SPR741, an antibiotic adjuvant, potentiates the in vitro and in vivo activity of rifampin against clinically relevant XDR-Acinetobacter baumannii [PublishAheadOfPrint]

Acinetobacter baumannii is responsible for 10% of all nosocomial infections and has >50% mortality rates when causing ventilator-associated pneumonia. In this proof-of-concept study, we evaluated SPR741, an antibiotic adjuvant that permeabilizes the Gram-negative membrane, in combination with rifampin against AB5075, an XDR-A. baumannii strain. In standard in vitro assays and in a murine pulmonary model, we found this drug combination can significantly reduce bacterial burden and promote animal survival despite an aggressive infection.

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