Tumor Treating Fields (TTFields)—A Novel Cancer Treatment Modality: Translating Preclinical Evidence and Engineering Into a Survival Benefit with Delayed Decline in Quality of Life

Tumor treating fields (TTFields) is a novel non-ionizing radiation cancer treatment modality using a patient-operated home-use device that delivers 200 kHz alternating electrical fields to the brain. TTFields interfere with cell division and selectively disrupt mitosis by interfering with the spatial alignment of polar macromolecules within the cell. TTFields also inhibit DNA damage repair of double strand breaks. Maintenance of quality of life during therapy with TTFields was compared to standard therapy alone.

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