Cutaneous Malignancy

The skin is responsible for protecting us from temperature extremes, ultraviolet radiation, physical injury, and infection. As such, it is a complex and rich organ composed of diverse cell types, which have differentiated from the ectoderm, mesoderm, and neural crest. Malignancies that arise in the skin may originate from keratinocytes, melanocytes, Merkel cells, endothelial cells, adnexal structures, constituents of the connective tissue stroma, and skin-resident immune cells among others. The skin is also a common site for metastasis.

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