Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

TGF-β signaling has an unquestionable but still controversial role in the pathogenesis of aortic aneurysm. Da Ros et al. demonstrate that disruption of TGF-β signaling in SMCs activates an autocrine IL-1β pathway that acts as a danger signal to recruit innate immune cells in the adventitia through CCL2.

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