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We would like to thank Degraeuwe for his comments. We agree that the neonatal Early-Onset Sepsis (EOS) calculator was not designed to be applied to a subpopulation of infants such as those exposed to clinical chorioamnionitis. We agree that the calculator was not meant to be used as a diagnostic tool. Unfortunately, many physicians across the country are using it for this purpose, as evidenced by several published papers, quality improvement projects, and surveys of physician practice.1-4 However, even when it is applied appropriately to assess the risk of early-onset sepsis in all infants born ≥34 weeks of gestation, it still performs poorly as a screening tool for sepsis.

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