Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity

T cell-APC interactions modulate outcomes in chronic viral infections, but the division of labor between APC subtypes is unclear. Chang et al. reveal a dichotomy in costimulatory molecule expression whereby CD80 and CD86 are expressed mainly on classical DCs, and monocyte-derived APCs provide TNF family ligands for the post-priming accumulation of CD4+ T cells.

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