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Πέμπτη 12 Ιανουαρίου 2023

Approaches to minimize tooth staining associated with silver diamine fluoride: A systematic review

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Abstract

Objective

To the effectiveness of different strategies to overcome silver diamine fluoride (SDF)-mediated tooth staining.

Materials and Methods

Four online databases (PubMed, ScienceDirect, Scopus, and Web of Science) were searched using different MeSH terms and Boolean Operators to retrieve the articles (until June 2021), followed by a hand-search of the reference list of the included articles. All full-text, original studies in English that evaluated SDF staining and at least one SDF modification/alternative were included.

Results

Among the assessed studies, nine studies explored the stain-minimization effect of potassium iodide (KI) post-application following SDF treatment. Among these, eight concluded that KI application after SDF treatment significantly reduced tooth staining, while one showed marginal staining following glass ionomer restoration of the SDF-treated dentine. Additionally, one study applied potassium fluoride (KF) and silver nitrate (AgNO3) concurrently to mitigate SDF-mediated staining. One study compared SDF staining with polyethylene glycol (PEG)-coated nanoparticles containing sodium fluoride (NaF), and another used nanosilver fluoride (NSF) for staining comparison with SDF.

Conclusions

Within the limitations of this study, the addition of different materials to SDF has proven to be a beneficial strategy for overcoming tooth staining associated with SDF. Future studies are warranted, particularly clinical trials, to validate these findings.

Clinical Significance

SDF-mediated tooth staining is a serious concern that limits its clinical use. A review of various strategies to overcome this problem will help clinicians enhance its clinical use and patient acceptance.

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Targeting therapeutic against C3b/C4b, SB002, on the inflammation‐induced bone loss in experimental periodontitis

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Abstract

Aims

To use experimental periodontitis models in rats to investigate the correlation between local expression of complement components C3b and C4b in periodontal tissues and disease severity, and to assess the therapeutic effects of targeting C3b/C4b on inflammatory bone loss.

Methods

The gingival expression of C3, C3b, and C4b in animal experimental periodontitis models was analyzed immunohistochemically. The therapeutic effects of C3b/C4b inhibitor (SB002) on ligation-induced experimental periodontitis was examined using biochemical, histological, and immunohistochemical analysis.

Results

The gingival expression levels of C3, C3b, and C4b were positively correlated with the severity of periodontitis. Moreover, both single and multiple injections of the C3b/C4b inhibitor had preventive and therapeutic effects on alveolar bone loss in ligation-induced experimental periodontitis with no associated adverse consequences.

Conclusions

The association between C3b/C4b and periodontitis may provide a basis for the development of novel therapeutic strategies for periodontitis and other inflammatory diseases.

This article is protected by copyright. All rights reserved.

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Oncologic Outcomes After Clinically Node-Negative Salvage Laryngectomy

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This cohort study investigates the association of electiv e neck dissection vs observation with oncologic outcomes among patients who received clinically node-negative salvage total laryngectomy.
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Long-term Outcomes of Turbinate Surgery in Patients With Allergic Rhinitis

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This systematic review and meta-analysis investigates the long-term outcomes and safety of turbinate surgery in patients with medically refractory allergic rhinitis.
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Somatic genomic imbalances in ‘tumour-free’ surgical margins of oral cancer

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Up to 30% of oral squamous cell carcinoma (OSCC) patients develop local recurrence and distant metastasis. The molecular status of histologically cancer-free tumour margins could be a critical factor in predicting tumour behaviour. The aim of this study was to detect somatic genomic imbalances in OSCC with emphasis on the surgical margins. DNA was isolated from tumour tissues, margin tissues, and blood samples (used as control) obtained from 11 OSCC patients, and genome-wide array comparative genomic hybridization was performed. (Source: International Journal of Oral and Maxillofacial Surgery)
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