Are There Upper Limits in Tumor Burden for Down‐staging of HCC to Liver Transplant? Analysis of the All‐comers Protocol

Abstract

Patients with hepatocellular carcinoma (HCC) within University of California, San Francisco down‐staging (UCSF‐DS) criteria (1 lesion >5cm and <8cm; 2‐3 lesions each <5cm or 4‐5 lesions each <3cm with total tumor diameter <8cm) who achieved successful down‐staging (DS) to Milan criteria had similar outcomes after liver transplant (LT) compared to HCC initially meeting Milan criteria. Nevertheless, little is known about the outcome of DS in patients with initial tumor burden exceeding UCSF‐DS criteria, defined as "all‐comers" (AC). We compared the intention‐to‐treat outcomes of DS between 74 patients in the AC group and 133 patients in the UCSF‐DS group. Successful DS to Milan was observed in 64.8% of the AC group versus 84.2% of the UCSF‐DS group (p<0.001). The sum of tumor number and largest tumor diameter was significantly associated with successful DS (hazard ratio (HR) 0.87, p<0.05). The cumulative probability of dropout within 1 and 3 years was 53.5% and 80.0% for AC versus 25.0% and 36.1% for UCSF‐DS (p<0.0001). Factors predicting dropout included sum of tumor number and largest tumor diameter >8 (HR 1.79, p=0.049) and Child's Class B and C (HR 2.54, p=0.001). The AC group also had a significantly lower LT rate (13.5% vs 59.0%, p<0.001). Intention‐to‐treat survival at 1 and 5 years was 77.4% and 21.1% in AC versus 85.5% and 56.0% in UCSF‐DS (p<0.001). Three of 10 patients in the AC group who underwent LT developed HCC recurrence. Conclusion: We observed a significantly lower LT probability and inferior intention‐to‐treat survival with DS in the AC versus the UCSF‐DS group. Our results suggest that an upper limit in tumor burden exists beyond which successful LT after DS becomes an unrealistic goal.

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