Organs at Risk Considerations for Thoracic Stereotactic Body Radiation Therapy: What Is Safe for Lung Parenchyma?

Data were pooled from published reports to analyze dosimetric and clinical predictors of radiation-induced lung toxicity (RILT) after thoracic stereotactic body radiotherapy. Most reviewed studies report safe treatment for mean combined lung dose ≤ 8 Gy (3-5 fractions) and percent total combined lung V20≤10-15%. Interstitial lung disease is a particular risk factor. More detailed dosimetric and endpoint reporting is needed to facilitate future development of accurate quantitative models of RILT.

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