3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling

Que, Zhang, and colleagues established an efficient approach to differentiate human pluripotent stem cells (hPSCs) into esophageal progenitor cells (EPCs). Combined use of hPSC-derived EPCs and mouse genetic models demonstrates the important role of BMP and NOTCH signaling in promoting squamous differentiation of EPCs.

https://ift.tt/2xCUcn2