Predictors of early recurrence prior to planned post-operative radiation therapy for oral cavity squamous cell carcinoma and outcomes following salvage intensified radiation therapy

Identification of recurrence before planned PORT in OSCC is critical to allow treatment intensification. Retrospective review was performed for 601 OSCC patients treated with PORT following curative-intent surgery. We have identified rates and risk factors of early recurrence, and predictors of outcomes following salvage therapy with higher dose PORT+/-concurrent chemotherapy. Understanding the characteristics and outcomes of this very high-risk group may allow alternate treatment strategies to be explored in the future.

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