Wed Aug 05, 2020 16:49
Abstract Antihypertensive medications are commonly prescribed and well‐studied. Given the widespread use and potential side effects, various theories have been made about the relationship between antihypertensives and malignancy, including melanoma. This review describes the current understanding of the most commonly prescribed antihypertensives and their associations with melanoma. The literature demonstrates that diuretics, specifically hydrochlorothiazide and indapamide, may increase the risk...
Wed Aug 05, 2020 14:59
In this paper, we present two patients with unresectable insulinomas and a literature review. Patient 1: A 58-year-old woman was diagnosed at age 42, with an insulinoma in the pancreatic tail and hepatic metastasis. She underwent distal pancreatectomy, splenectomy, hepatic wedge resection, and chemoembolization, with resolution of her symptoms. By age 48, her symptoms returned, with new hepatic metastasis. She started long-acting octreotide, with subsequent resolution of her symptoms. She has since...
09:52
Cholangiocarcinoma is a very heterogenous cancer and “target-rich” disease. While the current classifications are based on the anatomic location of these tumors (intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer), tumors within and across these disease groups have unique and often mutually exclusive molecular aberrations. Amongst these, fibroblast growth factor receptor 2 (FGFR2) fusion is one of the first amongst the list of “actionable” targets for which the...
Wed Aug 05, 2020 14:28
Preliminary findings from Konstantina M. Stankovic, MD, PhD, director of the Division of Otology and Neurotology at Mass Eye and Ear, and Albert Edge, PhD, Principal Investigator, Eaton-Peabody Laboratories, may pave the way for trials to test bone density medications for hearing loss.Hearing loss caused by damaged nerves, whether from sound exposure or aging, is irreversible. There are currently no medications approved by the Food and Drug Administration (FDA) to treat and reverse the most common...
Wed Aug 05, 2020 15:36
Abstract Rationale Bile duct ligation (BDL) in rodents can cause impaired liver function and cognition deficits. Curcumin has shown a preventive and therapeutic role in memory impairment. Objectives Therefore, this study aimed to explore the effect of curcumin on the performance of male adult Wistar rats that underwent BDL, a model of hepatic encephalopathy...
03:00
Abstract Background Previous studies have shown that patients with schizophrenia have higher smoking rates and worse cognitive function than healthy controls. However, there is no consistent conclusion about the relationship between smoking and cognitive impairment. Objectives The main purpose of this study was to explore the effects of smoking on cognitive...
Wed Aug 05, 2020 03:00
The population genetic diversity and demographic history of the longtail tuna Thunnus tonggol in Malaysian waters was investigated using mitochondrial DNA D-loop and NADH dehydrogenase subunit 5 (ND5). A total of 203 (D-loop) and 208 (ND5) individuals of T. tonggol were sampled from 11 localities around the Malaysian coastal waters. Low genetic differentiation between populations was found, possibly due to the past demographic history, dispersal potential during egg and larval stages, seasonal migration...
03:00
Background Kawasaki disease (KD) is an acute febrile illness of early childhood. The exact etiology of the disease remains unknown. At present, research on KD is mostly limited to susceptibility genes, infections, and immunity. However, research on the correlation between gut microbiota and KD is rare. Methods Children with a diagnosis of acute KD and children undergoing physical examination during the same period were included. At the time of admission, the subjects’ peripheral venous...
03:00
Abstract Background Submental artery island flap (SIF) is a viable alternative to free flaps for selected oral‐cavity defects, however, concerns about its oncologic safety still exists. A novel harvesting technique and its outcome is described in here. Methods This is a prospective study for patients with lateralized oral tongue and/or floor of mouth (FOM) cancers who undergone reconstruction using pedicled SIF based on contralateral submental vessels (CSIF) following resection. Results...
Wed Aug 05, 2020 16:29
Abstract Background Lymphoid neoplasms in serous effusions are uncommon, and the details of lymphoid neoplasms in serous effusions from China are still unclear. Methods Between January 2004 and December 2019, all patients with lymphoid neoplasms in pleural effusions, ascites, and pericardial effusions in our hospital, were reviewed. Results A total of 65 patients with lymphoid neoplasms were collected during this period. The top three neoplasms were diffuse large B‐cell lymphoma (DLBCL)...
Wed Aug 05, 2020 18:58
Abstract Background Little is known about the diagnostic approaches for immediate hypersensitivity reactions (IHRs) due to 5‐nitroimidazole antibiotics. The aim was to evaluate the usefulness of in vivo tests and basophil activation test (BAT) for the diagnosis of IHRs due metronidazole and ornidazole and to determine possible cross reactivity in between. Methods Forty‐nine patients with a clear history of IHRs due to these drugs and 20 healthy subjects who were known to tolerate these...
Wed Aug 05, 2020 16:50
Abstract Background Gastric electrical simulation has been shown to relieve nausea and vomiting in medically refractory patients. Efficacy of gastric electrical stimulation has been reported mostly in short‐term studies, but none has evaluated its efficacy beyond 10 years after implantation. Methods Patients implanted at our center for medically refractory severe and chronic nausea and/or vomiting were evaluated before and over 10 years after implantation using symptomatic scale and quality...
Wed Aug 05, 2020 15:09
Abstract Most previous diagnostic methods for lymphedema are invasive. Laser scanning confocal microscopy (LSCM) combines laser and computer image processing technology, is capable of increasing the resolution of optical microscopy by 30–40%, and boasts a comparable resolution to that of histological examination. We constructed the rat tail lymphedema model to simulate secondary lymphedema and to validate the noninvasive technique of in vivo reflectance LSCM for the diagnosis...
03:00
Abstract The methylotrophic yeast Komagataella phaffii is among the most popular hosts for recombinant protein synthesis. Most recombinant proteins have been expressed in the wild-type Mut+ host strain from the methanol-inducible alcohol oxidase (AOX) promoter PAOX1. Since methanol metabolism has undesirable consequences, two additional host strains, Muts (Δaox1) and Mut− (Δaox1Δaox2), were introduced which consume less methanol and reportedly also express...
03:00
Abstract Bacterial cellulose (BC) is a biopolymer with a wide range of potential applications starting from the food industry and biomedicine to electronics and cosmetics. Despite that, BC industrial production to date still is associated with certain difficulties. One of them is the high cost of growth media, which can reach up to 30% of production costs. To decrease production costs, use of industrial and agricultural by-products, including whey, as...
03:00
Abstract Language deprivation syndrome (LDS) is a permanent and preventable disability affecting language, cognition, and behavior that is epidemic in the deaf population. Since 1990, systemic and technological changes in the health care of deaf children have created a new paradigm that perpetuates this crisis. Physicians and other professionals have been largely unaware of their roles in this recent epidemic. An evidenced based system of care that addresses the causes and potential...
03:00
Abstract Streptococcus parasanguinis is a primary colonizer of dental plaque and an opportunistic pathogen for subacute endocarditis. A putative fibronectin binding protein (Spaf_1409) that lacks both an N-terminal signal peptide and a C-terminal cell wall-anchoring motif was identified from the S. parasanguinis FW213 genome. Spaf_1409 was abundantly present in the cytoplasm and also was found in the cell wall preparation and culture supernatant. By using an isogenic mutant strain,...
03:00
Abstract Secondary metabolites of bacteria associated with honey bees were evaluated as part of an investigation on their potentiality for apiary health. Low molecular weight compounds released into culture filtrates by the four bacterial isolates taken from surface of healthy honey bees were analyzed using time-of-flight mass spectrometry. Only one low molecular weight compound was found in the culture filtrate of each isolate. Bacillus thuringiensis, Bifidobacterium asteroides...
Wed Aug 05, 2020 03:00
Diversity, Inclusion and Equity in the Journal of Neurosurgical Anesthesiology: A Look to the Future
No abstract available
Wed Aug 05, 2020 03:00
An ecological study using secondary open data from Japanese government statistics was conducted. The study aimed to verify differences in three measures of healthy life expectancy (HLE); namely, disability-fre...
Wed Aug 05, 2020 03:00
Skin Damage Prevention Strategies During COVID-19: Assessing Their Effect on N95 Mask Seal Integrity
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Wed Aug 05, 2020 09:54
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Deoxycholic acid (BELKYRATM, Allergan, Markham, ON, Canada) is a minimally invasive injectable treatment approved by Health Canada for the nonsurgical reduction of submental fullness. Multiple phase III clinical trials have proven the efficacy and safety of deoxycholic acid. In the clinical trials, the most common adverse events (AEs) reported, such as injection site pain, numbness, swelling, bruising and induration, were transient and mild-to-moderate...
Wed Aug 05, 2020 08:33
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Immune checkpoint inhibitors have proven to be efficacious for a broad spectrum of solid organ malignancies. These monoclonal antibodies lead to cytotoxic T-cell activation and subsequent elimination of cancer cells. However, they can also lead to immune intolerance and immune-related adverse event (irAEs) that are new and specific to these therapies. Cutaneous irAEs are the most common, arising in up to 34% of patients on PD-1 inhibitors...
Tue Aug 04, 2020 08:41
In critically ill patients, tigecycline (TGC) remains an important therapeutic option due to its efficacy against multiresistant Gram-positive and Gram-negative bacteria. TGC is metabolized and eliminated pred...
Tue Aug 04, 2020 03:00
Perianal and genital defects occur due to a vast etiology and making the reconstruction of function and aesthetics remains challenging. Depending on the extent of the defect, different techniques have been employed for coverage including skin grafts, local skin flaps, musculocutaneous flaps and pedicled perforator flaps. The pedicled vertical posteromedial thigh (vPMT) flap is a new perforator flap that has rarely been employed for this kind of reconstruction. The purpose of this article is to focus...
Wed Aug 05, 2020 03:00
Finger nail deformity is common yet current methods used to define cosmetic appearance following trauma are mainly descriptive. In order to quantify cosmetic appearance of the finger nail we developed the Oxford Finger Nail Appearance Score using a three stage iterative process. The score has five cosmetic components marked as binary outcomes composed of nail shape, nail adherence, eponychial appearance, nail surface appearance and presence of a split. In the first stage two assessors independently...
Wed Aug 05, 2020 03:00
Abstract Purpose of Review Capsaicin is a natural substance used to treat neuropathic pain because of its ability to be used in a more direct form on patients and efficiently treat their pain without the amount of side effects seen in the use of oral medications. Recent Findings Currently, the treatments for neuropathic pain are, control...
03:00
Oncogenesis, Published online: 05 August 2020; doi:10.1038/s41389-020-00255-1AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1
Wed Aug 05, 2020 03:00
Claas KirchhelleEn la Edad de Oro los hombres vivían como dioses, con el corazón libre de preocupaciones, sin fatigas ni miseria; no se cernía sobre ellos la vejez despreciable, sino que, siempre con igual vitalidad en piernas y brazos, se recreaban con fiestas, ajenos a cualquier clase de males. Morían como sumidos en un sueño…" Hesíodo. Los Trabajos y los Días. "Otra victoria como ésta y estaré vencido". Pirro de Epiro, tras su segunda y última victoria sobre los Romanos.La Edad de Oro pertenece...
01:09
Asterids comprise around 100,000 flowering plants, from heather to tomatoes. Up to now, their family relationships had not yet been fully clarified. A new study has now somewhat closed this knowledge gap. It is the world's most detailed phylogenetic analysis ever conducted for asterids.
Wed Aug 05, 2020 18:01
Biologists have sequenced the genome of the tuatara, a lizard-like creature that lives on the islands of New Zealand.
Wed Aug 05, 2020 19:40
Abstract It has been known for decades that proteins undergo conformational changes in response to binding ligands. Such changes are usually accompanied by a loss of entropy by the protein, and thus conformational changes are integral to the thermodynamics of ligand association. Methods to detect these alterations are numerous; here, we focus on the sedimentation velocity (SV) mode of AUC, which has several advantages, including ease of use and rigorous data-selection criteria....
Wed Aug 05, 2020 03:00
Publication date: Available online 5 August 2020Source: Revista de Logopedia, Foniatría y AudiologíaAuthor(s): Laura Ferinu, Nadia Ahufinger, Fernanda Pacheco-Vera, Llorenç Andreu, Mònica Sanz-Torrent
Wed Aug 05, 2020 22:31
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