Neulasta regimen for the hematopoietic ARS: effects beyond neutrophil recovery

This study aims to characterize the protective effects of Neulasta beyond its well-defined role of myelosuppression reversal following acute radiation exposure. Twenty male Göttingen minipigs irradiated at the LD70/45 were administered with either Neulasta or dextrose vehicle. In addition to improving survival and ameliorating neutropenia, here we report that Neulasta upregulates molecular pathways involved in cardiovascular health, prevents occurrence of endothelial dysfunction, and ameliorates endothelial barrier function.

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