Opioid Toxicity in Inflammatory Bowel Disease Patients Likely Includes Direct Enterocyte Effects That Exacerbate Disease

We read the article by Burr et al1 with great interest. Opioid use in patients with inflammatory bowel disease is unfortunately all too common, and it is important that the risks of opioid therapy in this population be well understood. The authors mention several possible mechanisms by which opioids may be increasing mortality, including canonical opioid toxicities (such as respiratory depression), and that opioid use may be associated with more severe disease and thus worse outcomes.

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