The transcriptional landscape of radiation-treated human prostate cancer: analysis of a prospective tissue cohort

Variability in response to radiation therapy is a major issue in the treatment of localized prostate cancer, and lacks predictive molecular biomarkers. We performed quantitative transcriptional profiling on matched pre- and post-radiation biopsies from a selected prospective cohort of five patients with intermediate-risk prostate cancer treated with high-dose-rate brachytherapy. We recognised both known radiation-responsive pathways plus other more novel genes with no current association with radiation response, along with a strong network of immune-related alterations.

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