Response:

We would like to thank Zhang et al1 for their interest in and comments on our study.2 Randomization based on a single sequence of random assignments is defined as a simple randomization. This technique maintains complete randomness of the assignment of a subject to a particular group. It is simple and easy to implement in clinical research. Simple randomization works well for large trials (n >100) and small to moderate clinical trials (n <100) without covariates.3 In our study, we simply aimed to compare the 2 most common methods that have been used to improve the success rate of biliary cannulation, without any covariates; therefore, we prefered to use the simple randomization method.

https://ift.tt/2IksvYC