BioEssays 10∕2017

Many strains of human viruses, including HCV, HIV1, and a number of Adeno-, Pox- and Herpesviruses, including CMV, encode the substrates for mammalian prenylation enzymes. As discussed by Marakasova et al. in article number 1700014, prenylation suppression by FT/GGT and FPPS inhibitors as well as the statins has antiviral effects, which may be especially pronounced in case of African Swine Fever virus. [Image credits are to Alexandra Filatova and Dr. Mikhail Skoblov (Research Centre for Medical Genetics, Moscow)].

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