Upregulation of Apoptosis Pathway Genes in Peripheral Blood Mononuclear Cells of HIV-Infected Individuals with Antiretroviral Therapy-Associated Mitochondrial Toxicity [PublishAheadOfPrint]

A case-control study of the effect of antiretroviral therapy (ART) on apoptosis pathway genes; cases (N=16, HIV-infected with mitochondrial toxicity) and controls (N=16, HIV-uninfected). 26 of 84 genes of the apoptosis pathway were differentially expressed. Two genes, DFFA and TNFRSF1A, classified 75% of study participants correctly into either cases or controls. Thus apoptosis may be in the causal pathway of ART-associated mitochondrial toxicity. These two genes could be markers for detecting and monitoring ART-induced mitochondrial toxicity.

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