Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

Skeletal muscle stem cells (MuSCs) in aged animals exhibit a higher incidence of cell death via mitotic catastrophe upon activation, limiting their survival and self-renewal during muscle regeneration. MuSC mitotic catastrophe is regulated by a Notch-p53 axis. Pharmacologic enhancement of p53 levels promotes the survival of aged MuSCs.

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