Microdosimetric evaluation of current and alternative brachytherapy sources - a Geant4-DNA simulation study

Radioisotopes such as 75Se, 169Yb and 153Gd have photon energy spectra and half-lives that make them excellent candidates as alternatives to 192Ir for high dose rate brachytherapy. The aim of this study was to evaluate the relative biological effectiveness (RBE) of current (192Ir, 125I, 103Pd) and alternative (75Se, 169Yb, 153Gd) brachytherapy radionuclides using Monte Carlo (MC) simulations of lineal energy distributions.

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