Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype

Kim and colleagues show that tissue regeneration elicits formation of tumors originating from adult stem cells. Purification of tumor cells enabled identification of oncogenic drivers, including Duxbl, that are normally expressed in early zygotes. Dux factors initiate tumorigenesis through an MET-like transition and define a broad range of human cancers.

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