Comparative analyses of DHA‐phosphatidylcholine forage and liposomes on Alzheimer's disease in SAMP8 mice

Abstract

The present work was to comparatively evaluate the efficacy of docosahexaenoic acid ‐ phosphatidylcholine (DHA‐PC) forage and liposome on Alzheimer's disease (AD) in the senescence‐accelerated prone 8 (SAMP8) mice and illustrate the potential mechanism. The dose of DHA‐PC in forage group (1% of total diets) was equal to that of liposome group. The results of Morris maze test showed that both DHA‐PC forage and liposome obviously alleviated cognitive impairment (P < 0.05). Moreover, the administration of DHA‐PC liposome showed advantage than forage in reducing Aβ accumulation (P < 0.05). Meanwhile, DHA‐PC forage exhibited excellent inhibition on the IL‐1β protein expression (P < 0.05) and improvement in the protein levels of SYN and BDNF (P < 0.05). These data are the first to perform comparative analysis of DHA‐PC forage and liposome on Alzheimer's disease.

Practical Applications: The outcomes in the present study might be help to understand the bioactivities of DHA‐PC forage and liposomes, which might exert potential application value for dietary supplement with neuroprotective effects.

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