Related Articles H2AX Promoter Demethylation at Specific Sites Plays a Role in STAT5-Induced Tumorigenesis. J Mammary Gland Biol Neoplasia. 2020 Aug 03;: Authors: Havusha-Laufer S, Kosenko A, Kisliouk T, Barash I Abstract Deregulated STAT5 activity in the mammary gland of transgenic mice results in parity-dependent latent tumorigenesis. The trigger for cell transformation was previously associated with hyperactivation of the H2AX proximal...
Wed Aug 05, 2020 13:42
Related Articles Towards better combination regimens of cytarabine and FLT3 inhibitors in acute myeloid leukemia. Cancer Chemother Pharmacol. 2020 Aug 03;: Authors: Elmeliegy M, Den Haese J, Talati C, Wetzler M, Jusko WJ Abstract BACKGROUND: AML patients with FLT3/ITD mutations have poor response to cytarabine-based chemotherapy. FLT3 inhibitors (FLT3i) may resensitize cells to cytarabine (CYT). Improving treatment outcome of this combination...
Wed Aug 05, 2020 13:42
Related Articles Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration. Basic Res Cardiol. 2020 Aug 03;115(5):52 Authors: Abbas N, Perbellini F, Thum T Abstract Soon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved treatment and reperfusion strategies, the uncompensated cardiomyocyte...
Wed Aug 05, 2020 13:42
Related Articles microRNA-524-5p inhibits proliferation and induces cell cycle arrest of osteosarcoma cells via targeting CDK6. Biochem Biophys Res Commun. 2020 Jul 31;: Authors: Chen H, Cheng C, Gao S Abstract BACKGROUND: Osteosarcoma (OS) is one of the most commonly diagnosed malignant tumors that mainly affects children and adolescents. The underlying molecular mechanisms that are responsible for the initiation and development of OS...
Wed Aug 05, 2020 13:42
Related Articles A combined prophylactic modality of podophyllotoxin and rutin alleviates radiation induced injuries to the lymphohematopoietic system of mice by modulating cytokines, cell cycle progression and apoptosis. Free Radic Res. 2020 Aug 03;:1-32 Authors: Verma S, Gupta ML, Kumar K Abstract The present study was conceptualized to delineate radioprotective efficacy of a formulation G-003M (a combination of podophyllotoxin and rutin)...
Wed Aug 05, 2020 13:42
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for the Treatment of Nonlesional Insular Epilepsy in Pediatric Patients: Technical Considerations. Pediatr Neurosurg. 2020 Aug 04;:1-8 Authors: Alexander H, Cobourn K, Fayed I, Oluigbo CO Abstract INTRODUCTION: The insula presents anatomic challenges to surgical exploration and intervention. Open neurosurgical intervention is associated with high rates of complications despite improved...
Wed Aug 05, 2020 13:59
Related Articles Clinical evaluation of automated quantitative MRI reports for assessment of hippocampal sclerosis. Eur Radiol. 2020 Aug 04;: Authors: Goodkin O, Pemberton HG, Vos SB, Prados F, Das RK, Moggridge J, De Blasi B, Bartlett P, Williams E, Campion T, Haider L, Pearce K, Bargallό N, Sanchez E, Bisdas S, White M, Ourselin S, Winston GP, Duncan JS, Cardoso J, Thornton JS, Yousry TA, Barkhof F Abstract OBJECTIVES: Hippocampal sclerosis...
Wed Aug 05, 2020 13:59
Related Articles Retraining and control therapy for pediatric psychogenic non-epileptic seizures. Ann Clin Transl Neurol. 2020 Aug 03;: Authors: Fobian AD, Long DM, Szaflarski JP Abstract OBJECTIVE: Our aim was to conduct a pilot randomized controlled trial of a novel cognitive behaviorally based intervention for pediatric PNES called Retraining and Control Therapy (ReACT). METHODS: Participants were randomized to receive either eight...
Wed Aug 05, 2020 13:59
Related Articles Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy. Mol Neurobiol. 2020 Aug 03;: Authors: Hossain M, Williams S, Ferguson L, Bingaman W, Ghosh A, Najm IM, Ghosh C Abstract Pharmacoresistance in epilepsy is a major challenge to successful clinical therapy. Glucocorticoid receptor (GR) dysregulation can affect the underlying disease pathogenesis....
Wed Aug 05, 2020 13:59
Related Articles Evaluation of fecal Lactobacillus populations in dogs with idiopathic epilepsy: a pilot study. Anim Microbiome. 2020;2(1): Authors: Muñana KR, Jacob ME, Callahan BJ Abstract Background: Idiopathic epilepsy is a common neurological disorder of dogs characterized by recurrent seizures for which no underlying basis is identified other than a presumed genetic predisposition. The pathogenesis of the disorder remains poorly understood,...
Wed Aug 05, 2020 13:59
Related Articles Characterising the binding and function of TARP γ8-selective AMPA receptor modulators. J Biol Chem. 2020 08 03;: Authors: Dohrke JN, Watson JF, Birchall K, Greger IH Abstract AMPA-type glutamate receptors (AMPARs) are the predominant excitatory neurotransmitter receptors in the brain, where they mediate synaptic transmission and plasticity. Excessive AMPAR activation leads to diseases such as epilepsy. AMPAR properties are modulated...
Wed Aug 05, 2020 13:59
Related Articles Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 02;58(2):124-128 Authors: Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L Abstract Introduction: Although over half of US states have legalized marijuana for medical indications, there is limited research in use in the pediatric...
Wed Aug 05, 2020 13:59
Related Articles Fifteen-minute consultation: When medicines don't work-the child with poorly controlled seizures. Arch Dis Child Educ Pract Ed. 2019 06;104(3):135-140 Authors: Harijan P, Seal AK, Prasad M, Whitehouse WP Abstract Drug-resistant epilepsy (DRE) occurs in 20%-30% of children with epilepsy with significant impact on their quality of life. Management of this group of children has greatly improved in the recent years with streamlining...
Wed Aug 05, 2020 13:59
Related Articles The role of adenosine in epilepsy. Brain Res Bull. 2019 09;151:46-54 Authors: Weltha L, Reemmer J, Boison D Abstract Adenosine is a well-characterized endogenous anticonvulsant and seizure terminator of the brain. Through a combination of adenosine receptor-dependent and -independent mechanisms, adenosine affects seizure generation (ictogenesis), as well as the development of epilepsy and its progression (epileptogenesis)....
Wed Aug 05, 2020 13:59
Related Articles The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission. Sci Rep. 2020 Aug 03;10(1):13020 Authors: Moroz LL, Romanova DY, Nikitin MA, Sohn D, Kohn AB, Neveu E, Varoqueaux F, Fasshauer D Abstract Nitric oxide (NO) is a ubiquitous gaseous messenger, but we know little about its early evolution. Here, we analyzed NO synthases (NOS) in four different...
Wed Aug 05, 2020 13:40
28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 14:45
28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 13:45
A New Multi-action Pt(IV) Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells. Angew Chem Int Ed Engl. 2020 Aug 04;: Authors: Kostrhunova H, Zajac J, Markova L, Brabec V, Kasparkova J Abstract HER2-positive breast cancer represents aggressive subtype typical of poor response to standard chemotherapy. To design an anticancer drug selective for HER2 expressing breast...
Wed Aug 05, 2020 13:56
Diagnostic meta-analysis of the Pediatric Sleep Questionnaire, OSA-18, and pulse oximetry in detecting pediatric obstructive sleep apnea syndrome. Sleep Med Rev. 2020 Jul 15;54:101355 Authors: Wu CR, Tu YK, Chuang LP, Gordon C, Chen NH, Chen PY, Hasan F, Kurniasari MD, Susanty S, Chiu HY Abstract The aim of this meta-analysis was to compare the pooled sensitivity and specificity of the Pediatric Sleep Questionnaire (PSQ), Obstructive Sleep...
Wed Aug 05, 2020 13:32
Hypoglossal Nerve Stimulator Twiddler's Syndrome. Laryngoscope. 2020 Aug 04;: Authors: Miglani A, Mecham JC, Hines JP, Hinni ML, Miller BW, Bansberg SF PMID: 32750163 [PubMed - as supplied by publisher]
Wed Aug 05, 2020 13:32
Case Report: Lateral Chest Placement of IPG for Hypoglossal Nerve Stimulator Implantation. Laryngoscope. 2020 Aug 04;: Authors: Weiner JS Abstract Hypoglossal nerve stimulation for the treatment of obstructive sleep apnea is an increasingly common procedure. The hypoglossal nerve is stimulated by an implanted pulse generator that is placed in a subcutaneous pocket in the upper chest over the pectoralis muscle. A pressure sensor is placed through...
Wed Aug 05, 2020 13:32
Related Articles The association of hypertension with obstructive sleep apnea and polysomnographic features. Anatol J Cardiol. 2020 Aug;24(2):123-124 Authors: Akyüz A PMID: 32749242 [PubMed - as supplied by publisher]
Wed Aug 05, 2020 13:32
Related Articles Validation of the GOAL Questionnaire as an Obstructive Sleep Apnea Screening Instrument in Bariatric Surgery Candidates: a Brazilian Single-Center Study. Obes Surg. 2020 Aug 04;: Authors: Duarte RLM, Magalhães-da-Silveira FJ, Gozal D Abstract OBJECTIVE: To validate the GOAL questionnaire as obstructive sleep apnea (OSA) screening tool in bariatric surgery (BS) patients and compare it with other existing instruments. ...
Wed Aug 05, 2020 13:32
Related Articles Sleep-related breathing disorders and pulmonary hypertension. Eur Respir J. 2020 Aug 03;: Authors: Adir Y, Humbert M, Chaouat A Abstract Sleep-related breathing disorders include obstructive apnoea, central apnoea and sleep-related hypoventilation. These nocturnal events have the potential to increase pulmonary arterial pressure during sleep but also in the waking state. "Pure" obstructive sleep apnoea syndrome is responsible...
Wed Aug 05, 2020 13:32
Related Articles Polycystic ovary syndrome and aging: Health implications after menopause. Maturitas. 2020 Sep;139:12-19 Authors: Helvaci N, Yildiz BO Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogenous clinical manifestations. The evidence indicates that PCOS is associated with long-term health risks including type 2 diabetes, metabolic syndrome, obstructive sleep apnea, endometrial cancer, and mood disorders....
Wed Aug 05, 2020 13:32
Related Articles Drug-Induced Sleep Endoscopy in Children With Positional Obstructive Sleep Apnea. Otolaryngol Head Neck Surg. 2020 Aug 04;:194599820941018 Authors: Kirkham EM, Melendez JB, Hoi K, Chervin RD Abstract OBJECTIVE: Positional obstructive sleep apnea (POSA)-defined as obstructive sleep apnea twice as severe supine than nonsupine-may offer clues to the underlying pattern of upper airway collapse in children. We compared drug-induced...
Wed Aug 05, 2020 13:32
Related Articles Anaplastic transformation of thyroid cancer in mesentery metastases presenting as intestinal perforation: a case report. Surg Case Rep. 2020 Aug 03;6(1):194 Authors: Hosoda K, Kusama K, Yanagisawa N, Machida T, Nishio A, Nakata S, Ito I, Watanabe M, Sodeyama H Abstract BACKGROUND: Anaplastic thyroid carcinoma is a highly aggressive form of thyroid cancer associated with a very poor prognosis. Anaplastic transformation most...
Wed Aug 05, 2020 14:16
Related Articles Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells. Am J Rhinol Allergy. 2020 Aug 03;:1945892420946968 Authors: Kwak S, Choi YS, Na HG, Bae CH, Song SY, Kim YD Abstract BACKGROUND: Glyoxal (GO), and methylglyoxal (MGO) are among the most toxic compounds emitted by electronic cigarette (E-cig) and regular tobacco cigarette smoke....
Wed Aug 05, 2020 14:25
Related Articles The Prevalence of Olfactory Dysfunction in the General Population: A Systematic Review and Meta-analysis. Am J Rhinol Allergy. 2020 Aug 03;:1945892420946254 Authors: Desiato VM, Levy DA, Byun YJ, Nguyen SA, Soler ZM, Schlosser RJ Abstract BACKGROUND: Olfactory dysfunction (OD) is common and has been reported as an early indicator of COVID-19. However, the reported prevalence of OD in the general population varies widely...
Wed Aug 05, 2020 14:25
Related Articles Outcomes in Treatment of Rhinosinusitis in the Setting of Medication Induced Immunosuppression. Am J Rhinol Allergy. 2020 Aug 03;:1945892420947932 Authors: Alapati R, Nayak JV, Hwang PH, Patel ZM Abstract BACKGROUND: There is no data currently available to direct nuanced treatment for recurrent acute and chronic rhinosinusitis (RARS, CRS) in patients on daily, long term medications that suppress the immune system. ...
Wed Aug 05, 2020 14:25
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