The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

Migration of dendritic cells (DCs) into the lymph node (LN) initiates adaptive immunity and is thought to be solely dependent on CCR7. Sokol et al. show that in a cutaneous type 2 immune response, CCR8 synergizes with CCR7 and is necessary to promote the entry of allergen-activated DCs into the LN parenchyma, which is required for Th2 differentiation.

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