Objectives: In mechanical ventilation, normoventilation in terms of PCO2 can be achieved by titration of the respiratory rate and/or tidal volume. Although a linear relationship has been found between changes in respiratory rate and resulting changes in end-tidal cO2 ([DELTA]PetCO2) as well as between changes in respiratory rate and equilibration time (teq) for mechanically ventilated patients without lung injury, it is unclear whether a similar relationship holds for acute lung injury or altered hemodynamics. Design: We performed a prospective randomized controlled animal study of the change in PetCO2 with changes in respiratory rate in a lung-healthy, lung-injury, lung-healthy + altered hemodynamics, and lung-injury + altered hemodynamics pig model. Setting: University research laboratory. Subjects: Twenty mechanically ventilated pigs. Interventions: Moderate lung injury was induced by injection of oleic acid in 10 randomly assigned pigs, and after the first round of measurements, cardiac output was increased by approximately 30% by constant administration of noradrenalin in both groups. Measurements and Main Results: We systematically increased and decreased changes in respiratory rate according to a set protocol: +2, -4, +6, -8, +10, -12, +14 breaths/min and awaited equilibration of Petco2. We found a linear relationship between changes in respiratory rate and [DELTA]PetCO2 as well as between changes in respiratory rate and teq. A two-sample t test resulted in no significant differences between the lung injury and healthy control group before or after hemodynamic intervention. Furthermore, exponential extrapolation allowed prediction of the new PetCO2 equilibrium and teq after 5.7 +/- 5.6 min. Conclusions: The transition between PetCO2 equilibria after changes in respiratory rate might not be dependent on moderate lung injury or cardiac output but on the metabolic production or capacity of cO2 stores. Linear relationships previously found for lung-healthy patients and early prediction of PetCO2 equilibration could therefore also be used for the titration of respiratory rate on the PetCO2 for a wider range of pathologies by the physician or an automated ventilation system. Copyright (C) by 2015 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
from #Medicine via ola Kala on Inoreader http://ift.tt/21SX73V
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
-
▼
Δεκεμβρίου
(940)
-
▼
Δεκ 10
(49)
- Pretargeted immunoPET: Overcoming limitations of s...
- Perfusion Imaging in Clinical Practice: A Multimod...
- Pilot Comparison of 68Ga-RM2 PET and 68Ga-PSMA PET...
- A Population Based Gaussian Mixture Model Incorpor...
- Multiparametric analysis of the relationship betwe...
- The relation of neutrophil-to-lymphocyte ratio, pl...
- The Italian Diabetes and Exercise Study 2 (IDES-2)...
- Data from renewable energy assessments for resort ...
- Feedback-Related Potentials in a Gambling Task wit...
- Shotgun Analysis of Rough-Type Lipopolysaccharides...
- Development and validation of multiresidue analyti...
- Changes in Whole-Body Oxygen Consumption and Skele...
- The Equilibration of PCO2 in Pigs Is Independent o...
- Measurement of H2S in Crude Oil and Crude Oil Head...
- A Simple Flight Mill for the Study of Tethered Fli...
- Validation of a Mouse Model to Disrupt LINC Comple...
- William Shatner On Tinnitus
- Porphyra Species: A Mini-Review of Its Pharmacolog...
- Mice lack of LRG-47 display the attenuated outcome...
- Anthelmintic effects of Oroxylum indicum stem bark...
- Morphological and molecular characterization of My...
- Nanopipette-Based Electroplated Nanoelectrodes
- Sensitive Detection of Single-Nucleotide Mutation ...
- Ultrasensitive Detection of Single-Walled Carbon N...
- Best practices for assessing ocean health in multi...
- Mortality (1968-2008) in a French cohort of uraniu...
- A case-control study of mesothelioma in Minnesota ...
- The Lipidomic Analyses in Low and Highly Aggressiv...
- Preoperative versus postoperative ultrasound-guide...
- Comparison of total ankle replacement and ankle ar...
- Magnetic Graphene Nanosheet-Based Microfluidic Dev...
- IOP-details
- Full title with Editorial board members
- Instructions to Authors
- Detection of mcr-1 encoding plasmid-mediated colis...
- Colonisation with toxigenic Corynebacterium diphth...
- Authors' correction for Euro Surveill. 2015;20(45)
- Efficacy of Intensity Modulated Radiation Therapy ...
- Biomarkers in Patients With Respiratory Tract Dysp...
- Urine is a novel source of autologous mesenchymal ...
- Descending pain modulation in irritable bowel synd...
- Protocol for a systematic review of psychological ...
- Describe the outcomes of dysvascular partial foot ...
- Supporting systematic reviews using LDA-based docu...
- Repurposed therapeutic agents targeting the Ebola ...
- Biceps femoris and semitendinosus tendon/aponeuros...
- Ciliary muscle contraction force and trapezius mus...
- Immunostimulatory Activity of the Cytokine-Based B...
- OtoRhinoLaryngology & Medicine,New Articles,Decemb...
-
▼
Δεκ 10
(49)
-
▼
Δεκεμβρίου
(940)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.