Anthropometry has been used in the assessment of growth with "normal" range of growth being considered to span within ±2SD of median. Generally the practice is to make a child to grow within this standard devi...
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Σάββατο 9 Απριλίου 2016
Growth charts: do they reflect healthy growth in Sri Lankan children?
Managing diabetes in hospitalized patients with chronic kidney disease
MANAGING GLYCEMIC CONTROL in hospitalized patients with chronic kidney disease (CKD) and diabetes mellitus is a challenge, with no published guidelines. In this setting, avoiding...
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Treating and preventing acute exacerbations of COPD
IN CONTRAST TO STABLE chronic obstructive pulmonary disease (COPD),1 acute exacerbations of COPD pose special management challenges and can significantly increase the risk of morbidity and...
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The insect central complex as model for heterochronic brain development—background, concepts, and tools
Abstract
The adult insect brain is composed of neuropils present in most taxa. However, the relative size, shape, and developmental timing differ between species. This diversity of adult insect brain morphology has been extensively described while the genetic mechanisms of brain development are studied predominantly in Drosophila melanogaster. However, it has remained enigmatic what cellular and genetic mechanisms underlie the evolution of neuropil diversity or heterochronic development. In this perspective paper, we propose a novel approach to study these questions. We suggest using genome editing to mark homologous neural cells in the fly D. melanogaster, the beetle Tribolium castaneum, and the Mediterranean field cricket Gryllus bimaculatus to investigate developmental differences leading to brain diversification. One interesting aspect is the heterochrony observed in central complex development. Ancestrally, the central complex is formed during embryogenesis (as in Gryllus) but in Drosophila, it arises during late larval and metamorphic stages. In Tribolium, it forms partially during embryogenesis. Finally, we present tools for brain research in Tribolium including 3D reconstruction and immunohistochemistry data of first instar brains and the generation of transgenic brain imaging lines. Further, we characterize reporter lines labeling the mushroom bodies and reflecting the expression of the neuroblast marker gene Tc-asense, respectively.
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Toward a study of gene regulatory constraints to morphological evolution of the Drosophila ocellar region
Abstract
The morphology and function of organs depend on coordinated changes in gene expression during development. These changes are controlled by transcription factors, signaling pathways, and their regulatory interactions, which are represented by gene regulatory networks (GRNs). Therefore, the structure of an organ GRN restricts the morphological and functional variations that the organ can experience—its potential morphospace. Therefore, two important questions arise when studying any GRN: what is the predicted available morphospace and what are the regulatory linkages that contribute the most to control morphological variation within this space. Here, we explore these questions by analyzing a small "three-node" GRN model that captures the Hh-driven regulatory interactions controlling a simple visual structure: the ocellar region of Drosophila. Analysis of the model predicts that random variation of model parameters results in a specific non-random distribution of morphological variants. Study of a limited sample of drosophilids and other dipterans finds a correspondence between the predicted phenotypic range and that found in nature. As an alternative to simulations, we apply Bayesian networks methods in order to identify the set of parameters with the largest contribution to morphological variation. Our results predict the potential morphological space of the ocellar complex and identify likely candidate processes to be responsible for ocellar morphological evolution using Bayesian networks. We further discuss the assumptions that the approach we have taken entails and their validity.
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Size, shape, and form: concepts of allometry in geometric morphometrics
Abstract
Allometry refers to the size-related changes of morphological traits and remains an essential concept for the study of evolution and development. This review is the first systematic comparison of allometric methods in the context of geometric morphometrics that considers the structure of morphological spaces and their implications for characterizing allometry and performing size correction. The distinction of two main schools of thought is useful for understanding the differences and relationships between alternative methods for studying allometry. The Gould–Mosimann school defines allometry as the covariation of shape with size. This concept of allometry is implemented in geometric morphometrics through the multivariate regression of shape variables on a measure of size. In the Huxley–Jolicoeur school, allometry is the covariation among morphological features that all contain size information. In this framework, allometric trajectories are characterized by the first principal component, which is a line of best fit to the data points. In geometric morphometrics, this concept is implemented in analyses using either Procrustes form space or conformation space (the latter also known as size-and-shape space). Whereas these spaces differ substantially in their global structure, there are also close connections in their localized geometry. For the model of small isotropic variation of landmark positions, they are equivalent up to scaling. The methods differ in their emphasis and thus provide investigators with flexible tools to address specific questions concerning evolution and development, but all frameworks are logically compatible with each other and therefore unlikely to yield contradictory results.
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The sex-limited effects of mutations in the EGFR and TGF-β signaling pathways on shape and size sexual dimorphism and allometry in the Drosophila wing
Abstract
Much of the morphological diversity in nature—including among sexes within a species—is a direct consequence of variation in size and shape. However, disentangling variation in sexual dimorphism for both shape (SShD), size (SSD), and their relationship with one another remains complex. Understanding how genetic variation influences both size and shape together, and how this in turn influences SSD and SShD, is challenging. In this study, we utilize Drosophila wing size and shape as a model system to investigate how mutations influence size and shape as modulated by sex. Previous work has demonstrated that mutations in epidermal growth factor receptor (EGFR) and transforming growth factor-β (TGF-β) signaling components can influence both wing size and shape. In this study, we re-analyze this data to specifically address how they impact the relationship between size and shape in a sex-specific manner, in turn altering the pattern of sexual dimorphism. While most mutations influence shape overall, only a subset have a genotypic specific effect that influences SShD. Furthermore, while we observe sex-specific patterns of allometric shape variation, the effects of most mutations on allometry tend to be small. We discuss this within the context of using mutational analysis to understand sexual size and shape dimorphism.
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Measurement error in geometric morphometrics
Abstract
Geometric morphometrics—a set of methods for the statistical analysis of shape once saluted as a revolutionary advancement in the analysis of morphology —is now mature and routinely used in ecology and evolution. However, a factor often disregarded in empirical studies is the presence and the extent of measurement error. This is potentially a very serious issue because random measurement error can inflate the amount of variance and, since many statistical analyses are based on the amount of "explained" relative to "residual" variance, can result in loss of statistical power. On the other hand, systematic bias can affect statistical analyses by biasing the results (i.e. variation due to bias is incorporated in the analysis and treated as biologically-meaningful variation). Here, I briefly review common sources of error in geometric morphometrics. I then review the most commonly used methods to measure and account for both random and non-random measurement error, providing a worked example using a real dataset.
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Modularity and developmental stability in segmented animals: variation in translational asymmetry in geophilomorph centipedes
Abstract
Does a modular body organization present a challenge for developmental control? We investigate the idea of a possible developmental cost of modularity by examining the relationship between modularity and developmental stability in a multi-segmented arthropod taxon: the geophilomorph centipedes. In a sample of eight species, we tested the correlation between developmental stability, estimated from measures of translational fluctuating asymmetry, and the number of trunk segments and some other morphological traits, both at the species and individual levels. We found sizeable differences in size and shape patterns of variation at the level of species. However, we did not find any clear evidence of correlation between fluctuating asymmetry and the number of trunk segments or the other morphological traits considered. Thus, our results provide no support to the idea of a possible trade-off between the cardinality of a modular system and the level of developmental precision in the phenotypic expression of its modules. The results of this exploratory study invite further investigations of patterns of translational fluctuating asymmetry in segmented animals and other modular organisms, as these have the potential to reveal features of developmental stability that cannot be captured by the study of bilateral asymmetry alone.
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Engaging Older Adults in Health Care Decision-Making: A Realist Synthesis
Abstract
Background
Engagement in healthcare decision making has been recognized as an important, and often lacking, aspect of care, especially in the care of older adults who are major users of the healthcare system.
Objective
We aimed to conduct a review of available knowledge on engagement in healthcare decision making with a focus on older patients and their caregivers.
Methods
We conducted a realist synthesis focusing on strategies for engagement of older patients and their caregivers in healthcare decision making. The synthesis encompassed theoretical frameworks and both peer-reviewed and grey literature. Expert consultations included interviews (n = 2) with academics and group consultations (n = 3) with older adults and their caregivers. Abstracts that reported description, assessment, or evaluation of strategies for engagement of adult patients, families, or caregivers (i.e., that report on actual experiences of engagement) were included.
Results
The search generated 15,683 articles, 663 of which were pertinent to healthcare decision making. Theoretical and empirical work identified a range of strategies and levels of engagement of older patients and their families in healthcare decision making. The importance of communication emerged as a key recommendation for meaningful engagement among providers and patients and their caregivers. The principles developed in this study should be implemented with consideration of the context in which care is being provided.
Conclusions
We have developed a framework that promotes the engagement of patients and their caregivers as equal partners in healthcare decision making. Future research should implement and test the framework in various clinical settings.
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Cognitive Testing of an Electronic Version of the Faces Pain Scale-Revised with Pediatric and Adolescent Sickle Cell Patients
Abstract
Background
Patient diaries and pain scales can capture the course and complications of pain managed at home in children. The Faces Pain Scale-Revised (FPS-R) is a validated scale showing reliability in children, but it has not been validated in children with sickle cell disease (SCD).
Objective
The purpose of this study was to evaluate comprehension and usability of an electronic modified version of the FPS-R among pediatric patients with SCD.
Methods
This was a cross-sectional, qualitative study involving in-person interviews with children/adolescents from the USA and their parents/legal guardians. Interviews involved cognitive debriefing and usability testing of the FPS-R.
Results
In total, 22 children with SCD aged 4–17 years participated. Children aged 4–6 were generally unable to demonstrate clear understanding of the FPS-R and its response scale. Overall, children aged ≥7 years understood the instrument and could complete it on the electronic device, although children aged 7–8 often needed assistance from the parent. Children aged 9–17 years were able to read and complete the instrument independently. Most participants considered the electronic device easy to use.
Conclusions
The FPS-R was shown to be a comprehensible and usable pain measure for children aged 7–17 with SCD and to be beneficial for future clinical studies.
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Development of a Symptom-Based Patient-Reported Outcome Instrument for Functional Dyspepsia: A Preliminary Conceptual Model and an Evaluation of the Adequacy of Existing Instruments
Abstract
Objectives
The aim was to document, from the perspective of the empirical literature, the primary symptoms of functional dyspepsia (FD), evaluate the extent to which existing questionnaires target those symptoms, and, finally, identify any missing evidence that would impact the questionnaires' use in regulated clinical trials to assess treatment efficacy claims intended for product labeling.
Methods
A literature review was conducted to identify the primary symptoms of FD and existing symptom-based FD patient-reported outcome (PRO) instruments. Following a database search, abstracts were screened and articles were retrieved for review. The primary symptoms of FD were organized into a conceptual model and the PRO instruments were evaluated for conceptual coverage as well as compared against evidentiary requirements presented in the FDA's PRO Guidance for Industry.
Results
Fifty-six articles and 16 instruments assessing FD symptoms were reviewed. Concepts listed in the Rome III criteria for FD (n = 7), those assessed by existing FD instruments (n = 34), and symptoms reported by patients in published qualitative research (n = 6) were summarized in the FD conceptual model. Except for vomiting, all of the identified symptoms from the published qualitative research reports were also specified in the Rome III criteria. Only three of the 16 instruments, the Dyspepsia Symptom Severity Index (DSSI), Nepean Dyspepsia Index (NDI), and Short-Form Nepean Dyspepsia Index (SF-NDI), measure all seven FD symptoms defined by the Rome III criteria. Among these three, each utilizes a 2-week recall period and 5-point Likert-type scale, and had evidence of patient involvement in development. Despite their coverage, when these instruments were evaluated in light of regulatory expectations, several issues jeopardized their potential qualification for substantiation of a labeling claim.
Conclusions
No existing PRO instruments that measured all seven symptoms adhered to the regulatory principles necessary to support product labeling. As such, the development of a new FD symptom PRO instrument is supported.
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Endothelin-1 Plasma Levels and Acute Mountain Sickness
High Altitude Medicine & Biology , Vol. 0, No. 0.
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Recombinant Human Plasminogen Activator Inhibitor-1 Accelerates Odontoblastic Differentiation of Human Stem Cells from Apical Papilla
Tissue Engineering Part A , Vol. 0, No. 0.
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Chondroinduction from Naturally Derived Cartilage Matrix: A Comparison Between Devitalized and Decellularized Cartilage Encapsulated in Hydrogel Pastes
Tissue Engineering Part A , Vol. 0, No. 0.
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Concurrent and Sustained Delivery of FGF2 and FGF9 from Electrospun Poly(ester amide) Fibrous Mats for Therapeutic Angiogenesis
Tissue Engineering Part A , Vol. 0, No. 0.
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Identification of Human Juvenile Chondrocyte-Specific Factors that Stimulate Stem Cell Growth
Tissue Engineering Part A , Vol. 0, No. 0.
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Vitronectin-Based, Biomimetic Encapsulating Hydrogel Scaffolds Support Adipogenesis of Adipose Stem Cells
Tissue Engineering Part A , Vol. 0, No. 0.
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Enhanced Bone Repair by Guided Osteoblast Recruitment Using Topographically Defined Implant
Tissue Engineering Part A , Vol. 0, No. 0.
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The Effects of Cognitive Training for Elderly: Results from My Mind Project
Rejuvenation Research , Vol. 0, No. 0.
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Buyang Huanwu Decoction Vigorously Rescues PC12 Cells Against 6-OHDA-Induced Neurotoxicity via Akt/GSK3β Pathway Based on Serum Pharmacology Methodology
Rejuvenation Research , Vol. 0, No. 0.
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Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats
Rejuvenation Research , Vol. 0, No. 0.
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Commentary on Some Recent Theses Relevant to Combating Aging: April 2016
Rejuvenation Research , Vol. 0, No. 0.
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A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study
Rejuvenation Research , Vol. 0, No. 0.
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Is Low Hemoglobin Concentration Highly Associated with the Onset of Cognitive Impairment in Elderly People?
Rejuvenation Research , Vol. 0, No. 0.
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The Effects of Cognitive Training for Elderly: Results from My Mind Project
Rejuvenation Research , Vol. 0, No. 0.
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Buyang Huanwu Decoction Vigorously Rescues PC12 Cells Against 6-OHDA-Induced Neurotoxicity via Akt/GSK3β Pathway Based on Serum Pharmacology Methodology
Rejuvenation Research , Vol. 0, No. 0.
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Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats
Rejuvenation Research , Vol. 0, No. 0.
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Commentary on Some Recent Theses Relevant to Combating Aging: April 2016
Rejuvenation Research , Vol. 0, No. 0.
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A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study
Rejuvenation Research , Vol. 0, No. 0.
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Is Low Hemoglobin Concentration Highly Associated with the Onset of Cognitive Impairment in Elderly People?
Rejuvenation Research , Vol. 0, No. 0.
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IJMS, Vol. 17, Pages 530: Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury
Cervical-level injuries account for the majority of presented spinal cord injuries (SCIs) to date. Despite the increase in survival rates due to emergency medicine improvements, overall quality of life remains poor, with patients facing variable deficits in respiratory and motor function. Therapies aiming to ameliorate symptoms and restore function, even partially, are urgently needed. Current therapeutic avenues in SCI seek to increase regenerative capacities through trophic and immunomodulatory factors, provide scaffolding to bridge the lesion site and promote regeneration of native axons, and to replace SCI-lost neurons and glia via intraspinal transplantation. Induced pluripotent stem cells (iPSCs) are a clinically viable means to accomplish this; they have no major ethical barriers, sources can be patient-matched and collected using non-invasive methods. In addition, the patient's own cells can be used to establish a starter population capable of producing multiple cell types. To date, there is only a limited pool of research examining iPSC-derived transplants in SCI—even less research that is specific to cervical injury. The purpose of the review herein is to explore both preclinical and clinical recent advances in iPSC therapies with a detailed focus on cervical spinal cord injury.
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IJMS, Vol. 17, Pages 540: A Proteomic Approach for the Identification of Up-Regulated Proteins Involved in the Metabolic Process of the Leiomyoma
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Energies, Vol. 9, Pages 278: Robust Optimization-Based Scheduling of Multi-Microgrids Considering Uncertainties
Scheduling of multi-microgrids (MMGs) is one of the important tasks in MMG operation and it faces new challenges as the integration of demand response (DR) programs and renewable generation (wind and solar) sources increases. In order to address these challenges, robust optimization (RO)-based scheduling has been proposed in this paper considering uncertainties in both renewable energy sources and forecasted electric loads. Initially, a cost minimization deterministic model has been formulated for the MMG system. Then, it has been transformed to a min-max robust counterpart and finally, a traceable robust counterpart has been formulated using linear duality theory and Karush–Kuhn–Tucker (KKT) optimality conditions. The developed model provides immunity against the worst-case realization within the provided uncertainty bounds. Budget of uncertainty has been used to develop a trade-off between the conservatism of solution and probability of unfeasible solution. The effect of uncertainty gaps on internal and external trading, operation cost, unit commitment of dispatchable generators, and state of charge (SOC) of battery energy storage systems (BESSs) have also been analyzed in both grid-connected and islanded modes. Simulations results have proved the robustness of proposed strategy.
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Remote Sensing, Vol. 8, Pages 316: Stable Imaging and Accuracy Issues of Low-Altitude Unmanned Aerial Vehicle Photogrammetry Systems
Stable imaging of an unmanned aerial vehicle (UAV) photogrammetry system is an important issue that affects the data processing and application of the system. Compared with traditional aerial images, the large rotation of roll, pitch, and yaw angles of UAV images decrease image quality and result in image deformation, thereby affecting the ground resolution, overlaps, and the consistency of the stereo models. These factors also cause difficulties in automatic tie point matching, image orientation, and accuracy of aerial triangulation (AT). The issues of large-angle photography of UAV photogrammetry system are discussed and analyzed quantitatively in this paper, and a simple and lightweight three-axis stabilization platform that works with a low-precision integrated inertial navigation system and a three-axis mechanical platform is used to reduce this problem. An experiment was carried out with an airship as the flight platform. Another experimental dataset, which was acquired by the same flight platform without a stabilization platform, was utilized for a comparative test. Experimental results show that the system can effectively isolate the swing of the flying platform. To ensure objective and reliable results, another group of experimental datasets, which were acquired using a fixed-wing UAV platform, was also analyzed. Statistical results of the experimental datasets confirm that stable imaging of a UAV platform can help improve the quality of aerial photography imagery and the accuracy of AT, and potentially improve the application of images acquired by a UAV.
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Polymers, Vol. 8, Pages 136: The Effect of Molecular Structure and Environment on the Miscibility and Diffusivity in Polythiophene-Methanofullerene Bulk Heterojunctions: Theory and Modeling with the RISM Approach
Although better means to model the properties of bulk heterojunction molecular blends are much needed in the field of organic optoelectronics, only a small subset of methods based on molecular dynamics- and Monte Carlo-based approaches have been hitherto employed to guide or replace empirical characterization and testing. Here, we present the first use of the integral equation theory of molecular liquids in modelling the structural properties of blends of phenyl-C61-butyric acid methyl ester (PCBM) with poly(3-hexylthiophene) (P3HT) and a carboxylated poly(3-butylthiophene) (P3BT), respectively. For this, we use the Reference Interaction Site Model (RISM) with the Universal Force Field (UFF) to compute the microscopic structure of blends and obtain insight into the miscibility of its components. Input parameters for RISM, such as optimized molecular geometries and charge distribution of interaction sites, are derived by the Density Functional Theory (DFT) methods. We also run Molecular Dynamics (MD) simulation to compare the diffusivity of the PCBM in binary blends with P3HT and P3BT, respectively. A remarkably good agreement with available experimental data and results of alternative modelling/simulation is observed for PCBM in the P3HT system. We interpret this as a step in the validation of the use of our approach for organic photovoltaics and support of its results for new systems that do not have reference data for comparison or calibration. In particular, for the less-studied P3BT, our results show that expectations about its performance in binary blends with PCBM may be overestimated, as it does not demonstrate the required level of miscibility and short-range structural organization. In addition, the simulated mobility of PCBM in P3BT is somewhat higher than what is expected for polymer blends and falls into a range typical for fluids. The significance of our predictive multi-scale modelling lies in the insights it offers into nanoscale morphology and charge transport behaviour in multi-component organic semiconductor blends.
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IJMS, Vol. 17, Pages 530: Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury
Cervical-level injuries account for the majority of presented spinal cord injuries (SCIs) to date. Despite the increase in survival rates due to emergency medicine improvements, overall quality of life remains poor, with patients facing variable deficits in respiratory and motor function. Therapies aiming to ameliorate symptoms and restore function, even partially, are urgently needed. Current therapeutic avenues in SCI seek to increase regenerative capacities through trophic and immunomodulatory factors, provide scaffolding to bridge the lesion site and promote regeneration of native axons, and to replace SCI-lost neurons and glia via intraspinal transplantation. Induced pluripotent stem cells (iPSCs) are a clinically viable means to accomplish this; they have no major ethical barriers, sources can be patient-matched and collected using non-invasive methods. In addition, the patient's own cells can be used to establish a starter population capable of producing multiple cell types. To date, there is only a limited pool of research examining iPSC-derived transplants in SCI—even less research that is specific to cervical injury. The purpose of the review herein is to explore both preclinical and clinical recent advances in iPSC therapies with a detailed focus on cervical spinal cord injury.
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Remote Sensing, Vol. 8, Pages 318: Integration of Hyperspectral Shortwave and Longwave Infrared Remote-Sensing Data for Mineral Mapping of Makhtesh Ramon in Israel
Hyperspectral remote-sensing in the reflected infrared and thermal infrared regions offers a unique and efficient alternative for mineral mapping, as most minerals exhibit spectral features in these regions, mainly in the shortwave and longwave infrared. Airborne hyperspectral data in both spectral regions, acquired with the AisaFENIX and AisaOWL (Specim) sensors over Makhtesh Ramon in Israel, were analyzed. Calculating the reflectance and emissivity spectra of each pixel in the shortwave infrared and longwave infrared region images, respectively, and determining mineral indices enabled identifying the dominant minerals in this area—kaolinite, calcite, dolomite, quartz, feldspars and gypsum—and mapping their spatial distribution in the surface. The benefit of using hyperspectral data from both reflected infrared and thermal infrared regions to improve mineral identification was demonstrated.
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Polymers, Vol. 8, Pages 131: Structural Properties and Antifungal Activity against Candida albicans Biofilm of Different Composite Layers Based on Ag/Zn Doped Hydroxyapatite-Polydimethylsiloxanes
Modern medicine is still struggling to find new and more effective methods for fighting off viruses, bacteria and fungi. Among the most dangerous and at times life-threatening fungi is Candida albicans. Our work is focused on surface and structural characterization of hydroxyapatite, silver doped hydroxyapatite and zinc doped hydroxyapatite deposited on a titanium substrate previously coated with polydimethylsiloxane (HAp-PDMS, Ag:HAp-PDMS, Zn:HAp-PDMS) by different techniques: Scanning Electron Microscopy (SEM), Glow Discharge Optical Emission Spectroscopy (GDOES) and Fourier Transform Infrared Spectroscopy (FTIR). The morphological studies revealed that the use of the PDMS polymer as an interlayer improves the quality of the coatings. The structural characterizations of the thin films revealed the basic constituents of both apatitic and PDMS structure. In addition, the GD depth profiles indicated the formation of a composite material as well as the successful embedding of the HAp, Zn:HAp and Ag:HAp into the polymer. On the other hand, in vitro evaluation of the antifungal properties of Ag:HAp-PDMS and Zn:HAp-PDMS demonstrated the fungicidal effects of Ag:HAp-PDMS and the potential antifungal effect of Zn:HAp-PDMS composite layers against C. albicans biofilm. The results acquired in this research complete previous research on the potential use of new complex materials produced by nanotechnology in biomedicine.
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Nutrients, Vol. 8, Pages 211: Flavonoids in Inflammatory Bowel Disease: A Review
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients' life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavonoids. Flavonoids are compounds with low molecular weight that are widely distributed throughout the vegetable kingdom, including in edible plants. They may be of great utility in conditions of acute or chronic intestinal inflammation through different mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties in the gut. In this review we have revised the main flavonoid classes that have been assessed in different experimental models of colitis as well as the proposed mechanisms that support their beneficial effects.
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IJMS, Vol. 17, Pages 540: A Proteomic Approach for the Identification of Up-Regulated Proteins Involved in the Metabolic Process of the Leiomyoma
Uterine leiomyoma is the most common benign smooth muscle cell tumor of the uterus. Proteomics is a powerful tool for the analysis of complex mixtures of proteins. In our study, we focused on proteins that were upregulated in the leiomyoma compared to the myometrium. Paired samples of eight leiomyomas and adjacent myometrium were obtained and submitted to two-dimensional gel electrophoresis (2-DE) and mass spectrometry for protein identification and to Western blotting for 2-DE data validation. The comparison between the patterns revealed 24 significantly upregulated (p < 0.05) protein spots, 12 of which were found to be associated with the metabolic processes of the leiomyoma and not with the normal myometrium. The overexpression of seven proteins involved in the metabolic processes of the leiomyoma was further validated by Western blotting and 2D Western blotting. Four of these proteins have never been associated with the leiomyoma before. The 2-DE approach coupled with mass spectrometry, which is among the methods of choice for comparative proteomic studies, identified a number of proteins overexpressed in the leiomyoma and involved in several biological processes, including metabolic processes. A better understanding of the mechanism underlying the overexpression of these proteins may be important for therapeutic purposes.
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Micromachines, Vol. 7, Pages 63: A One-Square-Millimeter Compact Hollow Structure for Microfluidic Pumping on an All-Glass Chip
A micro surface tension pump is a new type of low-cost, built-in, all-glass, microfluidic pump on a glass microchip fabricated by one-step glass etching. However, geometric minimization and optimization for practical use are challenging. Here, we report a one-square-millimeter, built-in, all-glass pump controlled by two-way digital gas pressure. The pump consists simply of two joint chambers and a piston between two gas control channels. It does not require pre-perfusion for initialization, and can immediately begin to run when a liquid enters its inlet channel. It is also more reliable than conventional micro pumps for practical use due to its ability to restart after the formation of a blocking bubble, which can serve as a valuable troubleshooting procedure. Its volumetric pump output was 0.5–0.7 nL·s−1 under a pump head pressure of 300 Pa.
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Nanomaterials, Vol. 6, Pages 65: Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents
Multi-modal imaging plays a key role in the earlier detection of disease. In this work, a facile bioinspired method was developed to synthesize Gd-functionalized gold nanoclusters (Gd-Au NCs). The Gd-Au NCs exhibit a uniform size, with an average size of 5.6 nm in dynamic light scattering (DLS), which is a bit bigger than gold clusters (3.74 nm, DLS), while the fluorescent properties of Gd-Au NCs are almost the same as that of Au NCs. Moreover, the Gd-Au NCs exhibit a high longitudinal relaxivity value (r1) of 22.111 s−1 per mM of Gd in phosphate-buffered saline (PBS), which is six times higher than that of commercial Magnevist (A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, Gd-DTPA, r1 = 3.56 mM−1·s−1). Besides, as evaluated by nano single photon emission computed tomography (SPECT) and computed tomography (CT) the Gd-Au NCs have a potential application as CT contrast agents because of the Au element. Finally, the Gd-Au NCs show little cytotoxicity, even when the Au concentration is up to 250 μM. Thus, the Gd-Au NCs can act as multi-modal imaging contrast agents.
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Molecules, Vol. 21, Pages 470: Identification of 3′,4′-Dimethoxy Flavonol-3-β-d-Glucopyranoside Metabolites in Rats by Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry
A method using liquid chromatography-electrospray ionization ion trap mass spectrometry was established for the identification of metabolites in feces, urine and bile in rats after oral administration of 3′,4′-dimethoxy flavonol-3-β-d-glucopyranoside (abbreviated DF3G). Seven metabolites in rat feces, urine and bile were firstly identified on the basis of their MS fragmentation behaviors. Three metabolites were identified in the feces, 6 in the urine and 2 in the bile, which suggested that demethylation, deglycosylation and deglycosylation followed by glucuronide conjugation were the major metabolic pathways for DF3G in vivo. Hydrolyzation might be the first step in the absorption and metabolism of DF3G. The possible metabolic pathway was proposed for the first time. The established method was simple, reliable and sensitive, revealing that it could be used to rapidly screen and identify the structures of metabolites of DF3G to better understand its metabolism in vivo.
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Religions, Vol. 7, Pages 38: The Changing Landscape of Sacred Groves in Kerala (India): A Critical View on the Role of Religion in Nature Conservation
Sacred groves are an age-old and world-wide phenomenon, traditionally consisting of forest zones, protected by people based on their spiritual relationship with the deities or ancestral spirits believed to reside there. India alone counts nearly 50,000 sacred groves, with 2000 in Kerala where they are known as kaavu. Presently, the sacred groves are under serious threat with numbers of groves reducing drastically. In this article, the authors challenge one of the dominant theories that sacred groves, while previously protected by religion, now disappear due to the loss of traditional beliefs. Starting from the observation that the destruction of sacred groves has less to do with a loss of faith but more with a change of faith, the article focuses on the ambivalent role of religion and the impact the commercial offer of some specific Hindu rituals has on the declining number of sacred groves. Based on long-term ethnographic fieldwork among grove-owners in Kerala, the authors argue that it may be true that religious perceptions maintained the sacred groves for centuries, but that the same religious tradition now provides both justifications and marketable rituals for cutting them down.
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IJMS, Vol. 17, Pages 538: Pathogens Use and Abuse MicroRNAs to Deceive the Immune System
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IJMS, Vol. 17, Pages 537: Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics
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Remote Sensing, Vol. 8, Pages 317: The Impact of Geophysical Corrections on Sea-Ice Freeboard Retrieved from Satellite Altimetry
Satellite altimetry is the only method to monitor global changes in sea-ice thickness and volume over decades. Such missions (e.g., ERS, Envisat, ICESat, CryoSat-2) are based on the conversion of freeboard into thickness by assuming hydrostatic equilibrium. Freeboard, the height of the ice above the water level, is therefore a crucial parameter. Freeboard is a relative quantity, computed by subtracting the instantaneous sea surface height from the sea-ice surface elevations. Hence, the impact of geophysical range corrections depends on the performance of the interpolation between subsequent leads to retrieve the sea surface height, and the magnitude of the correction. In this study, we investigate this impact by considering CryoSat-2 sea-ice freeboard retrievals in autumn and spring. Our findings show that major parts of the Arctic are not noticeably affected by the corrections. However, we find areas with very low lead density like the multiyear ice north of Canada, and landfast ice zones, where the impact can be substantial. In March 2015, 7.17% and 2.69% of all valid CryoSat-2 freeboard grid cells are affected by the ocean tides and the inverse barometric correction by more than 1 cm. They represent by far the major contributions among the impacts of the individual corrections.
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Sensors, Vol. 16, Pages 505: Optimized Sharable-Slot Allocation Using Multiple Channels to Reduce Data-Gathering Delay in Wireless Sensor Networks
The demand for event-driven real-time applications for timely and reliable data acquisition is growing in industrial sectors. However, it is challenging to satisfy the requirements since constraints such as limited available energy and bandwidth are inherent in a wireless sensor network. To deal with timely delivery, one desirable approach is to improve network throughput so that more real-time applications with tighter time constraints can be satisfied in any given network. To deal with reliable delivery, the use of a carrier sense multiple access mechanism for data transmission is preferred, along with the use of a sharable slot within which multiple nodes compete to send data. Thus, we present a method of using multiple channels and a way to optimize the size of the sharable slot. The proposed channel-slot–scheduling algorithm tries to optimize the size of a sharable slot when multiple channels are used. The algorithm also deals with situations where nodes generate multiple data packets in each round of a data-gathering period. It is shown through simulation that our approach greatly outperforms others on some selected metrics.
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IJMS, Vol. 17, Pages 538: Pathogens Use and Abuse MicroRNAs to Deceive the Immune System
Emerging evidence has demonstrated that microRNAs (miRs) play a role in the survival and amplification of viruses, bacteria and other pathogens. There are various ways in which pathogens can benefit from miR-directed alterations in protein translation and signal transduction. Members of the herpesviridae family have previously been shown to encode multiple miRs, while the production of miRs by viruses like HIV-1 remained controversial. Recently, novel techniques have facilitated the elucidation of true miR targets by establishing miR-argonaute association and the subsequent interactions with their cognate cellular mRNAs. This, in combination with miR reporter assays, has generated physiologically relevant evidence that miRs from the herpesviridae family have the potential to downregulate multiple cellular targets, which are involved in immune activation, cytokine signaling and apoptosis. In addition, viruses and bacteria have also been linked to the induction of host cellular miRs, which have the capacity to mitigate immune activation, cytokine signaling and apoptosis. Interfering with miR expression may be clinically relevant. In the case of hepatitis C infection, the cellular miR-122 is already targeted therapeutically. This not only exemplifies how important miRs can be for the survival of specific viruses, but it also delineates the potential to use miRs as drug targets. In this paper we will review the latest reports on viruses and bacteria that abuse miR regulation for their benefit, which may be of interest in the development of miR-directed therapies.
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IJMS, Vol. 17, Pages 537: Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics
Dietary supplements (DS) are extensively consumed worldwide despite unproven efficacy. The true incidence of DS-induced liver injury (DSILI) is unknown but is probably under-diagnosed due to the general belief of safety of these products. Reported cases of herbals and DS-induced liver injury are increasing worldwide. The aim of this manuscript is to report a tabular listing with a description of DS associated with hepatotoxicity as well as review the phenotype and severity of DSILI. Natural remedies related to hepatotoxicity can be divided into herbal product-induced liver injury and DS-induced liver injury. In this article, we describe different DS associated with liver injury, some of them manufactured DS containing several ingredients (Herbalife™ products, Hydroxycut™, LipoKinetix™, UCP-1 and OxyELITE™) while others have a single ingredient (green tea extract, linoleic acid, usnic acid, 1,3-Dimethylamylamine, vitamin A, Garcinia cambogia and ma huang). Additional DS containing some of the aforementioned ingredients implicated in liver injury are also covered. We have also included illicit androgenic anabolic steroids for bodybuilding in this work, as they are frequently sold under the denomination of DS despite being conventional drugs.
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A Time-Motion Study of ICU Workflow and the Impact of Strain.
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A Serious Adult Intraosseous Catheter Complication and Review of the Literature.
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Histopathology of Septic Acute Kidney Injury: A Systematic Review of Experimental Data.
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Energies, Vol. 9, Pages 279: Modeling and Experimental Validation of a Volumetric Expander Suitable for Waste Heat Recovery from an Automotive Internal Combustion Engine Using an Organic Rankine Cycle with Ethanol
Waste heat recovery (WHR) in exhaust gas flow of automotive engines has proved to be a useful path to increase the overall efficiency of internal combustion engines (ICE). Recovery potentials of up to 7% are shown in several works in the literature. However, most of them are theoretical estimations. Some present results from prototypes fed by steady flows generated in an auxiliary gas tank and not with actual engine exhaust gases. This paper deals with the modeling and experimental validation of an organic Rankine cycle (ORC) with a swash-plate expander integrated in a 2 L turbocharged petrol engine using ethanol as working fluid. A global simulation model of the ORC was developed with a maximum difference of 5%, validated with experimental results. Considering the swash-plate as the main limiting factor, an additional specific submodel was implemented to model the physical phenomena in this element. This model allows simulating the fluid dynamic behavior of the swash-plate expander using a 0D model (Amesim). Differences up to 10.5% between tests and model results were found.
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The effects of public health policies on population health and health inequalities in European welfare states: protocol for an umbrella review
The welfare state is potentially an important macro-level determinant of health that also moderates the extent, and impact, of socio-economic inequalities in exposure to the social determinants of health. The ...
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Energies, Vol. 9, Pages 277: Short-Circuit Calculation in Distribution Networks with Distributed Induction Generators
This paper presents an improved current source equivalent model method to determine the short-circuit current of a distribution system with multiple fixed-speed and variable-speed induction generators (IGs). The correlation coefficients of flux components between stator and rotor under the unsymmetrical fault are analyzed using the positive and negative sequence steady-state equivalent circuits of an IG. The terminal voltage and current responses of fixed-speed and variable-speed IGs with and without the rotor slip changes under different penetration levels are compared to investigate the coupling relation between the short-circuit currents of IGs and the nodal voltages in the distribution network. Then the transient equivalent potential of an IG at the grid fault instant is derived. Sequence components of the short-circuit current in the network can be determined using the proposed technique. The correctness of the proposed method is verified using dynamic simulation.
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Intra-abdominal pressure interacts with a low-back belt to effect abdominal muscle thickness and activity
Publication date: Available online 8 April 2016
Source:Journal of Electromyography and Kinesiology
Author(s): Trevor W. Blanchard, Camille Smith, Sylvain G. Grenier
It has been shown that under isometric conditions, as the activity of the abdominal muscles increases, the thicknesses of the muscles also increase. The purpose of this experiment was to determine whether change in muscle thickness could be used as a measure of muscle activity during a deadlift as well as determining the effect of a weightlifting belt and/or the Valsalva maneuver on the muscle thicknesses. The Transversus Abdominis (TrA) and Internal Obliques (IO) muscles were analyzed at rest and during a deadlift. Muscle thickness was measured using ultrasound imaging and muscle activity was simultaneously recorded using electromyography. Each subject performed deadlift under normal conditions, while performing the Valsalva maneuver, while wearing a weightlifting belt and while both utilizing the belt and the Valsalva maneuver. There was no relationship between change in muscle thickness and muscle activity for both the TrA and IO (R2<0.13 for all conditions). However it was found that the Valsalva maneuver increased abdominal muscle thickness whereas the belt limited muscle expansion; each with an increase in activity. These results indicate that ultrasound cannot be used to measure muscle activity for a deadlift and that the belt affects how the IO and TrA function together.
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Use of a Backpack Alters Gait Initiation of High School Students
Publication date: Available online 8 April 2016
Source:Journal of Electromyography and Kinesiology
Author(s): Marcus Fraga Vieira, Georgia Cristina Lehnen, Matias Noll, Fábio Barbosa Rodrigues, Ivan Silveira de Avelar, Paula Hentschel Lobo da Costa
We assessed how backpack carriage influences the gait initiation (GI) process in high school students, who extensively use backpacks. GI involves different dynamics from gait itself, while the excessive use of backpacks can result in adverse effects. 117 high school students were evaluated in three experimental conditions: no backpack (NB), bilateral backpack, and unilateral backpack (UB). Two force plates were used to acquire ground reaction forces (GRFs) and moments for each foot separately. Center of pressure (COP) scalar variables were extracted, and statistical parametric mapping analysis was performed over the entire COP/GRFs time series. GI anticipatory postural adjustments (APAs) were reduced and were faster in backpack conditions; medial-lateral COP excursion was smaller in this phase. The uneven distribution of the extra load in the UB condition led to a larger medial-lateral COP shift in the support-foot unloading phase, with a corresponding vertical GRF change that suggests a more pronounced unloading swing foot/loading support foot mechanism. The anterior-posterior GRFs were altered, but the COP was not. A possible explanation for these results may be the forward trunk lean and the center of mass proximity of the base of support boundary, which induced smaller and faster APA, increased swing foot/support foot weight transfer, and increased load transfer to the first step.
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Sensors, Vol. 16, Pages 500: A Novel Arc Fault Detector for Early Detection of Electrical Fires
Arc faults can produce very high temperatures and can easily ignite combustible materials; thus, they represent one of the most important causes of electrical fires. The application of arc fault detection, as an emerging early fire detection technology, is required by the National Electrical Code to reduce the occurrence of electrical fires. However, the concealment, randomness and diversity of arc faults make them difficult to detect. To improve the accuracy of arc fault detection, a novel arc fault detector (AFD) is developed in this study. First, an experimental arc fault platform is built to study electrical fires. A high-frequency transducer and a current transducer are used to measure typical load signals of arc faults and normal states. After the common features of these signals are studied, high-frequency energy and current variations are extracted as an input eigenvector for use by an arc fault detection algorithm. Then, the detection algorithm based on a weighted least squares support vector machine is designed and successfully applied in a microprocessor. Finally, an AFD is developed. The test results show that the AFD can detect arc faults in a timely manner and interrupt the circuit power supply before electrical fires can occur. The AFD is not influenced by cross talk or transient processes, and the detection accuracy is very high. Hence, the AFD can be installed in low-voltage circuits to monitor circuit states in real-time to facilitate the early detection of electrical fires.
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
