Comprehensive genomic and transcriptomic analysis demonstrate that tumor-infiltrating T lymphocytes that react to mutated neoepitopes could be identified in recurrent ovarian cancer. Two of these T-cell populations reacted against TP53 hotspot missense mutations that are present in a wide variety of malignancies. Clin Cancer Res; 24(22); 5493–5. ©2018 AACR.
See related article by Deniger et al., p. 5562
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