An integrative database of {beta}-lactamase enzymes: sequences, structures, functions and phylogenetic trees [Epidemiology and Surveillance]

Beta-lactamase enzymes have attracted substential medical attention from researchers and clinicians because of their clinical, ecological, and evolutionary interest. Here, we present an online comprehensive database of β-lactamase enzymes. The current database is manually curated and incorporates the primary amino acid sequences, closest structural information in the external structure database (Protein Data Bank) and the functional profiles and phylogenetic trees of the four molecular classes (A, B, C, and D) of β-lactamases. The functional profiles are presented according to the minimum inhibitory concentrations and kinetic parameters that make them more useful for the investigators. Here, a total of 1,147 β-lactam resistance genes are analysed and described in the database. The latter is implemented in MySQL and the related website is developed with Zend Framework 2 on an Apache server, supporting all major web browsers. Users can easily retrieve and visualize biologically important information using a set of efficient queries from a graphical interface. This database is freely accessible at http://ifr48.timone.univ-mrs.fr/beta-lactamase/public/.

https://ift.tt/2Ir38EB