Research design can be improved to support double-guidewire technique

We have read with great interest the article by Eminler et al1 concerning how the method of wire-guided cannulation over a pancreatic stent (WGC-PS) increases the need for needle-knife precutting (NKP) in comparison with the double-guidewire technique (DGW) in patients with difficult biliary cannulation. This is an interesting prospective randomized study; however, we believe that the research design can still be improved.

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