A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

CD8+ T cells that recognize MHC I-peptide complexes contribute to protection or pathogenesis after infection. Van Braeckel-Budimir et al. demonstrate that a germline-encoded component of the T cell receptor functions as an Immune response (Ir) gene, controlling the CD8+ T cell response against a malaria epitope and the outcome of infection.

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