Development on PEG-modified Poly (Amino Acid) Copolymeric Micelles for Delivery of Anticancer Drug

Background: Polymeric micelles can provide a valid way for cancer treatment with several benefits including high water-solubility of lipophilic drugs, low unwanted effects of cytotoxic drugs by way of reduced systemic exposure and prolonged retention time in the circulatory system. Objective: Recently, there is an increasing interest in preparing poly (ethylene glycol)-poly (amino acid) copolymeric micelles as drug delivery carriers due to their multifunctional property, easy decoration and biosafety. The copolymer contains several functional groups, which show stronger interactions with drugs or can be transferred to develop different types of the copolymers showing pH-, reduction-, thermo-sensitive, targeted or double-function properties. In addition, conjugation of drugs with these copolymers also becomes a novel modification method with the aim of higher drug loading capacity and stability. Copolymeric micelles show exciting advantages on improving a drug's water-solubility, release behavior, in vitro activity, targeted delivery pharmacokinetic property and biodistribution. In this review, we will introduce the recent development of poly(ethylene glycol)-modified poly (amino acid) copolymeric micelles as anticancer drug delivery systems containing different stimuli (such as thermo-, pH-, reduction- or special enzyme- condition) functional groups and targeting ligands to improve cellular uptake or biostablility of drug-loaded micelles. Conclusion: Poly (ethylene glycol)-poly (amino acid) copolymeric micelles provide an opportunity to realize anticancer drug delivery with environment-responsive and/or targeting property.

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