Religions, Vol. 7, Pages 85: Towards an Existential Archeology of Capitalist Spirituality

Throughout his career, Michel Foucault sustained a trenchant critique of Jean-Paul Sartre, whom he accused of arguing that the subject "dispenses (all) significations". In contrast to existentialism's interests in subjective consciousness, Foucault pursues an archaeological method which he later develops into a genealogical approach to discourse that emphasizes the institutional practices and forms of knowledge/power that undergird historical epistemes. Taking contemporary networked Capitalism, the discourse of "workplace spirituality", and the life history of one management reformer as its case studies, this paper turns to the cognitive linguistics of George Lakoff and Mark Johnson in an effort to historicize experiences of neoliberal "spirituality", as an archaeology of knowledge might, while also attempting to account for intentionality and biography, as existential approaches would. Turning to work in contemporary critical theory, which associates strident anti-humanism in social theory with the rise of neoliberal discourse, I argue that sustained attention to the ways in which personal and social history always entail one another and are mutually arising makes not only for better phenomenology but makes for better critical scholarship as well.

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Polymers, Vol. 8, Pages 246: Review of Bionanocomposite Coating Films and Their Applications

The properties of a composite material depend on its constituent materials such as natural biopolymers or synthetic biodegradable polymers and inorganic or organic nanomaterials or nano-scale minerals. The significance of bio-based and synthetic polymers and their drawbacks on coating film application is currently being discussed in research papers and articles. Properties and applications vary for each novel synthetic bio-based material, and a number of such materials have been fabricated in recent years. This review provides an in-depth discussion on the properties and applications of biopolymer-based nanocomposite coating films. Recent works and articles are cited in this paper. These citations are ubiquitous in the development of novel bionanocomposites and their applications.

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Computed Tomography Manifestations and Excision Cross-Complementation Group 1 Expression of Stage I Non-Small-Cell Lung Cancer and Their Correlation With Prognosis.

Objective: The aim of this study was to evaluate the computed tomography (CT) manifestations and expression of the excision cross-complementation group 1 (ERCC1) and their correlation with prognosis in stage I non-small-cell lung cancer (NSCLC). Materials and Methods: A total of 133 patients with stage I NSCLC with complete 3- and 5-year disease-free survival (DFS) and overall survival (OS) data, who underwent thoracic CT and pathological examination, were included. Expression of ERCC1 in tumor samples was evaluated using semiquantitative immunohistochemical analysis. Results: The 3- and 5-year DFS rates for the 133 patients were 72.2% and 60.9%, respectively, and the 3- and 5-year OS rates were 89.5% and 82.0%, respectively. Significant differences in the 3- and 5-year DFS occurred (P = 0.003 and P = 0.001, respectively), whereas no significant differences in the 3- and 5-year OS were found (P = 0.099 and P = 0.062, respectively) between high and low ERCC1 protein expression. Patients with high expression of ERCC1 had a better prognosis. There was a significant correlation between tumors with an irregular edge and signs of spiculation on CT and low expression of ERCC1 evaluated using logistic regression analysis (P

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A Prototype Hybrid Gypsum-Based 3-Dimensional Printed Training Model for Computed Tomography-Guided Spinal Pain Management.

This article details design methodology of an anatomically realistic and accurate physical 3-dimensional model of the lumbosacral spine from computed tomography data utilizing 3-dimensional printing. This model is unique in that the radiodense bony lumbosacrum is reconstructed using gypsum, which because of its high calcium content allows for the appropriate imaging characteristics mimicking bone. The model allows trainees to become competent in needle placement for image-guided diagnostic and therapeutic procedures. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

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The Use of a Dynamic 4-Dimensional Computed Tomography Scan in the Diagnosis of Atraumatic Posterior Sternoclavicular Joint Instability.

Recurrent symptomatic sternoclavicular (SC) joint instability is rare and most commonly occurs following high-energy trauma or in patients with generalized ligamentous laxity. We report an unusual case of an atraumatic posterior subluxation of the SC joint, leading to a feeling of choking. The posterior subluxation, which occurred during shoulder motion and in supine body position, was demonstrated using a dynamic wide-volume 4-dimensional computed tomography scan. Based on continuing patient symptoms and imaging findings, surgical stabilization of the SC joint was undertaken. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

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Methodology for Morphometric Analysis of Modern Human Contralateral Premolars.

Objective: This study aimed at developing a standard methodology for morphometric analysis and comparison of contralateral human premolar pulp space using microcomputed tomography (micro-CT) and semiautomated software. The primary objective was to establish a method to compare the complex and minute morphological internal volumes of contralateral premolar pulp spaces and determine their degree of similarity. The secondary aim was to introduce new methodology for selecting contralateral premolars for the study of biomaterials and techniques. Methods: Forty-one intact human premolar pairs (n = 82) extracted from 28 patients were scanned with micro-CT. Quantitative comparative evaluation was performed through geometric morphometric deviation analysis of the pulp spaces after mirroring, automatic alignment, and coregistration with semiautomated software. Geometric parameters compared included volume, surface, and surface over volume. Shape deviation analysis of transformed mean distances and root mean square errors was conducted. Results: The geometric parameters of the contralateral premolar pulp spaces had significantly higher similarity coefficients than random pairs (P

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Assessment of Early Therapeutic Changes to Concurrent Chemoradiotherapy in Uterine Cervical Cancer Using Blood Oxygenation Level-Dependent Magnetic Resonance Imaging.

Objective: This study aimed to investigate blood oxygenation level-dependent magnetic resonance imaging (MRI) in assessing early therapeutic changes in cervical cancers to concurrent chemoradiotherapy (CCRT). Methods: Fifteen consecutive patients with cervical cancer treated with CCRT were evaluated with blood oxygenation level-dependent MRI at 3 T. Magnetic resonance imaging examinations were performed before treatment (preTx), 1 week after treatment (postT1) and 4 weeks after treatment (postT2). At each time, the rate of spin dephasing (R2*) values were measured in tumor and in normal uterus. Results: Tumor R2* increased from preTx to postT2 (P 0.05). A significant difference in R2* was found between the tumors and normal uterus at preTx (P = 0.001), postT1 (P

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Use of Susceptibility-Weighted Imaging (SWI) in the Detection of Brain Hemorrhagic Metastases from Breast Cancer and Melanoma.

Purpose: Susceptibility-weighted imaging (SWI) has significantly increased our sensitivity in detecting hemorrhagic brain lesions. We sought to explore the prevalence of intratumoral hemorrhage as detected by SWI in brain metastases from melanoma and breast cancer. Methods: Lesions with a size of 0.1 cm3 were categorized as micrometastases, whereas larger lesions were categorized as macrometastases. Susceptibility-weighted imaging findings on locations corresponding to enhancing lesions were categorized as either positive or negative based on presence/absence of signal dropout. The percentage of SWI positivity was then estimated as a function of lesion size. Two-tailed Fisher exact test was performed to examine differences in the contingency tables. Results: Magnetic resonance imaging studies from 73 patients with 1173 brain metastases, which enhanced on postcontrast T1-weighted imaging (T1WI) were selected for analysis. Of these lesions, 952 had SWI data available, and 342 of 952 were micrometastases. Only 10 of the 342 micrometastases and 410 (67.2%) of the 610 macrometastases were SWI positive (P

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Evaluation of Magnetic Resonance (MR) Biomarkers for Assessment of Response With Response Evaluation Criteria in Solid Tumors: Comparison of the Measurements of Neuroendocrine Tumor Liver Metastases (NETLM) With Various MR Sequences and at Multiple Phases of Contrast Administration.

Purpose: Our aim was to compare the interobserver and intraobserver variability for the measurement of the size of liver metastases in patients with carcinoid tumors with various magnetic resonance (MR) series. Materials and Methods: In this retrospective institutional review board-approved study, 30 patients with liver metastases from a carcinoid primary had a complete MR examination of the abdomen at 1.5 T with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). The complete MR examination included T1 (in-phase [IP]/out-of-phase [OOP], T2, diffusion-weighted imaging, pre-Gd-EOB-DTPA and post-Gd-EOB-DTPA 3D gradient echo (4 phases plus 20-minute hepatobiliary phase [HBP] Gd]). Four readers reviewed each series independently. The measurement for each lesion was compared to HBP-Gd images. The sensitivity for detection of each lesion was compared to HBP-Gd. Variance component analysis was used to estimate variance due to patient, lesion within patient, and reader by sequence. Linear mixed model was used to compare lesion size between sequences. Results: The HBP-Gd had the smallest interreader variability. There was no significant difference between series with respect to interreader variability. Lesion sizes measured in diffusion-weighted imaging was significantly higher. T2-weighted imaging was the closest to HBP-Gd. Lesion sizes measured with the other sequences were significantly smaller. There was significant difference in sensitivity of lesion detection of some series when compared to HBP-Gd. Conclusion: The HBP-Gd series had the smallest interreader variability and is the recommended series to measure lesion size for evaluation of response to treatment. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

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Intensive Blood Pressure Control in Adults Aged 75 Years or Older

This RCT evaluates the effects of intensive (less than 120 mm Hg) systolic blood pressure targets compared with standard (less than 140 mm Hg) systolic blood pressure targets in patients aged 75 years or older. Read the article at: http://ja.ma/28PeKe3. Download the video at: http://ja.ma/290xHKX.

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Nutrients, Vol. 8, Pages 398: Thyroid Function among Breastfed Children with Chronically Excessive Iodine Intakes

Iodine excess may impair thyroid function and trigger adverse health consequences for children. This study aims to describe iodine status among breastfed infants with high iodine exposure in the Saharawi refugee camps Algeria, and further assess thyroid function and iodine status among the children three years later. In 2010, a cross-sectional study among 111 breastfed children aged 0–6 months was performed (baseline study). In 2013, a second cross-sectional study (follow-up study) was conducted among 289 children; 213 newly selected and 76 children retrieved from baseline. Urinary iodine concentration (UIC) and breast milk iodine concentration (BMIC) were measured at baseline. UIC, thyroid hormones and serum thyroglobulin (Tg) were measured at follow-up. At baseline and follow-up, 88% and 72% had excessive iodine intakes (UIC ≥ 300 µg/L), respectively. At follow-up, 24% had a thyroid hormone disturbance and/or elevated serum Tg, including 9% with subclinical hypothyroidism (SCH), 4% with elevated fT3 and 14% with elevated Tg. Children with SCH had poorer linear growth and were more likely to be underweight than the children without SCH. Excessive iodine intakes and thyroid disturbances were common among children below four years of age in our study. Further, SCH seemed to be associated with poor growth and weight.

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Geriatrics, Vol. 1, Pages 15: Capturing Interactive Occupation and Social Engagement in a Residential Dementia and Mental Health Setting Using Quantitative and Narrative Data

Objectives: Despite an abundance of research acknowledging the value of interactive occupation and social engagement for older people, and the limits to these imposed by many residential settings, there is a lack of research which measures and analyzes these concepts. This research provides a method for measuring, analysing and monitoring interactive occupation and social engagement levels of residents in a secure residential setting for older people with mental health problems and dementia. It proposes suggestions for changes to improve the well-being of residents in residential settings. Method: In this case study design, the Assessment Tool for Occupational and Social Engagement (ATOSE) provided a 'whole room' time sampling technique to observe resident and staff interactive occupation and social engagement within the communal sitting room over a five-week period. Researchers made contemporaneous notes to supplement the ATOSE data and to contextualise the observations. Results: Residents in the sitting room were passive, sedentary, and unengaged for 82.73% of their time. Staff, who were busy and active 98.84% of their time in the sitting room, spent 43.39% of this time in activities which did not directly engage the residents. The physical, social and occupational environments did not support interactive occupation or social engagement. Conclusions: The ATOSE assessment tool, in combination with narrative data, provides a clear measurement and analysis of interactive occupation and social engagement in this and other residential settings. Suggestions for change include a focus on the physical, social, occupational, and sensory environments and the culture of care throughout the organization.

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Rethinking imperial infrastructure: A bottom-up perspective on the Inca Road

Publication date: September 2016
Source:Journal of Anthropological Archaeology, Volume 43
Author(s): Francisco Garrido
The Inca road has been the iconic example of imperial infrastructure inthe prehispanic Andes. However, scholarly attention to its role in expanding and consolidating the Inca domain has overshadowed analysis of how locals may have appropriated the Inca road for their own private benefit. Based on a full-coverage survey and excavations, this article presents the case of small mining communities along the Inca road and the use they made of it. I argue that they most likely leveraged on emerging imperial infrastructure, in order to expand their existing lapidary and pigment production and exchange in the Atacama desert. The Inca Road may thus have served as an unintended stimuli for local economic activities, since it improved transportation logistics, and served as a linear exchange nexus. I further demonstrate how the Inca Road was, to some extent, appropriated to serve local economic purposes. This provides a unique "bottom-up" perspective of how the Inca infrastructure could not be fully controlled by the elites. Thus, the "imperial landscape" created by the Inca Road was more permeable than what the Incas expected and scholars have assumed, despite the physical or ideological coercion elites may have enforced.

Graphical abstract

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Protein-RNA linkage and posttranslational modifications of feline calicivirus and murine norovirus VPg proteins

Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell culture systems and experimental tools for many of the members of the family. However, a number of caliciviruses replicate efficiently in cell culture and have robust reverse genetics systems available, most notably feline calicivirus (FCV) and murine norovirus (MNV). These are therefore widely used as representative members with which to examine the mechanistic details of calicivirus genome translation and replication. The replication of the calicivirus RNA genome occurs via a double-stranded RNA intermediate that is then used as a template for the production of new positive sense viral RNA, which is covalently linked to the virus-encoded protein VPg. The covalent linkage to VPg occurs during genome replication via the nucleotidylylation activity of the viral RNA-dependent RNA polymerase. Using FCV and MNV, we used mass spectrometry-based approach to identify the specific amino acid linked to the 5′ end of the viral nucleic acid. We observed that both VPg proteins are covalently linked to guanosine diphosphate (GDP) moieties via tyrosine positions 24 and 26 for FCV and MNV respectively. These data fit with previous observations indicating that mutations introduced into these specific amino acids are deleterious for viral replication and fail to produce infectious virus. In addition, we also detected serine phosphorylation sites within the FCV VPg protein with positions 80 and 107 found consistently phosphorylated on VPg-linked viral RNA isolated from infected cells. This work provides the first direct experimental characterization of the linkage of infectious calicivirus viral RNA to the VPg protein and highlights that post-translational modifications of VPg may also occur during the viral life cycle.

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A novel baculovirus-derived promoter with high activity in the baculovirus expression system

The baculovirus expression vector system (BEVS) has been widely used to produce a large number of recombinant proteins, and is becoming one of the most powerful, robust, and cost-effective systems for the production of eukaryotic proteins. Nevertheless, as in any other protein expression system, it is important to improve the production capabilities of this vector. The orf46 viral gene was identified among the most highly abundant sequences in the transcriptome of Spodoptera exigua larvae infected with its native baculovirus, the S. exigua multiple nucleopolyhedrovirus (SeMNPV). Different sequences upstream of the orf46 gene were cloned, and their promoter activities were tested by the expression of the GFP reporter gene using the Autographa californica nucleopolyhedrovirus (AcMNPV) vector system in different insect cell lines (Sf21, Se301, and Hi5) and in larvae from S. exigua and Trichoplusia ni. The strongest promoter activity was defined by a 120 nt sequence upstream of the ATG start codon for the orf46 gene. On average, GFP expression under this new promoter was more than two fold higher than the expression obtained with the standard polyhedrin (polh) promoter. Additionally, the orf46 promoter was also tested in combination with the polh promoter, revealing an additive effect over the polh promoter activity. In conclusion, this new characterized promoter represents an excellent alternative to the most commonly used baculovirus promoters for the efficient expression of recombinant proteins using the BEVS.

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Reciproc vs. hand instrumentation in dental practice: a study in routine care

Background. Little is known about the clinical impact of new root canal preparation systems in general dental practice under routine care conditions. Therefore, we compared hand instrumentation (H) with Reciproc (R) (VDW, Munich, Germany) preparation. The outcomes were endodontic related pain and oral health related quality of life (OHRQoL), evaluation of the procedures by the patients and the strain felt by the dentists during root canal therapy. Methods. Six dentists participated in the trial as practitioner–investigators. In the first phase of the trial they prepared root canals with H and in the second phase with R. The patients documented their pain felt with a visual analogue scale (VAS 100) and OHRQoL with the German short version of the oral health impact profile (OHIP-G-14) before treatment and before the completion of therapy and answered questions about how they experienced the treatment. The dentists documented their physical strain during treatment. Results. A total of 137 patients were included in the evaluation. 66 patients were treated with H, 71 with R. Pain reduction was 32.6 (SD 32.9) VAS (H) vs. 29.4 (SD 26.9) VAS (R) (p = 0.550), and the improvement of the OHIP-14 score was 5.5 (SD 9.2) (H) vs. 6.7 (SD 7.4) (R) (p = 0.383). There were no statistical differences in both groups. Significantly fewer patients felt stressed by the duration of treatment with R as with H (p = 0.018). Significantly more dentists reported that their general physical strain and the strain on their fingers were less severe with R than with H (p = 0.013 and p

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Using homogenization, sonication and thermo-sonication to inactivate fungi

Ultrasound (US), Thermo-sonication (TS) and High Pressure Homogenization (HPH) were studied as tools to inactivate the spores of Penicillium spp. and Mucor spp. inoculated in distilled water. For US, the power ranged from 40% to 100%, pulse from 2 to 10 s, and duration of the treatment from 2 to 10 min. TS was performed combining US (40–80% of power, for 8 min and pulse of 2 s) with a thermal treatment (50, 55 and 60°C at 4, 8 and 12 min). Homogenization was done at 30–150 MPa for 1, 2 and 3 times. Power was the most important factors to determine the antifungal effect of US and TS towards the conidia of Penicillium spp.; on the other hand, in US treatments Mucor spp. was also affected by pulse and time. HPH exerted a significant antifungal effect only if the highest pressures were applied for 2–3 times.

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Collecting reliable clades using the Greedy Strict Consensus Merger

Supertree methods combine a set of phylogenetic trees into a single supertree. Similar to supermatrix methods, these methods provide a way to reconstruct larger parts of the Tree of Life, potentially evading the computational complexity of phylogenetic inference methods such as maximum likelihood. The supertree problem can be formalized in different ways, to cope with contradictory information in the input. Many supertree methods have been developed. Some of them solve NP-hard optimization problems like the well-known Matrix Representation with Parsimony, while others have polynomial worst-case running time but work in a greedy fashion (FlipCut). Both can profit from a set of clades that are already known to be part of the supertree. The Superfine approach shows how the Greedy Strict Consensus Merger (GSCM) can be used as preprocessing to find these clades. We introduce different scoring functions for the GSCM, a randomization, as well as a combination thereof to improve the GSCM to find more clades. This helps, in turn, to improve the resolution of the GSCM supertree. We find this modifications to increase the number of true positive clades by 18% compared to the currently used Overlap scoring.

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Modulation of the behavioral and electrical responses to the repellent DEET elicited by the pre-exposure to the same compound in Blattella germanica

Insects under different stimuli from the environment modify behavioural responses due to changes in the sensitivity of neurons at the peripheral and/or at the central level of the nervous system. This phenomenon is called neuronal plasticity, and sensory adaptation is an example of it. An insect repellent is a chemical that produces oriented movements of the insects away from its source. In this work we studied the modulation of the behavioural and electrical response to the repellent N, N-diethyl-3-methylbenzamide (DEET) in males of the German cockroach B. germanica produced by previous exposure to the same repellent. Methods. We determined repellency using a circular arena, one half of which was treated with DEET. The time spent by insects in each half of the arena was measured, and a repellency coefficient (RC) was calculated. The RCs of pre-exposed and non-pre-exposed insects were compared. To determine a possible role of nitric oxide in the modulation of the response to DEET after pre-exposure, the nitric oxide donor S-nitroso-acetyl-cysteine (SNAC) was applied on cockroaches' antennae. The electrical activity of the cockroaches' antennae in response to DEET was recorded using electroantennogram (EAG) technique. The response to DEET was recorded also after a long stimulation with the same repellent, and after topical application of SNAC and dbcGMP (a cGMP analogue) on the antennae. Results. We found that previous exposure of B. germanica males to the repellent DEET produced an increase of the repellency at the behavioural level, measured as RC. A possible role of nitric oxide (NO) in the transduction pathway of this phenomenon is suggested, since treatment of the cockroaches with the NO donor SNAC also produced an increase of the repellency elicited by DEET. On the other hand, the response of the cockroaches' antennae exposed to DEET was determined electrophysiologically. The electrical activity in response to DEET decreased when the insects' antennae were stimulated with a long pulse of the repellent. The activity of the antennae was restored after 10 min. Treatment of the antennae either with SNAC or dbGMPc also produced a decrease in the response of the antennae to the repellent. Discussion.The previous exposure to a chemical stimulus can modify the behaviour associated to the same stimulus, increasing or decreasing the behavioural response. In the case of DEET we found that pre-exposure increased DEET repellency in male cockroaches. We also found NO involvement in a similar phenomenon. On the other hand, the test showed that DEET is perceived by insects' antennae as an odour. A long exposure of the antennae to DEET caused a transient decrease in the response of the antennae to the same compound. The same effect was achieved by treating the antennae with SNAC or dbcGMP, suggesting the involvement of the NO/cGMP system in the transduction pathway of the sensory adaptation phenomenon elicited by an odour in this species.

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Shapes of leaves with parallel venation. Modelling of the Epipactis sp. (Orchidaceae) leaves with the help of a system of coupled elastic beams

Static properties of leaves with parallel venation, with particular emphasis on the genus EpipactisZinn, 1757 (Orchidaceae, Neottieae) have been modelled with coupled quasi-parallel elastic "beams." The non-linear theory of strongly bended beams have been employed. The resulting boundary-value problem has been solved numerically with the help of the finite-difference method. Possible dislocations resulting in additional Dirac-delta like forces have been take into account. Morphological similarity of the model and real leaves has been obtained. In particular, the concentrated forces have been shown to cause undulation in the leaves.

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Complete plastid genome sequence of Primula sinensis (Primulaceae): structure comparison, sequence variation and evidence for accD transfer to nucleus

Species-rich genus Primula L. is a typical plant group with which to understand genetic variance between species in different levels of relationships. Chloroplast genome sequences are used to be the information resource for quantifying this difference and reconstructing evolutionary history. In this study, we reported the complete chloroplast genome sequence of Primula sinensis and compared it with other related species. This genome of chloroplast showed a typical circular quadripartite structure with 150,859 bp in sequence length consisting of 37.2% GC base. Two inverted repeated regions (25,535 bp) were separated by a large single-copy region (82,064 bp) and a small single-copy region (17,725 bp). The genome consists of 112 genes, including 78 protein-coding genes, 30 tRNA genes and four rRNA genes. Among them, seven coding genes, seven tRNA genes and four rRNA genes have two copies due to their locations in the IR regions. The accD and infA genes lacking intact open reading frames (ORF) were identified as pseudogenes. SSR and sequence variation analyses were also performed on the plastome of Primula sinensis, comparing with another available plastome of P. poissonii. The four most variable regions, rpl36–rps8, rps16–trnQ, trnH–psbA and ndhC–trnV, were identified. Phylogenetic relationship estimates using three sub-datasets extracted from a matrix of 57 protein-coding gene sequences showed the identical result that was consistent with previous studies. A transcript found from P. sinensis transcriptome showed a high similarity to plastid accD functional region and was identified as a putative plastid transit peptide at the N-terminal region. The result strongly suggested that plastid accD has been functionally transferred to the nucleus in P. sinensis.

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Design and validation of a next generation sequencing assay for hereditary BRCA1 and BRCA2 mutation testing

Hereditary breast and ovarian cancer syndrome, caused by a germline pathogenic variant in the BRCA1 or BRCA2 (BRCA1/2) genes, is characterized by an increased risk for breast, ovarian, pancreatic and other cancers. Identification of those who have a BRCA1/2 mutation is important so that they can take advantage of genetic counseling, screening, and potentially life-saving prevention strategies. We describe the design and analytic validation of the Counsyl Inherited Cancer Screen, a next-generation-sequencing-based test to detect pathogenic variation in the BRCA1 and BRCA2 genes. We demonstrate that the test is capable of detecting single-nucleotide variants (SNVs), short insertions and deletions (indels), and copy-number variants (CNVs, also known as large rearrangements) with zero errors over a 114-sample validation set consisting of samples from cell lines and deidentified patient samples, including 36 samples with BRCA1/2pathogenic germline mutations.

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Microbiota affect the rate of transplant acceptance and rejection

The University of Chicago Medical Center News

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Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer

Journal of Clinical Pharmacy and Therapeutics

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Exenatide in obese or overweight patients without diabetes: A systematic review and meta-analyses of randomized controlled trials

International Journal of Cardiology

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Effects of acotiamide on the esophageal motility function in patients with esophageal motility disorders: A pilot study

Digestion

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Epidural analgesia combined with a comprehensive physiotherapy program after Cytoreductive Surgery and HIPEC is associated with enhanced post-operative recovery and reduces intensive care unit stay: A retrospective study of 124 patients

European Journal of Surgical Oncology

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Hepatitis C viral dynamics during ribavirin priming differ according to prior treatment response and HCV type

Journal of Viral Hepatitis

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Association between primary care visits and colorectal cancer screening outcomes in the era of population health outreach

Journal of General Internal Medicine

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Alterations of gut microbiota in patients with irritable bowel syndrome: A systematic review and meta-analysis

Journal of Gastroenterology and Hepatology

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Obesity and psychotropic medication: A prospective register linkage study among midlife women and men

BMC Psychiatry

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Iodine-125 implantation plus transarterial chemoembolization for the treatment of hepatocellular carcinoma of 3-5cm: A propensity score matching study

Digestive and Liver Diseases

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Prevalence and burden of HCV co-infection in people living with HIV: A global systematic review and meta-analysis

The Lancet Infectious Diseases

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Use of aminothiophenol as an indicator for the analysis of silver nanoparticles in consumer products by surface-enhanced Raman spectroscopy

Analyst, 2016, Advance Article
DOI: 10.1039/C6AN00835F, Paper

Trang H. D. Nguyen, Peng Zhou, Azlin Mustapha, Mengshi Lin
Silver nanoparticles (Ag NPs) are one of the top five engineered nanoparticles that have been used in various products.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

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IJERPH, Vol. 13, Pages 640: Spectral Estimation Model Construction of Heavy Metals in Mining Reclamation Areas

The study reported here examined, as the research subject, surface soils in the Liuxin mining area of Xuzhou, and explored the heavy metal content and spectral data by establishing quantitative models with Multivariable Linear Regression (MLR), Generalized Regression Neural Network (GRNN) and Sequential Minimal Optimization for Support Vector Machine (SMO-SVM) methods. The study results are as follows: (1) the estimations of the spectral inversion models established based on MLR, GRNN and SMO-SVM are satisfactory, and the MLR model provides the worst estimation, with R2 of more than 0.46. This result suggests that the stress sensitive bands of heavy metal pollution contain enough effective spectral information; (2) the GRNN model can simulate the data from small samples more effectively than the MLR model, and the R2 between the contents of the five heavy metals estimated by the GRNN model and the measured values are approximately 0.7; (3) the stability and accuracy of the spectral estimation using the SMO-SVM model are obviously better than that of the GRNN and MLR models. Among all five types of heavy metals, the estimation for cadmium (Cd) is the best when using the SMO-SVM model, and its R2 value reaches 0.8628; (4) using the optimal model to invert the Cd content in wheat that are planted on mine reclamation soil, the R2 and RMSE between the measured and the estimated values are 0.6683 and 0.0489, respectively. This result suggests that the method using the SMO-SVM model to estimate the contents of heavy metals in wheat samples is feasible.

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Forests, Vol. 7, Pages 132: Regional Differences in Upland Forest to Developed (Urban) Land Cover Conversions in the Conterminous U.S., 1973–2011

In this U.S. Geological Survey study of forest land cover across the conterminous U.S. (CONUS), specific proportions and rates of forest conversion to developed (urban) land were assessed on an ecoregional basis. The study period was divided into six time intervals between 1973 and 2011. Forest land cover was the source of 40% or more of the new urban land in 35 of the 84 ecoregions located within the CONUS. In 11 of these ecoregions this threshold exceeded in every time interval. When the percent of change, forest to urban, was compared to the percent of forest in each ecoregion, 58 ecoregions had a greater percent of change and, in six of those, change occurred in every time interval. Annual rates of forest to urban land cover change of 0.2% or higher occurred in 12 ecoregions at least once and in one ecoregion in all intervals. There were three ecoregions where the above conditions were met for nearly every time interval. Even though only a small number of the ecoregions were heavily impacted by forest loss to urban development within the CONUS, the ecosystem services provided by undeveloped forest land cover need to be quantified more completely to better inform future regional land management.

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IJERPH, Vol. 13, Pages 635: Lysyl Oxidase Gene G473A Polymorphism and Cigarette Smoking in Association with a High Risk of Lung and Colorectal Cancers in a North Chinese Population

The relationship among the lysyl oxidase (LOX) G473A single nucleotide polymorphism (SNP), cigarette smoking and lung, colorectal, colon and rectum cancer susceptibility was studied in 200 cases of lung cancer, 335 cases of colorectal cancer including 130 cases of colon cancer and 205 cases of rectum cancer, and 335 healthy people in Tangshan, China. Peripheral blood DNA samples were collected, DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) performed, followed by multivariate logistic regression analysis. In comparison to LOX473GG genotype carriers, individuals with LOX473AA exhibited a higher susceptibility to lung, colon-rectum, colon, and rectum cancers with OR values amounting to 3.84-, 2.74-, 2.75-, and 2.74-fold of the control, respectively. In the LOX 473AA-positive population, females were more susceptible than males to carcinogenesis with OR values (female vs. male): 5.25 vs. 3.23, 2.29 vs. 1.51, 2.27 vs. 1.45, and 2.25 vs. 1.53, respectively, for lung, colon-rectum combined, colon, and rectum cancers. LOX G473A polymorphism apparently elevated human sensitivity to cigarette smoking carcinogens for eliciting cancers in the lung and colon only. Thus, LOX G473A polymorphism positively correlates with carcinogenesis and it may be used as an ideal intrinsic biomarker for prediction or diagnosis of carcinogenesis in humans.

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Foods, Vol. 5, Pages 48: Modified Atmosphere Systems and Shelf Life Extension of Fish and Fishery Products

This review aims at summarizing the findings of studies published over the past 15 years on the application of modified atmosphere (MA) systems for shelf life extension of fish and fishery products. This review highlights the importance of CO2 in the preservation of seafood products, and underscores the benefits of combining MA technology with product storage in the superchilled temperature range. It is generally accepted that MA technology cannot improve product quality and should not be utilized as a substitute for good sanitation and strict temperature control. Benefits derived from application of MA, however, can significantly impact preservation of product quality and it subsequent shelf-life. For this reason, this review is the first of its kind to propose detailed handling and quality guidelines for fresh fish to realize the maximum benefit of MA technology.

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Sustainability, Vol. 8, Pages 602: The Quest for Rural Sustainability in Russia

Rural depopulation and the disappearance of villages in rural Russia occurred as part of the historical process of urbanization and industrialization. Rural depopulation also occurred for structural reasons having to do with village location, and for behavioral reasons whereby villagers react to primitive living conditions and poor economic prospects. Three possible strategies for addressing the problem of sustainable villages are considered. The government is attempting to improve rural living conditions, but rural depopulation is likely to continue. Characteristics of sustainable villages are outlined. Agro-tourism is analyzed for its potential to support sustainable villages.

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Pharmacy, Vol. 4, Pages 22: Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients

Background:Continuous infusion ketorolac is sometimes utilized for analgesia in postoperative coronary artery bypass graft (CABG) patients despite contraindications for use. Limited literature surrounds this topic; therefore, this study was conducted to evaluate the safety of this practice. Methods: This retrospective cohort study evaluated the primary outcome of mortality and secondary outcomes of incidence of bleeding and myocardial infarction (MI). All patients who underwent isolated CABG surgeries and received continuous infusion ketorolac during the study period were included. An equal number of randomly selected isolated CABG patients served as control patients. Electronic medical records and the Society of Thoracic Surgeons (STS) database were utilized to determine baseline characteristics and outcomes; Results: One hundred and seventy-eight patients met inclusion; 89 in each group. More patients in the control group underwent on-pump surgeries (78.6% vs. 29.2%, p = 0.01) and had higher STS risk scores (1.1% vs. 0.6%, p = 0.003). There was no difference in mortality between the ketorolac group and control group (2.2% vs. 3.3%, p = 0.605). Additionally, no patients experienced a MI and there was no difference in bleeding incidence (5.5% vs. 6.7%, p = 0.58); Conclusions: No association was found between continuous infusion ketorolac and increased risk of mortality, MI, or bleeding events in postoperative CABG patients. Considerations to differences in baseline characteristics must be made when interpreting results.

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Micromachines, Vol. 7, Pages 108: 3D Printed Paper-Based Microfluidic Analytical Devices

As a pump-free and lightweight analytical tool, paper-based microfluidic analytical devices (μPADs) attract more and more interest. If the flow speed of μPAD can be programmed, the analytical sequences could be designed and they will be more popular. This reports presents a novel μPAD, driven by the capillary force of cellulose powder, printed by a desktop three-dimensional (3D) printer, which has some promising features, such as easy fabrication and programmable flow speed. First, a suitable size-scale substrate with open microchannels on its surface is printed. Next, the surface of the substrate is covered with a thin layer of polydimethylsiloxane (PDMS) to seal the micro gap caused by 3D printing. Then, the microchannels are filled with a mixture of cellulose powder and deionized water in an appropriate proportion. After drying in an oven at 60 °C for 30 min, it is ready for use. As the different channel depths can be easily printed, which can be used to achieve the programmable capillary flow speed of cellulose powder in the microchannels. A series of microfluidic analytical experiments, including quantitative analysis of nitrite ion and fabrication of T-sensor were used to demonstrate its capability. As the desktop 3D printer (D3DP) is very cheap and accessible, this device can be rapidly printed at the test field with a low cost and has a promising potential in the point-of-care (POC) system or as a lightweight platform for analytical chemistry.

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Viruses, Vol. 8, Pages 181: Development of Neutralization Assay Using an eGFP Chikungunya Virus

Chikungunya virus (CHIKV), a member of the Alphavirus genus, is an important human emerging/re-emerging pathogen. Currently, there are no effective antiviral drugs or vaccines against CHIKV infection. Herein, we construct an infectious clone of CHIKV and an eGFP reporter CHIKV (eGFP-CHIKV) with an isolated strain (assigned to Asian lineage) from CHIKV-infected patients. The eGFP-CHIKV reporter virus allows for direct visualization of viral replication through the levels of eGFP expression. Using a known CHIKV inhibitor, ribavirin, we confirmed that the eGFP-CHIKV reporter virus could be used to identify inhibitors against CHIKV. Importantly, we developed a novel and reliable eGFP-CHIKV reporter virus-based neutralization assay that could be used for rapid screening neutralizing antibodies against CHIKV.

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IJERPH, Vol. 13, Pages 638: Falls from Height in the Construction Industry: A Critical Review of the Scientific Literature

Globally, falls from height (FFH) are a substantial public health jeopardy and are among the important leading causes of serious and fatal injuries for construction workers. A comprehensive understanding of the causal factors in FFH incidents is urgently required; however, the literature appears to lack a scientific review of FFH. In this study, 297 articles that contribute to the topic of fall incidents were reviewed. Seventy-five (75) articles met the criteria for relevance and were aggregated in a database to support a critical review. A synthesis of macro-variables approach was adopted rather than a structured meta-analysis. Such a method of analysis provides the flexibility to combine previous studies' findings. The most common factors associated with FFH are risky activities, individual characteristics, site conditions, organizational characteristics, agents (scaffolds/ladders) and weather conditions. The outcomes contributed to identifying the most significant research area for safety enhancement by improving engineering facilities, behaviour investigations and FFH prevention methods.

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Healthcare, Vol. 4, Pages 35: Understanding the Needs of Young Women Regarding Breast Cancer Risk Assessment and Genetic Testing: Convergence and Divergence among Patient-Counselor Perceptions and the Promise of Peer Support

Young women from hereditary breast and ovarian cancer (HBOC) families face a series of medical decisions regarding their cancer risk management and integrating this information into their life planning. This presents unique medical and psychosocial challenges that exist without comprehensive intervention. To help lay the groundwork for intervention, we conducted a qualitative study among young women from HBOC families (N = 12; Mean age = 22) and cancer genetic counselors (N = 12) to explicate domains most critical to caring for this population. Women and counselors were interviewed by telephone. The predominant interview themes included preventative care planning and risk management, decision making around the pros and cons of cancer risk assessment, medical management, and psychosocial stresses experienced. Young women endorsed psychosocial stress significantly more frequently than did counselors. Both groups noted the short- and long-term decision making challenges and the support and conflict engendered among familial relationships. Our results suggest young women value the support they receive from their families and their genetic counselors, but additional, external supports are needed to facilitate adaptation to HBOC risk. In feedback interviews focused on intervention planning with a subset of these young women (N = 9), they endorsed the predominant interview themes discovered as important intervention content, a structure that would balance discussion of medical information and psychosocial skill-building that could be tailored to the young women's needs, and delivery by trained peers familiar with HBOC risk.

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Technologies, Vol. 4, Pages 19: Scale-Up Effects of CO2 Capture by Methyldiethanolamine (MDEA) Solutions in Terms of Loading Capacity

In the present study, results from three different CO2 capture experimental scales (laboratory, pilot unit, and a larger pilot unit), using aqueous amine solutions of methyldiethanolamine (MDEA) 20 wt %, are compared in terms of loading capacity. All three tested scales produced results regarding CO2 absorption using MDEA aqueous solutions, which were largely in accordance with the theoretical loading capacity of the used amine. Nevertheless, the observed differences between the theoretical and actual absorption behaviors of MDEA solutions for the different scales can be justified with the relative weight that process variables exhibit when the process is scaled up. Therefore, in order to achieve a correct scale-up of the process, simulations should be performed in order to define the best set of operational parameters in order to achieve high production yields and therefore more process profitability.

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Energies, Vol. 9, Pages 493: An Integrated Multifunctional Bidirectional AC/DC and DC/DC Converter for Electric Vehicles Applications

This paper presents an on-board vehicular battery charger that integrates bidirectional AC/DC converter and DC/DC converter to achieve high power density for application in electric vehicles (EVs). The integrated charger is able to transfer electrical energy between the battery pack and the electric traction system and to function as an AC/DC battery charger. The integrated charger topology is presented and the design of passive components is discussed. The control schemes are developed for motor drive system and battery-charging system with a power pulsation reduction circuit. Simulation results in MATLAB/Simulink and experiments on a 30-kW motor drive and 3.3-kW AC/DC charging prototype validate the performance of the proposed technology. In addition, power losses, efficiency comparison and thermal stress for the integrated charger are illustrated. The results of the analyses show the validity of the advanced integrated charger for electric vehicles.

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Water, Vol. 8, Pages 268: Urban Drainage System Improvement for Climate Change Adaptation

Recently, urban areas have experienced frequent, large-scale flooding, a situation that has been aggravated by climate change. This study aims to improve the urban drainage system to facilitate climate change adaptation. A methodology and a series of mitigation strategies are presented to efficiently improve the urban drainage system in light of climate change. In addition, we assess the impact of climate change and predict the scale of potential future flood damage by applying the methodology and mitigation strategies to urban areas. Based on the methodology presented, urban flood prevention measures for Gyeyang-gu (Province), Incheon, Korea, was established. The validity of the proposed alternatives is verified by assessing the economic feasibility of the projects to reduce flood damage. We expect that the methodology presented will aid the decision-making process and assist in the development of reasonable strategies to improve the urban drainage system for adaptation to climate change.

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Applied Sciences, Vol. 6, Pages 185: Modal Processor Effects Inspired by Hammond Tonewheel Organs

In this design study, we introduce a novel class of digital audio effects that extend the recently introduced modal processor approach to artificial reverberation and effects processing. These pitch and distortion processing effects mimic the design and sonics of a classic additive-synthesis-based electromechanical musical instrument, the Hammond tonewheel organ. As a reverb effect, the modal processor simulates a room response as the sum of resonant filter responses. This architecture provides precise, interactive control over the frequency, damping, and complex amplitude of each mode. Into this framework, we introduce two types of processing effects: pitch effects inspired by the Hammond organ's equal tempered "tonewheels", "drawbar" tone controls, vibrato/chorus circuit, and distortion effects inspired by the pseudo-sinusoidal shape of its tonewheels and electromagnetic pickup distortion. The result is an effects processor that imprints the Hammond organ's sonics onto any audio input.

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Structure, Organization, and Delivery of Critical Care in Asian ICUs.

Objectives: Despite being the epicenter of recent pandemics, little is known about critical care in Asia. Our objective was to describe the structure, organization, and delivery in Asian ICUs. Design: A web-based survey with the following domains: hospital organizational characteristics, ICU organizational characteristics, staffing, procedures and therapies available in the ICU and written protocols and policies. Setting: ICUs from 20 Asian countries from April 2013 to January 2014. Countries were divided into low-, middle-, and high-income based on the 2011 World Bank Classification. Subjects: ICU directors or representatives. Measurements and Main Results: Of 672 representatives, 335 (50%) responded. The average number of hospital beds was 973 (SE of the mean [SEM], 271) with 9% (SEM, 3%) being ICU beds. In the index ICUs, the average number of beds was 21 (SEM, 3), of single rooms 8 (SEM, 2), of negative-pressure rooms 3 (SEM, 1), and of board-certified intensivists 7 (SEM, 3). Most ICUs (65%) functioned as closed units. The nurse-to-patient ratio was 1:1 or 1:2 in most ICUs (84%). On multivariable analysis, single rooms were less likely in low-income countries (p = 0.01) and nonreferral hospitals (p = 0.01); negative-pressure rooms were less likely in private hospitals (p = 0.03) and low-income countries (p = 0.005); 1:1 nurse-to-patient ratio was lower in private hospitals (p = 0.005); board-certified intensivists were less common in low-income countries (p

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Effect of Continuous Renal Replacement Therapy on Outcome in Pediatric Acute Liver Failure.

Objectives: To establish the effect of continuous renal replacement therapy on outcome in pediatric acute liver failure. Design: Retrospective cohort study. Setting: Sixteen-bed PICU in a university-affiliated tertiary care hospital and specialist liver centre. Patients: All children (0-18 yr) admitted to PICU with pediatric acute liver failure between January 2003 and December 2013. Interventions: Children with pediatric acute liver failure were managed according to a set protocol. The guidelines for continuous renal replacement therapy in pediatric acute liver failure were changed in 2011 following preliminary results to indicate the earlier use of continuous renal replacement therapy for both renal dysfunction and detoxification. Measurements and Main Results: Of 165 children admitted with pediatric acute liver failure, 136 met the inclusion criteria and 45 of these received continuous renal replacement therapy prior to transplantation or recovery. Of the children managed with continuous renal replacement therapy, 26 (58%) survived: 19 were successfully bridged to liver transplantation and 7 spontaneously recovered. Cox proportional hazards regression model clearly showed reducing hyperammonemia by 48 hours after initiating continuous renal replacement therapy significantly improved survival (HR, 1.04; 95% CI, 1.013-1.073; p = 0.004). On average, for every 10% decrease in ammonia from baseline at 48 hours, the likelihood of survival increased by 50%. Time to initiate continuous renal replacement therapy from PICU admission was lower in survivors compared to nonsurvivors (HR, 0.96; 95% CI, 0.916-1.007; p = 0.095). Change in practice to initiate early and high-dose continuous renal replacement therapy led to increased survival with maximum effect being visible in the first 14 days (HR, 3; 95% CI, 1.0-10.3; p = 0.063). Among children with pediatric acute liver failure who did not receive a liver transplant, use of continuous renal replacement therapy significantly improved survival (HR, 4; 95% CI, 1.5-11.6; p = 0.006). Conclusion: Continuous renal replacement therapy can be used successfully in critically ill children with pediatric acute liver failure to provide stability and bridge to transplantation. Inability to reduce ammonia by 48 hours confers poor prognosis. Continuous renal replacement therapy should be considered at an early stage to help prevent further deterioration and buy time for potential spontaneous recovery or bridge to liver transplantation. Copyright (C) by 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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JFMK, Vol. 1, Pages 276-281: The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Joint Biomechanics of Running

We are glad to introduce the second Journal Club. On the occasion of the recent Global Running Day, the first of June 2016, the second edition is focused on several relevant studies published recently in the field of Joint Biomechanics of Running, chosen by our Scientific Board members. We hope to stimulate your curiosity in this field and to share with you the passion for the sport seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture.

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Geosciences, Vol. 6, Pages 31: Motivated for Action and Collaboration: The Abrahamic Religions and Climate Change

Leaders of Judaism, Christianity, and Islam have publicly advocated action to mitigate the adverse effects of human-forced climate change. Particularly prominent prior to, during, and after the 21st Conference of the Parties of the United Nations Framework Convention on Climate Change were Rabbi Arthur Waskow, Pope Francis, and Patriarch Bartholomew. Also prominent was a group of Islamic clerics, leaders of organizations, and scholars who collaborated in issuing a declaration on climate change three months prior to COP 21. Informed by the Earth sciences, these leaders shared their faith-based rationales for acting locally to internationally as indicated in the documents explored in this article. Examples of organizations motivated by their leaders' faith perspectives demonstrate their readiness to act informed by scientists. To work effectively, these religious leaders and activist groups require well-substantiated conclusions from data collected to counter unsubstantiated claims by climate skeptics. Earth scientists will find among the religious leaders and groups allies in the quest for a flourishing planet.

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