Efficacy of Co Q10 as Supplementation for Migraine: A Meta‐Analysis

Abstract

Objectives

Migraine ranks among the most frequent neurological disorders globally. Co‐enzyme Q10 (CoQ10) is a nutritional agent that might play a preventative role in migraine. This meta‐analysis aimed to investigate the effects of CoQ10 as a supplemental agent in migraine.

Subjects and methods

Web of Science, PubMed and Cochrane Library were searched for potential articles that assessed the effects of CoQ10 on migraine. Data were extracted by two independent reviewers and analyzed with Revman 5.2 software.

Results

We included 5 studies with 346 patients (120 pediatric and 226 adult subjects) in the meta‐analysis. CoQ10 was comparable with placebo with respect to migraine attacks/month (P = 0.08) and migraine severity/day (P = 0.08). However, CoQ10 was more effective than placebo in reducing migraine days/month (P <0.00001) and migraine duration (P = 0.009).

Conclusion

This is the first study to demonstrate the effects of CoQ10 supplementation on migraine. The results support the use of CoQ10 as a potent therapeutic agent with respect to migraine duration and migraine days per month. Nonetheless, more studies are needed to support the conclusions.

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