Role of a brain-gut axis in energy balance [Physiology]

The starvation-inducible coactivator cAMP response element binding protein (CREB)–cAMP-regulated transcription coactivator (Crtc) has been shown to promote starvation resistance in Drosophila by up-regulating CREB target gene expression in neurons, although the underlying mechanism is unclear. We found that Crtc and its binding partner CREB enhance energy homeostasis by stimulating the...

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