be also based on simple parameters rather than only composite parameters such as fluency, irradiance and energy. Laser irradiation of frozen/thawed bovine semen led to an increase on mitochondrial function and motility parameters that could potentially improve fertility rates.

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Identification and Characterization of Mitochondrial Subtypes in Caenorhabditis elegans via Analysis of Individual Mitochondria by Flow Cytometry

Analytical Chemistry

DOI: 10.1021/acs.analchem.6b00542

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Improvement of core-fucosylated glycoproteome coverage via alternating HCD and ETD fragmentation

Publication date: Available online 6 June 2016
Source:Journal of Proteomics
Author(s): Cheng Ma, Jingyao Qu, Xu Li, Xinyuan Zhao, Lei Li, Cong Xiao, Garrett Edmunds, Ebtesam Gashash, Jing Song, Peng George Wang
Core-fucosylation (CF) plays important roles in regulating biological processes in eukaryotes. Alterations of CF-glycosites or CF-glycans in bodily fluids correlate with cancer development. Therefore, global research of protein core-fucosylation with an emphasis on proteomics can explain pathogenic and metastasis mechanisms and aid in the discovery of new potential biomarkers for early clinical diagnosis. In this study, a precise and high throughput method was established to identify CF-glycosites from human plasma. We found that alternating HCD and ETD fragmentation (AHEF) can provide a complementary method to discover CF-glycosites. A total of 407 CF-glycosites among 267 CF-glycoproteins were identified in a mixed sample made from six normal human plasma samples. Among the 407 CF-glycosites, 10 are without the N-X-S/T/C consensus motif, representing 2.5% of the total number identified. All identified CF-glycopeptide results from HCD and ETD fragmentation were filtered with neutral loss peaks and characteristic ions of GlcNAc from HCD spectra, which assured the credibility of the results. This study provides an effective method for CF-glycosites identification and a valuable biomarker reference for clinical research.Biological significanceCF-glycosytion plays an important role in regulating biological processes in eukaryotes. Alterations of the glycosites and attached CF-glycans are frequently observed in various types of cancers. Thus, it is crucial to develop a strategy for mapping human CF-glycosylation. Here, we developed a complementary method via alternating HCD and ETD fragmentation (AHEF) to analyze CF-glycoproteins. This strategy reveals an excellent complementarity of HCD and ETD in the analysis of CF-glycoproteins, and provides a valuable biomarker reference for clinical research.

Graphical abstract

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Comparative leaf proteomics of drought-tolerant and -susceptible peanut in response to water stress

Publication date: Available online 6 June 2016
Source:Journal of Proteomics
Author(s): Ramesh Katam, Katsumi Sakata, Prashanth Suravajhala, Tibor Pechan, Devaiah M. Kambiranda, Karamthot Sivasankar Naik, Baozhu Guo, Sheikh M. Basha
Water stress (WS) predisposes peanut plants to fungal infection resulting in pre-harvest aflatoxin contamination. Major changes during water stress including oxidative stress, lead to destruction of photosynthetic apparatus and other macromolecules within cells. Two peanut cultivars with diverse drought tolerance characteristics were subjected to WS, and their leaf proteome was compared using two-dimensional electrophoresis complemented with MALDI-TOF/TOF mass spectrometry. Ninety-six protein spots were differentially abundant to water stress in both cultivars that corresponded to 60 non-redundant proteins. Protein interaction prediction analysis suggests that 42 unique proteins showed interactions in tolerant cultivar while 20 showed interactions in the susceptible cultivar, activating other proteins in directed system response networks. Four proteins: glutamine ammonia ligase, chitin class II, actin isoform B, and beta tubulin, involved in metabolism, defense and cellular biogenesis, are unique in tolerant cultivar and showed positive interactions with other proteins. In addition, four proteins: serine/threonine protein phosphate PP1, choline monooxygenase, peroxidase 43, and SNF1-related protein kinase regulatory subunit beta-2, that play a role as cryoprotectants through signal transduction, were induced in drought tolerant cultivar following WS. Eleven interologs of these proteins were found in Arabidopsis interacting with several proteins and it is believed that similar mechanisms/pathways exist in peanut.SignificancePeanuts (Arachis hypogaea L.) are a major source of plant protein grown in subtropical and tropical regions of the world. Pre-harvest aflatoxin contamination is a major problem that affects peanut crop yield and food safety. Poor understanding of molecular and cellular mechanisms associated with aflatoxin resistance is largely responsible for the lack of progress in elucidating a process/methodology for reducing aflatoxin contamination in peanuts. Drought perturbs the invasion of the aflatoxin producing fungus and thus affects the quality and yield of peanut. Therefore, more studies involving the effects of drought stress to determine the molecular changes will enhance our understanding of the key metabolic pathways involved in the combined stresses. The changes associated with the biotic and abiotic interactions within the peanut will be used to determine the metabolic pathways involved in the stress tolerance. This research would be beneficial in identifying the tolerant molecular signatures and promoting food safety and consumer health through breeding superior quality peanut cultivars.

Graphical abstract

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Variation in patterns of aging [Evolution]

Do all species experience the declines of old age? No. Do we currently have theories that accurately predict which species escape these declines? In PNAS, Warner et al. (1) demonstrate that the answer to this question is also "no." Understanding the breadth and diversity of the patterns of aging across...

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Role of a brain-gut axis in energy balance [Physiology]

The starvation-inducible coactivator cAMP response element binding protein (CREB)–cAMP-regulated transcription coactivator (Crtc) has been shown to promote starvation resistance in Drosophila by up-regulating CREB target gene expression in neurons, although the underlying mechanism is unclear. We found that Crtc and its binding partner CREB enhance energy homeostasis by stimulating the...

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Odor combinations influence mouse behavior [Neuroscience]

The mechanisms by which odors induce instinctive behaviors are largely unknown. Odor detection in the mouse nose is mediated by >1, 000 different odorant receptors (ORs) and trace amine-associated receptors (TAARs). Odor perceptions are encoded combinatorially by ORs and can be altered by slight changes in the combination of activated...

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SMIT1/myo-inositol regulate ion channels via PIP2 [Neuroscience]

Myo-inositol is an important cellular osmolyte in autoregulation of cell volume and fluid balance, particularly for mammalian brain and kidney cells. We find it also regulates excitability. Myo-inositol is the precursor of phosphoinositides, key signaling lipids including phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. However, whether myo-inositol accumulation during osmoregulation affects signaling and excitability...

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Folding of the serpin antithrombin III [Biochemistry]

Although proteins generally fold to their thermodynamically most stable state, some metastable proteins populate higher free energy states. Conformational changes from metastable higher free energy states to lower free energy states with greater stability can then generate the work required to perform physiologically important functions. However, how metastable proteins fold...

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Dopaminergic reinnervation by 24-y-old transplants [Neuroscience]

Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the long term, as demonstrated by in vivo brain imaging using 18F-fluorodopa and 11C-raclopride positron emission tomography. Here we report the postmortem analysis of a patient with Parkinson's disease who...

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Relevance of in vitro biophysical studies [Biological Sciences]

In his letter, Alberti (1) does not challenge any of the central results in our paper (2), including the main proof that upward curvature in the logarithm of the unfolding rate of a protein as a function of an applied mechanical force implies that underlying energy landscape is multidimensional. However,...

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Computational power of network exploration [Physical Sciences]

We very much appreciate Einarsson's interest in our work (1) and his well-articulated observations regarding the computational complexity of dynamic programming algorithms for the Subset Sum Problem (SSP) (2). We would like to distinguish clearly between the concept we propose and the physical device we used to demonstrate that concept....

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Genes and sociality [Anthropology]

Unraveling the complex sequence of molecular, biochemical, and neuronal cascades that transpire between gene action and behavioral phenotypes has been an exceptionally tough scientific nut to crack. The difficulties in connecting the links between genes and behavior have been especially problematic for social phenotypes, including species-typical social structure, in which...

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Population projections with migration uncertainty [Statistics]

We produce probabilistic projections of population for all countries based on probabilistic projections of fertility, mortality, and migration. We compare our projections to those from the United Nations' Probabilistic Population Projections, which uses similar methods for fertility and mortality but deterministic migration projections. We find that uncertainty in migration projection...

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How to tune an enhancer [Genetics]

Every cell's genome contains two main classes of functional DNA. The best understood type of DNA sequence, which was also the first to be discovered, is that which encodes RNA and protein products via the near-universal "genetic code" (1). A more mysterious but equally important class of functional DNA is...

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Anchored protein folding [Biological Sciences]

In a recent article in PNAS, Zhuravlev et al. (1) determine unfolding trajectories of the Src tyrosine kinase SH3 (Src homology 3) domain [Protein Data Base (PDB) ID code 1SRL]. Using laser optical tweezing, constant force was applied to the SH3 N and C termini (residues 9 and 59), and...

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Salmonella Typhi typhoid toxin [Microbiology]

Salmonella Typhi is the cause of typhoid fever, a disease that has challenged humans throughout history and continues to be a major public health concern. Unlike infections with most other Salmonellae, which result in self-limiting gastroenteritis, typhoid fever is a life-threatening systemic disease. Furthermore, in contrast to most Salmonellae, which...

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Fetal grafts for Parkinson{#x2019}s disease [Neuroscience]

In PNAS, Li et al. (1) report the pathological findings in a single patient with Parkinson's disease (PD) who received transplantation of embryonic dopamine grafts derived from four donors placed into the right putamen 24 y before death. The patient was 59 y of age at the time of surgery...

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Enhanced thermopower in ZnO 2D electron gas [Physics]

Control of dimensionality has proven to be an effective way to manipulate the electronic properties of materials, thereby enabling exotic quantum phenomena, such as superconductivity, quantum Hall effects, and valleytronic effects. Another example is thermoelectricity, which has been theoretically proposed to be favorably controllable by reducing the dimensionality. Here, we...

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AGP-rich nanoparticles drive surface adhesion [Engineering]

Over 130 y have passed since Charles Darwin first discovered that the adventitious roots of English ivy (Hedera helix) exude a yellowish mucilage that promotes the capacity of this plant to climb vertical surfaces. Unfortunately, little progress has been made in elucidating the adhesion mechanisms underlying this high-strength adhesive. In...

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Development of Neandertal body form [Anthropology]

Neandertal and modern human adults differ in skeletal features of the cranium and postcranium, and it is clear that many of the cranial differences—although not all of them—are already present at the time of birth. We know less, however, about the developmental origins of the postcranial differences. Here, we address...

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Multimode oscillator search for supersolid in 4He [Physics]

In 2004, Kim and Chan (KC) reported a decrease in the period of torsional oscillators (TO) containing samples of solid 4He, as the temperature was lowered below 0.2 K [Kim E, Chan MHW (2004) Science 305(5692):1941–1944]. These unexpected results constituted the first experimental evidence that the long-predicted supersolid state of...

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Tautomerism in catalytic H2 evolution [Chemistry]

Efficient generation of hydrogen from renewable resources requires development of catalysts that avoid deep wells and high barriers. Information about the energy landscape for H2 production can be obtained by chemical characterization of catalytic intermediates, but few have been observed to date. We have isolated and characterized a key intermediate...

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OGT in H3.3 deposition and cellular senescence [Biochemistry]

The histone chaperone HIRA complex, consisting of histone cell cycle regulator (HIRA), Ubinuclein1 (UBN1), and calcineurin binding protein 1 (CABIN1), deposits histone variant H3.3 to genic regions and regulates gene expression in various cellular processes, including cellular senescence. How HIRA-mediated nucleosome assembly of H3.3–H4 is regulated remains not well understood....

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Phlegmasia cerulea dolens

Introduction

Phlegmasia cerulea dolens (PCD, painful blue leg) is a rare manifestation of deep vein thrombosis. It is a medical emergency and can rapidly lead to venous gangrene of the extremity.1 Early bedside diagnosis is crucial in order to allow time for interventions to salvage the limb.

Case report

A 58-year-old woman with metastatic breast cancer presented with acute onset of pain in her right lower leg for 1 day. The pain was constant, non-radiating, throbbing, and worsened over a few hours to a 9/10. The patient denied any prior history of foot surgery. On physical examination, she had severe cachexia and pitting oedema in the right lower leg, with purple discolouration and mottling of the toes (figure 1). Dorsalis pedis and posterior tibialis pulses were palpable and equal on both sides. Her platelet count and coagulation profile were within normal limits. Doppler ultrasound of the lower extremity...

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Frameless Stereotactic Radiosurgery: Winning Articles Announced!

Eighteen published articles. More than 300 SIQ scorings. Over 10,500 views. And now, three winning articles! Congratulations are in order for the following authors – as their articles 1st place: '3D-Printing of Arteriovenous Malformations for Radiosurgical Treatment: Pushing Anatomy Understanding to Real Boundaries' by Conti, Pontoriero, Lati, Marino, La Torre, Vinci, Germano, Pergolizzi and Tomasello 2nd place: 'Prognostic Value of […]

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