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Πέμπτη 6 Αυγούστου 2020


Icariin Ameliorates Lower Back Pain in Rats via Suppressing the Secretion of Cytokine-Induced Neutrophil Chemoatractant-1
Purpose. To investigate whether icariin (ICA), a well-known medicine extracted from the stem and leaf of Epimedium brevicornum Maxim, had analgesic effect on lower back pain (LBP) in rats. Methods. In a puncture-induced LBP rat model, the severity of LBP was quantified using the paw/foot withdrawal threshold method after intragastric administration of ICA at a dosage of 50 mg/kg/d or 100 mg/kg/d. The pain-related peptides of substance P (SP) and calcitonin gene-related peptide (CGRP) were also measured...
BioMed Research International
Wed Aug 05, 2020 18:05
Study on the Diagnosis of Gastric Cancer by Magnetic Beads Extraction and Mass Spectrometry
Objective. This study constructed a model for the early diagnosis of gastric cancer by comparing the serum peptides profiles of patients with advanced gastric cancer and healthy people. And that model may be the potential to be applied for the efficacy evaluation and recurrence monitoring in gastric cancer. Methods. Serums of 30 healthy people and 30 advanced gastric cancer patients were matched by age and gender were collected. The serum peptide spectrum was obtained by MB-WCX concentration and...
BioMed Research International
Wed Aug 05, 2020 17:35
A Comparative Study on 5hmC Targeting Regulation of Neurons in AD Mice by Several Natural Compounds
A series of studies have confirmed that DNA methylation disorder (5mC/5hmC) is closely related to the occurrence and development of some diseases, such as Alzheimer’s disease (AD). This study aims at discovering natural compounds that could adjust and control 5-hydroxymethylcytosine (5hmC) levels and improve Alzheimer’s disease (AD) neuronal status. Cordycepin and cordycepic acid were selected as research materials, with resveratrol as positive control. The results of Dot Blot indicated that cordycepin,...
BioMed Research International
Wed Aug 05, 2020 13:05
Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development
Giant Cell Tumour of Bone (GCTB) is a rare bone tumour. Locally aggressive and recurrent, it might evolve into pulmonary metastases. Our present work is aimed at investigating the involvement of the epidermal growth factor receptor (ErbB) family and its downstream effectors in the development and recurrence of GCTB. For this purpose, we used a cohort of 32 GCTB patients and we evaluated the clinicohistological features and the expression of RANKL, EGFR, and HER2. The mutation status of KRAS, PI3KCA,...
BioMed Research International
Wed Aug 05, 2020 13:05
Hepatic Polarization Accelerated by Mechanical Compaction Involves HNF4α Activation
There remain few data about the role of homeostatic compaction in hepatic polarization. A previous study has found that mechanical compaction can accelerate hepatocyte polarization; however, the cellular mechanism underlying the effect is mostly unclear. Hepatocyte nuclear factor 4 alpha (HNF4α) is crucial for hepatic polarization in liver morphogenesis. Therefore, we sought to identify any possible involvement of HNF4α in the process of hepatocyte polarization accelerated by mechanical compaction....
BioMed Research International
Wed Aug 05, 2020 12:50
Influence of Implant Thread Morphology on Primary Stability: A Prospective Clinical Study
Objectives. The purpose of this study was to evaluate the primary stability of two implants with the same macro- and micromorphology but different thread design and analyze their clinical outcomes over a one-year period. Materials and Methods. 14 patients needing a partial rehabilitation with a delayed loading approach (DEL group: 9 patients) or a full-arch rehabilitation treated with immediately loaded fixed prostheses supported by 4 implants following the Columbus Bridge Protocol (CBP) (IL group:...
BioMed Research International
Wed Aug 05, 2020 12:35
Impact of Acute Pancreatic Injury on Sphingolipid Metabolism in the Salivary Glands
Acute pancreatic injury can be related to both parenchymal (responsible for exocrine functions) and islet (mainly β-cells, responsible for endocrine functions) damage. During embryonic development, both the salivary glands and the pancreas originate from the foregut, which explains many of the observed histological and functional similarities between these two organs. The relationship between several diseases of the pancreas and salivary glands, resulting from morphological and functional similarities,...
BioMed Research International
Wed Aug 05, 2020 12:35
The Impact of Comorbid Diabetes on Short-Term Postoperative Outcomes in Stage I/II Colon Cancer Patients Undergoing Open Colectomy
Purpose. This study aimed at evaluating the impact of comorbid diabetes on short-term postoperative outcomes in patients with stage I/II colon cancer after open colectomy. Methods. The data were extracted from the National Inpatient Sample database (2005-2010). Short-term surgical outcomes included in-hospital mortality, postoperative complications, and hospital length of stay. Results. A total of 49,064 stage I/II colon cancer patients undergoing open surgery were included, with a mean age of 70.35...
BioMed Research International
Wed Aug 05, 2020 12:35
Impact of Matching Point Selections on Image Registration Accuracy between Optical Scan and Computed Tomography
The point-based surface registration method involves the manual selection process of paired matching points on the data of computed tomography and optical scan. The purpose of this study was to investigate the impact of selection error and distribution of fiducial points on the accuracy of image matching between 3-dimensional (3D) images in dental planning software programs. Computed tomography and optical scan images of a partial edentulous dental arch were obtained. Image registration of the optical...
BioMed Research International
Wed Aug 05, 2020 12:20
Visual Binocular Disorders and Their Relationship with Baropodometric Parameters: A Cross-Association Study
The aim of this study was to establish a relationship between nonstrabismic binocular dysfunction and baropodometric parameters. A total of 106 participants underwent binocular vision assessment by evaluating horizontal heterophoria, horizontal and vertical fusional vergence ranges, and vergence facility. Posturography was measured using the FreeMED baropodometric platform. Among the variables that the software calculates are foot surface, foot load, and foot pressure. Our results showed that in...
BioMed Research International
Wed Aug 05, 2020 12:20
Revisiting the Warburg Effect: Diet-Based Strategies for Cancer Prevention
It is widely acknowledged that cancer cell energy metabolism relies mainly on anaerobic glycolysis; this phenomenon is described as the Warburg effect. However, whether the Warburg effect is caused by genetic dysregulation in cancer or is the cause of cancer remains unknown. The exact reasons and physiology of this abnormal metabolism are unclear; therefore, many researchers have attempted to reduce malignant cell growth in tumors in preclinical and clinical studies. Anticancer strategies based on...
BioMed Research International
Wed Aug 05, 2020 12:20
Somatom On.site Portable CT Scanner FDA Cleared
Siemens Healthineers won FDA clearance for the company’s SOMATOM On.site mobile head CT scanner. The device can be easily brought in directly into patient rooms thanks to its powered wheels and an on-board battery. Normally, patients have to be moved to the CT scanner, wherever it may be within a hospital. With the SOMATOM On.site, patients that need head scans do not have to be unnecessarily disturbed, reducing the potential for injury and further aggravation of a condition...
Medgadget
Wed Aug 05, 2020 19:59
NexStride Helps Overcome Freeze of Gait in Parkinson’s
People with Parkinson’s disease and some other neurological disorders often suffer from a condition known as freezing of gait. For poorly understood reasons, initiating a step is often a challenge. Patients report a feeling of disassociation between one’s will to move and the legs not responding accordingly. This is both frustrating and can lead to falls in many cases. With many neurological conditions, fooling the brain, by diverting attention and using other tricks, often works to...
Medgadget
Wed Aug 05, 2020 19:24
Identification of olfactory genes of a forensically important blow fly, Aldrichina grahami (Diptera: Calliphoridae)
Background The time-length between the first colonization of necrophagous insect on the corpse and the beginning of investigation represents the most important forensic concept of minimum post-mortem inference (PMImin). Before colonization, the time spent by an insect to detect and locate a corpse could significantly influence the PMImin estimation. The olfactory system plays an important role in insect food foraging behavior. Proteins like odorant binding proteins (OBPs), chemosensory proteins...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
Spatio-temporal variation of ecosystem services value in the Northern Tianshan Mountain Economic zone from 1980 to 2030
Rapid agricultural land expansion and urbanization have accelerated land use and land cover changes (LUCC) in the Northern Tianshan Mountain Economic Zone and have significantly impacted on the ecosystem services (ESs). However, the spatiotemporal variations of ecosystem service value (ESV) to LUCC are not well understood. Based on the land use and land cover (LULC) data from 1980 to 2019, we used a CA-Markov model to predict LUCC in 2020 and 2030, assess the spatial-temporal changes of ESV and LULC...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
Impact of proximal cavities and primary molar absence on space in the dental arches
Background A recently proposed treatment protocol for dental caries in primary teeth, called Ultra Conservative Treatment (UCT), keeps medium to large cavities open so that children can keep them clean with tooth brushing and fluoride toothpaste. However, carious lesions have been related to malocclusion and decrease of space for the eruption of the permanent successor. Methods This cross-sectional study evaluated dental casts of 235 schoolchildren, aged 6–7 years old of six public schools...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
Slumber in a cell: honeycomb used by honey bees for food, brood, heating… and sleeping
Sleep appears to play an important role in the lives of honey bees, but to understand how and why, it is essential to accurately identify sleep, and to know when and where it occurs. Viewing normally obscured honey bees in their nests would be necessary to calculate the total quantity and quality of sleep and sleep’s relevance to the health and dynamics of a honey bee and its colony. Western honey bees (Apis mellifera) spend much of their time inside cells, and are visible only by the tips of their...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
The brain-derived neurotrophic factor Val66Met polymorphism increases segregation of structural correlation networks in healthy adult brains
Background Although structural correlation network (SCN) analysis is an approach to evaluate brain networks, the neurobiological interpretation of SCNs is still problematic. Brain-derived neurotrophic factor (BDNF) is well-established as a representative protein related to neuronal differentiation, maturation, and survival. Since a valine-to-methionine substitution at codon 66 of the BDNF gene (BDNF Val66Met single nucleotide polymorphism (SNP)) is well-known to have effects on brain...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
A prognostic gene model of immune cell infiltration in diffuse large B-cell lymphoma
Background Immune cells in the tumor microenvironment are an important prognostic indicator in diffuse large B-cell lymphoma (DLBCL). However, information on the heterogeneity and risk stratification of these cells is limited. We sought to develop a novel immune model to evaluate the prognostic intra-tumoral immune landscape of patients with DLBCL. Methods The ESTIMATE and CIBERSORT algorithms were used to estimate the...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
Medial knee cartilage is unlikely to withstand a lifetime of running without positive adaptation: a theoretical biomechanical model of failure phenomena
Runners on average do not have a high risk of developing knee osteoarthritis, even though running places very high loads on the knee joint. Here we used gait analysis, musculoskeletal modeling, and a discrete-element model of knee contact mechanics to estimate strains of the medial knee cartilage in walking and running in 22 young adults (age 23 ± 3 years). A phenomenological model of cartilage damage, repair, and adaptation in response to these strains then estimated the failure probability of the...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
DNA barcoding of commercially important reef fishes in Weh Island, Aceh, Indonesia
Knowledge on the precise identification of fish resources is critical for sustainable fisheries management. This study employs the DNA barcoding approach to generate a molecular taxonomic catalogue of commercially important reef fishes in the waters of Weh Island (Aceh Province), the most northerly inhabited island in the biodiverse Indonesian Archipelago. The waters not only support artisanal fisheries but also a feeder for the industry in the greater island of Aceh. In total, 230 specimens from...
PeerJ Computer Science
Wed Aug 05, 2020 03:00
Potentiating anti-tumor efficacy through radiation and sustained intratumoral delivery of anti-CD40 and anti-PDL1
Publication date: Available online 5 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Hsuan-Chen Liu, Dixita I. Viswanath, Federica Pesaresi, Yitian Xu, Licheng Zhang, Nicola Di Trani, Jesus Paez-Mayorga, Nathanael Hernandez, Yu Wang, Donald R. Erm, Jeremy Ho, Antonia Susnjar, Xuewu Liu, Sandra Demaria, Shu-Hsia Chen, Bin S. Teh, Edward Brian Butler, Corrine Ying Xuan Chua, Alessandro Grattoni
Radiation Molecular Biology.
Wed Aug 05, 2020 14:05
ILROG Lymphoma Mini-Atlas Part II, Hodgkin Lymphoma
Publication date: Available online 4 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Bouthaina Shbib Dabaja, Andrea K. Ng, Stephanie A. Terezakis, John P. Plastaras, Micheal Yunes, Lynn D. Wilson, Joanna Yang, Jillian R. Gunther, Lena Specht, Joachim Yahalom
Radiation Molecular Biology.
Wed Aug 05, 2020 14:05

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