Comparative study of electrical and rheological properties of different solutions used in EMR

Abstract

Background and Aim

The study of electrical and rheological properties of solutions to perform endoscopic resection procedures could determinate the best candidate. An ex vivo study with porcine stomachs was conducted to analyze electrical resistivity (R) and rheological properties (temperature, viscosity, height and lasting of the cushion) of different substances used in these techniques.

Methods

Tested solutions were: 0.9% Saline (S), platelet‐rich plasma (PRP), Gliceol^® (GC), Hyaluronic acid 2% (HA), Pluronic‐F127 20% (PL), Glucosated serum 10% (GS), Gelaspan (GP), TriBio (TB) and PRP with TB (PRP+TB). Measurements of electrical and rheological properties were done at 0, 15, 30, 45 and 60 minutes after submucosal injection

Results

Solutions showed a wide variability of trans‐epithelial R after submucosal injection. Substances able to long‐term maintain the highest R after 60 min postinjection were TB (7x10⁴ Ω), HA (7x10⁴ Ω) and PL (7x10⁴ Ω). Protective solutions against deep thermal injury (Tª lower than 60°C) were PL (47.6 °C), TB (55 °C) and HA (56.63 °C). Shortest time to perform resections were observed with GC (17.66''), PRP (20.3'') and GS (23.45''). Solutions with less cushion descrease (<25%) after 60 min were: TB (11.74%), PL (18.63%) and PRP (22.12%)

Conclusions

TB, PL and HA were the best solutions with long‐term protective effects (trans‐epithelial R, lower thermal injury and less cushion descrease). Solutions with quicker resection time were GC, PRP and GS.

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