Functional Liver Imaging and Dosimetry to Predict Hepatotoxicity Risk in Cirrhotic Patients with Primary Liver Cancer

This study evaluated the ability of global liver function and functional liver dosimetry derived from pre-radiotherapy [99mTc]-sulfur colloid SPECT/CT imaging to predict hepatotoxicity in primary liver cancer patients with underlying cirrhosis treated with radiotherapy. We identified novel functional dosimetry predictors and constraints that were complementary to conventional clinical metrics and anatomic dosimetry, which has implications for improved patient risk-stratification and precision radiotherapy planning.

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