Computer-aided confocal laser endomicroscopy in inflammatory bowel disease: probing deeper into what it means

Confocal laser endomicroscopy (CLE) is an endoscopic tool that enables micron-level spatial resolution and imaging of the GI mucosa during endoscopy.1 Given the potential for in vivo assessment, this technology has the potential to improve our real-time assessment of mucosa-based disease during endoscopy.2-4 One area with emerging data regarding the use of CLE for disease-specific assessment is inflammatory bowel disease (IBD). Various studies have examined whether CLE can detect mucosal changes related to inflammation, and they have described features of inflamed mucosa such as irregular or tortuous crypts, wider lumens, and fluorescein leakage to the interstitial space.

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