Πέμπτη 10 Δεκεμβρίου 2015
Pilot Comparison of 68Ga-RM2 PET and 68Ga-PSMA PET in Patients with Biochemically Recurrent Prostate Cancer
Objectives: Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HBED-CC)] (68Ga-PSMA) is a positron emission tomography (PET) tracer that can detect prostate cancer relapses and metastases by binding to the extracellular domain of PSMA. 68Ga-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe- Gln-Trp-Ala-Val- Gly-His-Sta-Leu-NH2 (68Ga-RM2) is a synthetic bombesin receptor antagonist that targets gastrin-releasing peptide receptors (GRPr). We present pilot data on the biodistribution of these PET tracers in a small cohort of patients with biochemically recurrent prostate cancer (BCRPC). Methods: Seven men (mean age ± SD: 74.3±5.9 year-old) with BCRPC had both 68Ga-PSMA PET/CT and 68Ga-RM2 PET/MRI scans. The maximum standardized uptake value (SUVmax) and mean SUV (SUVmean) measurements were recorded in normal tissues and areas of uptake outside the expected physiologic biodistribution. Results: All patients had rising prostate-specific antigen (PSA) (mean±SD: 13.5±11.5) and non-contributory conventional imaging. 68Ga-PSMA had the highest physiologic uptake in the salivary glands and small bowel, with hepatobiliary and renal clearance noted, while 68Ga-RM2 had the highest physiologic uptake in the pancreas, with renal clearance noted. Uptake values uptake outside the expected physiologic biodistribution were not statistically different between 68Ga-PSMA and 68Ga-RM2; however, 68Ga-PSMA localized in a lymph node and seminal vesicle in a patient with no abnormal 68Ga-RM2 uptake. Abdominal periaortic lymph nodes were more easily visualized by 68Ga-RM2 in two patients due to lack of interference by radioactivity accumulation in the small intestine. Conclusion: 68Ga-PSMA and 68Ga-RM2 have distinct biodistribution in this small cohort of patients with BCRPC. The findings here indicate that additional work is needed to understand the expression of PSMA and GRPr in different types of prostate cancer.
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A Population Based Gaussian Mixture Model Incorporating 18F-FDG-PET and DW-MRI Quantifies Tumor Tissue Classes
The aim of our study was to create a novel Gaussian Mixture Modeling (GMM) pipeline in order to model the complementary information derived from 2-deoxy-2-(18F)-fluoro-D-glucose (18F-FDG)-Positron Emission Tomography (PET) and Diffusion Weighted Magnetic Resonance Imaging (DW-MRI) measurements to separate the tumor microenvironment into relevant tissue compartments and follow the development of these compartments in a longitudinal manner. Methods: Serial 18F-FDG-PET and Apparent Diffusion Coefficient (ADC) maps derived from DW-MR images of NCI-H460 xenograft tumors were co-registered and a population based GMM was implemented on the complementary imaging data. The tumor microenvironment was segmented into three distinct regions and correlated with histological stainings. An analysis of covariance (ANCOVA) was applied to gauge how well the total tumor volume was a predictor for the ADC and 18F-FDG, or if ADC was a good predictor of 18F-FDG for average values in the whole tumor or average necrotic and viable tissues. Results: The co-registered PET/MR images were in excellent agreement with histology, both visually and quantitatively, and allowed for validation of the last time point measurements. Strong correlations were found for the necrotic (r = 0.88) and viable fractions (r = 0.87) between histology and the clustering. The GMM provided probabilities for each compartment with uncertainties expressed as a mixture of tissues in which the resolution of scans was inadequate to accurately separate tissues. The ANCOVA suggested that both ADC and 18F-FDG in the whole tumor (P = 0.0009, P = 0.02) as well as necrotic (P = 0.008, P = 0.02) and viable (P = 0.003, P = 0.01) tissues were a positive, linear function of total tumor volume. ADC proved to be a positive predictor of 18F-FDG in the whole tumor (P = 0.001) and necrotic (P = 0.02) and viable (P = 0.0001) tissues. Conclusion: The complementary information of 18F-FDG and ADC longitudinal measurements in xenograft tumors allows for segmentation into distinct tissues when utilizing the novel GMM pipeline. Leveraging the power of multi-parametric PET/MR imaging in this manner has the potential to take the assessment of disease outcome beyond the Response Evaluation Criteria in Solid Tumors and could provide an important impact to the field of precision medicine.
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Multiparametric analysis of the relationship between tumor hypoxia and perfusion using 18F-FAZA and 15O-H2O PET
18F-fluoroazomycin-arabinoside (18F-FAZA) is a positron emission tomography (PET) tracer of tumor hypoxia. However, as hypoxia often is associated with decreased perfusion, delivery of 18F-FAZA might be compromised, potentially disturbing the association between tissue hypoxia and 18F-FAZA uptake. The aim of this study was to gain insight in the relationship between tumor perfusion and 18F-FAZA uptake. Methods: Ten patients diagnosed with advanced non-small cell lung cancer (NSCLC) underwent subsequent dynamic 15O-H2O and 18F-FAZA PET scans with arterial sampling. Parametric images of both 15O-H2O derived perfusion (TBF) and volume of distribution (VT) of 18F-FAZA were generated. Next, multiparametric classification was performed using lesional and global thresholds. Voxels were classified as low or high TBF and 18F-FAZA VT, respectively. Finally, by combining these initial classifications, voxels were allocated to four categories (lowTBF-lowVT, lowTBF-highVT, highTBF-lowVT and highTBF-highVT). Results: A total of thirteen malignant lesions were identified in the ten patients. Average TBF and 18F-FAZA VT across all lesions were 0.45±0.20 mL·cm-3·min-1 and 0.94±0.31 mL·cm-3, respectively. The average of all lesional median values were 0.37±0.15 mL·cm-3·min-1 and 0.85±0.18 mL·cm-3 for TBF and 18F-FAZA VT, respectively. Multiparametric analysis showed that classified voxels were clustered rather than randomly distributed. Several intralesional areas could be identified where 18F-FAZA VT was inversely related to TBF. On the other hand, there were also distinct areas where TBF as well as 18F-FAZA VT were decreased or increased. Conclusion: The present data indicate that spatial variation of 18F-FAZA uptake is not necessarily inversely related with TBF. This suggests that decreased TBF may result in flow limited delivery of 18F-FAZA. Areas with both high 18F-FAZA uptake and high TBF suggest that high 18F-FAZA uptake, possibly suggesting hypoxia, may occur in regions despite having high TBF. In conclusion, multiparametric evaluation of the spatial distribution of both TBF and 18F-FAZA uptake may be helpful for understanding the 18F-FAZA signal.
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The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behçet's syndrome
Publication date: Available online 10 December 2015
Source:The Kaohsiung Journal of Medical Sciences
Author(s): Sevil Alan, Serpil Tuna, Elif Betül Türkoğlu
Behçet's syndrome (BS) is associated with chronic inflammation and endothelial dysfunction. Although there have been extensive investigations on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in many diseases, their roles in BS is unclear. The purpose of the present study was to evaluate NLR, PLR, and MPV levels in BS patients and explore their clinical significance. The study included 254 patients with BS and 173 healthy individuals. Age, sex, age of onset, duration of disease, smoking, Behçet activity score, total white blood counts, neutrophil, platelet, and T lymphocyte counts of the patients were recorded. White blood cell (WBC), neutrophil, platelet, NLR, and PLR were significantly higher in patients with BS when compared with healthy controls (all p < 0.001). Lymphocyte counts and MPVs of the BS group were not statistically different from healthy controls (all p ˃ 0.05). In the BS group, PLR and MPV were significantly different among the three severity groups (p = 0.037 and p = 0.016, respectively). We showed that any laboratory markers were not associated with joint, eye, central nervous system, large vessel, or gastrointestinal involvement in BS. NLR was shown to be an independent factor for BS by multivariate analysis. We suggest that NLR can be considered to be a diagnostic criterion of BS given the support of the findings from larger prospective studies.
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The Italian Diabetes and Exercise Study 2 (IDES-2): a long-term behavioral intervention for adoption and maintenance of a physically active lifestyle
Background: Physical activity (PA)/exercise have become an integral part of the management of type 2 diabetes mellitus (T2DM). However, current guidelines are difficult to put into action in this population due to a number of barriers, especially the lack of acceptable, feasible, and validated behavioral intervention strategies. The present manuscript reports the rationale, study design and methods, and design considerations of the Italian Diabetes and Exercise Study (IDES)-2, a randomized controlled trial testing the efficacy of a behavior change strategy in increasing total daily PA and reducing sedentary time (SED-time) in patients with T2DM.Methods/DesignStarting 7 January 2014, the IDES_2 began enrolling 300 patients with known T2DM of at least 1-year duration in three tertiary referral outpatient Diabetes Clinics in Rome. Additional requirements are age 40 to 80 years, body mass index 27 to 40 kg/m 2 , sedentary lifestyle, and physically inactive for at least 6 months, ability to walk 1.6 km without assistance, and eligibility after cardiovascular evaluation. Patients are randomized by center and within each center, by age and type of diabetes treatment to either the intervention or the control group. Patients in the intervention (INT) group (n = 150) receive theoretical and practical exercise counseling consisting of aggregated behavior change techniques (one individual theoretical counseling session plus eight twice-a-week individual theoretical and practical exercise counseling sessions) once a year for 3 years. Patients in the control (CON) group (n = 150), receive standard care, including general physician recommendations for daily PA. The primary outcomes are total daily PA and SED-time, as measured objectively by the use of an accelerometer. Secondary outcomes include physical fitness, modifiable cardiovascular risk factors, musculoskeletal disturbances, well-being/depression, and health-related quality of life.DiscussionThe behavioral intervention strategy tested in the IDES_2 is based on solid theoretical grounds and uses several behavioral change techniques, two factors which were found to improve effectiveness of behavioral intervention. In addition, physicians and exercise specialists have been specifically trained for counselling/prescribing and supervising PA/exercise, respectively, in subjects suffering from metabolic disorders. Finally, the large sample size, the long study duration, and the objective measurement of PA allow statistically significant and scientifically robust conclusions to be drawn on the feasibility and efficacy of this intervention in T2DM patients.Trial registrationClinicalTrials.gov; NCT01600937; 10 October 2012.
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Data from renewable energy assessments for resort islands in the South China Sea
Publication date: March 2016
Source:Data in Brief, Volume 6
Author(s): M. Reyasudin Basir Khan, Razali Jidin, Jagadeesh Pasupuleti
Renewable energy assessments for resort islands in the South China Sea were conducted that involves the collection and analysis of meteorological and topographic data. The meteorological data was used to assess the PV, wind and hydropower system potentials on the islands. Furthermore, the reconnaissance study for hydro-potentials were conducted through topographic maps in order to determine the potential sites suitable for development of run-of-river hydropower generation. The stream data was collected for 14 islands in the South China Sea with a total of 51 investigated sites. The data from this study are related to the research article "Optimal combination of solar, wind, micro-hydro and diesel systems based on actual seasonal load profiles for a resort island in the South China Sea" published in Energy (Khan et al., 2015) [1].
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Feedback-Related Potentials in a Gambling Task with Randomised Reward
Publication date: Available online 10 December 2015
Source:Data in Brief
Author(s): Faisal Mushtaq, Pablo Puente Guillen, Richard M. Wilkie, Mark A. Mon-Williams, Alexandre Schaefer
Event-related potentials (ERPs) time-locked to decision outcomes are reported. Participants engaged in a gambling task (see [1] for details] in which they decided between a risky and a safe option (presented as different coloured shapes) on each trial (416 in total). Each decision was accompanied with (fully randomised) feedback about the reward outcome (Win/Loss) and its magnitude (varying as a function of decision response; 5–9 points for Risky decisions and 1–4 points for Safe decisions). Here, we show data demonstrating: (a) The influence of Win feedback in the preceding outcome (Outcomet−1) on activity related to the current outcome (Outcomet); (b) Difference wave analysis for outcome expectancy- separating Expected Outcomes (consecutive loss trials subtracted from consecutive reward) from Unexpected Outcomes (subtracting Losst−1Wint trials from Wint−1Losst trials); (c) Difference waves separating Switch and Stay responses for Outcome Expectancy; (d) The effect of magnitude induced by decisions (Riskt vs. Safet) on Outcome Expectancy; and finally, (e) Expectations reflected by response switch direction (Risk to Safe responses vs. Safe to Riskt) on the FRN at Outcomet.
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Shotgun Analysis of Rough-Type Lipopolysaccharides Using Ultraviolet Photodissociation Mass Spectrometry
Analytical Chemistry
DOI: 10.1021/acs.analchem.5b04218
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Development and validation of multiresidue analytical method in cotton and groundnut oil for 87 pesticides using low temperature and dispersive cleanup on gas chromatography and liquid chromatography-tandem mass spectrometry
Abstract
A method was developed and validated for the analysis of 87 pesticides in cotton and groundnut oil by GC with ECD and FPD detectors and LC-MS/MS. The extraction procedure based on QuEChERS followed by low-temperature freezing and dispersive cleanup steps was validated in two oil matrices for 87 pesticides of different classes. Linearity, expressed as coefficient of variation, was within the acceptable range. Of those tested, 77–83 and 77–89 % pesticides showed recoveries within the acceptable range of 70–120 % on LC-MS/MS in cottonseed oil and groundnut oil, respectively, at different spiking levels. In case of GC analysis, 63–65 and 53–82 % pesticides showed recoveries within the acceptable range of 70–120 % on GC in cottonseed oil and groundnut oil, respectively, at different spiking levels. The exceptions to these recoveries were the few organochlorines which consistently gave lower recoveries. Recovery factors can be employed while analysing these pesticides by this method as the results obtained were consistent in both oils. RSD was less than 20 % for most of the pesticides. The calculated limit of quantitation (LOQ) for most of the pesticides satisfies the maximum residue level (MRL) requirements as per European Union (EU) guidelines and Food Safety and Standards Authority of India (FSSAI).
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Changes in Whole-Body Oxygen Consumption and Skeletal Muscle Mitochondria During Linezolid-Induced Lactic Acidosis.
Objective: To better clarify the pathogenesis of linezolid-induced lactic acidosis. Design: Case report. Setting: ICU. Patient: A 64-year-old man who died with linezolid-induced lactic acidosis. Interventions: Skeletal muscle was sampled at autopsy to study mitochondrial function. Measurements and Main Results: Lactic acidosis developed during continuous infusion of linezolid while oxygen consumption and oxygen extraction were diminishing from 172 to 52 mL/min/m2 and from 0.27 to 0.10 mL/min/m2, respectively. Activities of skeletal muscle respiratory chain complexes I, III, and IV, encoded by nuclear and mitochondrial DNA, were abnormally low, whereas activity of complex II, entirely encoded by nuclear DNA, was not. Protein studies confirmed stoichiometric imbalance between mitochondrial (cytochrome c oxidase subunits 1 and 2) and nuclear (succinate dehydrogenase A) DNA-encoded respiratory chain subunits. These findings were not explained by defects in mitochondrial DNA or transcription. There were no compensatory mitochondrial biogenesis (no induction of nuclear respiratory factor 1 and mitochondrial transcript factor A) or adaptive unfolded protein response (reduced concentration of heat shock proteins 60 and 70). Conclusions: Linezolid-induced lactic acidosis is associated with diminished global oxygen consumption and extraction. These changes reflect selective inhibition of mitochondrial protein synthesis (probably translation) with secondary mitonuclear imbalance. One novel aspect of linezolid toxicity that needs to be confirmed is blunting of reactive mitochondrial biogenesis and unfolded protein response. Copyright (C) by 2015 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
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The Equilibration of PCO2 in Pigs Is Independent of Lung Injury and Hemodynamics.
Objectives: In mechanical ventilation, normoventilation in terms of PCO2 can be achieved by titration of the respiratory rate and/or tidal volume. Although a linear relationship has been found between changes in respiratory rate and resulting changes in end-tidal cO2 ([DELTA]PetCO2) as well as between changes in respiratory rate and equilibration time (teq) for mechanically ventilated patients without lung injury, it is unclear whether a similar relationship holds for acute lung injury or altered hemodynamics. Design: We performed a prospective randomized controlled animal study of the change in PetCO2 with changes in respiratory rate in a lung-healthy, lung-injury, lung-healthy + altered hemodynamics, and lung-injury + altered hemodynamics pig model. Setting: University research laboratory. Subjects: Twenty mechanically ventilated pigs. Interventions: Moderate lung injury was induced by injection of oleic acid in 10 randomly assigned pigs, and after the first round of measurements, cardiac output was increased by approximately 30% by constant administration of noradrenalin in both groups. Measurements and Main Results: We systematically increased and decreased changes in respiratory rate according to a set protocol: +2, -4, +6, -8, +10, -12, +14 breaths/min and awaited equilibration of Petco2. We found a linear relationship between changes in respiratory rate and [DELTA]PetCO2 as well as between changes in respiratory rate and teq. A two-sample t test resulted in no significant differences between the lung injury and healthy control group before or after hemodynamic intervention. Furthermore, exponential extrapolation allowed prediction of the new PetCO2 equilibrium and teq after 5.7 +/- 5.6 min. Conclusions: The transition between PetCO2 equilibria after changes in respiratory rate might not be dependent on moderate lung injury or cardiac output but on the metabolic production or capacity of cO2 stores. Linear relationships previously found for lung-healthy patients and early prediction of PetCO2 equilibration could therefore also be used for the titration of respiratory rate on the PetCO2 for a wider range of pathologies by the physician or an automated ventilation system. Copyright (C) by 2015 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
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Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection
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A Simple Flight Mill for the Study of Tethered Flight in Insects
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Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
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William Shatner On Tinnitus
William Shatner on Tinnitus: When He Developed It
Tinnitus is a condition that affects around 50 million people in the United States. It is a condition where a person frequently experience buzzing or ringing in the ears. Tinnitus has a tendency to get worse with age. It can also be a sign of an underlying health condition, such as high blood pressure. In some cases, tinnitus occurs as the result of an injury to the ear.
Anyone can develop tinnitus. William Shatner, an actor whose career has lasted over 50 years, is one of the many people who have struggled with tinnitus. He stated that his battle with tinnitus began when he was a star on the popular 1960s show "Star Trek".
He stated that he was filming an episode entitled "Arena." He said that he stood very close to a special effects explosion during the filming. William has stated that he believes the sound of the explosion is what caused his tinnitus.
William Shatner on Tinnitus: His Struggle with the Condition
William Shatner struggled with tinnitus for many years. He was bothered by the constant ringing in his ears. He stated that he was tormented by tinnitus, and there were days when he felt like he could not go on because the condition was so bothersome.
William Shatner on Tinnitus: Overcoming the Condition
William Shatner stated that his life changed for the better after he discovered the American Tinnitus Foundation. He describes the foundation as being a "Ray of Light." Williams said that he used a technique called tinnitus retraining therapy in order to overcome tinnitus. This technique involves the use of white noise.
The theory behind the use of white noise is that if you keep exposing yourself to white noise, then your brain will become accustomed to it. This training also helps your brain get adjusted to tinnitus so that you will forget that you even have it. William said that he noticed a 95 percent reduction in his symptoms after he used tinnitus retraining therapy.
Even though there are millions of people in America who have tinnitus, they often feel like they are left to suffer in silence. William Shatner has teamed up with the American Tinnitus Foundation to raise awareness about this condition and to let people know that they are not alone. The American Tinnitus Foundation is also working towards finding a cure for this condition.
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Porphyra Species: A Mini-Review of Its Pharmacological and Nutritional Properties
Journal of Medicinal Food , Vol. 0, No. 0.
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Mice lack of LRG-47 display the attenuated outcome of infection with Schistosoma japonicum
Abstract
Interferon-inducible GTPase LRG-47 (also named immune-related GTPase M, Irgm1) is a member of the p47 GTPase family that has been shown to regulate host resistance to intracellular pathogens. Little knowledge has been known about the role of LRG-47 in host's responses to extracellular pathogens. To investigate possible roles of LRG-47 in the course of Schistosoma japonicum infection, LRG-47-deficient (LRG-47−/−) and wild-type (WT) mice were challenged with cercariae of S. japonicum, and the cellular and humoral responses in mice were analyzed. At the acute stage of S. japonicum infection, in contrast to WT mice, LRG-47−/− mice showed the significantly decreased egg burden, low schistosome-specific antibody response, and the decreased Th1 and increased Tc1 responses. Additionally, Schistosoma japonicum-specific egg antigen immunization also produced the similar humoral and cellular immune responses as S. japonicum infection. Taken together, these data suggested that the deficiency of LRG-47 might affect host's CD4+ T cell immune response via the weakening of IFN-γ downstream signaling; however, the specific function of LRG-47 on dealing with extracellular worm needs to be further studied.
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Anthelmintic effects of Oroxylum indicum stem bark extract on juvenile and adult stages of Hymenolepis diminuta (Cestoda), an in vitro and in vivo study
Abstract
Worldwide, traditional usage of herbal medicines is a common practice to treat various parasitic infections. In India, bark decoction of Oroxylum indicum (L.) Kurz. (Bignoniaceae) is used as a traditional medicine to cure intestinal-helminthic infections. This study investigated the anthelmintic efficacy of methanolic bark extract of O. indicum on Hymenolepis diminuta (Cestoda), using both in vitro and in vivo methods. Utilizing a mini-questionnaire, first, we collected information about the pattern of anthelmintic use of this plant. Later, in vitro efficacy of extract was tested at 10, 20 and 30 mg/ml on both the artificially excysted juveniles and adult H. diminuta worms. Herein, scanning electron microscopy (SEM) was also utilized to determine the possible effects of extract on tegumental surfaces of juvenile and adult cestode. In vivo, extract was tested at 250, 500 and 1000 mg/kg in H. diminuta albino rat model, against juvenile and adult cestode. Praziquantel (PZQ) served as reference drug in anthelmintic assays. The acute toxicity of extract was determined as per the OECD guidelines. The field questionnaire data revealed that 78 % of people in the area use O. indicum stem bark against intestinal helminths, and of these, 75 % of people also believed it highly efficacious anthelmintic remedy. In vitro testing of extract revealed significant effects on juvenile worms, and 30 mg/ml of extract caused mortality of juveniles at the initial period (0.25 ± 0.00 h). Conversely, PZQ (1 mg/ml) showed paralysis and mortality of juvenile cestodes in 0.44 ± 0.04 and 1.11 ± 0.06 h, respectively. As determined by SEM, in vitro exposure to extract showed substantial effects on both juveniles and adult worms in the form of wrinkled scolex, distorted tegument and eroded microtriches. In vivo study revealed better efficacy of extract against juveniles than adult stages of parasite. Treatment of rats with 1000 mg/kg of extract caused 79.3 % reduction in EPG counts and 70.8 % of reduction in worm counts, which compared well to PZQ efficacy. In acute toxicity study, administration of a single oral dose of 2000 mg/kg of extract to mice did not cause any signs of toxicity or mortality within 2-week observation. Hence, the LD50 of extract was estimated to be greater than 2000 mg/kg. In conclusion, the bark extract of O. indicum possesses concentration-dependent effects against the larval and adult H. diminuta worms, and thus the extract holds promise in the control of intestinal helminthiases. This also supports the common belief of people about the reputation of this plant as anthelmintic in traditional medicine. There is a need to standardize the formulations of this plant for their possible use as standardized herbal anthelmintic agents in the future.
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Morphological and molecular characterization of Myxobolus mucosus sp. n. (Myxosporea: Myxobolidae) with basifilamental sporulation in two cyprinid fishes, Rutilus rutilus (L.) and Leuciscus leuciscus (L.) in Russia
Abstract
A new Myxobolus species, Myxobolus mucosus sp. n., was found in the basifilamental location of roach, Rutilus rutilus, and common dace, Leuciscus leuciscus, during the investigation of fish myxosporean fauna in Finnish Bay of Baltic Sea and Lake Ladoga in 2014. Plasmodia from the two hosts share similar morphometric and morphological features which are whitish and slightly elongated oval and measured 300–500 μm in diameter. Mature spores of M. mucosus sp. n. are ellipsoidal in frontal view and lemon shaped in sutural view, measuring 13.6 ± 0.62 (12.8–14.2) μm in length, 10.7 ± 0.51 (10.3–11.4) μm in width, 7.8 ± 0.41 (7.2–8.3) μm in thickness and 13.0 ± 0.89 (11.5–14.2) μm in length, 10.8 ± 0.77 (10.2–11.5) μm in width, 7.7 ± 0.52 (7.3–8.0) μm in thickness from roach and common dace, respectively. Polar capsules were pyriform, equal in size, converging anteriorly, with 5.9 ± 0.22 (5.7–6.3) μm in length and 3.9 ± 0.3 (3.5–4.1) μm in width and 5.6 ± 0.38 (5.1–6.2) μm in length and 3.8 ± 0.24 (3.5–4.0) μm in width from roach and common dace, respectively. Spore valves are relatively thin, symmetrical, and smooth. The most remarkable morphological character of this new Myxobolus species is the distinct mucous envelope, surrounding the full myxospore valves, up to 25 and 32 μm, respectively, in roach and common dace. The partial 18S ribosomal DNA (rDNA) sequence variation of myxospores from two hosts is very tiny (below 0.8 %) but significantly differing from all available sequences of myxosporeans in GenBank. Therefore, it can be concluded that this myxosporean from these two closely related cyprinids are conspecific by combining morphological characteristics, tissue specificity, and molecular data. Phylogenetic analysis showed that this newly described species cluster with several gill-infecting Myxobolus species from cyprinid fish inhabiting in Eastern Europe.
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Nanopipette-Based Electroplated Nanoelectrodes
Analytical Chemistry
DOI: 10.1021/acs.analchem.5b03548
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Sensitive Detection of Single-Nucleotide Mutation in the BRAF Mutation Site (V600E) of Human Melanoma Using Phosphate–Pyrene-Labeled DNA Probes
Analytical Chemistry
DOI: 10.1021/acs.analchem.5b03523
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Ultrasensitive Detection of Single-Walled Carbon Nanotubes Using Surface Plasmon Resonance
Analytical Chemistry
DOI: 10.1021/acs.analchem.5b03722
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Best practices for assessing ocean health in multiple contexts using tailorable frameworks
Marine policy is increasingly calling for maintaining or restoring healthy oceans while human activities continue to intensify. Thus, successful prioritization and management of competing objectives requires a comprehensive assessment of the current state of the ocean. Unfortunately, assessment frameworks to define and quantify current ocean state are often site-specific, limited to a few ocean components, and difficult to reproduce in different geographies or even through time, limiting spatial or temporal comparisons as well as the potential for shared learning. Ideally, frameworks should be tailorable to accommodate use in disparate locations and contexts, removing the need to develop frameworks de novo and allowing efforts to focus on the assessments themselves to advise action. Here, we present some of our experiences using the Ocean Health Index (OHI) framework, a tailorable and repeatable approach that measures health of coupled human-ocean ecosystems in different contexts by accommodating differences in local environmental characteristics, cultural priorities, and information availability and quality. Since its development in 2012, eleven assessments using the OHI framework have been completed at global, national, and regional scales, four of which have been led by independent academic or government groups. We have found the following to be best practices for conducting assessments: Incorporate key characteristics and priorities into the assessment framework design before gathering information; Strategically define spatial boundaries to balance information availability and decision-making scales; Maintain the key characteristics and priorities of the assessment framework regardless of information limitations; and Document and share the assessment process, methods, and tools. These best practices are relevant to most ecosystem assessment processes, but also provide tangible guidance for assessments using the OHI framework. These recommendations also promote transparency around which decisions were made and why, reproducibility through access to detailed methods and computational code, repeatability via the ability to modify methods and computational code, and ease of communication to wide audiences, all of which are critical for any robust assessment process.
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Mortality (1968-2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds
Objectives
Until recently, enrichment of uranium for civil and military purposes in France was carried out by gaseous diffusion using rapidly soluble uranium compounds. We analysed the relationship between exposure to soluble uranium compounds and exposure to external -radiation and mortality in a cohort of 4688 French uranium enrichment workers who were employed between 1964 and 2006.
MethodsData on individual annual exposure to radiological and non-radiological hazards were collected for workers of the AREVA NC, CEA and Eurodif uranium enrichment plants from job-exposure matrixes and external dosimetry records, differentiating between natural, enriched and depleted uranium. Cause-specific mortality was compared with the French general population via standardised mortality ratios (SMR), and was analysed via Poisson regression using log-linear and linear excess relative risk models.
ResultsOver the period of follow-up, 131 161 person-years at risk were accrued and 21% of the subjects had died. A strong healthy worker effect was observed: all causes SMR=0.69, 95% CI 0.65 to 0.74. SMR for pleural cancer was significantly increased (2.3, 95% CI 1.06 to 4.4), but was only based on nine cases. Internal uranium and external -radiation exposures were not significantly associated with any cause of mortality.
ConclusionsThis is the first study of French uranium enrichment workers. Although limited in statistical power, further follow-up of this cohort, estimation of internal uranium doses and pooling with similar cohorts should elucidate potential risks associated with exposure to soluble uranium compounds.
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A case-control study of mesothelioma in Minnesota iron ore (taconite) miners
Objectives
An excess of mesothelioma has been observed in iron ore miners in Northeastern Minnesota. Mining and processing of taconite iron ore generate exposures that include elongate mineral particles (EMPs) of amphibole and non-amphibole origin. We conducted a nested case–control study of mesothelioma in a cohort of 68 737 iron ore miners (haematite and taconite ore miners) to evaluate the association between mesothelioma, employment and EMP exposures from taconite mining.
MethodsMesothelioma cases (N=80) were identified through the Minnesota Cancer Surveillance System (MCSS) and death certificates. Four controls of similar age were selected for each case with 315 controls ultimately eligible for inclusion. Mesothelioma risk was evaluated by estimating rate ratios and 95% CIs with conditional logistic regression in relation to duration of taconite industry employment and cumulative EMP exposure [(EMP/cc)xyears], defined by the National Institute for Occupational Safety and Health (NIOSH) 7400 method. Models were adjusted for employment in haematite mining and potential exposure to commercial asbestos products used in the industry.
ResultsAll mesothelioma cases were male and 57 of the cases had work experience in the taconite industry. Mesothelioma was associated with the number of years employed in the taconite industry (RR=1.03, 95% CI 1.00 to 1.06) and cumulative EMP exposure (RR=1.10, 95% CI 0.97 to –1.24). No association was observed with employment in haematite mining.
ConclusionsThese results support an association between mesothelioma and employment duration and possibly EMP exposure in taconite mining and processing. The type of EMP was not determined. The potential role of commercial asbestos cannot be entirely ruled out.
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The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines
Abstract
Despite huge advances in the research of epithelial ovarian cancer (EOC), it remains the most lethal gynecological malignancy. Peritoneal tumor cell dissemination with cell survival and drug-resistance to taxane and platinum-based chemotherapy are two of the major challenges of EOC treatment. We have generated highly aggressive EOC cell lines (ID8-P1 lines or P1) from ID8-P0 (without in vivo passage, or P0) through in vivo passage in mice. We conducted lipidomic analyses in cells from ID8-P0 versus three ID8-P1 cell lines using ultra-high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry. A total of 16 classes of lipids (149 individual lipids) were analyzed and compared between P0 and P1 cells. In addition to overall lipid profiles in EOC cells, we had several novel observations. Several classes and species of lipids have been identified to be differentially present in P0 versus P1 cells, which are potentially involved in the acquired aggressiveness of P1 cells. Triacylglycerols (TAG) were dramatically increased under detachment stress in EOC cells. Since survival of EOC cells under detachment is one of the major obstacles for EOC treatment, further studies identifying the molecular mechanisms controlling TAG increase may lead to new treatment modalities for EOC.
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Preoperative versus postoperative ultrasound-guided rectus sheath block for improving pain, sleep quality and cytokine levels of patients with open midline incisions undergoing transabdominal gynaecological operation: study protocol for a randomised controlled trial
Background: Rectus sheath block (RSB) is used for postoperative pain relief in patients undergoing abdominal surgery with midline incision. Preoperative RSB has been shown to be effective, but it has not been compared with postoperative RSB. The aim of the present study is to evaluate postoperative pain, sleep quality and changes in the cytokine levels of patients undergoing gynaecological surgery with RSB performed preoperatively versus postoperatively.Methods/DesignThis study is a prospective, randomised, controlled (randomised, parallel group, concealed allocation), single-blinded trial. All patients undergoing transabdominal gynaecological surgery will be randomised 1:1 to the treatment intervention with general anaesthesia as an adjunct to preoperative or postoperative RSB. The objective of the trial is to evaluate postoperative pain, sleep quality and changes in the cytokine levels of patients undergoing gynaecological surgery with RSB performed preoperatively (n = 32) versus postoperatively (n = 32). All of the patients, irrespective of group allocation, will receive patient-controlled intravenous analgesia (PCIA) with oxycodone.The primary objective is to compare the interval between leaving the post-anaesthesia care unit and receiving the first PCIA bolus injection on the first postoperative night between patients who receive preoperative versus postoperative RSB. The secondary objectives will be to compare (1) cumulative oxycodone consumption at 24 hours after surgery; (2) postoperative sleep quality, as measured using a BIS-Vista monitor during the first night after surgery; and (3) cytokine levels (interleukin-1, interleukin-6, tumour necrosis factor-α and interferon-γ) during surgery and at 24 and 48 hours postoperatively.DiscussionClinical experience has suggested that RSB is a very effective postoperative analgesic technique, and we will answer the following questions with this trial. Do preoperative block and postoperative block have the same duration of analgesic effects? Can postoperative block extend the analgesic time? The results of this study could have actual clinical applications that could help to reduce postoperative pain and shorten hospital stays.Trial registrationCurrent Controlled Trials NCT02477098 15 June 2015.
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Comparison of total ankle replacement and ankle arthrodesis in patients with haemophilia using gait analysis: two case reports
Background: Severe hemophilia is an inherited, lifelong bleeding disorder characterized by spontaneous bleeding, which results in painful joint deformities. Currently two surgical treatments are available to treat haemophilia-related ankle joint destruction: ankle arthrodesis and total ankle replacement. The aim of the present study was to compare these two surgical procedures in haemophiliac subjects.Case presentationKinematic and dynamic parameters were quantified using a three-dimensional gait-analysis system in two similar clinical cases. In Caucasian case 1, ankle arthrodesis was chosen because of a kinematic ankle flexion defect and lack of dynamic power regeneration. The defect in energy absorption was compensated for by the contralateral side. Total ankle replacement in Caucasian case 2 allowed sparing the ipsilateral knee (maximum 0.27 preoperatively vs. 0.71 W/kg postoperatively) and hip joints powers (maximum 0.43 preoperatively vs. 1.25 W/kg postoperatively) because of the small ankle dorsiflexion motion. Conclusions: Total ankle replacement is recommended for haemophiliac patients who present with a preserved ankle range of motion.
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Magnetic Graphene Nanosheet-Based Microfluidic Device for Homogeneous Real-Time Electronic Monitoring of Pyrophosphatase Activity Using Enzymatic Hydrolysate-Induced Release of Copper Ion
Analytical Chemistry
DOI: 10.1021/acs.analchem.5b04005
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IOP-details
Publication date: December 2015
Source:International Journal of Psychophysiology, Volume 98, Issue 3, Part 2
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Full title with Editorial board members
Publication date: December 2015
Source:International Journal of Psychophysiology, Volume 98, Issue 3, Part 2
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Instructions to Authors
Publication date: December 2015
Source:International Journal of Psychophysiology, Volume 98, Issue 3, Part 2
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Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015
The plasmid-mediated colistin resistance gene, mcr-1, was detected in an Escherichia coli isolate from a Danish patient with bloodstream infection and in five E. coli isolates from imported chicken meat. One isolate from chicken meat belonged to the epidemic spreading sequence type ST131. In addition to IncN2, an incX4 replicon was found to be linked to mcr-1. This report follows a recent detection of mcr-1 in E. coli from animals, food and humans in China.
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Colonisation with toxigenic Corynebacterium diphtheriae in a Scottish burns patient, June 2015
On 12 June 2015, Corynebacterium diphtheriae was identified in a skin swab from a burns patient in Scotland. The isolate was confirmed to be genotypically and phenotypically toxigenic. Multilocus sequence typing of three patient isolates yielded sequence type ST 125. The patient was clinically well. We summarise findings of this case, and results of close contact identification and screening: 12 family and close contacts and 32 hospital staff have been found negative for C. diphtheriae.
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Efficacy of Intensity Modulated Radiation Therapy After Surgery in Early Stage of Esophageal Carcinoma;
Conditions: Esophageal Neoplasm; Esophageal Cancer TNM Staging Primary Tumor (T) T2; Esophageal Cancer TNM Staging Primary Tumor (T) T3; Esophageal Cancer TNM Staging Regional Lymph Nodes (N) N0; Esophageal Cancer TNM Staging Distal Metastasis (M) M0
Intervention: Radiation: Prophylactic postoperative radiation therapy
Sponsors: Chinese Academy of Medical Sciences; Sichuan Cancer Hospital and Research Institute; Tianjin Medical University Cancer Institute and Hospital
Recruiting - verified December 2015
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Intervention: Radiation: Prophylactic postoperative radiation therapy
Sponsors: Chinese Academy of Medical Sciences; Sichuan Cancer Hospital and Research Institute; Tianjin Medical University Cancer Institute and Hospital
Recruiting - verified December 2015
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Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
Conditions: Esophageal Cancer; Head and Neck Cancer; Lung Cancer; Precancerous Condition
Interventions: Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: sputum cytology; Procedure: biopsy
Sponsors: University of Colorado, Denver; National Cancer Institute (NCI)
Recruiting - verified December 2015
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Interventions: Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: sputum cytology; Procedure: biopsy
Sponsors: University of Colorado, Denver; National Cancer Institute (NCI)
Recruiting - verified December 2015
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Urine is a novel source of autologous mesenchymal stem cells for patients with epidermolysis bullosa
Background: Regenerative medicine is strictly dependent on stem cells as a source for a high diversity of somatic cells. However, the isolation of such from individuals suffering from severe genetic skin blistering diseases like epidermolysis bullosa (EB) is often associated with further organ damage. Methods: Stem cells were isolated from 112 urine samples from 21 different healthy donors, as well as from 33 urine samples from 25 donors with EB. The cultivation of these cells was optimized by testing different media formulations and pre-coating of culture vessels with collagen. The identity of cells was confirmed by testing marker expression, differentiation potential and immune-modulatory properties. Results: We provide here an optimized protocol for the reproducible isolation of mesenchymal stem cells from urine, even from small volumes as obtained from patients with EB. Furthermore, we offer a basic characterization of those urine-derived stem cells (USCs) from healthy donors, as well as from patients with EB, and demonstrate their potential to differentiate into chondrocytes, osteoblasts and adipocytes, as well as their immune-modulatory properties. Conclusions: Thus, USCs provide a novel and non-invasive source of stem cells, which might be applied for gene-therapeutic approaches to improve medical conditions of patients with EB.
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Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other...
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Protocol for a systematic review of psychological interventions for cancer-related fatigue in post-treatment cancer survivors
Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. Some evidence has been reported for interventions for fatigue during active treatment. However, to date, the...
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Describe the outcomes of dysvascular partial foot amputation and how these compare to transtibial amputation: a systematic review protocol for the development of shared decision-making resources
Helping people make well-informed decisions about dysvascular partial foot amputation is becoming increasingly important as improvements in diabetes care and vascular surgery make more distal amputations incre...
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Supporting systematic reviews using LDA-based document representations
Identifying relevant studies for inclusion in a systematic review (i.e. screening) is a complex, laborious and expensive task. Recently, a number of studies has shown that the use of machine learning and text ...
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Repurposed therapeutic agents targeting the Ebola virus: a protocol for a systematic review
The recent Ebola epidemic in western Africa developed into an acute public health emergency of unprecedented level in modern times. The treatment provided in most cases has been limited to supportive care, as ...
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Biceps femoris and semitendinosus tendon/aponeurosis strain during passive and active (isometric) conditions
Publication date: Available online 10 December 2015
Source:Journal of Electromyography and Kinesiology
Author(s): Eleftherios Kellis
The purpose of this study was to quantify strain and elongation of the long head of the biceps femoris (BFlh) and the semitendinosus (ST) tendon/aponeurosis. Forty participants performed passive knee extension trials from 90° of knee flexion to full extension (0°) followed by ramp isometric contractions of the knee flexors at 0, 45 and 90° of knee flexion. Two ultrasound probes were used to visualize the displacement of BFlh and ST tendon/aponeurosis. Three-way analysis of variance designs indicated that: (a) Tendon/aponeurosis (passive) elongation and strain were higher for the BFlh than the ST as the knee was passively extended (p<0.05) (b) Contraction at each angular position was accompanied by a smaller BFlh tendon/aponeurosis (active) strain and elongation than the ST at higher levels of effort (p <0.05) and c) Combined (passive and active) strain was significantly higher for the BFlh than ST during ramp contraction at 0° but the opposite was observed for the 45° and 90° flexion angle tests (p < 0.05). Passive elongation of tendon/aponeurosis has an important effect on the tendon/aponeurosis behavior of the hamstrings and may contribute to a different loading of muscle fibers and tendinous tissue between BFlh and ST.
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Ciliary muscle contraction force and trapezius muscle activity during manual tracking of a moving visual target
Publication date: Available online 10 December 2015
Source:Journal of Electromyography and Kinesiology
Author(s): Dmitry Domkin, Mikael Forsman, Hans O. Richter
Previous studies have shown an association of visual demands during near work and increased activity of the trapezius muscle. Those studies were conducted under stationary postural conditions with fixed gaze and artificial visual load. The present study investigated the relationship between ciliary muscle contraction force and trapezius muscle activity across individuals during performance of a natural dynamic motor task under free gaze conditions. Participants (N=11) tracked a moving visual target with a digital pen on a computer screen. Tracking performance, eye refraction and trapezius muscle activity were continuously measured. Ciliary muscle contraction force was computed from eye accommodative response. There was a significant Pearson correlation between ciliary muscle contraction force and trapezius muscle activity on the tracking side (0.78, p<0.01) and passive side (0.64, p<0.05). The study supports the hypothesis that high visual demands, leading to an increased ciliary muscle contraction during continuous eye-hand coordination, may increase trapezius muscle tension and thus contribute to the development of musculoskeletal complaints in the neck-shoulder area. Further experimental studies are required to clarify whether the relationship is valid within each individual or may represent a general personal trait, when individuals with higher eye accommodative response tend to have higher trapezius muscle activity.
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Immunostimulatory Activity of the Cytokine-Based Biologic, IRX-2, on Human Papillomavirus-Exposed Langerhans Cells
Journal of Interferon & Cytokine Research , Vol. 0, No. 0.
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OtoRhinoLaryngology & Medicine,New Articles,December 10th,2015
Double-Eyelid Surgery Using Septoaponeurosis Junctional Thickening Results in Dynamic Fold
Double-Eyelid Surgery Using Septoaponeurosis Junctional Thickening Results in Dynamic Fold in Asians: [image: image] Background: To avoid a static double-eyelid fold characterized by nonmobile overdepression of the fold, we propose a new surgical approach of using septoaponeurosis junctional thickening (SAJT) to create a dynamic fold. Methods: Six hundred eighty patients underwent double-eyelid surgery using the SAJT fixation technique. The orbital septum was exposed and transversely opened superior to the incision margin. The lower septal stump was trimmed to expose the SAJT. The d...περισσότερα »
Six Split-thickness Skin Graft Donor-site Dressing Materials
Evaluation of Six Split-thickness Skin Graft Donor-site Dressing Materials in a Swine Model: [image: image]Background: Numerous dressings for split-thickness skin graft donor sites are commercially available with no conclusive evidence-based consensus regarding the optimal dressing choice. This study was conducted to identify which of 5 commonly used materials promotes wound healing most effectively for use on split-thickness donor sites in comparison with our standard dressing, Xeroform (petrolatum gauze). Methods: Twenty-four partial-thickness wounds were created on the backs of 4 ...περισσότερα »
Bovine versus Porcine Acellular Dermal Matrix
Bovine versus Porcine Acellular Dermal Matrix: A Comparison of Mechanical Properties: Background: Porcine and bovine acellular dermal matrices (PADM and BADM, respectively) are the most commonly used biologic meshes for ventral hernia repair. A previous study suggests a higher rate of intraoperative device failures using PADM than BADM. We hypothesize that this difference is, in part, related to intrinsic mechanical properties of the matrix substrate and source material. The following study directly compares these 2 matrices to identify any potential differences in mechanical proper... περισσότερα »
Intraoral Approach and Stereolithographic-guided Large Mandibular Reconstruction with Fibula Free Flap
Intraoral Approach and Stereolithographic-guided Large Mandibular Reconstruction with Fibula Free Flap: [image: image]Summary: The reconstruction of mandibular defects has always been of great concern, and it still represents a challenge for head-and-neck reconstructive surgeons. The mandible plays a major role in mastication, articulation, swallowing, respiration, and facial contour. Thus, when undertaking mandibular reconstruction, restoration of both function and cosmetics should be considered as the measure of success. Microsurgical reconstruction is the gold-standard method to ... περισσότερα »
Epidermal Healing in Burns: Autologous Keratinocyte Transplantation as a Standard Procedure: Update and Perspective
Epidermal Healing in Burns: Autologous Keratinocyte Transplantation as a Standard Procedure: Update and Perspective: Background: Treatment of burned patients is a tricky clinical problem not only because of the extent of the physiologic abnormalities but also because of the limited area of normal skin available. Methods: Literature indexed in the National Center (PubMed) has been reviewed using combinations of key words (burns, children, skin graft, tissue engineering, and keratinocyte grafts). Articles investigating the association between burns and graft therapeutic modalities hav... περισσότερα »
Scalp Surgery: Quantitative Analysis of Follicular Unit Growth
Scalp Surgery: Quantitative Analysis of Follicular Unit Growth: [image: image]Background: Over the years, different kinds of hair transplantation have been compared in an attempt to overcome male pattern alopecia and, at the same time, maximize both the survival and growth rate of grafted hair. In this study, we have assessed the survival and growth rate of follicular units (FU) in an in vitro model, as compared with that of conventional hair micrografts, to experimentally evaluate and elaborate on the differences between these 2 approaches in hair transplantation procedures. Methods... περισσότερα »
Perpendicular Strut Injection of Hyaluronic Acid Filler for Deep Wrinkles
Perpendicular Strut Injection of Hyaluronic Acid Filler for Deep Wrinkles: Summary: Although various injection techniques of hyaluronic acid (HA) filler for facial rejuvenation have been developed, correction of deep wrinkles/grooves, such as the nasolabial fold (NLF), with intradermal or subdermal injections remains difficult. We tested the intradermal HA injection method to place multiple HA struts by (1) inserting a small needle perpendicularly to the wrinkle and (2) injecting HA as intradermal struts with the skin fully stretched by the practitioner’s fingers. The results of bot... περισσότερα »
Perioperative use of centrally acting angiotensin-converting enzyme inhibitor may increase patients’ risk for postoperative nausea and vomiting
Perioperative use of centrally acting angiotensin-converting enzyme inhibitor may increase patients’ risk for postoperative nausea and vomiting via ScienceDirect Publication: Medical Hypotheses Publication date: January 2016 *Source:*Medical Hypotheses, Volume 86 Author(s): Chao Xiong, Liting Wang, Dongjiao An, Meijiang Lu, Wenzhen Shen, Yun Wang, Yun Yue, Anshi Wu Substance P (SP) is involved in the development of postoperative nausea and vomiting (PONV). It is hydrolyzed by angiotensin-converting enzyme (ACE). Centrally acting ACE inhibitors (CACE-Is) are widely used in the periopera... περισσότερα »
CSF generation by pineal gland results in a robust melatonin circadian rhythm in the third ventricle
as an unique light/dark signal via ScienceDirect Publication: Medical Hypotheses Publication date: January 2016 *Source:*Medical Hypotheses, Volume 86 Author(s): Dun-Xian Tan, Lucien C. Manchester, Russel J. Reiter Pineal gland is an important organ for the regulation of the bio-clock in all vertebrate species. Its major secretory product is melatonin which is considered as the chemical expression of darkness due to its circadian peak exclusively at night. Pineal melatonin can be either released into the blood stream or directly enter into the CSF of the third ventricle via the pineal... περισσότερα »
Predictability in orbital reconstruction
. A human cadaver study, part III: Implant-oriented navigation for optimized reconstruction via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery, Volume 43, Issue 10 Author(s): Leander Dubois, Harald Essig, Ruud Schreurs, Jesper Jansen, Thomas J.J. Maal, Peter J.J. Gooris, Alfred G. Becking Navigation-assisted orbital reconstruction remains a challenge, because the surgeon focuses on a two-dimensional multiplanar view in relation to the preoperative planning. This study explored the additi... περισσότερα »
Effects of Effortful Swallow on Cardiac Autonomic Regulation
Effects of Effortful Swallow on Cardiac Autonomic Regulation: AbstractSwallowing-induced changes in heart rate have been recently reported. However, it is not apparent the responses of heart rate variability (HRV) elicited by effortful swallow maneuver. We investigated the acute effects of effortful swallowing maneuver on HRV. This study was performed on 34 healthy women between 18 and 35 years old. We assessed heart rate variability in the time (SDNN, RMSSD, and pNN50) and frequency (HF, LF, and LF/HF ratio) domains and, visual analysis through the Poincaré plot. The subjects rema...περισσότερα »
Selection of Voice Therapy Methods
. Results of an Online Survey via Voice *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Iris Burg, Birte Meier, Katharina Nolte, Tina Oppermann, Verena Rogg, Ulla Beushausen ObjectivesProviding an evidence basis for voice therapy in the German-speaking countries faces the challenge that—for historical reasons—a variety of direct voice therapy methods is available. The aim of this study was to clarify which therapy methods are chosen and the underlying principles for this selection.MethodsAn online survey was implemented to identify to what extent the variety of methods descr... περισσότερα »
Vocal Fold Vibration in Vocal Fold Atrophy
: Quantitative Analysis With High-Speed Digital Imaging via Voice Publication date: November 2015 *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Akihito Yamauchi, Hisayuki Yokonishi, Hiroshi Imagawa, Ken-Ichi Sakakibara, Takaharu Nito, Niro Tayama, Tatsuya Yamasoba IntroductionVocal fold vibrations of vocal fold atrophy (VFA), a rapidly increasing voice disorder owing to worldwide societal aging, have not been clarified by high-speed digital imaging (HSDI).MethodsThe HSDI method was performed on 46 patients (33 males and 13 females) with VFA and 20 vocally healthy subjects (8... περισσότερα »
Hormonal influences on speech articulation
Speech Articulation of Low-Dose Oral Contraceptive Users via Voice Publication date: November 2015 *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Eliséa Maria Meurer, Giana Valeria Fagundez Fontoura, Helena von Eye Corleta, Edison Capp ObjectivesIn the female life cycle, hormonal fluctuations may result in impaired verbal efficiency and vocal worsening during the premenstrual phase. Oral contraceptives may interfere with vocal range. Voice, resonance, and articulation variations clarify speech content. To investigate the phonoarticulatory sounds produced by oral contraceptive...περισσότερα »
Semioccluded Vocal Tract Exercises
The Effect of Traditional Singing Warm-Up Versus Semioccluded Vocal Tract Exercises on the Acoustic Parameters of Singing Voice via Voice *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Emily Duke, Laura W. Plexico, Mary J. Sandage, Matthew Hoch Objectives/hypothesesThis study investigated the effect of traditional vocal warm-up versus semioccluded vocal tract exercises on the acoustic parameters of voice through three questions: does vocal warm-up condition significantly alter the singing power ratio of the singing voice? Is singing power ratio dependent upon vowel? Is perce... περισσότερα »
Intensive Voice Therapy for Vocal Fold Nodules
Delivery of Intensive Voice Therapy for Vocal Fold Nodules Via Telepractice: A Pilot Feasibility and Efficacy Study via Voice *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Sherry Fu, Deborah G. Theodoros, Elizabeth C. Ward ObjectivesThis pilot study examined voice outcomes and patient perceptions after intensive voice therapy for vocal fold nodules via telepractice.Study Design.Pilot, within-subjects experimental trial.MethodsParticipants included 10 women diagnosed with bilateral vocal fold nodules who received intensive voice treatment via a free videoconferencing platfor...περισσότερα »
Cervical Muscular Contraction Affect the Measurement for Electroglottographic Perturbation Parameters
Does Cervical Muscular Contraction Affect the Measurement for Electroglottographic Perturbation Parameters? via Voice Publication date: November 2015 *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Kiyohito Hosokawa, Makoto Ogawa, Toshihiko Iwahashi, Michiko Hashimoto, Hidenori Inohara ObjectivesThe purpose was to assess whether cervical muscular contraction during phonation influences the period and amplitude perturbation quotients (PPQ and APQ, respectively) of electroglottographic (EGG) signals, and whether high-pass filtering can attenuate these effects.Study DesignProspe... περισσότερα »
Advanced CO2 Laser Cordectomy
Longitudinal Voice Outcomes Following Advanced CO2 Laser Cordectomy for Glottic Cancer via Voice *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Abie H. Mendelsohn, Nayla Matar, Vincent Bachy, Georges Lawson, Marc Remacle ObjectiveCO2 laser cordectomy for glottic carcinoma offers excellent oncologic control on a per stage basis as compared with primary radiotherapy. We aim to further investigate the fluctuations of postoperative vocal outcomes following extended laser cordectomy for glottic cancer.DesignSingle center retrospective cohort study.MethodsEleven patients with gl...περισσότερα »
Time-Dependent Pressure and Flow Behavior of a Self-oscillating Laryngeal Model With Ventricular Folds
Time-Dependent Pressure and Flow Behavior of a Self-oscillating Laryngeal Model With Ventricular Folds via Voice Publication date: November 2015 *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Fariborz Alipour, Ronald C. Scherer ObjectiveThe purpose of the study was to better understand the pressure-flow behavior of a self-oscillating vocal fold model at various stages of the glottal cycle.MethodsAn established self-oscillating vocal fold model was extended to include the false vocal folds (FVFs) and was used to study time-dependent pressure and velocity distributions through ...περισσότερα »
Respiratory Muscle Strength, Sound Pressure Level, and Vocal Acoustic Parameters and Waist Circumference of Children
Respiratory Muscle Strength, Sound Pressure Level, and Vocal Acoustic Parameters and Waist Circumference of Children With Different Nutritional Status via Voice Publication date: Available online 10 December 2015 *Source:*Journal of Voice Author(s): Fernanda dos Santos Pascotini, Vanessa Veis Ribeiro, Mara Keli Christmann, Lidia Lis Tomasi, Amanda Alves Dellazzana, Leris Salete Bonfanti Haeffner, Carla Aparecida Cielo ObjectiveRelate respiratory muscle strength (RMS), sound pressure (SP) level, and vocal acoustic parameters to the abdominal circumference (AC) and nutritional status of...περισσότερα »
Vocal Fold Adjustment Caused by Phonation Into a Tube
: A Double-Case Study Using Computed Tomography via Voice Publication date: November 2015 *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Vít Hampala, Anne-Maria Laukkanen, Marco A. Guzman, Jaromír Horáček, Jan G. Švec ObjectivesPhonation into a tube is a widely used method for vocal training and therapy. Previous studies and practical experience show that the phonation becomes easier and louder after such an exercise. The purpose of this study was to find out whether there are systematic changes in the vocal fold adjustment after the exercise.MethodsTwo volunteer subjects (1 ... περισσότερα »
Fitzmaurice Voicework (FV) teacher certification program
Fitzmaurice Voicework Pilot Study via Voice Publication date: November 2015 *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Lynn Watson, Sadhana Nayak Objectives/DesignA repeated-measures pilot study was used to investigate acoustic changes in the voices of participants in a Fitzmaurice Voicework (FV) teacher certification program. Maximum phonation time (MPT) was also measured.MethodsEleven participants with no reported voice problems were studied. Pretraining and posttraining recordings were made of each participant. Measures of MPT were made, and the recordings were analyze... περισσότερα »
Injection Augmentation for Chronic Cough
Injection Augmentation for Chronic Cough via Voice Publication date: November 2015 *Source:*Journal of Voice, Volume 29, Issue 6 Author(s): Brianna K. Crawley, Thomas Murry, Lucian Sulica Objectives/HypothesisChronic cough (CC) is a pervasive and expensive health problem in the United States. Almost as diverse as its etiologies are the available therapeutic options. When vocal fold paresis and CC coincide, injection augmentation may provide an alternative to standard medical and behavioral treatments for CC. Our objective was to assess the effect of injection augmentation in a selected...περισσότερα »
Dystrophic calcification: A rare pediatric parotid mass
Dystrophic calcification: A rare pediatric parotid mass via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 10 December 2015 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Sean P. Chislett, Bryan J. Liming, Derek J. Rogers Dystrophic calcification, the ectopic deposition of calcium in previously damaged or inflamed tissues, is an uncommon finding in the head and neck. Only a few cases have been reported in the parotidomasseteric region, and all of them have been located within and adjacent to the masseter. We present ...περισσότερα »
Oral administration of erythromycin decreases RNA toxicity
Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy: Abstract Objective Myotonic dystrophy type 1 (DM1) is caused by the expansion of a CTG repeat in the 3′ untranslated region of *DMPK*. The transcripts containing an expanded CUG repeat (CUGexp) result in a toxic gain-of-function by forming ribonuclear foci that sequester the alternative splicing factor muscleblind-like 1 (MBNL1). Although several small molecules reportedly ameliorate RNA toxicity, none are ready for clinical use because of the lack of safety data. Here, we undertook a drug-repositioni...περισσότερα »
Anatomical study of the motor branches of the median nerve to the forearm and guidelines for selective neurectomy
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Abstract Purpose The median nerve is responsible for the motor innervation of most of the muscles usually involved in upper limb spasticity. Selective neurectomy is one of the treatments utilized to reduce spasticity. The purpose of this study was to describe the variations of the motor branches of the median nerve in the forearm and draw recommendations for an appropriate planning of selective neurectomy. Materials and methods The median nerve was dissected in the forearm of 20 fresh cadaver upper limbs. Measurements included number, origin, division, and entry point of each mot... περισσότερα »
Superior mesenteric origin of the proper hepatic artery: embryological and clinical implications
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Abstract The hepatic arteries are subject to a great deal of anatomical variation, potentially complicating hepatobiliary surgical procedures as well as general gastrointestinal procedures that involve foregut and midgut structures. We report a case of a rare variant of the proper hepatic artery discovered during dissection of an 84-year-old male cadaver. In this individual, the common hepatic artery was absent and the proper hepatic artery was replaced directly to the superior mesenteric artery. The gastroduodenal artery and the right inferior phrenic artery took origin from the ... περισσότερα »
Results of the first universal newborn hearing screening in Algeria
*Farid Boudjenah, Mokhtar Hasbellaoui, Omar Zemirli* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):54-58 Introduction Hearing loss is the most common congenital pathology at birth. Its prevalence increases during the infant period, especially in children at risk. The application of hearing screening in three stages with follow-up of children at risk of developing hearing loss allows to optimize the screening. Goals The aim of this study was to evaluate the prevalence of hearing loss in the neonatal population and identify newborns at risk and to investigate the best w... περισσότερα »
Neuroplastic changes in musician's brain: A review
*Himanshu Kumar Sanju* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):43-44 Neuroplasticity refers to any change or modification in the central nervous system because of any adaptation or experience to environmental demands. Musical training and experience can lead to neuroplasticity because music requires cognitive and neural challenges that need accurate and precise timing of many actions, exact interval control of pitch not involved in language, and various different way of producing sound. It was also reported that a musician's brain is best to study neuroplastic c...περισσότερα »
Pharmacotherapy of vestibular disorders
*Hesham Mahmoud Samy* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):39-42 Dizziness and vertigo are symptoms directly related to dysfunction of the vestibular system. Imbalance is the most common complaint, especially in the elderly population, which results in falls and mobility restriction. There is no common drug for the management of balance disorders. Medications should be prescribed carefully, and according to clear diagnosis. The pharmacotherapy of vertigo can be optimized with detailed knowledge of the drugs effective in vertigo, as well as their side effects....περισσότερα »
Vestibular evoked myogenic potentials and video head impulse tests in different stages of Meniere's disease
*Doaa M Elmoazen, Ossama A Sobhy, Fathy Abd Elbaky* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):45-53 Introduction Meniere's disease (MD) is characterized by intermittent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural pressure. Histopathologically, endolymphatic hydrops is seen initially in the cochlear duct and the saccule; with the progression of the disease, subsequent affection of the utricle and semicircular canals (SCC) occur. Objectives The aim of this study was to assess the function of the saccule, the utricle, and the thre... περισσότερα »
Sensitivity of CHIRP auditory brainstem response and auditory steady state response for detecting normal hearing in children
*Haider W Alsarhan* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):59-63 Background In recent years, great development of electrophysiological procedures for detection of hearing level in infants and children has been achieved - click auditory brainstem response (ABR), tone burst ABR, and notched noise ABR. The two most recent methods are CHIRP signal ABR and auditory steady state response (ASSR). Aim of the study The aim of this study was to identify the best electrophysiological method for detecting normal hearing thresholds. Patients and methods A prospective study ...περισσότερα »
Internet and Audiology: A Review of the First International Meeting.
*Internet and Audiology: A Review of the First International Meeting.* Am J Audiol. 2015 Sep 1;24(3):269-270 Authors: Andersson G, Lunner T, Laplante-Lévesque A, Preminger JE Abstract Purpose: The purpose of this research forum article is to describe the impetus for holding the First International Meeting on Internet and Audiology (October 2014) and to introduce the special research forum that arose from the meeting. Method: The rationale for the First International Meeting on Internet and Audiology is described. This is followed by a short description of the research sections and... περισσότερα »
Internet and Audiology: A Review of the First International Meeting.
*Internet and Audiology: A Review of the First International Meeting.* Am J Audiol. 2015 Sep 1;24(3):269-270 Authors: Andersson G, Lunner T, Laplante-Lévesque A, Preminger JE Abstract Purpose: The purpose of this research forum article is to describe the impetus for holding the First International Meeting on Internet and Audiology (October 2014) and to introduce the special research forum that arose from the meeting. Method: The rationale for the First International Meeting on Internet and Audiology is described. This is followed by a short description of the research sections and... περισσότερα »
MRSA, VRE, and Clostridium difficile : Automated ultraviolet-C–emitting devices
Postdischarge decontamination of MRSA, VRE, and Clostridium difficile isolation rooms using 2 commercially available automated ultraviolet-C–emitting devices via ScienceDirect Publication: American Journal of Infection Control Publication date: Available online 9 December 2015 *Source:*American Journal of Infection Control Author(s): Titus Wong, Tracey Woznow, Mike Petrie, Elena Murzello, Allison Muniak, Amin Kadora, Elizabeth Bryce BackgroundTwo ultraviolet-C (UVC)–emitting devices were evaluated for effectiveness in reducing methicillin-resistant Staphylococcus aureus (MRSA), vancomy... περισσότερα »
Impact of pulsed xenon ultraviolet light on hospital-acquired infection rates
in a community hospital via ScienceDirect Publication: American Journal of Infection Control Publication date: Available online 9 December 2015 *Source:*American Journal of Infection Control Author(s): Pedro G. Vianna, Charles R. Dale, Sarah Simmons, Mark Stibich, Carmelo M. Licitra BackgroundThe role of contaminated environments in the spread of hospital-associated infections has been well documented. This study reports the impact of a pulsed xenon ultraviolet no-touch disinfection system on infection rates in a community care facility.MethodsThis study was conducted in a community h...περισσότερα »
Oral microbiome, periodontitis and risk of head and neck cancer
Oral microbiome, periodontitis and risk of head and neck cancer via ScienceDirect Publication: Oral Oncology Publication date: Available online 10 December 2015 *Source:*Oral Oncology Author(s): Leonardo Victor Galvão-Moreira, Maria Carmen Fontoura Nogueira da Cruz A wide range of studies has been successfully exploring the association between the human microenvironment, sustained inflammation, and cancer. Growing evidence has then emerged in this field over the past few years. Nevertheless, reliable data addressing the impact of the oral microbiome and periodontitis on the pathogenesi...περισσότερα »
Head and neck oncology specimens
Discordance in routine second opinion pathology review of head and neck oncology specimens: A single-center five year retrospective review via ScienceDirect Publication: Oral Oncology Publication date: Available online 9 December 2015 *Source:*Oral Oncology Author(s): Gefei Alex Zhu, Ruth Lira, Alexander Dimitrios Colevas ObjectivesSecond opinion review of pathology specimens is a common institutional practice, supported by large retrospective studies demonstrating significant histologic discordance. Since the most recent study of head and neck-specific pathology review was conducted, r... περισσότερα »
Oral cancer survivors
Supportive care needs of oral cancer survivors: Prevalence and correlates via ScienceDirect Publication: Oral Oncology Publication date: Available online 9 December 2015 *Source:*Oral Oncology Author(s): Morgan S. Lee, Ashley M. Nelson, Lora M.A. Thompson, Kristine A. Donovan ObjectivesMany cancer survivors experience unmet supportive care needs. The oral cancer survivor population is growing; however, little is known about the unique needs of this group. The present study aimed to determine the supportive care needs of persons with oral cancer who had completed active treatment at lea...περισσότερα »
Methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis
Clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis from a center with a high MRSA prevalence via ScienceDirect Publication: American Journal of Infection Control Publication date: Available online 9 December 2015 *Source:*American Journal of Infection Control Author(s): Nada S. Harik, Gulnur Com, Xinyu Tang, Maria Melguizo Castro, Mary E. Stemper, John L. Carroll BackgroundWe describe the clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fi...περισσότερα »
HNO Nachrichten
Ihr liebstes Titelbild? Haben Sie auch eine fachliche Frage? Neubildungen an den Stimmlippen interdisziplinär diagnostizieren und therapieren Patientendaten künftig direkt an MDK Bis die Übermittlung der Patientendaten endlich elektronisch laufen kann, ist doch wenigstens einmal noch der bisherige Postweg aus Sicherheitsgründen zu modifizieren. Tonsillopharyngitis: strenge Indikationsstellung für Antibiotika Radiochemotherapie oder Operation bei HNSCC? Welche Strategie ist für Patienten mit nicht metastasiertem Plattenepithelkarzinom an Kopf oder Hals (HNSCC) im Stadium III/IV bess... περισσότερα »
Vagus Nerve Stimulator Implantation
Vagus Nerve Stimulator Implantation: A UK Otolaryngology Department's 9-year experience of implanting 56 patients: Abstract 1.Vagus nerve stimulation (VNS) is a valuable treatment for intractable epilepsy. Our case series is from one of the UK's only Otolaryngology Departments performing this procedure. 2.Between 2006 and 2014, fifty-six patients underwent sixty two VNS procedures. These included 51 primary implantations, 2 lead changes, 8 generator replacements (of which 5 were originally implanted elsewhere), and one explantation, with two patients lost to follow up. 3.Over half o... περισσότερα »
Novel outcome measurement tool of the nasal valve surgery: Image Analysis Using Endoscopic System for Smartphones
Novel outcome measurement tool of the nasal valve surgery: Image Analysis Using Endoscopic System for Smartphones: Nasal obstruction may occur at the level of the external or internal nasal valve as well as more posteriorly due to septal or turbinate derangement (1). The external nasal valve comprises the alar cartilages, lateral nasal margin, and the columella. The internal nasal valve is the angle formed by the junction of the upper lateral cartilages, between the anterior end of the inferior turbinate and the nasal septum. The internal nasal valve is better-known and studied and... περισσότερα »
A Novel Approach to the Challenging Injection Laryngoplasty
A Novel Approach to the Challenging Injection Laryngoplasty: Introduction: Injection laryngoplasty (IL) is typically performed either awake or under general anesthesia with paralysis. There is a subgroup of patients, however, for whom neither of these is a good option. For such patients, we report a hybrid technique that allows for a percutaneous injection without paralysis but with sedation to increase patient tolerance. Supraglottic airway laryngotracheal intervention (SALTI) brings the benefits of injection laryngoplasty to a group of patients previously underserved. Methods: In... περισσότερα »
Subtotal Petrosectomy for Cochlear Implantation
Subtotal Petrosectomy for Cochlear Implantation: Lessons Learned After 110 Cases: Objectives: The purpose of this study was to review the indications for subtotal petrosectomy for cochlear implantation, report our management of complications, as well as review those technical factors that are critical for successful implantation. Methods: Patients (n = 104) that underwent subtotal petrosectomy with closure of the external auditory canal and obliteration of the cavity with abdominal fat in combination with cochlear implantation were analyzed. Results: The most frequent indication ... περισσότερα »
The Effect of Initial Tracheoesophageal Voice Prosthesis Size on Postoperative Complications and Voice Outcomes
The Effect of Initial Tracheoesophageal Voice Prosthesis Size on Postoperative Complications and Voice Outcomes: Objectives: The optimal initial size of tracheoesophageal voice prosthesis (TEVP) for tracheoesophageal voice restoration (TEVR) remains unclear. As purported advantages exist favoring the placement of both 16F and 20F prostheses, this study compares complications and voicing outcomes after placement of 16 and 20 French (F) prostheses. Methods: All cases of TEVR at an academic medical center were retrospectively reviewed (2007-2013). Complications including dislodgement,...περισσότερα »
Comprehensive Emergency Airway Response Team (EART) Training and Education: Impact on Team Effectiveness, Personnel Confidence, and Protocol Knowledge
Comprehensive Emergency Airway Response Team (EART) Training and Education: Impact on Team Effectiveness, Personnel Confidence, and Protocol Knowledge: Objective: To evaluate the efficacy and utility of simulation of the Emergency Airway Response Team (EART) at a tertiary care hospital to improve team dynamics and confidence and knowledge in managing an emergency airway. Methods: This was a descriptive, quantitative performance improvement study. From September 1, 2013, to December 1, 2013, 177 members of the EART from anesthesia, otolaryngology, trauma surgery, emergency medicine,... περισσότερα »
The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes
The effect of iodine supplementation in pregnancy on early childhood neurodevelopment and clinical outcomes: results of an aborted randomised placebo-controlled trial: Background: Concern that mild iodine deficiency in pregnancy may adversely affect neurodevelopment of offspring has led to recommendations for iodine supplementation in the absence of evidence from randomised controlled trials. The primary objective of the study was to investigate the effect of iodine supplementation during pregnancy on childhood neurodevelopment. Secondary outcomes included pregnancy outcomes, materna... περισσότερα »
Otological complications associated with hyperbaric oxygen therapy
Otological complications associated with hyperbaric oxygen therapy: AbstractThe objective of the present study was to clarify the features of otological complications for hyperbaric oxygen therapy (HBOT) and the risk factors for these complications. We enrolled 1115 patients (776 males and 339 females; age 5–89 years) who underwent HBOT. All otological symptoms experienced during HBOT sessions were evaluated, and risk factors were analysed using multivariate logistic regression analysis. Otoscopic findings and interventions for otological complications were assessed in 58 symptomat... περισσότερα »
Endoscopic Endonasal Repair of Sphenoid Sinus Cerebrospinal Fluid Leaks: Our Experience
Endoscopic Endonasal Repair of Sphenoid Sinus Cerebrospinal Fluid Leaks: Our Experience: AbstractEndoscopic endonasal approaches are becoming increasingly popular over transcranial approaches for repair of cerebrospinal leak defects. Sphenoid sinus CSF leaks pose a significant challenge and carry the risk of life-threatening intracranial complications. Their management depends upon identifying the leak using imaging techniques followed by intraoperative endoscopic localization. Our experience in the endoscopic endonasal management of sphenoid sinus CSF leaks is reported in this pap... περισσότερα »
Objective assessment of surgical technique in rotation and nasal projection variation
Objective assessment of surgical technique in rotation and nasal projection variation via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 10 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Marina Serrato Coelho Fagundes, Ana Tereza Moreira, Elizabeth Mila Tambara, Sérgio Bernardo Tenório, Rogério de Fraga, Rogerio Hamerschmidt IntroductionIn rhinoplasty, facial esthetic analysis is critical for proper surgical planning. Parameters such as rotation and nasal projection should be routinely evaluated. Few st...περισσότερα »
Electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants
Analysis of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 10 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Fernanda Ferreira Caldas, Carolina Costa Cardoso, Monique Antunes de Souza Chelminski Barreto, Marina Santos Teixeira, Anacléia Melo da Silva Hilgenberg, Lucieny Silva Martins Serra, Fayez Bahmad IntroductionThe cochlear implant device has the capacity to measure the electrically evoked compound action potential of the auditory nerve. The neural response telemetry is used in order to measure ... περισσότερα »
The Effect of Aging and the High-Frequency Auditory Threshold on Speech-Evoked Mismatch Negativity in a Noisy Background
The Effect of Aging and the High-Frequency Auditory Threshold on Speech-Evoked Mismatch Negativity in a Noisy Background: Mismatch negativity (MMN) has been widely used to study the function of central auditory processing in the elderly. However, current research has not yet considered the effect of noise and high-frequency hearing threshold on MMN in the elderly. The aim of this study was to evaluate the effect of aging and high-frequency hearing loss on speech-related MMN in noisy backgrounds. Additionally, the possible mechanisms of central auditory processing dysfunction in the ...περισσότερα »
Auditory streaming of tones of uncertain frequency, level, and duration
Auditory streaming of tones of uncertain frequency, level, and duration: Stimulus uncertainty is known to critically affect auditory masking, but its influence on auditory streaming has been largely ignored. Standard ABA-ABA tonesequences were made increasingly uncertain by increasing the sigma of normal distributions from which the frequency, level, or duration of tones were randomly drawn. Consistent with predictions based on a model of masking by Lutfi, Gilbertson, Chang, and Stamas [J. Acoust. Soc. Am. 134, 2160–2170 (2013)], the frequency difference for which A and B tones for... περισσότερα »
Sequential streaming, binaural cues and lateralization
Sequential streaming, binaural cues and lateralization: Interaural time differences(ITDs) and interaural level differences (ILDs) associated with monaural spectral differences (coloration) enable the localization of sound sources. The influence of these spatial cues as well as their relative importance on obligatory stream segregation were assessed in experiment 1. A temporal discrimination task favored by integration was used to measure obligatory stream segregation for sequences of speech-shaped noises.Binaural and monaural differences associated with different spatial positions ... περισσότερα »
Auditory streaming of tones of uncertain frequency, level, and duration
Auditory streaming of tones of uncertain frequency, level, and duration: Stimulus uncertainty is known to critically affect auditory masking, but its influence on auditory streaming has been largely ignored. Standard ABA-ABA tonesequences were made increasingly uncertain by increasing the sigma of normal distributions from which the frequency, level, or duration of tones were randomly drawn. Consistent with predictions based on a model of masking by Lutfi, Gilbertson, Chang, and Stamas [J. Acoust. Soc. Am. 134, 2160–2170 (2013)], the frequency difference for which A and B tones for... περισσότερα »
Sensitivity of CHIRP auditory brainstem response and auditory steady state response for detecting normal hearing in children
Sensitivity of CHIRP auditory brainstem response and auditory steady state response for detecting normal hearing in children: *Haider W Alsarhan* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):59-63 Background In recent years, great development of electrophysiological procedures for detection of hearing level in infants and children has been achieved - click auditory brainstem response (ABR), tone burst ABR, and notched noise ABR. The two most recent methods are CHIRP signal ABR and auditory steady state response (ASSR). Aim of the study The aim of this study was to... περισσότερα »
Neuroplastic changes in musician's brain
Neuroplastic changes in musician's brain: A review: *Himanshu Kumar Sanju* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):43-44 Neuroplasticity refers to any change or modification in the central nervous system because of any adaptation or experience to environmental demands. Musical training and experience can lead to neuroplasticity because music requires cognitive and neural challenges that need accurate and precise timing of many actions, exact interval control of pitch not involved in language, and various different way of producing sound. It was also reported... περισσότερα »
Universal newborn hearing screening
Results of the first universal newborn hearing screening in Algeria: *Farid Boudjenah, Mokhtar Hasbellaoui, Omar Zemirli* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):54-58 Introduction Hearing loss is the most common congenital pathology at birth. Its prevalence increases during the infant period, especially in children at risk. The application of hearing screening in three stages with follow-up of children at risk of developing hearing loss allows to optimize the screening. Goals The aim of this study was to evaluate the prevalence of hearing loss in the neonat... περισσότερα »
Noise in the passenger cars of high-speed trains
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Noise in the passenger cars of high-speed trains: The aim of this study is to investigate the effects of both room acoustic conditions and spectralcharacteristics of noises on acoustic discomfort in a high-speed train's passenger car. Measurement of interior noises in a high-speed train was performed when the train was operating at speeds of 100 km/h and 300 km/h. Acoustic discomfort caused by interior noises was evaluated by paired comparison methods based on the variation of reverberation time (RT) in a passenger car and the spectral differences in interior noises. The effect of ... περισσότερα »
Vestibular evoked myogenic potentials and video head impulse tests in different stages of Meniere's disease
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Vestibular evoked myogenic potentials and video head impulse tests in different stages of Meniere's disease: *Doaa M Elmoazen, Ossama A Sobhy, Fathy Abd Elbaky* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):45-53 Introduction Meniere's disease (MD) is characterized by intermittent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural pressure. Histopathologically, endolymphatic hydrops is seen initially in the cochlear duct and the saccule; with the progression of the disease, subsequent affection of the utricle and semicircular canals (... περισσότερα »
Batteries, Vol. 1, Pages 74-90: Structure, Hydrogen Storage, and Electrochemical Properties of Body-Centered-Cubic Ti40V30Cr15Mn13X2 Alloys (X = B, Si, Mn, Ni, Zr, Nb, Mo, and La)
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Structure, gaseous phase hydrogen storage, and electrochemical properties of a series of TiVCrMn-based body-centered-cubic (BCC) alloys with different partial substitutions for Mn with covalent elements (B and Si), transition metals (Ni, Zr, Nb, and Mo), and rare earth element (La) were investigated. Although the influences from substitutions on structure and gaseous phase storage properties were minor, influences on electrochemical discharge capacity were significant. The first cycle capacity ranged from 16 mAh·g−1 (Si-substituted) to 247 mAh·g−1 (Mo-substituted). Severe alloy pa... περισσότερα »
Foods, Vol. 4, Pages 698-701: Dietary Carotenoids and the Nervous System
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
This issue of Foods is focused on the general topic of carotenoids within the nervous system. The focus is on the effects of the xanthophylls on the central nervous system (CNS), reflecting the majority of work in this area. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1HWnnUG via IFTTT
JFMK, Vol. 1, Pages 30-38: Changes in Foot Shape after Long-Distance Running
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Changes in foot shape during long-distance running may lead to alteration in shoe fit. However, little information is available on changes in foot shape following long-distance running. The purpose of this study was to assess changes in foot shape in experienced runners after a single long-distance run. Data from the right feet of 21 subjects were obtained using a foot scanner before and after running 35 km on an asphalt road. After the run, the dorsal height, navicular height, and arch height ratio were significantly decreased. Midfoot cross-sectional shape after the run was defo... περισσότερα »
Chemosensors, Vol. 3, Pages 274-283: Electrochemical Sensors for the Estimation of the Inhibitory Effect of Phenylcarbamates to Cholinesterase
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
The inhibitory effect of nine phenylcarbamates with various substituents was studied. For this purpose, electrochemical sensors were applied under two different conditions: if an enzyme was present in the solution or if the enzyme was immobilized onto the electrode surface. In both cases, 3-[(ethoxycarbonyl)amino]phenyl (4-chloro-phenyl)carbamate was found as the most effective inhibitor for butyrylcholinesterase. The best inhibitors for acetylcholinesterase were determined as well, depending on the used method. Thus, 3‑[(butoxycarbonyl)-amino]phenyl phenylcarbamate with the enzyme...περισσότερα »
Molecules, Vol. 20, Pages 22128-22136: Limonin, a Component of Dictamni Radicis Cortex, Inhibits Eugenol-Induced Calcium and cAMP Levels and PKA/CREB Signaling Pathway in Non-Neuronal 3T3-L1 Cells
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Limonin, one of the major components in dictamni radicis cortex (DRC), has been shown to play various biological roles in cancer, inflammation, and obesity in many different cell types and tissues. Recently, the odorant-induced signal transduction pathway (OST) has gained attention not only because of its function in the perception of smell but also because of its numerous physiological functions in non-neuronal cells. However, little is known about the effects of limonin and DRC on the OST pathway in non-neuronal cells. We investigated odorant-stimulated increases in Ca2+ and cAM...περισσότερα »
Pharmacotherapy of vestibular disorders
Pharmacotherapy of vestibular disorders: *Hesham Mahmoud Samy* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):39-42 Dizziness and vertigo are symptoms directly related to dysfunction of the vestibular system. Imbalance is the most common complaint, especially in the elderly population, which results in falls and mobility restriction. There is no common drug for the management of balance disorders. Medications should be prescribed carefully, and according to clear diagnosis. The pharmacotherapy of vertigo can be optimized with detailed knowledge of the drugs effecti... περισσότερα »
Trends in the Use of Regional Anesthesia: Neuraxial and Peripheral Nerve Blocks.
*Trends in the Use of Regional Anesthesia: Neuraxial and Peripheral Nerve Blocks.* Reg Anesth Pain Med. 2015 Dec 8; Authors: Cozowicz C, Poeran J, Zubizarreta N, Mazumdar M, Memtsoudis SG Abstract BACKGROUND: A growing body of evidence indicates that the use of regional anesthesia offers advantages over general anesthesia, not only in terms of reducing complications but also regarding resource utilization and patient satisfaction. Because of the paucity of data on the nationwide adoption of regional anesthesia techniques, we aimed to elucidate trends in the use of neuraxial anes...περισσότερα »
Efficacy and Safety of Methylnaltrexone for Opioid-Induced Constipation in Patients With Chronic Noncancer Pain: A Placebo Crossover Analysis.
*Efficacy and Safety of Methylnaltrexone for Opioid-Induced Constipation in Patients With Chronic Noncancer Pain: A Placebo Crossover Analysis.* Reg Anesth Pain Med. 2015 Dec 8; Authors: Viscusi ER, Barrett AC, Paterson C, Forbes WP Abstract BACKGROUND AND OBJECTIVES: In patients with chronic noncancer pain, subcutaneous methylnaltrexone for opioid-induced constipation (OIC) was examined in a randomized controlled trial (RCT) followed by an open-label extension (OLE). This study examined the reproducibility of RCT findings by analyzing data from placebo-treated patients who cross... περισσότερα »
Comparison of Needle Path, Anesthetic Dispersion, and Quality of Anesthesia in Retrobulbar and Peribulbar Blocks.
*Comparison of Needle Path, Anesthetic Dispersion, and Quality of Anesthesia in Retrobulbar and Peribulbar Blocks.* Reg Anesth Pain Med. 2015 Dec 8; Authors: Carneiro HM, Teixeira KI, Ávila MP, Limongi RM, Magacho L Abstract BACKGROUND AND OBJECTIVES: To compare the needle path during retrobulbar ophthalmic block with that during peribulbar ophthalmic block, its relation with anesthetic spread, and the quality of the anesthesia. METHODS: This is a prospective comparative study in selected candidates of ophthalmic blocks for phacoemulsification. The procedure used a 22-gauge 1 nee... περισσότερα »
Serum Triamcinolone Levels Following Interlaminar Epidural Injection.
*Serum Triamcinolone Levels Following Interlaminar Epidural Injection.* Reg Anesth Pain Med. 2015 Dec 8; Authors: Hooten WM, Nicholson WT, Gazelka HM, Reid JM, Moeschler SM, Lamer TJ Abstract BACKGROUND: Lumbar interlaminar epidural steroid injections (ESIs) are one of the most commonly performed procedures in pain medicine, but little is known about the serum levels of steroids following injection into the epidural space. The primary objective of this study was to investigate the pharmacokinetics of fluoroscopy-guided epidural-administered triamcinolone acetonide in a cohort of...περισσότερα »
A Clinical Comparison of Intravenous and Epidural Local Anesthetic for Major Abdominal Surgery.
*A Clinical Comparison of Intravenous and Epidural Local Anesthetic for Major Abdominal Surgery.* Reg Anesth Pain Med. 2015 Dec 8; Authors: Terkawi AS, Tsang S, Kazemi A, Morton S, Luo R, Sanders DT, Regali LA, Columbano H, Kurtzeborn NY, Durieux ME Abstract BACKGROUND: Epidural analgesia provides good pain control after many postoperative procedures, but it can lead to complications, has some contraindications, and occasionally fails. Intravenous lidocaine infusion has been suggested as an alternative. We assessed, in our clinical practice, the effects of perioperative intraven...περισσότερα »
Regional Versus General Anesthesia and the Incidence of Unplanned Health Care Resource Utilization for Postoperative Pain After Wrist Fracture Surgery: Results From a Retrospective Quality Improvement Project.
*Regional Versus General Anesthesia and the Incidence of Unplanned Health Care Resource Utilization for Postoperative Pain After Wrist Fracture Surgery: Results From a Retrospective Quality Improvement Project.* Reg Anesth Pain Med. 2015 Dec 8; Authors: Sunderland S, Yarnold CH, Head SJ, Osborn JA, Purssell A, Peel JK, Schwarz SK Abstract BACKGROUND AND OBJECTIVES: The establishment at our center of a dedicated regional anesthesia service in 2008-2009 has resulted in a marked increase in single-shot brachial plexus blocks (sBPBs) for ambulatory wrist fracture surgery. Despite th... περισσότερα »
Protein Geranylgeranyltransferase Type 1 as a Target in Cancer.
*Protein Geranylgeranyltransferase Type 1 as a Target in Cancer.* Curr Cancer Drug Targets. 2015 Dec 3; Authors: Ullah N, Mansha M, Casey PJ Abstract The process of protein prenylation involves the covalent linkage of either farnesyl (15-carbon) or geranylgeranyl (20-carbon) isoprenoid lipds to conserved cysteine residues in the carboxyl-terminus of proteins. Protein geranylgeranyltransferase I (GGTase-I) is the enzyme that catalyzes the addition of the geranylgeranyl moiety from geranylgeranyl pyrophosphate to the target protein, which contains a C-terminal consensus sequence te... περισσότερα »
Novel Synthetic Lethality Approaches for Drug Combinations and Early Drug Development.
*Novel Synthetic Lethality Approaches for Drug Combinations and Early Drug Development.* Curr Cancer Drug Targets. 2015 Dec 3; Authors: Ocana A, Pandiella A Abstract Preclinical evaluation of drug combinations is challenging. In this mini-review we discuss the concept of synthetic lethality and how this can impact on the evaluation of drug combinations and its clinical development. We will also review novel combinations with immunologic agents and the concept of collateral lethality. We suggest that identification of synthetic lethality interactions including collateral lethalit... περισσότερα »
Absence of germline CDKN2A mutation in Sicilian Patients with Familial Malignant Melanoma: could it be a population-specific genetic signature?
*Absence of germline CDKN2A mutation in Sicilian Patients with Familial Malignant Melanoma: could it be a population-specific genetic signature?* Cancer Biol Ther. 2015 Dec 9;:0 Authors: Di Lorenzo S, Fanale D, Corradino B, Calo V, Rinaldi G, Bazan V, Giordano A, Cordova A, Russo A Abstract Germline CDKN2A mutations have been described in 25% to 40% of melanoma families from several countries. Sicilian population is genetically different from the people of Europe and Northern Italy because of its historical background, therefore familial melanoma could be due to genes different ...περισσότερα »
Poly (ADP) Ribose Polymerase Inhibition: A Potential Treatment of Malignant Peripheral Nerve Sheath Tumor.
*Poly (ADP) Ribose Polymerase Inhibition: A Potential Treatment of Malignant Peripheral Nerve Sheath Tumor.* Cancer Biol Ther. 2015 Dec 9;:0 Authors: Kivlin CM, Watson KL, Al Sannaa GA, Belousov R, Ingram DR, Huang KL, May CD, Bolshakov S, Landers SM, Kalam AA, Slopis JM, McCutcheon IE, Pollock RE, Lev D, Lazar AJ, Torres KE Abstract Poly (ADP) ribose polymerase (PARP) inhibitors, first evaluated nearly a decade ago, are primarily used in malignancies with known defects in DNA repair genes, such as alterations in breast cancer, early onset 1/2 (BRCA1/2). While no specific mutati... περισσότερα »
Climate, Vol. 3, Pages 1035-1056: Processes Prior and during the Early 18th Century Irish Famines—Weather Extremes and Migration
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
This paper advances the current debates on famine and famine history, with a focus on the first half of the 18th century in Ireland. Ireland was often hit by severe famines and two of them, specifically the famines of 1728–1729 and 1740–1741, are at the center of this article. The analysis of those famines will show the relevance of weather extremes as one driver in the functional chain of famines. Analyzing the linkage between weather extremes and social, political and economic vulnerabilities of the society further enhances the debate on past famines. Additionally, this paper fo... περισσότερα »
Horticulturae, Vol. 1, Pages 44-54: Comparative Leaf Phenology of White Oak and Northern Red Oak
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
In the landscape, loss of interveinal tissue in developing leaves (leaf tatters) is common for white oak (Quercus alba L.), but not northern red oak (Quercus rubra L.). Previous research identified the cause of leaf tatters, as exposure of unfolding leaves, to low concentrations of chloroacetanilide herbicides. Both white oak and northern red oak were injured by these herbicides at the leaf unfolding stage. Reports from landowners suggest white oak is injured more often than red oak, leading us to theorize that white and northern red oak leaves emerge at different times, and white... περισσότερα »
JoF, Vol. 1, Pages 397-421: Masking the Pathogen: Evolutionary Strategies of Fungi and Their Bacterial Counterparts
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Pathogens reduce immune recognition of their cell surfaces using a variety of inert structural polysaccharides. For example, capsular polysaccharides play critical roles in microbial survival strategies. Capsules are widely distributed among bacterial species, but relatively rare in eukaryotic microorganisms, where they have evolved considerable complexity in structure and regulation and are exemplified by that of the HIV/AIDS-related fungus Cryptococcus neoformans. Endemic fungi that affect normal hosts such as Histoplasma capsulatum and Blastomyces dermatitidis have also evolved... περισσότερα »
JCM, Vol. 4, Pages 1998: Correction: Ripamonti, C.; Trippa, F.; Barone, G.; Maranzano, E. Prevention and Treatment of Bone Metastases in Breast Cancer. J. Clin. Med. 2013, 2, 151–175
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
The authors wish to make the following corrections to this paper [1]: The authors' names: [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1jQ5cnT via IFTTT
Catalysts, Vol. 5, Pages 2122-2133: Selective Production of Aromatics from 2-Octanol on Zinc Ion-Exchanged MFI Zeolite Catalysts
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
The aromatization of 2-octanol derived from castor oil as a byproduct in the formation of sebacic acid was investigated on various zeolite catalysts. Zn ion-exchanged MFI (ZSM-5) zeolites with small silica/alumina ratios and zinc contents of 0.5 to 2.0 wt. % were determined to exhibit good and stable activity for the reaction at 623 to 823 K. The yield of aromatics was 62% at 773 K and the space velocity 350 to 1400 h−1. The temperature and contact time dependences of the product distributions indicated the reaction pathways of 2-octanol→dehydration to 2-octene→decomposition to C5... περισσότερα »
IJFS, Vol. 3, Pages 557-586: Do Markets Cointegrate after Financial Crises? Evidence from G-20 Stock Markets
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
The results of the single-equation cointegration tests indicate that patterns of cointegration in the two main and four sub-periods are not homogeneous. Two key findings emerge from the study. First, fewer stock markets cointegrated with S&P 500 during the crisis period than they did during the pre-crisis. In other words, as the 2008 financial crisis deepened, S&P 500 and G-20 stock indices moved towards less cointegration. The decreasing number of cointegrating relationships implies that the U.S. stock markets and other G-20 markets have experienced different driving forces since...περισσότερα »
Nanomaterials, Vol. 5, Pages 2212-2230: Structural and Morphological Tuning of LiCoPO4 Materials Synthesized by Solvo-Thermal Methods for Li-Cell Applications
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Olivine-type lithium metal phosphates (LiMPO4) are promising cathode materials for lithium-ion batteries. LiFePO4 (LFP) is commonly used in commercial Li-ion cells but the Fe3+/Fe2+ couple can be usefully substituted with Mn3+/Mn2+, Co3+/Co2+, or Ni3+/Ni2+, in order to obtain higher redox potentials. In this communication we report a systematic analysis of the synthesis condition of LiCoPO4 (LCP) using a solvo-thermal route at low temperature, the latter being a valuable candidate to overcome the theoretical performances of LFP. In fact, LCP shows higher working potential (4.8 V v...περισσότερα »
Molecules, Vol. 20, Pages 22069-22083: Synthesis and Regioselective Reaction of Some Unsymmetrical Heterocyclic Chalcone Derivatives and Spiro Heterocyclic Compounds as Antibacterial Agents
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
A number of novel heterocyclic chalcone derivatives can be synthesized by thermal and microwave tools. Treatment of 4-(4-Acetylamino- and/or 4-bromo-phenyl)-4-oxobut-2-enoic acids with hydrogen peroxide in alkaline medium were afforded oxirane derivatives 2. Reaction of the epoxide 2 with 2-amino-5-aryl-1,3,4-thiadiazole derivatives yielded chalcone of imidazo[2,1-b]thiadiazole derivative 4 via two thermal routes. In one pot reaction of 4-bromoacetophenone, diethyloxalate, and 2-amino-5-aryl-1,3,4-thiadiazole derivatives in MW irradiation (W 250 and T 150 °C) under eco-friendly co... περισσότερα »
Efficiently detecting outlying behavior in video-game players
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
In this paper, we propose a method for automatically detecting the times during which game players exhibit specific behavior, such as when players commonly show excitement, concentration, immersion, and surprise. The proposed method detects such outlying behavior based on the game players' characteristics. These characteristics are captured non-invasively in a general game environment. In this paper, cameras were used to analyze observed data such as facial expressions and player movements. Moreover, multimodal data from the game players (i.e., data regarding adjustments to the vo... περισσότερα »
Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Proper glycemic control is one of the most important goals in perioperative patient management. Insulin secretion from pancreatic β-cells in response to an increased blood glucose concentration plays the most critical role in glycemic control. Several animal and human studies have indicated that volatile anesthetics impair glucose-stimulated insulin secretion (GSIS). A convincing GSIS model has been established, in which the activity of ATP-dependent potassium channels (KATP) under the control of intracellular ATP plays a critical role. We previously reported that pimonidazole addu... περισσότερα »
Metagenomic and satellite analyses of red snow in the Russian Arctic
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Cryophilic algae thrive in liquid water within snow and ice in alpine and polar regions worldwide. Blooms of these algae lower albedo (reflection of sunlight), thereby altering melting patterns (Kohshima, Seko & Yoshimura, 1993; Lutz et al., 2014; Thomas & Duval, 1995). Here metagenomic DNA analysis and satellite imaging were used to investigate red snow in Franz Josef Land in the Russian Arctic. Franz Josef Land red snow metagenomes confirmed that the communities are composed of the autotroph Chlamydomonas nivalis that is supporting a complex viral and heterotrophic bacterial com...περισσότερα »
Drug delivery systems for ovarian cancer treatment: a systematic review and meta-analysis of animal studies
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Current ovarian cancer treatment involves chemotherapy that has serious limitations, such as rapid clearance, unfavorable biodistribution and severe side effects. To overcome these limitations, drug delivery systems (DDS) have been developed to encapsulate chemotherapeutics for delivery to tumor cells. However, no systematic assessment of the efficacy of chemotherapy by DDS compared to free chemotherapy (not in a DDS) has been performed for animal studies. Here, we assess the efficacy of chemotherapy in DDS on survival and tumor growth inhibition in animal studies. We searched Pub...περισσότερα »
Results of the first universal newborn hearing screening in Algeria
*Farid Boudjenah, Mokhtar Hasbellaoui, Omar Zemirli* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):54-58 Introduction Hearing loss is the most common congenital pathology at birth. Its prevalence increases during the infant period, especially in children at risk. The application of hearing screening in three stages with follow-up of children at risk of developing hearing loss allows to optimize the screening. Goals The aim of this study was to evaluate the prevalence of hearing loss in the neonatal population and identify newborns at risk and to investigate the best w... περισσότερα »
Neuroplastic changes in musician's brain: A review
*Himanshu Kumar Sanju* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):43-44 Neuroplasticity refers to any change or modification in the central nervous system because of any adaptation or experience to environmental demands. Musical training and experience can lead to neuroplasticity because music requires cognitive and neural challenges that need accurate and precise timing of many actions, exact interval control of pitch not involved in language, and various different way of producing sound. It was also reported that a musician's brain is best to study neuroplastic c...περισσότερα »
Pharmacotherapy of vestibular disorders
*Hesham Mahmoud Samy* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):39-42 Dizziness and vertigo are symptoms directly related to dysfunction of the vestibular system. Imbalance is the most common complaint, especially in the elderly population, which results in falls and mobility restriction. There is no common drug for the management of balance disorders. Medications should be prescribed carefully, and according to clear diagnosis. The pharmacotherapy of vertigo can be optimized with detailed knowledge of the drugs effective in vertigo, as well as their side effects....περισσότερα »
Vestibular evoked myogenic potentials and video head impulse tests in different stages of Meniere's disease
*Doaa M Elmoazen, Ossama A Sobhy, Fathy Abd Elbaky* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):45-53 Introduction Meniere's disease (MD) is characterized by intermittent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural pressure. Histopathologically, endolymphatic hydrops is seen initially in the cochlear duct and the saccule; with the progression of the disease, subsequent affection of the utricle and semicircular canals (SCC) occur. Objectives The aim of this study was to assess the function of the saccule, the utricle, and the thre... περισσότερα »
Sensitivity of CHIRP auditory brainstem response and auditory steady state response for detecting normal hearing in children
*Haider W Alsarhan* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):59-63 Background In recent years, great development of electrophysiological procedures for detection of hearing level in infants and children has been achieved - click auditory brainstem response (ABR), tone burst ABR, and notched noise ABR. The two most recent methods are CHIRP signal ABR and auditory steady state response (ASSR). Aim of the study The aim of this study was to identify the best electrophysiological method for detecting normal hearing thresholds. Patients and methods A prospective study ...περισσότερα »
The current state of epilepsy guidelines: A systematic review
Summary Objective The International League Against Epilepsy (ILAE) Epilepsy Guidelines Task Force, composed of 14 international members, was established in 2011 to identify, using systematic review methodology, international epilepsy clinical care guidelines, assess their quality, and determine gaps in areas of need of development. Methods A systematic review of the literature (1985–2014) was performed in six electronic databases (e.g. Medline, Embase) using a broad search strategy without initial limits to language or study design. Six gray literature databases (e.g., American ... περισσότερα »
Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action
Summary Objective Rapid distribution to the brain is a prerequisite for antiepileptic drugs used for treatment of acute seizures. The preclinical studies described here investigated the high-affinity synaptic vesicle glycoprotein 2A (SV2A) antiepileptic drug brivara-cetam (BRV) for its rate of brain penetration and its onset of action. BRV was compared with levetiracetam (LEV). Methods In vitro permeation studies were performed using Caco-2 cells. Plasma and brain levels were measured over time after single oral dosing to audiogenic mice and were correlated with anticonvulsant ac... περισσότερα »
Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE)
Summary Evaluation of behavioral impairment during epileptic seizures is critical for medical decision making, including accurate diagnosis, recommendations for driving, and presurgical evaluation. We investigated the quality of behavioral testing during inpatient video–electroencephalography (EEG) monitoring at an established epilepsy center, and introduce a technical innovation that may improve clinical care. We retrospectively reviewed video-EEG data from 152 seizures in 33 adult or pediatric patients admitted for video-EEG monitoring. Behavioral testing with questions or comman... περισσότερα »
Epilepsy, seizures, physical exercise, and sports: A report from the ILAE Task Force on Sports and Epilepsy
Summary People with epilepsy (PWEs) are often advised against participating in sports and exercise, mostly because of fear, overprotection, and ignorance about the specific benefits and risks associated with such activities. Available evidence suggests that physical exercise and active participation in sports may favorably affect seizure control, in addition to producing broader health and psychosocial benefits. This consensus paper prepared by the International League Against Epilepsy (ILAE) Task Force on Sports and Epilepsy offers general guidance concerning participation of PWEs...περισσότερα »
Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy
Abstract Objective Myotonic dystrophy type 1 (DM1) is caused by the expansion of a CTG repeat in the 3′ untranslated region of *DMPK*. The transcripts containing an expanded CUG repeat (CUGexp) result in a toxic gain-of-function by forming ribonuclear foci that sequester the alternative splicing factor muscleblind-like 1 (MBNL1). Although several small molecules reportedly ameliorate RNA toxicity, none are ready for clinical use because of the lack of safety data. Here, we undertook a drug-repositioning screen to identify a safe and effective small molecule for upcoming clinical t... περισσότερα »
Effect of sustained release of rhBMP-2 from dried and wet hyaluronic acid hydrogel carriers compared with direct dip coating of rhBMP-2 on peri-implant osteogenesis of dental implants in canine mandibles
Publication date: Available online 10 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Hui Pan, Jeong Joon Han, Yong-Doo Park, Tae Hyung Cho, Soon Jung Hwang Hyaluronic acid (HA) hydrogel has been used as a carrier of recombinant human bone morphogenetic protein (rhBMP)-2 for sustained delivery. To enhance peri-implant osteogenesis, a dried coating of rhBMP-2 HA hydrogel (BMP-HAH) on dental implants was designed; this approach provides the advantage of omitting in situ preparation of wet HA hydrogel. Sustained release of rhBMP-2 was more efficient for dried ... περισσότερα »
Etiology and injury patterns of maxillofacial fractures from the years 2010 to 2013 in Mecklenburg-Western Pomerania, Germany: A retrospective study of 409 patients
Publication date: December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery, Volume 43, Issue 10 Author(s): Daniel Schneider, Peer W. Kämmerer, Gerhard Schön, Christian Dinu, Sarah Radloff, Reinhard Bschorer ObjectiveThe aim of the present study was to illustrate the injury patterns and the etiology of accident victims with maxillofacial fractures in the state of Mecklenburg-Western Pomerania (M-P), Germany.Material and methodsBetween 2010 and 2013, patients with maxillofacial fractures from the Department of Oral and Maxillofacial Surgery at the Helios Kliniken Schwerin, were ...περισσότερα »
Predictability in orbital reconstruction. A human cadaver study, part III: Implant-oriented navigation for optimized reconstruction
Publication date: December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery, Volume 43, Issue 10 Author(s): Leander Dubois, Harald Essig, Ruud Schreurs, Jesper Jansen, Thomas J.J. Maal, Peter J.J. Gooris, Alfred G. Becking Navigation-assisted orbital reconstruction remains a challenge, because the surgeon focuses on a two-dimensional multiplanar view in relation to the preoperative planning. This study explored the addition of navigation markers in the implant design for three-dimensional (3D) orientation of the actual implant position relative to the preoperative planning for m... περισσότερα »
Author Index: Volume 43
Publication date: December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery, Volume 43, Issue 10 from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1M4BCkW via IFTTT
[The very severe sensorineural deafness patients caused by rubella virus infection: two cases report].
*[The very severe sensorineural deafness patients caused by rubella virus infection: two cases report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1567-8 Authors: Ma J, Wan L, Xu F Abstract To explore the audiological features in children who were sever sensorineural hearing loss infected with rubella virus. There were two cases of rubella virus infection in children who were deaf, they conducted the distortion product otoacoustic emission, ABR and auditory steady-state evoked response (ASSR) examination, then analyzed the results comprehensively. Two patie... περισσότερα »
[Atypical carcinoid of larynx: a case report].
*[Atypical carcinoid of larynx: a case report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1565-7 Authors: Gu W, Wang X, Shi J Abstract An 70-year-old male come for swallowing pain 5 years, turning worse 10 months. Laryngoscopy showed a tumor with rough surface at the laryngeal surface of epiglottic. Outpatient pathology: poorly differentiated carcinoma of the larynx. CT: the root of epiglottic is slightly thickened. He accepted the partial laryngectomy, tracheotomy, bilateral functional neck dissection. Pathology: atypical carcinoid of larynx. PMID: 266475... περισσότερα »
[Two nasal endoscopic nasal septum diorthosis tamping observation].
*[Two nasal endoscopic nasal septum diorthosis tamping observation].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1563-4 Authors: Mao Y, Yang J PMID: 26647546 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1OT92ta via IFTTT
[Multi-function electric ion fenestration combined with anisodamine and other drugs in the treatment of pseudocyst of auricle].
*[Multi-function electric ion fenestration combined with anisodamine and other drugs in the treatment of pseudocyst of auricle].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1561-2 Authors: Wu Y, Yan P, Cui L PMID: 26647545 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1NOG2h7 via IFTTT
[The experimental study on repair of noise-induced hearing loss in guinea pigs by bone marrow NTCSCs transplantation].
*[The experimental study on repair of noise-induced hearing loss in guinea pigs by bone marrow NTCSCs transplantation].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1556-60 Authors: Zhang Y, Liang G, Liu L, Lu L, Liu J Abstract OBJECTIVE: To observe the repairing effects of bone marrow transplantation with nerve tissue committed stem cell (NTCSCs) on experimental rats with injury of noise-induced hearing loss. METHOD: Guinea pigs were randomly divided into control group, noise exposure group and the transplanting group. A week after white noise exposure of 110... περισσότερα »
[Analysis of the characteristic of pharyngeal paraesthesia patients by high resolution manometry].
*[Analysis of the characteristic of pharyngeal paraesthesia patients by high resolution manometry].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1553-5 Authors: Gu Y, Qian W Abstract OBJECTIVE: To discuss the pressure changing characteristics of upper esophageal sphincter (UES), lower esophageal sphincter (LES) and the esophagus kinetic characteristics of pharyngeal paraesthesia patients. METHOD: To take high resolution manometry in 44 cases of pharyngeal paraesthesia patients and 23 normal subjects separately. According to the RSI score,the 44 patients were d... περισσότερα »
[Subtype analysis and clinical significance of HPV infection in laryngeal squamous cell carcinoma and precancerous lesions].
*[Subtype analysis and clinical significance of HPV infection in laryngeal squamous cell carcinoma and precancerous lesions].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1549-52 Authors: Guan L, Sun N, Sun G, Fang Q, Meng Y, Zhao X, Meng L Abstract OBJECTIVE: To investigate the correlation of laryngeal squamous cell carcinoma (LSCC) and precancerous lesion with HPV infection subtypes and possible clinical relationship. METHOD: Eighty-three cases in paraffin embedded tissues were detected with thirty seven HPV subtypes by flow-through hybridization and gene chi... περισσότερα »
[Expressions and correlations of Survivin, Ki67 and p53 in laryngeal squmous cell carcinoma].
*[Expressions and correlations of Survivin, Ki67 and p53 in laryngeal squmous cell carcinoma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1545-8 Authors: Wang J, Yang B, Pei S, Wang X, Zhang Q, Qu F, Zhang H Abstract OBJECTIVE: To investigate the expression of Survivin, p53 and Ki67 in laryngeal carcinoma and the relation with clinical data. METHOD: Immunohistochemical staining (SP) was used to detect expression of Survivin, p53 and Ki67 of 64 cases with laryngeal carcinoma, 26 cases with precancerosis, 34 cases with vocal polyps. RESULT: The positive express...περισσότερα »
[Psychiatric disorders in pharyngitis patients and its associated factor analysis].
*[Psychiatric disorders in pharyngitis patients and its associated factor analysis].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1541-4 Authors: Huang H, He H, Wu X Abstract OBJECTIVE: To investigate the characteristics of psychiatric comorbidity in pharyngitis patients. METHOD: The psychological investigation and evaluation were done in 100 pharyngitis patients by using self-reporting inventory 90 (SCL-90). All the results were compared with healthy Chinese population, including factors of gender, age, course of disease and education level, using rank-sum te... περισσότερα »
[Lexical tone perception in sensorineural hearing-impaired and auditory neuropathy spectrum disorder].
*[Lexical tone perception in sensorineural hearing-impaired and auditory neuropathy spectrum disorder].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Sep;29(17):1537-40 Authors: Wang S, Dong R, Wang Y, Liu D, Chen J, Wu Y Abstract OBJECTIVE: This study was aimed at investigating the ability of lexical tone perception in listeners with sensorineural hearing impairment and auditory. neuropathy spectrum disorder. METHOD: Three groups of subjects were recruited in this study, including 11 subjects with normal hearing, 14 subjects with sensorineural hearing impairment, and 25 ... περισσότερα »
Advanced Arab Academy of Audio-Vestibulogy Journal
Pharmacotherapy of vestibular disorders *Hesham Mahmoud Samy* Advanced Arab Academy of Audio-Vestibulogy Journal 2015 2(2):39-42 Dizziness and vertigo are symptoms directly related to dysfunction of the vestibular system. Imbalance is the most common complaint, especially in the elderly population, which results in falls and mobility restriction. There is no common drug for the management of balance disorders. Medications should be prescribed carefully, and according to clear diagnosis. The pharmacotherapy of vertigo can be optimized with detailed knowledge of the drugs effective in... περισσότερα »
HPV and oropharyngeal cancer: etiology and prognostic importance.
*HPV and oropharyngeal cancer: etiology and prognostic importance.* Semin Cutan Med Surg. 2015 Dec;34(4):178-181 Authors: Yom SS Abstract HPV is the most common sexually transmitted disease, but the overwhelming majority of individuals clear the infection. A small percentage of individuals develop persistence of oncogenic HPV types, especially HPV-16; and as a result, squamous cell carcinoma can develop in the tonsils and base of the tongue. Over 70% of oropharyngeal cancers are now thought to be associated with oncogenic HPV infection. Immunohistochemistry for p16 protein is of... περισσότερα »
Chronic rhinosinusitis identification in administrative databases and health surveys: A systematic review.
*Chronic rhinosinusitis identification in administrative databases and health surveys: A systematic review.* Laryngoscope. 2015 Dec 9; Authors: Macdonald KI, Kilty SJ, van Walraven C Abstract OBJECTIVES/HYPOTHESIS: Much of the epidemiological data on chronic rhinosinusitis (CRS) are based on large administrative databases and health surveys. The accuracy of CRS identification with these methods is unknown. METHODS: A systematic review was performed to identify studies that measured the accuracy of CRS diagnoses in large administrative databases or within health surveys. The Quali... περισσότερα »
Methionine sulfoxide reductase B3-targeted in utero gene therapy rescues hearing function in a mouse model of congenital sensorineural hearing loss.
*Methionine sulfoxide reductase B3-targeted in utero gene therapy rescues hearing function in a mouse model of congenital sensorineural hearing loss.* Antioxid Redox Signal. 2015 Dec 9; Authors: Kim MA, Cho HJ, Bae SH, Lee B, Oh SK, Kwon TJ, Ryoo ZY, Kim HY, Cho JH, Kim UK, Lee KY Abstract AIMS: Methionine sulfoxide reductase 3 (MsrB3), which stereospecifically repairs methionine-R-sulfoxide, is an important Msr protein that is associated with auditory function in mammals. MsrB3 deficiency leads to profound congenital hearing loss due to the degeneration of stereociliary bundles...περισσότερα »
Response to Colebatch and Rosengren: "Safe Levels of Acoustic Stimulation for Vemps" Comment on "Sudden Bilateral Hearing Loss After Cervical and Ocular Vestibular Evoked Myogenic Potentials".
*Response to Colebatch and Rosengren: "Safe Levels of Acoustic Stimulation for Vemps" Comment on "Sudden Bilateral Hearing Loss After Cervical and Ocular Vestibular Evoked Myogenic Potentials".* Otol Neurotol. 2016 Jan;37(1):118-119 Authors: Mattingly JK, Cass SP, Portnuff CD, Hondorp BM PMID: 26649613 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1jPSrJL via IFTTT
Birth and Evolution of Chiselling and Drilling Techniques for Removing Ear Canal Exostoses.
*Birth and Evolution of Chiselling and Drilling Techniques for Removing Ear Canal Exostoses.* Otol Neurotol. 2016 Jan;37(1):109-114 Authors: Mudry A, Hetzler D Abstract The main surgical techniques used to remove ear canal exostoses are drilling and/or, chiselling. The aim of this study was to identify the origins and subsequent evolution of, the surgical removal of ear canal exostoses in the 19th century. A critical review and, compilation of primary and secondary historical sources was conducted. Two techniques for removal of exostoses were developed in the latter part of the ... περισσότερα »
A Neuromonitoring Approach to Facial Nerve Preservation During Image-guided Robotic Cochlear Implantation.
*A Neuromonitoring Approach to Facial Nerve Preservation During Image-guided Robotic Cochlear Implantation.* Otol Neurotol. 2016 Jan;37(1):89-98 Authors: Ansó J, Dür C, Gavaghan K, Rohrbach H, Gerber N, Williamson T, Calvo EM, Balmer TW, Precht C, Ferrario D, Dettmer MS, Rösler KM, Caversaccio MD, Bell B, Weber S Abstract HYPOTHESIS: A multielectrode probe in combination with an optimized stimulation protocol could provide sufficient sensitivity and specificity to act as an effective safety mechanism for preservation of the facial nerve in case of an unsafe drill distance during...περισσότερα »
Characteristics of Wax Occlusion in the Surgical Repair of Superior Canal Dehiscence in Human Temporal Bone Specimens.
*Characteristics of Wax Occlusion in the Surgical Repair of Superior Canal Dehiscence in Human Temporal Bone Specimens.* Otol Neurotol. 2016 Jan;37(1):83-88 Authors: Cheng YS, Kozin ED, Remenschneider AK, Nakajima HH, Lee DJ Abstract HYPOTHESIS: Superior canal dehiscence (SCD) repair using surgical bone wax may result in variable outcomes if large wax volumes are applied. BACKGROUND: SCD is a disorder characterized by a pathologic defect in the bony labyrinth of the superior semicircular canal (SSC), resulting in vestibular and/or auditory symptoms. Repair of SCD using bone wax ca... περισσότερα »
Lamb Temporal Bone as a Surgical Training Model of Round Window Cochlear Implant Electrode Insertion.
*Lamb Temporal Bone as a Surgical Training Model of Round Window Cochlear Implant Electrode Insertion.* Otol Neurotol. 2016 Jan;37(1):52-56 Authors: Mantokoudis G, Huth ME, Weisstanner C, Friedrich HM, Nauer C, Candreia C, Caversaccio MD, Senn P Abstract OBJECTIVE: The preservation of residual hearing in cochlear implantation opens the door for optimal functional results. This atraumatic surgical technique requires training; however, the traditional human cadaveric temporal bones have become less available or unattainable in some institutions. This study investigates the suitabi... περισσότερα »
Cost-Utility of Bilateral Versus Unilateral Cochlear Implantation in Adults: A Randomized Controlled Trial.
*Cost-Utility of Bilateral Versus Unilateral Cochlear Implantation in Adults: A Randomized Controlled Trial.* Otol Neurotol. 2016 Jan;37(1):38-45 Authors: Smulders YE, van Zon A, Stegeman I, van Zanten GA, Rinia AB, Stokroos RJ, Free RH, Maat B, Frijns JH, Mylanus EA, Huinck WJ, Topsakal V, Grolman W Abstract OBJECTIVE: To study the cost-utility of simultaneous bilateral cochlear implantation (CI) versus unilateral CI. STUDY DESIGN: Randomized controlled trial (RCT). SETTING: Five tertiary referral centers. PATIENTS: Thirty-eight postlingually deafened adults eligible for cochlear...περισσότερα »
Relationship Between Electrode-to-Modiolus Distance and Current Levels for Adults With Cochlear Implants.
*Relationship Between Electrode-to-Modiolus Distance and Current Levels for Adults With Cochlear Implants.* Otol Neurotol. 2016 Jan;37(1):31-37 Authors: Davis TJ, Zhang D, Gifford RH, Dawant BM, Labadie RF, Noble JH Abstract HYPOTHESIS: Electrode-to-modiolus distance is correlated with clinically programmed stimulation levels. BACKGROUND: Conventional wisdom has long supposed a significant relationship between cochlear implant (CI) stimulation levels and electrode-to-modiolus distance; however, to date, no such formal investigation has been completed. Thus, the purpose of this pr... περισσότερα »
A Systematic Review of the Diagnostic Value of CT Imaging in Diagnosing Otosclerosis.
*A Systematic Review of the Diagnostic Value of CT Imaging in Diagnosing Otosclerosis.* Otol Neurotol. 2016 Jan;37(1):9-15 Authors: Wegner I, van Waes AM, Bittermann AJ, Buitinck SH, Dekker CF, Kurk SA, Rados M, Grolman W Abstract OBJECTIVE: To evaluate the diagnostic value of computed tomography (CT) in detecting otosclerosis in patients with conductive hearing loss and a clinical suspicion of otosclerosis. DATA SOURCES: PubMed, Embase, and the Cochrane Library. STUDY SELECTION: A systematic search was conducted. Studies reporting original study data were included. DATA EXTRACTI... περισσότερα »
Salivary detection of human Papilloma virus 16 & 18 in pre-malignant and malignant lesions of oral cavity: Is it feasible in Pakistani context of Socio-Cultural Taboos?
*Salivary detection of human Papilloma virus 16 & 18 in pre-malignant and malignant lesions of oral cavity: Is it feasible in Pakistani context of Socio-Cultural Taboos?* Pak J Med Sci. 2015 Sep-Oct;31(5):1104-1109 Authors: Khyani IA, Qureshi MA, Mirza T, Farooq MU Abstract OBJECTIVE: To evaluate salivary detection of HPV-16 & 18 would be feasible and informative biomarker for oral pre-malignant and malignant lesion in our population. METHODS: This non-interventional, case control study was carried out at department of E.N.T, Head and Neck Surgery, Dow University of Health Scien...περισσότερα »
Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells
Oxygen concentration should be carefully regulated in all living tissues, beginning at the early embryonic stages. Unbalances in oxygen regulation can lead to cell death and disease. However, to date, few studies have investigated the consequences of variations in oxygen levels for fetal-like cells. Therefore, in the present work, human neural progenitor cells (NPCs) derived from pluripotent stem cells grown in 3% oxygen (v/v) were compared with NPCs cultured in 21% (v/v) oxygen. Low oxygen concentrations altered the mitochondrial content and oxidative functions of the cells, which...περισσότερα »
Viruses, Vol. 7, Pages 6526-6536: CDC42 Use in Viral Cell Entry Processes by RNA Viruses
The cellular actin cytoskeleton presents a barrier that must be overcome by many viruses, and it has become increasingly apparent many viral species have developed a diverse repertoire of mechanisms to hijack cellular actin-regulating signalling pathways as part of their cell entry processes. The Rho family GTPase Cdc42 is appreciated as a key moderator of cellular actin dynamics, and the development of specific Cdc42-inhibiting agents has given us an unprecedented ability to investigate its individual role in signalling pathways. However, investigative use of said agents, and the ... περισσότερα »
Risks, Vol. 3, Pages 599-623: Dependence Uncertainty Bounds for the Expectile of a Portfolio
We study upper and lower bounds on the expectile risk measure of risky portfolios when the joint distribution of the risky components is not fully specified. First, we summarize methods for obtaining bounds when only the marginal distributions of the components are known, but not their interdependence (unconstrained bounds). In particular, we provide the best-possible upper bound and the best-possible lower bound (under some conditions), as well as numerical procedures to compute them. We also derive simple analytic bounds that appear adequate in various situations of interest. Se...περισσότερα »
Internet and Audiology: A Review of the First International Meeting.
*Internet and Audiology: A Review of the First International Meeting.* Am J Audiol. 2015 Sep 1;24(3):269-270 Authors: Andersson G, Lunner T, Laplante-Lévesque A, Preminger JE Abstract Purpose: The purpose of this research forum article is to describe the impetus for holding the First International Meeting on Internet and Audiology (October 2014) and to introduce the special research forum that arose from the meeting. Method: The rationale for the First International Meeting on Internet and Audiology is described. This is followed by a short description of the research sections an... περισσότερα »
Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation
Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves has emerged as a potential treatment for patients with severe emphysema. This treatment was previously investigated in the randomized, controlled Endobronchial Valve for Emphysema Palliation Trial (VENT), which showed… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Y4hB50 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OUEqFO via IFTTT
Comprehensive pulmonary rehabilitation in home-based online groups: a mixed method pilot study in COPD
Background: Comprehensive multidisciplinary pulmonary rehabilitation is vital in the management of chronic obstructive pulmonary disease (COPD) and is considered for any stage of the disease. Rehabilitation programmes are often centre-based and organised in groups. However, the distance from the patient's home to the centre and lack of transportation may hinder participation. Rehabilitation at home can improve access to care for patients regardless of disease severity. We had previously studied the technology usability and acceptability of a comprehensive home rehabilitation progr... περισσότερα »
A comparison of fallout 236U and 239Pu uptake by Australian vegetation
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): M.B. Froehlich, M.M.A. Dietze, S.G. Tims, L.K. Fifield The isotopes 236U and 239Pu, both produced during nuclear weapons tests carried out in the 1950s and 1960s, are present in the environment and may be used as tracers for soil erosion studies. Although these radionuclides occur only at ultra-trace levels in nature, they can be readily measured by accelerator mass spectrometry with the 14UD heavy ion accelerator at the Australia...περισσότερα »
The International Conference on Radioecology and Environmental Radioactivity, 2014, (ICRER-2014)
Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Per Strand, Justin Brown from Radiology via ola Kala on Inoreader http://ift.tt/1U6wtzj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NOg0ui via IFTTT
Main results of the 2012 joint Norwegian–Russian expedition to the dumping sites of the nuclear submarine K-27 and solid radioactive waste in Stepovogo Fjord, Novaya Zemlya
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Justin P. Gwynn, Aleksander Nikitin, Viacheslav Shershakov, Hilde Elise Heldal, Bjørn Lind, Hans-Christian Teien, Ole Christian Lind, Rajdeep Singh Sidhu, Gunnar Bakke, Alexey Kazennov, Denis Grishin, Anastasia Fedorova, Oxana Blinova, Ingrid Sværen, Penny Lee Liebig, Brit Salbu, Cato Christian Wendell, Elisabeth Strålberg, Nailja Valetova, Galina Petrenko, Ivan Katrich, Igor Logoyda, Iolanda Osvath, Isabelle Levy, Jean Bartocci,... περισσότερα »
Environmental impact and risk assessments and key factors contributing to the overall uncertainties
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Brit Salbu There is a significant number of nuclear and radiological sources that have contributed, are still contributing, or have the potential to contribute to radioactive contamination of the environment in the future. To protect the environment from radioactive contamination, impact and risk assessments are performed prior to or during a release event, short or long term after deposition or prior and after implementation of c... περισσότερα »
Behavior of accidentally released radiocesium in soil–water environment: Looking at Fukushima from a Chernobyl perspective
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): A. Konoplev, V. Golosov, G. Laptev, K. Nanba, Y. Onda, T. Takase, Y. Wakiyama, K. Yoshimura Quantitative characteristics of dissolved and particulate radiocesium wash-off from contaminated watersheds after the FDNPP accident are calculated based on published monitoring data. Comparative analysis is provided for radiocesium wash-off parameters and distribution coefficients, Kd, between suspended matter and water in rivers and surfa... περισσότερα »
Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.
Related Articles *Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.* Oncotarget. 2015 Dec 4; Authors: Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL, Telomere Group EC, Samani NJ, Wiencke JK, Wrensch MR Abstract Telomere maintenance has emerged as an important molecular feature with impacts on adult glioma susceptibility and prognosis. Whether longer or shorter leuk... περισσότερα »
Review: circulating tumor cells in the practice of breast cancer oncology.
Related Articles *Review: circulating tumor cells in the practice of breast cancer oncology.* Clin Transl Oncol. 2015 Dec 8; Authors: Ramos-Medina R, Moreno F, Lopez-Tarruella S, Del Monte-Millán M, Márquez-Rodas I, Durán E, Jerez Y, Garcia-Saenz JA, Ocaña I, Andrés S, Massarrah T, González-Rivera M, Martin M Abstract The primary cause of tumor-related death in breast cancer is still represented by distant metastasization. The dissemination of tumor cells from the primary tumor to distant sites through bloodstream cannot be early detected by standard imaging methods. Circulating ...περισσότερα »
Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma.
Related Articles *Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma.* Oncotarget. 2015 Dec 5; Authors: Tiedemann RL, Hlady RA, Hanavan PD, Lake DF, Tibes R, Lee JH, Choi JH, Ho TH, Robertson KD Abstract Clear cell renal cell carcinomas (ccRCCs) harbor frequent mutations in epigenetic modifiers including SETD2, the H3K36me3 writer. We profiled DNA methylation (5mC) across the genome in cell line-based models of SETD2 inactivation and SETD2 mutant primary tumors because 5mC has been linked to H3K36me3 and is therapeutically targetable. SETD2 deplet... περισσότερα »
Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori.
Related Articles *Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori.* Mol Ther Nucleic Acids. 2015;4:e269 Authors: Santos RS, Dakwar GR, Xiong R, Forier K, Remaut K, Stremersch S, Guimarães N, Fontenete S, Wengel J, Leite M, Figueiredo C, De Smedt SC, Braeckmans K, Azevedo NF Abstract Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H. pylori ... περισσότερα »
Complementary therapy and survival in glioblastoma.
*Complementary therapy and survival in glioblastoma.* Neurooncol Pract. 2015 Sep;2(3):122-126 Authors: Mulpur BH, Nabors LB, Thompson RC, Olson JJ, LaRocca RV, Thompson Z, Egan KM Abstract BACKGROUND: Complementary therapy (CAM) is common in cancer patients. We undertook this study to assess the association of complementary therapy usage with mortality in glioblastoma (GBM) patients. METHODS: The analysis was based on 470 patients. Information on current use of CAM was collected in structured interviews conducted a median of 6 weeks following GBM diagnosis. Proportional hazards r... περισσότερα »
EACMFS Prizes and Awards
The Council of EACMFS wishes to ensure that all members of the Association are aware of the current awards and prizes that are available. These are designed to provide educational support and also to allow the opportunity for trainees and those who have recently achieved specialist status to visit units outside their own departments. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1lwzcH9 via IFTTT
Adipocyte-Like Differentiation in a Posttreatment Embryonal Rhabdomyosarcoma
We describe a 16-year-old boy with rhabdomyosarcoma, consistent with embryonal subtype, of the lower extremity who received systemic neoadjuvant chemotherapy and subsequent excision. Microscopic sections of the postchemotherapy excision demonstrated diffuse, prominent, and immature adipocyte-like differentiation, in addition to skeletal muscle differentiation. Adipocyte-like differentiation was confirmed by a combination of positive Oil Red O and adipophilin immunohistochemical staining. To our knowledge, this represents the first report of an unusual phenomenon of differentiation... περισσότερα »
Is the performance of ImmunoCAP ISAC 112 sufficient to diagnose peach and apple allergies?
Publication date: Available online 10 December 2015 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Carmen M. D'Amelio, María José Goikoetxea, Rubén Martínez-Aranguren, Blanca E. García, Francisca Gómez, Javier Fernández, Joan Bartra, Natalia Blanca-López, Araceli Díaz-Perales, María Luisa Sanz from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1lRaK2F via IFTTT
The domestic cat as a natural animal model of Alzheimer’s disease
Abstract Introduction Alzheimer's disease (AD) is the most dominant neurodegenerative disorder that causes dementia, and no effective treatments are available. To study its pathogenesis and develop therapeutics, animal models representing its pathologies are needed. Although many animal species develop senile plaques (SP) composed of amyloid-β (Aβ) proteins that are identical to those found in humans, none of them exhibit neurofibrillary tangles (NFT) and subsequent neurodegeneration, which are integral parts of the pathology of AD. Results The present study shows that Aβ accumul...περισσότερα »
Erratum to: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse
from Neurology via xlomafota13 on Inoreader http://ift.tt/1jPM2hQ via IFTTT
Analysis of catechol- O -methyltransferase gene mutation and identification of new pathogenic gene for paroxysmal kinesigenic dyskinesia
Abstract We aimed to analyze the mutation site and frequency of catechol-*O*-methyltransferase (COMT) gene, to explore the relationship between COMT genotype and phenotype, and to find new pathogenic genes for paroxysmal kinesigenic dyskinesia (PKD). PKD patients who were treated from December 2011 to January 2014 were selected and subjected to genetic testing in the exon region of COMT. Two patients and one intrafamilial healthy control were subjected to exome sequencing using whole exome capture in combination with high-throughput sequencing to find candidate pathogenic gene site... περισσότερα »
Transcranial sonography in movement disorders: an interesting tool for diagnostic perspectives
Abstract Transcranial sonography has become an important tool for the diagnosis of various movement disorders. In most patients with idiopathic Parkinson disease, a markedly hyperechogenic substantia nigra (SN) was detected on at least one side. We have highlighted the sonographic features that might help the differential diagnosis of PD and other movement disorders. Our investigation involved 30 patients (age 45–85 years) with idiopathic Parkinson disease, 2 multiple system atrophy, 3 progressive supranuclear palsy and 2 patients with restless legs syndrome. In accordance with se... περισσότερα »
Accumulation of plutonium in mammalian wildlife tissues following dispersal by accidental-release tests
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): M.P. Johansen, D.P. Child, E.A. Caffrey, E. Davis, J.J. Harrison, M.A.C. Hotchkis, T.E. Payne, A. Ikeda-Ohno, S. Thiruvoth, J.R. Twining, N.A. Beresford We examined the distribution of plutonium (Pu) in the tissues of mammalian wildlife inhabiting the relatively undisturbed, semi-arid former Taranaki weapons test site, Maralinga, Australia. The accumulation of absorbed Pu was highest in the skeleton (83% ± 6%), followed by muscle ...περισσότερα »
236U and 239,240Pu ratios from soils around an Australian nuclear weapons test site
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): S.G. Tims, M.B. Froehlich, L.K. Fifield, A. Wallner, M. De Cesare The isotopes 236U, 239Pu and 240Pu are present in surface soils as a result of global fallout from nuclear weapons tests carried out in the 1950's and 1960's. These isotopes potentially constitute artificial tracers of recent soil erosion and sediment movement. Only Accelerator Mass Spectrometry has the requisite sensitivity to measure all three isotopes at these en... περισσότερα »
Influence of nutrient medium composition on uranium toxicity and choice of the most sensitive growth related endpoint in Lemna minor
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Nele Horemans, May Van Hees, Eline Saenen, Arne Van Hoeck, Valérie Smolders, Ronny Blust, Hildegarde Vandenhove Uranium (U) toxicity is known to be highly dependent on U speciation and bioavailability. To assess the impact of uranium on plants, a growth inhibition test was set up in the freshwater macrophyte Lemna minor. First growth media with different compositions were tested in order to find a medium fit for testing U toxicity...περισσότερα »
Influence of group II metals on Radium-226 concentration ratios in the native green plum (Buchanania obovata) from the Alligator Rivers Region, Northern Territory, Australia
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): Peter Medley, Andreas Bollhöfer In this study, uptake of Ra from soil, and the influence of group II metals on Ra uptake, into the stones and edible flesh of the fruit of the wild green plum, Buchanania obovata, was investigated. Selective extraction of the exchangeable fraction of the soil samples was undertaken but was not shown to more reliably predict Ra uptake than total soil Ra activity concentration. Comparison of the group... περισσότερα »
Measurement of fallout radionuclides, 239,240Pu and 137Cs, in soil and creek sediment: Sydney Basin, Australia
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): B.S. Smith, D.P. Child, D. Fierro, J.J. Harrison, H. Heijnis, M.A.C. Hotchkis, M.P. Johansen, S. Marx, T.E. Payne, A. Zawadzki Soil and sediment samples from the Sydney basin were measured to ascertain fallout radionuclide activity concentrations and atom ratios. Caesium-137 ( 137Cs) was measured using gamma spectroscopy, and plutonium isotopes (239Pu and 240Pu) were quantified using accelerator mass spectrometry (AMS).Fallout radi... περισσότερα »
European roe deer antlers as an environmental archive for fallout 236U and 239Pu
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): M.B. Froehlich, P. Steier, G. Wallner, L.K. Fifield Anthropogenic 236U and 239Pu were measured in European roe deer antlers hunted between 1955 and 1977 which covers and extends beyond the period of intensive nuclear weapons testing (1954–1962). The antlers were hunting trophies, and hence the hunting area, the year of shooting and the approximate age of each animal is given. Uranium and plutonium are known to deposit in skeletal ... περισσότερα »
Measurement of 233U/234U ratios in contaminated groundwater using alpha spectrometry
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): Jennifer J. Harrison, Timothy E. Payne, Kerry L. Wilsher, Sangeeth Thiruvoth, David P. Child, Mathew P. Johansen, Michael A.C. Hotchkis The uranium isotope 233U is not usually observed in alpha spectra from environmental samples due to its low natural and fallout abundance. It may be present in samples from sites in the vicinity of nuclear operations such as reactors or fuel reprocessing facilities, radioactive waste disposal sit...περισσότερα »
Editorial board
Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 from Radiology via ola Kala on Inoreader http://ift.tt/1TCuJNs via IFTTT
A comparison of fallout 236U and 239Pu uptake by Australian vegetation
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): M.B. Froehlich, M.M.A. Dietze, S.G. Tims, L.K. Fifield The isotopes 236U and 239Pu, both produced during nuclear weapons tests carried out in the 1950s and 1960s, are present in the environment and may be used as tracers for soil erosion studies. Although these radionuclides occur only at ultra-trace levels in nature, they can be readily measured by accelerator mass spectrometry with the 14UD heavy ion accelerator at the Australia...περισσότερα »
The International Conference on Radioecology and Environmental Radioactivity, 2014, (ICRER-2014)
Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Per Strand, Justin Brown from Radiology via ola Kala on Inoreader http://ift.tt/1U6wtzj via IFTTT
Main results of the 2012 joint Norwegian–Russian expedition to the dumping sites of the nuclear submarine K-27 and solid radioactive waste in Stepovogo Fjord, Novaya Zemlya
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Justin P. Gwynn, Aleksander Nikitin, Viacheslav Shershakov, Hilde Elise Heldal, Bjørn Lind, Hans-Christian Teien, Ole Christian Lind, Rajdeep Singh Sidhu, Gunnar Bakke, Alexey Kazennov, Denis Grishin, Anastasia Fedorova, Oxana Blinova, Ingrid Sværen, Penny Lee Liebig, Brit Salbu, Cato Christian Wendell, Elisabeth Strålberg, Nailja Valetova, Galina Petrenko, Ivan Katrich, Igor Logoyda, Iolanda Osvath, Isabelle Levy, Jean Bartocci,... περισσότερα »
Environmental impact and risk assessments and key factors contributing to the overall uncertainties
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Brit Salbu There is a significant number of nuclear and radiological sources that have contributed, are still contributing, or have the potential to contribute to radioactive contamination of the environment in the future. To protect the environment from radioactive contamination, impact and risk assessments are performed prior to or during a release event, short or long term after deposition or prior and after implementation of c... περισσότερα »
Behavior of accidentally released radiocesium in soil–water environment: Looking at Fukushima from a Chernobyl perspective
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): A. Konoplev, V. Golosov, G. Laptev, K. Nanba, Y. Onda, T. Takase, Y. Wakiyama, K. Yoshimura Quantitative characteristics of dissolved and particulate radiocesium wash-off from contaminated watersheds after the FDNPP accident are calculated based on published monitoring data. Comparative analysis is provided for radiocesium wash-off parameters and distribution coefficients, Kd, between suspended matter and water in rivers and surfa... περισσότερα »
Genetic and clinical analysis of spinocerebellar ataxia type 36 in Mainland China
Abstract Spinocerebellar ataxia type 36 (SCA36) is a new SCA subtype recently reported in Japanese and Spanish pedigrees. To assess the frequency and clinical characteristics of SCA36 in patients from Mainland China, we combined the repeat-primed polymerase chain reaction method and Southern blot analysis to detect the GGCCTG hexanucleotide repeats of *NOP56* in 364 probands with SCA, 126 probands with hereditary spastic paraplegia (HSP) and 99 probands with amyotrophic lateral sclerosis (ALS). Systematic and targeted clinical evaluations and investigations were conducted in the S... περισσότερα »
The Genetics and Pathogenesis of Thoracic Aortic Aneurysm Disorder and Dissections
Abstract Major advances have been made over the last twenty years to better elucidate the molecular basis of aortic aneurysmal diseases. Thoracic aortic aneurysm disorder and dissections (TAADs) have a high mortality rate, and one-fifth of TAADs patients have a high familial prevalence of the disease. Clinical presentations of TAADs are different, from no symptom to aortic insufficiency that may result in sudden death. The identification of the genetic factors associated with familial TAADs is beneficial for screening and early intervention of TAADs and provides a paradigm for the ... περισσότερα »
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies
Abstract The cytoplasmic dynein-dynactin genes are attractive candidates for neurodegenerative disorders given their functional role in retrograde transport along neurons. The cytoplasmic dynein heavy chain (*DYNC1H1)* gene has been implicated in various neurodegenerative disorders, and dynactin 1 (*DCTN1*) genes have been implicated in a wide spectrum of disorders including motor neuron disease, Parkinson's disease, spinobulbar muscular atrophy and hereditary spastic paraplegia. However, the involvement of other dynactin genes with inherited peripheral neuropathies (IPN) namely, ...περισσότερα »
Expanding the MYBPC1 phenotypic spectrum: a novel homozygous mutation causes arthrogryposis multiplex congenita
Abstract Arthrogryposis multiplex congenita (AMC) is characterized by heterogeneous non-progressive multiple joint contractures appearing at birth. We present a consanguineous Israeli-Druze family with several members presenting with AMC. A variable intra-familial phenotype and pected autosomal recessive inheritance prompted molecular diagnosis by whole-exome sequencing. Variant analysis focused on rare homozygous changes, revealed a missense variant in *MYBPC1*, NM_002465:c.556G>A (p.E286K), affecting the last nucleotide of exon 8. This novel variant was not observed in the common... περισσότερα »
Homozygous FIBP nonsense variant responsible of syndromic overgrowth, with overgrowth, macrocephaly, retinal coloboma and learning disabilities
Abstract The acidic fibroblast growth factor (FGF) intracellular binding protein (FIBP) interacts directly with the fibroblast growth factor FGF1. Although FIBP is known to be implicated in the FGF-signaling pathway, its precise function remains unclear. Gain-of-function variants in several FGF receptors (FGFRs) are implicated in a wide spectrum of growth disorders from achondroplasia to overgrowth syndromes. In a unique case from a consanguineous union presenting with overgrowth, macrocephaly, retinal coloboma, large thumbs, severe varicose veins and learning disabilities, exome ... περισσότερα »
Synergistic improvement of crop physiological status by combination of cadmium immobilization and micronutrient fertilization
Abstract Wollastonite application in cadmium-contaminated soils can reduce cadmium concentrations in plant, while the side effect is the synchronous immobilization of micronutrients, which reduces micronutrient uptake in plant, inducing micronutrient deficient symptoms. Accordingly, we investigated whether the supplement of Zn and Mn fertilizers after the wollastonite addition could promote the growth and photosynthesis in amaranth (*Amaranthus tricolor* L.). In this study, plants were cultivated in cadmium-contaminated soil under micronutrient fertilization alone, wollastonite ad... περισσότερα »
Pollution characteristics and ecological risk assessment of HCHs and DDTs in estuary wetland sediments from the Bohai Bay, North China
Abstract Hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs) tend to persist in the environment for long periods of time. The concentration and distribution of HCHs and DDTs were investigated in surface sediments of Yongdingxinhe wetland and Binhai wetland by gas chromatography-mass spectrometer (GC-MS). All isomers of HCHs and DDTs were detected in all of the samples. The concentrations of total HCHs (ΣHCHs) in two wetland sediments ranged from 69.81 to 379.28 ng · g −1, with a mean value of 224.55 ng · g −1. The concentrations of total DDTs (ΣDDTs) ranged f...περισσότερα »
Simulation study of dispersion and removal of particulate matter from traffic by road-side vegetation barrier
Abstract Well-positioned and configured vegetation barriers (VBs) have been suggested as one of the green infrastructures that could improve near-road (local) air quality. This is because of their influence on the underlying mechanisms: dispersion and mass removal (by deposition). Some studies have investigated air quality improvement by near-road vegetation barrier using the dispersion-related method while few studies have done the same using the deposition-related method. However, decision making on vegetation barrier's configuration and placement for need-based maximum benefit ... περισσότερα »
Attempts to improve nitrogen utilization efficiency of aquaponics through nitrifies addition and filler gradation
Abstract Aquaponics has attracted worldwide attention in recent years and is considered as an alternative technology for conventional aquaculture. In this study, common carp (*Cyprinus carpio*) and pakchoi (*Brassica chinensis*) were cultured in lab-scale aquaponics, and attempts were conducted to enhance its nitrogen utilization efficiency (NUE) through two optimization methods, i.e., nitrifies addition (NA) and filler gradation (FG). Results showed that NA and FG could improve the NUE of aquaponics by 8.8 and 16.0 %, respectively, compared with control. The total ammonia (TAN) a... περισσότερα »
Air quality improvement during 2010 Asian games on blood coagulability in COPD patients
Abstract Exposure to elevated levels of ambient air pollutants can lead to adverse cardiovascular effects. Perturbation of the coagulation balance is one of the potential mechanisms. However, evidence regarding the impact of improvement in air pollution on blood coagulability in COPD patients has never been reported. Coagulation processes are known to be of relevance for cardiovascular pathology; therefore, this study aimed to investigate the association of short-term air pollution exposure with blood marker (D-dimer) of coagulation. A 3-year (through the Asian game) cohort study ... περισσότερα »
Microdeletions of the 7q32.2 imprinted region are associated with Silver–Russell syndrome features
The association of maternal uniparental disomy of human chromosome 7 (upd(7) mat) and the growth retardation disorder Silver–Russell syndrome (SRS) is well established, but the causative gene or region is currently unknown. However, several observations indicate that molecular alterations of the genomically imprinted *MEST* region in 7q32.2 are associated with growth retardation and a phenotype reminiscent to SRS. We now report on a second patient with a similar phenotype and a de novo 7q32.2 microdeletion including *MEST* affecting the paternal allele. This confirms the central ... περισσότερα »
Clonorchis sinensis ova in bile juice cytology from a patient with severe hyperbilirubinemia and portal vein thrombosis
Infection with the trematode *Clonorchis sinensis* is the most common human fluke infection in East Asian populations. Although this infection is associated with obstructive jaundice or choledocholithiasis, portal vein thrombosis has not been reported. Here, we report the first case of a 60-year-old man who had both *C. sinensis* infection and portal vein thrombosis with severe hyperbilirubinemia (75.4 mg/dl). He initially presented with abdominal pain and jaundice. Computed tomography revealed gallstones, common bile duct calculus, and thrombus in the left main branch of the por... περισσότερα »
Cytodiagnosis of distant metastases from follicular thyroid carcinoma
Introduction Follicular carcinoma of the thyroid is second most common primary malignancy of the thyroid gland after papillary carcinoma and metastasis is uncommonly seen in these patients. Aims and objectives To describe the cytomorphologic features for the accurate diagnosis of distant metastases from follicular carcinoma of thyroid. Materials and methods A total of 10 aspirates reported as metastatic follicular carcinoma of thyroid were reviewed for the available clinical and radiological details. Results All the patients were females. Six of these patients presented with s... περισσότερα »
Assessment of cytotechnologist–cytopathologist interpretative agreement using the Bethesda system for reporting thyroid cytopathology
Background The Bethesda system for reporting thyroid cytopathology was proposed to provide a clinically relevant framework for interpretations to improve interobserver agreement. Limited data is available regarding the level of interobserver agreement between groups of cytotechnologists (CTs) and cytopathologists (CPs) examining the same thyroid fine needle aspirate (FNA) samples. Methods Retrospective review of 1,229 thyroid FNAs from 976 patients between 03/2010 and 08/2012 was performed. FNAs received preliminary evaluation by a CT followed by final interpretation by a CP. We...περισσότερα »
IGF-binding protein 2 is a candidate target of therapeutic potential in cancer
Abstract Insulin-like growth factor (IGF)-binding protein 2(IGFBP2), a key member of IGF family, has been reported as a notable oncogene in most human epithelium cancers. Increasing evidences suggested that IGFBP2 might be a candidate target of therapuetic potential by regulating key cancer metastasis and invasion-associated signaling networks, but there is still confusion about the mechanism on how IGFBP2 takes part in these processes. In this review, we summarized the current points of view that IGFBP2 functions in signaling pathways during tumorigenesis and tumor progression an...περισσότερα »
Disruption of in vivo chronic lymphocytic leukemia tumor-microenvironment interactions by ibrutinib - findings from an investigator initiated phase 2 study
Purpose: Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental interactions for proliferation and survival that are at least partially mediated through B cell receptor (BCR) signaling. Ibrutinib, a Bruton's tyrosine kinase inhibitor, disrupts BCR signaling and leads to the egress of tumor cells from the microenvironment. While the on-target effects on CLL cells are well defined, the impact on the microenvironment is less well studied. We therefore sought to characterize the in vivo effects of ibrutinib on the tumor microenvironment. Experimental Design: Patients re... περισσότερα »
Romidepsin and azacitidine synergize in their epigenetic modulatory effects to induce apoptosis in CTCL
Purpose Cutaneous T cell lymphomas (CTCL) are a heterogeneous group of malignancies that despite available therapies commonly relapse. The emergences of combination epigenetic therapies in other hematologic malignancies have made investigation of such combinations in CTCL a priority. Here, we explore the synergistic anti-proliferative effects of romidepsin, an HDAC inhibitor, and azacitidine, a demethylating agent, combination in CTCL. Experimental Design The growth inhibition under combination treatment and single agent was explored by the MTT cell viability assay and the Annexin... περισσότερα »
The anti-tumor efficacy of IL-2/IL-21-cultured polyfunctional neu-specific T-cells is TNF-alpha/IL-17 dependent
Purpose:Infusion of HER2 specific T-cells, derived from vaccine-primed patients and expanded with IL-2/IL-12, has induced tumor regression in a minority of patients with metastatic treatment-refractory HER2+ breast cancer. We questioned whether alteration of cytokine growth factors used to culture vaccine-primed T-cells could improve anti-tumor activity. Experimental Design:Using the TgMMTV-neu murine mammary tumor model we cultured T-cells derived from mice immunized with a previously defined neu class II peptide, p98-114 (neu p98), and evaluated different cytokine combinations f... περισσότερα »
Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy
Small molecule inhibitors of the phosphatidylinositol 3-kinase (PI3K), Akt and mTOR pathway currently in the clinic produce a paradoxical reactivation of the pathway they are intended to suppress. Furthermore, fresh experimental evidence with PI3K antagonists in melanoma, glioblastoma and prostate cancer shows that mitochondrial metabolism drives an elaborate process of tumor adaptation culminating with drug resistance and metastatic competency. This is centered on reprogramming of mitochondrial functions to promote improved cell survival and to fuel the machinery of cell motility ...περισσότερα »
SEOM guidelines for cervical cancer
Abstract Cervical cancer (CC) is the second most common cancer worldwide, strongly linked to high-risk human papilloma virus infection. Although screening programs have led to a relevant reduction in the incidence and mortality due to CC in developed countries, it is still an important cause of mortality in undeveloped countries. Clinical stage is still the most relevant prognostic factor. In early stages, the primary treatment is surgery or radiotherapy, whereas concomitant chemo-radiotherapy is the conventional approach in locally advanced stages. In the setting of recurrent or ... περισσότερα »
The relationship between RRM1 gene polymorphisms and effectiveness of gemcitabine-based first-line chemotherapy in advanced NSCLC patient
Abstract Purpose Chemotherapy with platinum compounds and gemcitabine is frequently used in first-line treatment of advanced non-small cell lung cancer (NSCLC) patients in which tyrosine kinase inhibitors (EGFR or ALK) cannot be administered. Unfortunately, less than half of the patients achieve the benefit from chemotherapy. Gemcitabine is an analog of deoxycytidine (pyrimidine antimetabolite) with antitumor activity. The excess of deoxycytidine synthesized by RRM1 enzyme activity may be a cause of competitive displacement of gemcitabine, which reduces the efficacy of this cytost...περισσότερα »
Ventral foramen magnum neurenteric cysts: a case series and review of literature
Abstract Neurenteric cysts (NEC) are uncommon, benign, congenital lesions. Ventral foramen magnum (FM) location is very rare. The difficulties in diagnosis and management aspects are detailed with a review of the pertinent literature. We report four new cases of ventral FM NEC, all managed surgically and present a literature review of ventral FM NEC. A retrospective analysis of histopathologically confirmed cases of ventral FM NEC, operated from 2010–2013 at our institute, was performed. For review, only those cases of NEC extending from the lower clivus to the C2 level constitutin... περισσότερα »
Pancreatic trauma: The role of computed tomography for guiding therapeutic approach.
Related Articles *Pancreatic trauma: The role of computed tomography for guiding therapeutic approach.* World J Radiol. 2015 Nov 28;7(11):415-420 Authors: Moschetta M, Telegrafo M, Malagnino V, Mappa L, Ianora AA, Dabbicco D, Margari A, Angelelli G Abstract AIM: To evaluate the role of computed tomography (CT) for diagnosing traumatic injuries of the pancreas and guiding the therapeutic approach. METHODS: CT exams of 6740 patients admitted to our Emergency Department between May 2005 and January 2013 for abdominal trauma were retrospectively evaluated. Patients were identified thro... περισσότερα »
A randomised comparison of the Ambu® AuraGain™ and the LMA® supreme in infants and children,..
[image: logo.gif] Switch to one email a weekUnsubscribe from daily digest Hi Alexandros G. Sfakianakis, This daily digest contains latest stories from the sites you've added on Feedspot. View All New Stories Feedspot reviewRSS ReaderAppAnaesthesia Remove A randomised comparison of the Ambu® AuraGain™ and the LMA® supreme in infants and children by N. Jagannathan, J. Hajduk, L. Sohn, A. Huang, A. Sawardekar, E. R. Gebhardt, K. Johnson, G. S. De Oliveira, 15 hours ago . Save . Twitter Summary We conducted a randomised trial in 100 children in order to compare the clinical perf... περισσότερα »
Subscription Information
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Y49fdJ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lQUtuw via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Y4hPZW via IFTTT
IGF-binding protein 2 is a candidate target of therapeutic potential in cancer
Abstract Insulin-like growth factor (IGF)-binding protein 2(IGFBP2), a key member of IGF family, has been reported as a notable oncogene in most human epithelium cancers. Increasing evidences suggested that IGFBP2 might be a candidate target of therapuetic potential by regulating key cancer metastasis and invasion-associated signaling networks, but there is still confusion about the mechanism on how IGFBP2 takes part in these processes. In this review, we summarized the current points of view that IGFBP2 functions in signaling pathways during tumorigenesis and tumor progression and...περισσότερα »
Contents
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Y49fKD via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XYfnJH via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Y4hOoM via IFTTT
Pseudotumoral hemicerebellitis as a mimicker of Lhermitte-Duclos disease in children: does neuroimaging help to differentiate them?
Abstract The clinical presentation and neuroimaging findings of children with pseudotumoral hemicerebellitis (PTHC) and Lhermitte-Duclos disease (LDD) may be very similar. The differentiation between these entities, however, is important because their management and prognosis are different. We report on three children with PTHC. For all three children, in the acute situation, the differentiation between PTHC and LDD was challenging. A review of the literature shows that a detailed evaluation of conventional and neuroimaging data may help to differentiate between these two entities. ... περισσότερα »
Editorial Board
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Y49eX4 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lQUsa5 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Y4hO8q via IFTTT
Synergistic improvement of crop physiological status by combination of cadmium immobilization and micronutrient fertilization
Abstract Wollastonite application in cadmium-contaminated soils can reduce cadmium concentrations in plant, while the side effect is the synchronous immobilization of micronutrients, which reduces micronutrient uptake in plant, inducing micronutrient deficient symptoms. Accordingly, we investigated whether the supplement of Zn and Mn fertilizers after the wollastonite addition could promote the growth and photosynthesis in amaranth (*Amaranthus tricolor* L.). In this study, plants were cultivated in cadmium-contaminated soil under micronutrient fertilization alone, wollastonite add... περισσότερα »
Nobel laureates lecture to a packed hall
This year's Nobel laureates in physiology or medicine received a very warm welcome from the audience at the Nobel Lecture at Karolinska Institutet on 7 December. Their discoveries have saved millions of lives from fatal and crippling parasite diseases. There were many people who wanted to come to KI to listen to the 2015 Nobel laureates in physiology or medicine Satoshi Ōmura, William Campbell and Youyou Tu, and those seeking a place at the head of the queue waited for hours outside Aula Medica in glorious December sunshine. Following Vice-Chancellor Anders Hamsten's welcome addres...περισσότερα »
Pollution characteristics and ecological risk assessment of HCHs and DDTs in estuary wetland sediments from the Bohai Bay, North China
Abstract Hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs) tend to persist in the environment for long periods of time. The concentration and distribution of HCHs and DDTs were investigated in surface sediments of Yongdingxinhe wetland and Binhai wetland by gas chromatography-mass spectrometer (GC-MS). All isomers of HCHs and DDTs were detected in all of the samples. The concentrations of total HCHs (ΣHCHs) in two wetland sediments ranged from 69.81 to 379.28 ng · g −1, with a mean value of 224.55 ng · g −1. The concentrations of total DDTs (ΣDDTs) ranged fr...περισσότερα »
Interspecific competition and protistan grazing affect the coexistence of freshwater betaproteobacterial strains
The competitive strength of four cosmopolitan freshwater betaproteobacterial isolates was investigated in presence or absence of bacterivorous flagellates during continuous cultivation in artificial minimal medium at two dilution rates. Bacteria reached similar abundances and growth rates in monocultures, however, in co-cultures, two strains ( *Acidovorax* sp. and *Massilia* sp.) displayed significantly higher numbers and growth rates. These potential cross-feeding benefits were also supported by a high nutritional versatility of the two strains. In contrast, *Hydrogenophaga* sp. w... περισσότερα »
Simulation study of dispersion and removal of particulate matter from traffic by road-side vegetation barrier
Abstract Well-positioned and configured vegetation barriers (VBs) have been suggested as one of the green infrastructures that could improve near-road (local) air quality. This is because of their influence on the underlying mechanisms: dispersion and mass removal (by deposition). Some studies have investigated air quality improvement by near-road vegetation barrier using the dispersion-related method while few studies have done the same using the deposition-related method. However, decision making on vegetation barrier's configuration and placement for need-based maximum benefit r... περισσότερα »
A new fungal large subunit ribosomal RNA primer for high throughput sequencing surveys
The inclusion of phylogenetic metrics in community ecology has provided insights into important ecological processes, particularly when combined with high throughput sequencing methods; however, these approaches have not been widely used in studies of fungal communities relative to other microbial groups. Two obstacles have been, 1. The internal transcribed spacer region (ITS) has limited utility for constructing phylogenies, and 2. Most PCR primers that target the large subunit ribosomal unit (LSU) generate amplicons that exceed current limits of high throughput sequencing platfo...περισσότερα »
Attempts to improve nitrogen utilization efficiency of aquaponics through nitrifies addition and filler gradation
Abstract Aquaponics has attracted worldwide attention in recent years and is considered as an alternative technology for conventional aquaculture. In this study, common carp (*Cyprinus carpio*) and pakchoi (*Brassica chinensis*) were cultured in lab-scale aquaponics, and attempts were conducted to enhance its nitrogen utilization efficiency (NUE) through two optimization methods, i.e., nitrifies addition (NA) and filler gradation (FG). Results showed that NA and FG could improve the NUE of aquaponics by 8.8 and 16.0 %, respectively, compared with control. The total ammonia (TAN) an... περισσότερα »
Biomechanics of Spine Stabilization
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 Author(s): John C. Liu from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1QxkCKr via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lQUsa9 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Y4hN4c via IFTTT
Air quality improvement during 2010 Asian games on blood coagulability in COPD patients
Abstract Exposure to elevated levels of ambient air pollutants can lead to adverse cardiovascular effects. Perturbation of the coagulation balance is one of the potential mechanisms. However, evidence regarding the impact of improvement in air pollution on blood coagulability in COPD patients has never been reported. Coagulation processes are known to be of relevance for cardiovascular pathology; therefore, this study aimed to investigate the association of short-term air pollution exposure with blood marker (D-dimer) of coagulation. A 3-year (through the Asian game) cohort study b... περισσότερα »
World Federation of Neurosurgical Societies
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1QxkCua via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XYfntp via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Y4hN4a via IFTTT
Impact of methionine on a partial-nitritation biofilter
Abstract It has been demonstrated that an anaerobic digestion process cannot attain an efficient removal of several amino acids, with methionine being one of the most persistent of these. Thus, the effect that methionine amino acid has over the partial-nitritation process with fixed-biofilm configuration in terms of performance and bacterial community dynamics has been investigated. With respect to the performance with no addition, 100 mg/L methionine loading decreased ammonium oxidation efficiency in 60 % and 100 % at concentrations of 300 and 500 mg/L methionine, respectively. Ba... περισσότερα »
Protein-protein interactions in DNA mismatch repair
Publication date: Available online 10 December 2015 *Source:*DNA Repair Author(s): Peter Friedhoff, Pingping Li, Julia Gotthardt The principal DNA mismatch repair proteins MutS and MutL are versatile enzymes that couple DNA mismatch or damage recognition to other cellular processes. Besides interaction with their DNA substrates this involves transient interactions with other proteins which is triggered by the DNA mismatch or damage and controlled by conformational changes. Both MutS and MutL proteins have ATPase activity, which adds another level to control their activity and intera...περισσότερα »
Ventral foramen magnum neurenteric cysts: a case series and review of literature
Abstract Neurenteric cysts (NEC) are uncommon, benign, congenital lesions. Ventral foramen magnum (FM) location is very rare. The difficulties in diagnosis and management aspects are detailed with a review of the pertinent literature. We report four new cases of ventral FM NEC, all managed surgically and present a literature review of ventral FM NEC. A retrospective analysis of histopathologically confirmed cases of ventral FM NEC, operated from 2010–2013 at our institute, was performed. For review, only those cases of NEC extending from the lower clivus to the C2 level constitutin... περισσότερα »
Pancreatic trauma: The role of computed tomography for guiding therapeutic approach.
Related Articles *Pancreatic trauma: The role of computed tomography for guiding therapeutic approach.* World J Radiol. 2015 Nov 28;7(11):415-420 Authors: Moschetta M, Telegrafo M, Malagnino V, Mappa L, Ianora AA, Dabbicco D, Margari A, Angelelli G Abstract AIM: To evaluate the role of computed tomography (CT) for diagnosing traumatic injuries of the pancreas and guiding the therapeutic approach. METHODS: CT exams of 6740 patients admitted to our Emergency Department between May 2005 and January 2013 for abdominal trauma were retrospectively evaluated. Patients were identified thro... περισσότερα »
A randomised comparison of the Ambu® AuraGain™ and the LMA® supreme in infants and children,..
[image: logo.gif] Switch to one email a weekUnsubscribe from daily digest Hi Alexandros G. Sfakianakis, This daily digest contains latest stories from the sites you've added on Feedspot. View All New Stories Feedspot reviewRSS ReaderAppAnaesthesia Remove A randomised comparison of the Ambu® AuraGain™ and the LMA® supreme in infants and children by N. Jagannathan, J. Hajduk, L. Sohn, A. Huang, A. Sawardekar, E. R. Gebhardt, K. Johnson, G. S. De Oliveira, 15 hours ago . Save . Twitter Summary We conducted a randomised trial in 100 children in order to compare the clinical perf... περισσότερα »
Pseudotumoral hemicerebellitis as a mimicker of Lhermitte-Duclos disease in children: does neuroimaging help to differentiate them?
Abstract The clinical presentation and neuroimaging findings of children with pseudotumoral hemicerebellitis (PTHC) and Lhermitte-Duclos disease (LDD) may be very similar. The differentiation between these entities, however, is important because their management and prognosis are different. We report on three children with PTHC. For all three children, in the acute situation, the differentiation between PTHC and LDD was challenging. A review of the literature shows that a detailed evaluation of conventional and neuroimaging data may help to differentiate between these two entities. ... περισσότερα »
Synergistic improvement of crop physiological status by combination of cadmium immobilization and micronutrient fertilization
Abstract Wollastonite application in cadmium-contaminated soils can reduce cadmium concentrations in plant, while the side effect is the synchronous immobilization of micronutrients, which reduces micronutrient uptake in plant, inducing micronutrient deficient symptoms. Accordingly, we investigated whether the supplement of Zn and Mn fertilizers after the wollastonite addition could promote the growth and photosynthesis in amaranth (*Amaranthus tricolor* L.). In this study, plants were cultivated in cadmium-contaminated soil under micronutrient fertilization alone, wollastonite add... περισσότερα »
Survival of children with trisomy 13 and trisomy 18: A multi-state population-based study
Trisomy 13 (T13) and trisomy 18 (T18) are among the most prevalent autosomal trisomies. Both are associated with a very high risk of mortality. Numerous instances, however, of long-term survival of children with T13 or T18 have prompted some clinicians to pursue aggressive treatment instead of the traditional approach of palliative care. The purpose of this study is to assess current mortality data for these conditions. This multi-state, population-based study examined data obtained from birth defect surveillance programs in nine states on live-born infants delivered during 1999–... περισσότερα »
Phenotypes of 8q13.2–q13.3 microdeletion: Case report and literature review of an emerging recurrent microdeletion syndrome
from Genes via ola Kala on Inoreader http://ift.tt/1NWOt0i via IFTTT
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Evolving Concepts and Transla... περισσότερα »
These new articles for Molecular Endocrinology are available online
These new articles for Molecular Endocrinology are available online ------------------------------ Early Release Molecular Endocrinology ------------------------------ [image: Molecular Endocrinology masthead] ------------------------------ ------------------------------ Molecular Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Research resource: A dual proteomic approach identifies regulated islet proteins during beta cell mass expansion in vivo Signe Horn, ...περισσότερα »
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish Aliesha Griffin, et al. | Endocrinology | Dec 9, 2015Hepatocyte-sp... περισσότερα »
These new articles for Endocrine Reviews are available online
These new articles for Endocrine Reviews are available online ------------------------------ Early Release Endocrine Reviews ------------------------------ [image: Endocrine Reviews masthead] ------------------------------ ------------------------------ Endocrine Reviews Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Post-transplant diabetes mellitus: Causes, treatment, and impact on outcomes Vijay Shivaswamy, et al. | Endocrine Reviews | Dec 9, 2015 --------------------... περισσότερα »
Ventral foramen magnum neurenteric cysts: a case series and review of literature
Abstract Neurenteric cysts (NEC) are uncommon, benign, congenital lesions. Ventral foramen magnum (FM) location is very rare. The difficulties in diagnosis and management aspects are detailed with a review of the pertinent literature. We report four new cases of ventral FM NEC, all managed surgically and present a literature review of ventral FM NEC. A retrospective analysis of histopathologically confirmed cases of ventral FM NEC, operated from 2010–2013 at our institute, was performed. For review, only those cases of NEC extending from the lower clivus to the C2 level constituti... περισσότερα »
A randomised comparison of the Ambu® AuraGain™ and the LMA® supreme in infants and children,..
Switch to one email a week Unsubscribe from daily digest Hi Alexandros G. Sfakianakis, This daily digest contains latest stories from the sites you've added on Feedspot. View All New Stories Feedspot review RSS Reader App Anaesthesia Remove A randomised comparison of the Ambu® AuraGain™ and the LMA® supreme in infants and children by N. Jagannathan, J. Hajduk, L. Sohn, A. Huang, A. Sawardekar, E. R. Gebhardt, K. Johnson, G. S. De Oliveira, 15 hours ago . Save . Twitter Summary We conducted a randomised trial in 100 children in order to compare the clinical perform... περισσότερα »
Impact of methionine on a partial-nitritation biofilter
Abstract It has been demonstrated that an anaerobic digestion process cannot attain an efficient removal of several amino acids, with methionine being one of the most persistent of these. Thus, the effect that methionine amino acid has over the partial-nitritation process with fixed-biofilm configuration in terms of performance and bacterial community dynamics has been investigated. With respect to the performance with no addition, 100 mg/L methionine loading decreased ammonium oxidation efficiency in 60 % and 100 % at concentrations of 300 and 500 mg/L methionine, respectively. B... περισσότερα »
Effects of spatiotemporal variation of soil salinity on fine root distribution in different plant configuration modes in new reclamation coastal saline field
Abstract In order to study the effects of salinity on plant fine roots, we considered three different plant configuration modes (tree stand model (TSM), shrub stand model (SSM), and tree–shrub stand model (TSSM)). Soil samples were collected with the method of soil drilling. Significant differences of electrical conductivity (EC) in the soil depth of 0–60 cm were observed among the three modes (*p* < 0.05). In the above three modes, the variation of soil salinity among various soil layers and monthly variation of soil salinity were the highest in SSM and reached 2.30 and 2.23 mS/c... περισσότερα »
Is the Fgap1 mediated response to oxidative stress chemotype-dependent in Fusarium graminearum?
This study aims to compare the role of the transcription factor *Fgap1* in oxidative stress response for two *Fusarium graminearum* strains belonging to the two chemotypes DON/ADON and NIV/FX. While the response to H2O2 was shown to be chemotype dependent, an opposite result was observed for diamide: whatever the chemotype, the global level of TCTB (i.e. trichothecene B) production was strongly increased by the treatment with diamide. *Fgap1* was shown to be involved in this regulation for both chemotypes. Our data show that the response to diamide is mediated by *Fgap1* whatever ...περισσότερα »
In vitro screening of mare's milk antimicrobial effect and antiproliverative activity
The aims of this study were to examine the effect of mare's milk on virulence gene expression of *Salmonella* Typhimurium and observe its potential activity on proliferation of adenocarcinoma Caco-2 cells*.* Different supernatants of mare's milk, raw or heat-treated at 65°C for 15 seconds or 30 minutes, were studied. The changes in *hilA* gene expression of *Salmonella* Typhimurium in presence of mare's milk supernatants were assessed using a reporter luminescent strain. A significant decrease in *hilA* gene expression was observed with all tested supernatants. Virulence gene expr...περισσότερα »
DOOR/RADAR: A gateway into the unknown?
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1IGguH7 via IFTTT
The epi-TAF for TDF?
Approximately 84% of HIV-infected US residents on antiretroviral therapy currently receive some form of tenofovir disoproxil fumarate (TDF) as part of their HIV treatment regimen. The TDF analog – tenofovir alafenamide fumarate (TAF) – has demonstrated equal efficacy but with decreased renal injury and bone mineral density loss, compared to TDF. We examine how much more society ought to be willing to pay for TAF over TDF, in exchange for its improved toxicity profile. Using cost-effectiveness methods, we find that current conditions warrant an annual premium of up to $1,010 over th... περισσότερα »
Response to Phillips et.al.
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1NO1G5c via IFTTT
Prevention of surgical site infections: decontamination with mupirocin based on pre-operative screening for Staphylococcus aureus carriers or universal decontamination?
Using a mathematical model and available epidemiological data, we explore the dynamics of mupirocin resistance and identify drivers of emerging resistance, when using a universal decolonization strategy for peri-operative *S. aureus* decontamination. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1IGgwyH via IFTTT
Towards Earlier Inclusion of Pregnant and Postpartum Women in TB Drug Trials: Consensus Statements from an International Expert Panel
Consensus statements from an expert panel to include pregnant and postpartum women in TB drug trials. High priority research areas in pregnancy include: preventing latent TB infection progression; evaluating new MDR-TB drugs; safety and PK data for current TB drugs. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1NO1FOG via IFTTT
Is Universal Mupirocin Decolonization a Viable Option for Surgical Site Infection Prevention-Who Nose?!
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Stemming the Tide: Can New Approaches to HIV Treatment Reverse the Trend of Rising Drug Prices in the United States?
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The cost-effectiveness and budget impact of two-drug dolutegravir-lamivudine regimens for the treatment of HIV infection in the United States
Two-drug dolutegravir-lamivudine as initial or maintenance therapy for ART-naïve HIV-infected individuals would be cost-effective under anticipated virologic efficacy estimates. Cost savings of these regimens, if adopted, could exceed $500 million in the US in the first five years. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1IGgqXP via IFTTT
Danhong injection in treatment of acute ischemic stroke
Evaluating the effects of Danhong injection in treatment of acute ischemic stroke: study protocol for a multicenter randomized controlled trial: Background: Danhong injection (DHI) has been widely prescribed to patients with acute ischemic stroke (AIS). However, due to methodological deficiencies, previous research has not yet provided rigorous evidence to support the use of DHI in the treatment of AIS. Therefore, we designed this multicenter, randomized, controlled, and double-blind trial to evaluate the efficacy and safety of DHI for AIS.Methods/DesignIt is a randomized, multicente...περισσότερα »
Early deterioration of residual hearing in patients with SLC26A4 mutations
Early deterioration of residual hearing in patients with SLC26A4 mutations: Objectives/Hypothesis To compare changes in hearing in patients with *SLC26A4* during early and late childhood. Study Design Retrospective chart review. Methods A total of 102 patients with biallelic *SLC26A4* mutations visited the tertiary referral otolaryngology department between March 2005 and February 2015. Newborn hearing screening tests had been performed on 22 of these patients. We analyzed 26 patients who underwent hearing tests more than twice using the same method (auditory brainstem response/audit...περισσότερα »
Social conversational skills development in early implanted children
Social conversational skills development in early implanted children: Objectives/Hypothesis Social conversational skills are a salient aspect of early pragmatic development in young children. These skills include two different abilities, assertiveness and responsiveness. This study investigated the development of these abilities in early implanted children and their relationships with lexical development and some language-sensitive variables. Study Design Prospective, observational, nonrandomized study. Methods Participants included 28 children with congenital profound sensorineural ... περισσότερα »
Dexmedetomidine versus propofol during drug-induced sleep endoscopy in sleep apnea patients
A comparison of dexmedetomidine versus propofol during drug-induced sleep endoscopy in sleep apnea patients: Objectives/Hypothesis In this study, we compared the effects of propofol and dexmedetomidine on the upper airway collapse pattern and cardiopulmonary parameters of patients with obstructive sleep apnea (OSA) undergoing drug-induced sleep endoscopy (DISE). Study Design Prospective, single center, observational study Materials and Methods The 50 patients with OSA underwent 30 minutes of DISE on 2 different days, the first time with propofol target-controlled infusion (TCI) and t... περισσότερα »
MRI of inner ear decompression sickness and barotrauma
Magnetic resonance imaging in a guinea pig model of inner ear decompression sickness and barotrauma: Objectives/Hypothesis Scuba diving may cause severe hearing loss and vertigo due to inner ear barotrauma and decompression sickness. These may be difficult to differentiate clinically. Decompression sickness requires costly and potentially dangerous hyperbaric therapy, whereas such treatment may worsen barotrauma. The objective of this study was to assess the potential utility of magnetic resonance imaging to identify and distinguish blood from air in the inner ear, manifestations o... περισσότερα »
Analysis of laryngoscopic features in patients with unilateral vocal fold paresis
Analysis of laryngoscopic features in patients with unilateral vocal fold paresis: Objectives/Hypothesis The diagnosis of paresis in patients with vocal fold motion impairment remains a challenge. More than 27 clinical parameters have been cited that may signify paresis. We hypothesize that some features are more significant than others. Study Design Prospective case series. Methods Two laryngologists rated laryngoscopy findings in 19 patients suspected of paresis. The diagnosis was confirmed with laryngeal electromyography. A standard set of 27 ratings was used for each examination... περισσότερα »
Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy
Summary Objective We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. Methods From March 2011 to March 2014, 104 patients aged 1–18 years who had refractory epilepsy were randomly assigned to each diet group ( ClinicalTrials.gov, number NCT2100501). A seizure diary record was used to compare seizure frequencies with the baseline prediet seizure frequency at the third and sixth months after diet therapy initiation. Results Fifty-one patients were assign... περισσότερα »
Contents
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 from Neurology via xlomafota13 on Inoreader http://ift.tt/1Y49fKD via IFTTT
Biomechanics of Spine Stabilization
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 Author(s): John C. Liu from Neurology via xlomafota13 on Inoreader http://ift.tt/1QxkCKr via IFTTT
Editorial Board
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 from Neurology via xlomafota13 on Inoreader http://ift.tt/1Y49eX4 via IFTTT
World Federation of Neurosurgical Societies
Publication date: December 2015 *Source:*World Neurosurgery, Volume 84, Issue 6 from Neurology via xlomafota13 on Inoreader http://ift.tt/1QxkCua via IFTTT
Internal auditory canal meningocele-perilabyrinthine/translabyrinthine fistula: Case report and imaging
Internal auditory canal meningocele-perilabyrinthine/translabyrinthine fistula: Case report and imaging: The case of a 17-year-old patient with progressive unilateral sensorineural hearing loss and temporal bone malformations concerning for internal auditory canal meningocele with translabyrinthine/perilabyrinthine cerebrospinal fluid fistula is presented with associated computed tomography and magnetic resonance imaging. As the second reported case of an unruptured internal auditory canal meningocele with translabyrinthine/perilabyrinthine fistula, the case presents several clini... περισσότερα »
The Laryngoscope
Chronic rhinosinusitis identification in administrative databases and health surveys: A systematic review Objectives/Hypothesis Much of the epidemiological data on chronic rhinosinusitis (CRS) are based on large administrative databases and health surveys. The accuracy of CRS identification with these methods is unknown. Methods A systematic review was performed to identify studies that measured the accuracy of CRS diagnoses in large administrative databases or within health surveys. The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to assess study quality. Result... περισσότερα »
Chronic rhinosinusitis identification in administrative databases and health surveys: A systematic review
Chronic rhinosinusitis identification in administrative databases and health surveys: A systematic review: Objectives/Hypothesis Much of the epidemiological data on chronic rhinosinusitis (CRS) are based on large administrative databases and health surveys. The accuracy of CRS identification with these methods is unknown. Methods A systematic review was performed to identify studies that measured the accuracy of CRS diagnoses in large administrative databases or within health surveys. The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to assess study quality. Resu... περισσότερα »
Refinement and Assessment of New Magnetic Resonance Imaging (MRI) Technologies for Neurological Exams
Refinement and Assessment of New Magnetic Resonance Imaging (MRI) Technologies for Neurological Exams: *Condition*: Nervous System Diseases *Intervention*: Procedure: MRI *Sponsors*: University of Michigan; General Electric; Philips Medical Systems Specific Measurement Are: 1. Scan speed - is the new method as fast or faster than regular method(s) 2. Signal to noise - Subjectively, or quantitatively do we get the same, better, or new contrast compared to the regular methods(s). 3. Image contrast - Subjectively, or quantitatively do we get the same or b... περισσότερα »
The Clinical and Immunologic Effects of ALT-803 in Patients With Advanced Solid Tumors
A Phase 1 Study of the Clinical and Immunologic Effects of ALT-803 in Patients With Advanced Solid Tumors: *Condition*: Advanced Solid Tumors *Intervention*: Biological: ALT-803 *Sponsors*: Altor Bioscience Corporation; National Cancer Institute (NCI) ArmsAssigned InterventionsExperimental: ALT-803Biological: ALT-803 Intravenous infusion for dose level 1-5; subcutaneous injection for dose level 5a-8; two 6-week treatment cycles: ALT-803 on Day 1, 8, 15, 22; stable or benefitting patients may receive up to two additional 6-week cycles
Observational Study on Biomarkers in Head and Neck Cancer (HNprädBio)
Observational Study on Biomarkers in Head and Neck Cancer (HNprädBio): *Condition*: Head and Neck Cancer *Intervention*: Biological: Biomarker analyses head & neck cancer tissue, blood specimen *Sponsor*: Technische Universität Dresden Groups/CohortsAssigned InterventionsBiomarker analyses head & neck cancer tissue, blood specimen Validation of prognostic biomarkers for local tumor control in definitive and adjuvant treatment of head and neck cancer. Biological: Biomarker analyses head & neck cancer tissue, blood specimen For biomarker analyses, tumor tissues from previous bi... περισσότερα »
Angiogenic Factor Expression During Fractionated Irradiation
Angiogenic Factor Expression During Fractionated Irradiation: *Condition*: Primary Esophageal Carcinoma *Intervention*: Drug: Bevacizumab *Sponsor*: VU University Medical Center ArmsAssigned InterventionsNo Intervention: on-treatment tumor biopsie patients will undergo an pre-treatment and on-treatment tumor biopsy, to measure VEGF expression, and identify the time point of induction of VEGF expression. Experimental: bevacizumab These patients will receive bevacizumab once a week during their chemoradiation, starting at the identified time point of enhanced VEGF expression. ... περισσότερα »
Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer
Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer: *Conditions*: Advanced Cancer; Breast Cancer; Gastric Cancer; Esophageal Cancer; Colorectal Cancer *Interventions*: Drug: Pembrolizumab; Drug: Trastuzumab; Drug: ado-trastuzumab emtansine; Drug: Cetuximab *Sponsor*: Western Regional Medical Center ArmsAssigned InterventionsExperimental: Arm 1 Pembrolizumab 2mg/kg administered intravenously over 30 minutes every 3 weeks. Intravenous (i.v.) trastuzumab 6 mg/kg on day 1 every 21 days. Drug: Pembrolizumab Drug: TrastuzumabExperimental: Arm 2 Pembroliz... περισσότερα »
Comparison of 18F-AIF-NOTA-PRGD2 and 18F-FDG Uptake in Lymph Node Metastasis of Differentiated Thyroid C,18F-Al-NOTA-PRGD2 in Cancer Diagnostics
*68Ga-NOTA-PRGD2 PET/CT for Integrin Imaging in Patients with Lung Cancer* *1. Kun Zheng1, 2. Naixin Liang1, 3. Jingjing Zhang1, 4. Lixin Lang2,5. Wei Zhang1, 6. Shanqing Li1, 7. Jun Zhao1, 8. Gang Niu2, 9. Fang Li1,10. Zhaohui Zhu3 and 11. Xiaoyuan Chen4* *+**Author Affiliations* 1. *1 PUMCH, China;* 2. *2 NIH;* 3. *3 Peking Union Medical College Hospital, China;* 4. *4 National Institutes of Health, United States* 1. *For correspondence or reprints contact: Xiaoyuan Chen, National Institutes of Health, 35A Convent Dr, GD937, Bethesda, MD 20892-3759, ... περισσότερα »
AlloVax™ combines an anti-tumor effect of mini-transplant procedures with patient specific tumor antigens : Comparing AlloVax™ to Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head & Neck
Study Comparing AlloVax™ to Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head & Neck: *Condition*: Squamous Cell Carcinoma Head and Neck *Interventions*: Biological: AlloVax™; Drug: Cisplatin *Sponsor*: Immunovative Therapies, Ltd. ArmsAssigned InterventionsExperimental: Immunotherapy Subjects in this arm will receive immunotherapy (AlloVax™: CRCL + AlloStim™) twice a week for 4 weeks and then every 4 weeks for an additional 12 weeks Biological: AlloVax™ AlloVax™ combines an anti-tumor effect of mini-transplant procedures with patient specific tumor ... περισσότερα »
Thyroid hydatid cyst
: An unusual site via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 8 December 2015 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): A. El Bousaadani, R. El Mahdoufi, M. Roubal, M. Mahtar [image: Ultrasound appearance of two echo-free thyroid cysts with posterior shadow.] [image: Total thyroidectomy operative specimen with typical macroscopic appearance of ...]
Endoscopic vs. conventional septoplasty
: A review of the literature via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 8 December 2015 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): C. Champagne, S. Ballivet de Régloix, L. Genestier, A. Crambert, O. Maurin, Y. Pons The aim of this review of literature was to compare conventional and endoscopic septoplasty in terms of operating time, functional efficacy and perioperative morbidity. A systematic review of the scientific literature was performed on the PubMed database, Google and Google Schol...περισσότερα »
International Journal of Pediatric Otorhinolaryngology
Article in Press Pediatric Epidermoid Cysts Masquerading as Ranulas: A Case Series - Abstract - Full Text - Images - References - PDF (555 KB) - Download Images(.ppt)About Images & Usage - Email Article - Add to My Reading List - Export Citation - Create Citation Alert - Cited by in Scopus (0) Abhita Reddy1[image: email] , Kathryn L. Kreicher2[image: email] , Neha A. Patel[image: correspondence][image: email] , Stimson Schantz3[image: email] , Shai Shinhar4[image: email] 1Phone: 5048581114. 2Phone: 2032736539. 3Phone: 646-943-7935. 4Phone: 21251469... περισσότερα »
Benefit of contralateral hearing aid
in adult cochlear implant bearers via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 8 December 2015 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D. Bouccara, E. Blanchet, P.E. Waterlot, M. Smadja, B. Frachet, B. Meyer, O. Sterkers ObjectivesThe present study assessed the interest of a contralateral hearing aid (HA) in adult cochlear implant (CI) bearers.Material and methodsThe study recruited 10 French-speaking adult HA bearers with postlingual bilateral hearing loss, fitted for at least 2 years w...περισσότερα »
Pediatric Epidermoid Cysts Masquerading as Ranulas: A Case Series
Pediatric Epidermoid Cysts Masquerading as Ranulas: A Case Series: Pediatric neck masses represent a variety of differential diagnoses. A common pathology in pediatric cystic neck tumors include ranulas, mucus retention cysts due to salivary gland obstruction. Epidermoid cysts are lesions infrequently encountered in the pediatric population and may appear similarly to ranulas on computed tomography imaging. MRI more easily differentiates these masses, and should therefore be the preferred imaging modality. Due to their distinct intraoperative management, ranulas and epidermoid cysts...περισσότερα »
Keratitis-ichthyosis-deafness (KID) syndrome (OMIM 148210)
Phenotype in a patient with p.D50N mutation in GJB2 gene resemble both KID and Clouston syndromes: Keratitis-ichthyosis-deafness (KID) syndrome (OMIM 148210) is a rare ectodermal dysplasia syndrome characterized by vascularizing keratitis, congenital profound sensorineural hearing loss, and progressive erythrokeratoderma. We have found a 148G-A transition in the GJB2 gene, resulting in an asp50-to-asn (D50N) substitution in a girl with congenital deafness. This finding allowed us to diagnose а KID syndrome. But clinical features were uncommon because of a mild skin manifestation, la... περισσότερα »
Dystrophic calcification: A rare pediatric parotid mass
Dystrophic calcification: A rare pediatric parotid mass: Dystrophic calcification, the ectopic deposition of calcium in previously damaged or inflamed tissues, is an uncommon finding in the head and neck. Only a few cases have been reported in the parotidomasseteric region, and all of them have been located within and adjacent to the masseter. We present a case of dystrophic calcification occurring entirely within the parotid gland in a 7-year-old girl without apparent inciting inflammation, infection, or trauma. Our patient's presentation highlights the diagnostic challenge associa...περισσότερα »
American Journal of Otolaryngology
Long-term radiological findings after endonasal endoscopic approach to the skull base To study the long-term radiological findings after endonasal endoscopic approach to the skull base. Oral dyclonine hydrochloride mucilage versus tetracaine spray in electronic flexible laryngoscopy: A prospective, randomized controlled trial Topical anesthesia is important for electronic flexible laryngoscopy (EFL) utilization. We hypothesized that oral dyclonine hydrochloride mucilage (ODHM) is superior to tetracaine spray (TS) in patients undergoing EFL examination. Hearing loss patterns after coch... περισσότερα »
Isavuconazole Therapy in a Patient with Acute Invasive Fungal Rhinosinusitis and Acquired Immune Deficiency Syndrome
Successful Isavuconazole Therapy in a Patient with Acute Invasive Fungal Rhinosinusitis and Acquired Immune Deficiency Syndrome: To report a case of acute invasive Mucorales rhinosinusitis in a patient with acquired immune deficiency syndrome and diabetes mellitus. To provide a literature review on the role of isavuconazole in the management of invasive Mucorales rhinosinusitis. AbstractObjectives To report a case of acute invasive Mucorales rhinosinusitis in a patient with acquired immune deficiency syndrome and diabetes mellitus. To provide a literature review on the role of is... περισσότερα »
Long-term radiological findings after endonasal endoscopic approach to the skull base
Long-term radiological findings after endonasal endoscopic approach to the skull base: To study the long-term radiological findings after endonasal endoscopic approach to the skull base. AbstractObjective To study the long-term radiological findings after endonasal endoscopic approach to the skull base. Material and methods Prospective study that included 55 patients who underwent advance endoscopic skull base surgery. All patients were evaluated with MRI before, 3 months and 12 months after surgery. We used the Lund-Mackay staging system for chronic rhinosinusitis to evaluate the... περισσότερα »
Oral dyclonine hydrochloride mucilage versus tetracaine spray in electronic flexible laryngoscopy: A prospective, randomized controlled trial
Oral dyclonine hydrochloride mucilage versus tetracaine spray in electronic flexible laryngoscopy: A prospective, randomized controlled trial: Topical anesthesia is important for electronic flexible laryngoscopy (EFL) utilization. We hypothesized that oral dyclonine hydrochloride mucilage (ODHM) is superior to tetracaine spray (TS) in patients undergoing EFL examination. AbstractBackground Topical anesthesia is important for electronic flexible laryngoscopy (EFL) utilization. We hypothesized that oral dyclonine hydrochloride mucilage (ODHM) is superior to tetracaine spray (TS) in... περισσότερα »
Endoscopic Autologous Cartilage Injection for the Patulous Eustachian tube
Endoscopic Autologous Cartilage Injection for the Patulous Eustachian tube Abstract Patulous eustachian tube (PET) can have a significant negative impact on a patient’s quality of life. Several methods of surgical management can be an option to treat PET, and our objective is to evaluate the safety and efficacy of autologous cartilage injection in patients with PET. Thirty-three ears of twenty-five patients with chronic PET refractory to conservative treatment were enrolled to this study. Autologous tragal cartilage was harvested, and chopped into fine pieces to allow its injecti... περισσότερα »
Hearing loss patterns after cochlear implantation via the round window in an animal model
Hearing loss patterns after cochlear implantation via the round window in an animal model: The mechanism and the type of hearing loss induced by cochlear implants are mostly unknown. Therefore, this study evaluated the impact and type of hearing loss induced by each stage of cochlear implantation surgery in an animal model. *Abstract**Purpose* The mechanism and the type of hearing loss induced by cochlear implants are mostly unknown. Therefore, this study evaluated the impact and type of hearing loss induced by each stage of cochlear implantation surgery in an animal model. *Stud...περισσότερα »
Voice deepening under testosterone treatment in female-to-male gender dysphoric individuals
Voice deepening under testosterone treatment in female-to-male gender dysphoric individuals: AbstractFemale-to-male gender dysphoric individuals rarely access medical services for voice problems arising out of hormonal treatment leading to “voice reassignment”. The aim of this study was a close monitoring of voice deepening in the first year following the commencement of testosterone treatment. Voice recordings from nine female-to-male (FTM) were analyzed with Praat software and values for speaking fundamental frequency (SFF) were calculated. Audio recordings were made prior to and...περισσότερα »
Otological complications associated with hyperbaric oxygen therapy
Otological complications associated with hyperbaric oxygen therapy: AbstractThe objective of the present study was to clarify the features of otological complications for hyperbaric oxygen therapy (HBOT) and the risk factors for these complications. We enrolled 1115 patients (776 males and 339 females; age 5–89 years) who underwent HBOT. All otological symptoms experienced during HBOT sessions were evaluated, and risk factors were analysed using multivariate logistic regression analysis. Otoscopic findings and interventions for otological complications were assessed in 58 symptomat... περισσότερα »
Efficacy of Intraoperative Neuro-Monitoring to Localize the External Branch of the Superior Laryngeal Nerve
Efficacy of Intraoperative Neuro-Monitoring to Localize the External Branch of the Superior Laryngeal Nerve: Thyroid , Vol. 0, No. 0. Author information Luis-Mauricio Hurtado-López, Pastor Israel Díaz-Hernández, Erich Basurto-Kuba, Felipe Rafael Zaldívar-Ramírez, and Abraham Pulido-Cejudo Thyroid Clinic, General Surgery Service, General Hospital of Mexico, Mexico City, Mexico. Address correspondence to: *Luis-Mauricio Hurtado-López* *Thyroid Clinic* *General Hospital of Mexico* *Dr. Balmis 148* *Colonia Doctores* *Mexico City, D.F. 06720* Mexico *E-mail:* hurtado@clinicadetiroides.co... περισσότερα »
Indeterminate Single Thyroid Nodule: Synergistic Impact of Mutational Markers and Sonographic Features in Triaging Patients to Appropriate Surgery
Indeterminate Single Thyroid Nodule: Synergistic Impact of Mutational Markers and Sonographic Features in Triaging Patients to Appropriate Surgery: Thyroid , Vol. 0, No. 0. Author information Luigi De Napoli,1,* Sohail Bakkar,1,* Carlo Enrico Ambrosini,1 Gabriele MaterazziAgnese Proietti,2Elisabetta Macerola,2 Fulvio Basolo,2 and Paolo Miccoli1 1Division of Surgery; University Hospital of Pisa, Pisa, Italy. 2Division of Pathology, Department of Surgical Pathology; University Hospital of Pisa, Pisa, Italy. *These authors contributed equally to this work. Address correspondence to: *... περισσότερα »
Pancreatic trauma: The role of computed tomography for guiding therapeutic approach.
Related Articles *Pancreatic trauma: The role of computed tomography for guiding therapeutic approach.* World J Radiol. 2015 Nov 28;7(11):415-420 Authors: Moschetta M, Telegrafo M, Malagnino V, Mappa L, Ianora AA, Dabbicco D, Margari A, Angelelli G Abstract AIM: To evaluate the role of computed tomography (CT) for diagnosing traumatic injuries of the pancreas and guiding the therapeutic approach. METHODS: CT exams of 6740 patients admitted to our Emergency Department between May 2005 and January 2013 for abdominal trauma were retrospectively evaluated. Patients were identified th... περισσότερα »
Partial correlation analyses of global diffusion tensor imaging-derived metrics in glioblastoma multiforme: Pilot study.
Related Articles *Partial correlation analyses of global diffusion tensor imaging-derived metrics in glioblastoma multiforme: Pilot study.* World J Radiol. 2015 Nov 28;7(11):405-414 Authors: Cortez-Conradis D, Rios C, Moreno-Jimenez S, Roldan-Valadez E Abstract AIM: To determine existing correlates among diffusion tensor imaging (DTI)-derived metrics in healthy brains and brains with glioblastoma multiforme (GBM). METHODS: Case-control study using DTI data from brain magnetic resonance imaging of 34 controls (mean, 41.47; SD, ± 21.94 years; range, 21-80 years) and 27 patients wit... περισσότερα »
Magnetic resonance imaging in assessment of stress urinary incontinence in women: Parameters differentiating urethral hypermobility and intrinsic sphincter deficiency.
Related Articles *Magnetic resonance imaging in assessment of stress urinary incontinence in women: Parameters differentiating urethral hypermobility and intrinsic sphincter deficiency.* World J Radiol. 2015 Nov 28;7(11):394-404 Authors: Macura KJ, Thompson RE, Bluemke DA, Genadry R Abstract AIM: To define the magnetic resonance imaging (MRI) parameters differentiating urethral hypermobility (UH) and intrinsic sphincter deficiency (ISD) in women with stress urinary incontinence (SUI). METHODS: The static and dynamic MR images of 21 patients with SUI were correlated to urodynamic ... περισσότερα »
Application of positron emission tomography/computed tomography in radiation treatment planning for head and neck cancers.
Related Articles *Application of positron emission tomography/computed tomography in radiation treatment planning for head and neck cancers.* World J Radiol. 2015 Nov 28;7(11):382-393 Authors: Awan MJ, Siddiqui F, Schwartz D, Yuan J, Machtay M, Yao M Abstract 18-fluorodeoxygluocose positron emission tomography/computed tomography ((18)FDG-PET/CT) provides significant information in multiple settings in the management of head and neck cancers (HNC). This article seeks to define the additional benefit of PET/CT as related to radiation treatment planning for squamous cell carcinomas... περισσότερα »
Iliac vein compression syndrome: Clinical, imaging and pathologic findings.
Related Articles *Iliac vein compression syndrome: Clinical, imaging and pathologic findings.* World J Radiol. 2015 Nov 28;7(11):375-381 Authors: Brinegar KN, Sheth RA, Khademhosseini A, Bautista J, Oklu R Abstract May-Thurner syndrome (MTS) is the pathologic compression of the left common iliac vein by the right common iliac artery, resulting in left lower extremity pain, swelling, and deep venous thrombosis. Though this syndrome was first described in 1851, there are currently no standardized criteria to establish the diagnosis of MTS. Since MTS is treated by a wide array of s... περισσότερα »
Role of magnetic resonance imaging in the detection and characterization of solid pancreatic nodules: An update.
Related Articles *Role of magnetic resonance imaging in the detection and characterization of solid pancreatic nodules: An update.* World J Radiol. 2015 Nov 28;7(11):361-374 Authors: Ansari NA, Ramalho M, Semelka RC, Buonocore V, Gigli S, Maccioni F Abstract Pancreatic ductal adenocarcinoma is the most common malignant tumor of the pancreas. The remaining pancreatic tumors are a diverse group of pancreatic neoplasms that comprises cystic pancreatic neoplasms, endocrine tumors and other uncommon pancreatic tumors. Due to the excellent soft tissue contrast resolution, magnetic reso... περισσότερα »
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
